Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPRASP1 Gene

Aliases for GPRASP1 Gene

  • G Protein-Coupled Receptor Associated Sorting Protein 1 2 3 5
  • GASP-1 3 4
  • GASP 3 4
  • KIAA0443 4
  • GASP1 3

External Ids for GPRASP1 Gene

Previous GeneCards Identifiers for GPRASP1 Gene

  • GC0XP101712
  • GC0XP101906
  • GC0XP091572

Summaries for GPRASP1 Gene

Entrez Gene Summary for GPRASP1 Gene

  • This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]

GeneCards Summary for GPRASP1 Gene

GPRASP1 (G Protein-Coupled Receptor Associated Sorting Protein 1) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is ARMCX6.

UniProtKB/Swiss-Prot for GPRASP1 Gene

  • Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.

Gene Wiki entry for GPRASP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRASP1 Gene

Genomics for GPRASP1 Gene

Regulatory Elements for GPRASP1 Gene

Promoters for GPRASP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPRASP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPRASP1 Gene

Chromosome:
X
Start:
102,651,366 bp from pter
End:
102,659,083 bp from pter
Size:
7,718 bases
Orientation:
Plus strand

Genomic View for GPRASP1 Gene

Genes around GPRASP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRASP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRASP1 Gene

Proteins for GPRASP1 Gene

  • Protein details for GPRASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JY77-GASP1_HUMAN
    Recommended name:
    G-protein coupled receptor-associated sorting protein 1
    Protein Accession:
    Q5JY77
    Secondary Accessions:
    • O43168
    • Q96LA1

    Protein attributes for GPRASP1 Gene

    Size:
    1395 amino acids
    Molecular mass:
    156865 Da
    Quaternary structure:
    • Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2 (By similarity), delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1. Interacts with BECN2; the interaction is direct.
    SequenceCaution:
    • Sequence=BAA23715.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPRASP1 Gene

Proteomics data for GPRASP1 Gene at MOPED

Post-translational modifications for GPRASP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPRASP1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GPRASP1

No data available for DME Specific Peptides for GPRASP1 Gene

Domains & Families for GPRASP1 Gene

Gene Families for GPRASP1 Gene

Protein Domains for GPRASP1 Gene

Suggested Antigen Peptide Sequences for GPRASP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JY77

UniProtKB/Swiss-Prot:

GASP1_HUMAN :
  • Belongs to the GPRASP family.
Family:
  • Belongs to the GPRASP family.
genes like me logo Genes that share domains with GPRASP1: view

Function for GPRASP1 Gene

Molecular function for GPRASP1 Gene

UniProtKB/Swiss-Prot Function:
Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.

Phenotypes for GPRASP1 Gene

genes like me logo Genes that share phenotypes with GPRASP1: view

Animal Models for GPRASP1 Gene

MGI Knock Outs for GPRASP1:

Animal Model Products

CRISPR Products

miRNA for GPRASP1 Gene

miRTarBase miRNAs that target GPRASP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPRASP1 Gene

Localization for GPRASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRASP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPRASP1 Gene COMPARTMENTS Subcellular localization image for GPRASP1 gene
Compartment Confidence
nucleus 4
cytosol 2
endosome 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for GPRASP1 Gene

Pathways & Interactions for GPRASP1 Gene

SuperPathways for GPRASP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPRASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990172 G-protein coupled receptor catabolic process IPI 23954414
genes like me logo Genes that share ontologies with GPRASP1: view

No data available for Pathways by source and SIGNOR curated interactions for GPRASP1 Gene

Drugs & Compounds for GPRASP1 Gene

No Compound Related Data Available

Transcripts for GPRASP1 Gene

Unigene Clusters for GPRASP1 Gene

G protein-coupled receptor associated sorting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPRASP1 Gene

No ASD Table

Relevant External Links for GPRASP1 Gene

GeneLoc Exon Structure for
GPRASP1
ECgene alternative splicing isoforms for
GPRASP1

Expression for GPRASP1 Gene

mRNA expression in normal human tissues for GPRASP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPRASP1 Gene

This gene is overexpressed in Pancreatic juice (43.6), Retina (15.9), and Brain (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPRASP1 Gene



SOURCE GeneReport for Unigene cluster for GPRASP1 Gene Hs.729265

mRNA Expression by UniProt/SwissProt for GPRASP1 Gene

Q5JY77-GASP1_HUMAN
Tissue specificity: Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.
genes like me logo Genes that share expression patterns with GPRASP1: view

Protein tissue co-expression partners for GPRASP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GPRASP1 Gene

Orthologs for GPRASP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRASP1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GPRASP1 35
  • 81.1 (n)
  • 69.28 (a)
GPRASP1 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gprasp1 35
  • 74.94 (n)
  • 60.27 (a)
Gprasp1 16
Gprasp1 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPRASP1 35
  • 96.13 (n)
  • 94.04 (a)
GPRASP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gprasp1 35
  • 74.77 (n)
  • 59.79 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ARMCX3 36
  • 18 (a)
OneToMany
Species with no ortholog for GPRASP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRASP1 Gene

ENSEMBL:
Gene Tree for GPRASP1 (if available)
TreeFam:
Gene Tree for GPRASP1 (if available)

Paralogs for GPRASP1 Gene

Paralogs for GPRASP1 Gene

(1) SIMAP similar genes for GPRASP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPRASP1: view

Variants for GPRASP1 Gene

Sequence variations from dbSNP and Humsavar for GPRASP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_026579 -
VAR_049263 -
VAR_049264 -

Structural Variations from Database of Genomic Variants (DGV) for GPRASP1 Gene

Variant ID Type Subtype PubMed ID
nsv526716 CNV Gain 19592680

Variation tolerance for GPRASP1 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.51; 71.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPRASP1 Gene

HapMap Linkage Disequilibrium report
GPRASP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRASP1 Gene

Disorders for GPRASP1 Gene

Relevant External Links for GPRASP1

Genetic Association Database (GAD)
GPRASP1
Human Genome Epidemiology (HuGE) Navigator
GPRASP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPRASP1

No disorders were found for GPRASP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRASP1 Gene

Publications for GPRASP1 Gene

  1. Identification of a novel family of G protein-coupled receptor associated sorting proteins. (PMID: 15086532) Simonin F. … Kieffer B.L. (J. Neurochem. 2004) 2 3 4 67
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  3. Modulation of postendocytic sorting of G protein-coupled receptors. (PMID: 12142540) Whistler J.L. … Von Zastrow M. (Science 2002) 3 23
  4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for GPRASP1 Gene

Sources for GPRASP1 Gene

Back to Top

Content