GPRASP1 Gene
protein-coding GIFtS: 53
GCID: GC0XP101906
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|
G protein-coupled receptor associated sorting protein 1
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Aliases
for GPRASP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Protein-Coupled Receptor Associated Sorting Protein 11 2 | | GASP1 2 3 5 | | GASP-12 3 | | KIAA04433 5 | | GASP12 | | G-Protein Coupled Receptor-Associated Sorting Protein 12 |
Export aliases for GPRASP1 gene to outside databasesPrevious GC identifers: GC0XP101712 GC0XP091572 |
Summaries
for GPRASP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GPRASP1:
This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The proteinmay modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targetsreceptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopaminereceptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) andcannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have beenidentified. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: GASP1_HUMAN, Q5JY77Function: May modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors.Targets receptors for degradation in lysosomes
Gene Wiki entry for GPRASP1
|
Genomic Views
for GPRASP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPRASP1 gene promoter:
C/EBPbeta AML1a Brachyury POU3F1 Egr-1 Tal-1beta E47 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPRASP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPRASP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22.1GPRASP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP101906: view genomic region
(about GC identifiers)
Start:
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101,906,294 bp from pter |
End:
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101,914,011 bp from pter |
Size:
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7,718 bases |
Orientation:
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plus strand |
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Proteins
for GPRASP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GASP1_HUMAN, Q5JY77 (See
protein sequence)Recommended Name: G-protein coupled receptor-associated sorting protein 1 Size: 1395 amino acids; 156865 Da
Subunit: Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2(By similarity), delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4.Interacts with PER1
Subcellular location: Cytoplasm
Sequence caution: Sequence=BAA23715.3; Type=Erroneous initiation;
Secondary accessions: O43168 Q96LA1Explore the universe of human proteins at neXtProt for GPRASP1: NX_Q5JY77
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5JY77
GPRASP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001092880.1 NP_001092881.1 NP_001171656.1 NP_055525.3
ENSEMBL proteins: ENSP00000355146 ENSP00000393691 ENSP00000409420 ENSP00000445683
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
GPRASP1 for ontologies About GeneDecksing
GPRASP1 Antibody Products:
Assay Products for GPRASP1: |
Protein
Domains /
Families
for GPRASP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPRASP1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5JY77ProtoNet protein and cluster: Q5JY77 1 Blocks protein family: IPB002345 Lipocalin signature
UniProtKB/Swiss-Prot: GASP1_HUMAN, Q5JY77Similarity: Belongs to the GPRASP family |
Function
for GPRASP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GASP1_HUMAN, Q5JY77Function: May modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors.Targets receptors for degradation in lysosomes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPRASP1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPRASP1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPRASP1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
GPRASP1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for GPRASP1:
Animal Models:
Mouse knock-outs for GPRASP1: Gprasp1tm1Ics Gprasp1tm1.1Jlw
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Gprasp1):
GPRASP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GPRASP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPRASP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/60 Interacting proteins for GPRASP1 (Q5JY771, 2, 3 ENSP000003551464) via UniProtKB, MINT, STRING, and/or I2D (see all 60)About this table
|
Drugs & Compounds
for GPRASP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GPRASP1
Search CenterWatch for drugs/clinical trials and news about GPRASP1 / GASP1
|
Transcripts
for GPRASP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPRASP1 gene (4 alternative transcripts): NM_001099410.1 NM_001099411.1 NM_001184727.1 NM_014710.4 Unigene Cluster for GPRASP1: G protein-coupled receptor associated sorting protein 1 Hs.729265 [show with all ESTs]Unigene Representative Sequence: NM_0011847275 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361600 ENST00000466098 ENST00000415986(uc004eji.4) ENST00000444152(uc010nod.3)
ENST00000537097(uc022cbc.1 uc004ejj.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPRASP1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPRASP1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): GPRASP1 (NM_014710) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPRASP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPRASP1 |
Additional cDNA sequence: AB007903.2 AY044233.1 BC114552.1 14 DOTS entries: DT.443405 DT.95265570 DT.97773899 DT.121305769 DT.121305794 DT.97845888 DT.100027519 DT.100821797 DT.121305856 DT.95262583 DT.100821796 DT.121305738 DT.441264 DT.95327779 24/206 AceView cDNA sequences (see all 206): CA416141 AI816502 BU622642 AA323438 AU129588 BI962806 BC047679 BQ012171 AW293629 BC000792 AA558940 AU151574 BX489726 AA992143 AA622241 T17057 AU152883 AA282644 BM727939 AK023031 AK096692 AI815557 BC064983 AI498726
GeneLoc Exon Structure
|
Expression
for GPRASP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPRASP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAAAAGAAC
About this image
See GPRASP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPRASP1
SOURCE GeneReport for Unigene cluster: Hs.729265
UniProtKB/Swiss-Prot: GASP1_HUMAN, Q5JY77Tissue specificity: Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra
SABiosciences Custom PCR Arrays for GPRASP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPRASP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPRASP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPRASP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPRASP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPRASP1 |
Orthologs
for GPRASP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GPRASP1 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ARMC106 |
Uncharacterized protein |
21(a) |
1 → many |
1(13884450-13891606) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
27(a) |
1 → many |
5(95306234-95312068) |
zebrafish
(Danio rerio) |
Actinopterygii |
CR391963.36 |
-- |
15(a) |
1 → many |
25(19368324-19378456) |
ENSEMBL Gene Tree for GPRASP1 (if available)
TreeFam Gene Tree for GPRASP1 (if available) |
Paralogs
for GPRASP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GPRASP1 gene
- ARMCX42 GPRASP22 ARMCX12 BHLHB92 ARMCX22 ARMCX52 ARMCX62 ARMC102
- ARMCX32
1 SIMAP similar gene for GPRASP1 using alignment to 1 protein entry: GASP1_HUMAN:GPRASP2
GPRASP1 for paralogs About GeneDecksing
|
Genomic Variants
for GPRASP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPRASP1 (101906294 - 101914011 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GPRASP1: --
Locus Specific Mutation Databases (LSDB): GPRASP1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPRASP1 |
|
Disorders
/ Diseases
for GPRASP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPRASP1 for disorders About GeneDecksing
OMIM gene information: 300417
OMIM disorders: --
5  diseases for GPRASP1: About MalaCardsanorexia nervosa macular degeneration asthma breast cancer
ataxia
Human Genome Epidemiology (HuGE) Navigator: GPRASP1 (2 documents)
Export disorders for GPRASP1 gene to outside databases
|
Publications
for GPRASP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPRASP1 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with GPRASP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel family of G protein-coupled receptor associated sorting proteins. (PubMed id 15086532)1, 2, 3 Simonin F....Kieffer B.L. (2004)
- Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
- Modulation of postendocytic sorting of G protein-coupled receptors. (PubMed id 12142540)1, 2, 9 Whistler J.L.... Von Zastrow M. (2002)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). (PubMed id 15452121)1, 2 Heydorn A.... Schwartz T.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker. (PubMed id 22483848)1 Zheng X....Tuszynski G.P. (2012)
- Strength training with blood flow restriction diminish es myostatin gene expression. (PubMed id 21900845)1 Laurentino G.C....Tricoli V. (2012)
- The GPCR-associated sorting protein 1 regulates ligand -induced down-regulation of GPR55. (PubMed id 21718301)1 Kargl J....Waldhoer M. (2012)
- G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer. (PubMed id 21791203)1 Tuszynski G.P....Chang F. (2011)
|
External Searches for GPRASP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPRASP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPRASP1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing GPRASP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPRASP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GPRASP1 gene:
Search GeneIP for patents involving GPRASP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPRASP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPRASP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPRASP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPRASP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPRASP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPRASP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPRASP1 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPRASP1 |
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