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GPRASP1 Gene

protein-coding   GIFtS: 55
GCID: GC0XP101906

G Protein-Coupled Receptor Associated Sorting Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor Associated Sorting Protein 11 2
GASP2 3 5
GASP-12 3
KIAA04433 5
GASP12
G-Protein Coupled Receptor-Associated Sorting Protein 12

External Ids:    HGNC: 248341   Entrez Gene: 97372   Ensembl: ENSG000001989327   OMIM: 3004175   UniProtKB: Q5JY773   

Export aliases for GPRASP1 gene to outside databases

Previous GC identifers: GC0XP101712 GC0XP091572


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPRASP1 Gene:
This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The
protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled
receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein
include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4
dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants
encoding the same protein have been identified. (provided by RefSeq, May 2010)

GeneCards Summary for GPRASP1 Gene:
GPRASP1 (G protein-coupled receptor associated sorting protein 1) is a protein-coding gene. An important paralog of this gene is ARMCX6.

UniProtKB/Swiss-Prot: GASP1_HUMAN, Q5JY77
Function: Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors.
Targets receptors for degradation in lysosomes via its interaction with BECN1P1/BECN2

Gene Wiki entry for GPRASP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the GPRASP1 gene promoter:
         C/EBPbeta   AML1a   Brachyury   POU3F1   Egr-1   Tal-1beta   E47   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPRASP1 promoter sequence
   Search Chromatin IP Primers for GPRASP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPRASP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

GPRASP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPRASP1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP101906:  view genomic region     (about GC identifiers)

Start:
101,906,294 bp from pter      End:
101,914,011 bp from pter
Size:
7,718 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GASP1_HUMAN, Q5JY77 (See protein sequence)
Recommended Name: G-protein coupled receptor-associated sorting protein 1  
Size: 1395 amino acids; 156865 Da
Subunit: Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine
receptor/DRD2 (By similarity), delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine
receptor/DRD4. Interacts with PER1. Interacts with BECN1P1/BECN2; the interaction is direct
Sequence caution: Sequence=BAA23715.3; Type=Erroneous initiation;
Secondary accessions: O43168 Q96LA1

Explore the universe of human proteins at neXtProt for GPRASP1: NX_Q5JY77

Explore proteomics data for GPRASP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys39
  • Modification sites at PhosphoSitePlus

  • See GPRASP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001092880.1  NP_001092881.1  NP_001171656.1  NP_055525.3  

    ENSEMBL proteins: 
     ENSP00000355146   ENSP00000393691   ENSP00000409420   ENSP00000445683  

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    antibodies-online proteins for GPRASP1 (2 products) 

     
    antibodies-online peptides for GPRASP1

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    antibodies-online kits for GPRASP1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARMC: Armadillo repeat containing

    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR006911 ARM-rpt_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q5JY77

    ProtoNet protein and cluster: Q5JY77

    1 Blocks protein domain: IPB002345 Lipocalin signature

    UniProtKB/Swiss-Prot: GASP1_HUMAN, Q5JY77
    Similarity: Belongs to the GPRASP family


    Find genes that share domains with GPRASP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GASP1_HUMAN, Q5JY77
    Function: Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors.
    Targets receptors for degradation in lysosomes via its interaction with BECN1P1/BECN2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15086532
         
    Find genes that share ontologies with GPRASP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPRASP1:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Gprasp1):
     behavior/neurological 

    Find genes that share phenotypes with GPRASP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GPRASP1: Gprasp1tm1Ics Gprasp1tm1.1Jlw

       genOway: Develop your customized and physiologically relevant rodent model for GPRASP1

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    SwitchGear 3'UTR luciferase reporter plasmidGPRASP1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GASP1_HUMAN, Q5JY77: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    endosome1
    lysosome1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with GPRASP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPRASP1
    Interactions:

        GeneGlobe Interaction Network for GPRASP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPRASP1 (Q5JY771, 2, 3 ENSP000003551464) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OPRD1P411431, 3, ENSP000002349614EBI-2514717,EBI-2624456 I2D: score=2 STRING: ENSP00000234961
    C8orf33Q9H7E92, 3MINT-65508 I2D: score=4 
    FAM203AQ9BTY72, 3MINT-65343 I2D: score=4 
    GLYATQ6IB772, 3MINT-63082 I2D: score=4 
    HMOX2P305192, 3MINT-63647 I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008333endosome to lysosome transport IMP--
    GO:1990172G-protein coupled receptor catabolic process IMP--

    Find genes that share ontologies with GPRASP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPRASP1 (GASP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPRASP1 gene (4 alternative transcripts): 
    NM_001099410.1  NM_001099411.1  NM_001184727.1  NM_014710.4  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361600 ENST00000466098 ENST00000415986(uc004eji.4) ENST00000444152(uc010nod.3)
    ENST00000537097(uc022cbc.1 uc004ejj.4)
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    hsa-miR-146a* hsa-miR-3671 hsa-miR-873 hsa-miR-3065-5p hsa-miR-888 hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidGPRASP1 3' UTR sequence
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    Selected AceView cDNA sequences (see all 206):

    BX952636 AI869048 AI816502 AL537480 AB007903 Z44856 AA622241 AV727869 
    AU151574 AU129588 BC064983 AW014017 AA282644 AA323438 CA416141 AU152883 
    AI492395 NM_014710 AK096692 AA725145 AA992143 BM727939 CD676934 BI962806 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPRASP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAAAGAAC
    GPRASP1 Expression
    About this image


    GPRASP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T-Cytotoxic Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Ovary (Reproductive System)
    GPRASP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPRASP1 Protein Expression

    UniProtKB/Swiss-Prot: GASP1_HUMAN, Q5JY77
    Tissue specificity: Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPRASP1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gprasp11 , 5 G protein-coupled receptor associated sorting protein more1, 5 74.94(n)1
    60.27(a)1
      X (57.26 cM)5
    672981  NM_001004359.21  NP_001004359.11 
     1357427335 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    22(a)
    1 → many
    1(12726364-12735694)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    24(a)
    1 → many
    5(95300984-95312074)
    zebrafish
    (Danio rerio)
    Actinopterygii ARMCX36
    armadillo repeat containing, X-linked 3
    18(a)
    1 → many
    25(19368321-19378457) ENSDARG00000062960


    ENSEMBL Gene Tree for GPRASP1 (if available)
    TreeFam Gene Tree for GPRASP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPRASP1 gene
    ARMCX62  GPRASP22  ARMCX12  ARMC102  BHLHB92  ARMCX22  ARMCX32  ARMCX52  
    1 SIMAP similar gene for GPRASP1 using alignment to 1 protein entry:     GASP1_HUMAN:
    GPRASP2

    Find genes that share paralogs with GPRASP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPRASP1 (see all 182)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898767661,2
    --101873426(+) TCAGTC/GGTTTG 3 -- us2k10--------
    rs120066341,2
    C,H--101873525(+) ATAAtG/Ctctcc 4 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs1821350531,2
    --101873549(+) TGGGTC/TAGGTT 4 -- us2k10--------
    rs1879685861,2
    --101873816(+) GATAGA/GTCTGG 4 -- us2k10--------
    rs1391302431,2
    --101874199(+) TAGCAA/GTCTTA 4 -- us2k10--------
    rs117977941,2
    C,F,H--101874263(+) ggacaT/Acttta 4 -- us2k15Minor allele frequency- A:0.00NS EA NA 422
    rs1931278071,2
    --101874652(+) CTGGCA/GGCATC 4 -- us2k10--------
    rs1132667991,2
    C--101874697(+) CTGAC-/AGGGAAA 4 -- us2k11Minor allele frequency- AG:0.00CSA 2
    rs1839932191,2
    --101874741(+) GCAATA/GCCAAC 4 -- us2k10--------
    rs1885341821,2
    C--101874796(+) AATGAC/GTCTGG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPRASP1 (101906294 - 101914011 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GPRASP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526716CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): GPRASP1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPRASP1
    DNA2.0 Custom Variant and Variant Library Synthesis for GPRASP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300417    OMIM disorders: --


    Find genes that share disorders with GPRASP1           About GenesLikeMe

    Genetic Association Database (GAD): GPRASP1
    Human Genome Epidemiology (HuGE) Navigator: GPRASP1 (2 documents)

    Export disorders for GPRASP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPRASP1 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with GPRASP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel family of G protein-coupled receptor associated sorting proteins. (PubMed id 15086532)1, 2, 3 Simonin F.... Kieffer B.L. (J. Neurochem. 2004)
    2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1997)
    3. Modulation of postendocytic sorting of G protein-coupled receptors. (PubMed id 12142540)1, 2, 9 Whistler J.L.... Von Zastrow M. (Science 2002)
    4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort. (PubMed id 19237393)1, 4 Blakey J.D.... Hall I.P. (Thorax 2009)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    7. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PubMed id 16221301)1, 3 Winter E.E. and Ponting C.P. (BMC Evol. Biol. 2005)
    8. A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). (PubMed id 15452121)1, 2 Heydorn A.... Schwartz T.W. (J. Biol. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. ARF6 and GASP-1 are post-endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine Da88 receptors mediated by GRK and PKC in transfected cells. (PubMed id 23082996)1 Cho D.I....Kim K.M. (Br. J. Pharmacol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9737 HGNC: 24834 AceView: GPRASP1andARMCX5 Ensembl:ENSG00000198932 euGenes: HUgn9737
    ECgene: GPRASP1 H-InvDB: GPRASP1

    (According to HUGE)
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    HUGE: KIAA0443

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPRASP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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