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Aliases for GPRASP1 Gene

Aliases for GPRASP1 Gene

  • G Protein-Coupled Receptor Associated Sorting Protein 1 2 3
  • GASP 3 4 6
  • KIAA0443 4 6
  • GASP-1 3 4
  • G-Protein Coupled Receptor-Associated Sorting Protein 1 3
  • GASP1 3

External Ids for GPRASP1 Gene

Previous GeneCards Identifiers for GPRASP1 Gene

  • GC0XP101712
  • GC0XP101906
  • GC0XP091572

Summaries for GPRASP1 Gene

Entrez Gene Summary for GPRASP1 Gene

  • This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]

GeneCards Summary for GPRASP1 Gene

GPRASP1 (G Protein-Coupled Receptor Associated Sorting Protein 1) is a Protein Coding gene. An important paralog of this gene is ARMCX6.

UniProtKB/Swiss-Prot for GPRASP1 Gene

  • Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.

Gene Wiki entry for GPRASP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRASP1 Gene

Genomics for GPRASP1 Gene

Regulatory Elements for GPRASP1 Gene

Genomic Location for GPRASP1 Gene

Start:
102,651,366 bp from pter
End:
102,659,083 bp from pter
Size:
7,718 bases
Orientation:
Plus strand

Genomic View for GPRASP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPRASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRASP1 Gene

Proteins for GPRASP1 Gene

  • Protein details for GPRASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JY77-GASP1_HUMAN
    Recommended name:
    G-protein coupled receptor-associated sorting protein 1
    Protein Accession:
    Q5JY77
    Secondary Accessions:
    • O43168
    • Q96LA1

    Protein attributes for GPRASP1 Gene

    Size:
    1395 amino acids
    Molecular mass:
    156865 Da
    Quaternary structure:
    • Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2 (By similarity), delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1. Interacts with BECN2; the interaction is direct.
    SequenceCaution:
    • Sequence=BAA23715.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPRASP1 Gene

Proteomics data for GPRASP1 Gene at MOPED

Post-translational modifications for GPRASP1 Gene

  • Ubiquitination at Lys39
  • Modification sites at PhosphoSitePlus

Other Protein References for GPRASP1 Gene

No data available for DME Specific Peptides for GPRASP1 Gene

Domains for GPRASP1 Gene

Gene Families for GPRASP1 Gene

HGNC:
  • ARMC :Armadillo repeat containing

Protein Domains for GPRASP1 Gene

Suggested Antigen Peptide Sequences for GPRASP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JY77

UniProtKB/Swiss-Prot:

GASP1_HUMAN :
  • Q5JY77
Family:
  • Belongs to the GPRASP family.
genes like me logo Genes that share domains with GPRASP1: view

Function for GPRASP1 Gene

Molecular function for GPRASP1 Gene

UniProtKB/Swiss-Prot Function: Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.

Gene Ontology (GO) - Molecular Function for GPRASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 15086532
genes like me logo Genes that share ontologies with GPRASP1: view

Phenotypes for GPRASP1 Gene

MGI mutant phenotypes for GPRASP1:
inferred from 2 alleles
GenomeRNAi human phenotypes for GPRASP1:
genes like me logo Genes that share phenotypes with GPRASP1: view

Animal Models for GPRASP1 Gene

MGI Knock Outs for GPRASP1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GPRASP1 Gene

Localization for GPRASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRASP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPRASP1 Gene COMPARTMENTS Subcellular localization image for GPRASP1 gene
Compartment Confidence
nucleus 3
cytosol 2
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GPRASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GPRASP1: view

Pathways for GPRASP1 Gene

SuperPathways for GPRASP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPRASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008333 endosome to lysosome transport IMP 23954414
GO:1990172 G-protein coupled receptor catabolic process IPI 23954414
genes like me logo Genes that share ontologies with GPRASP1: view

No data available for Pathways by source for GPRASP1 Gene

Transcripts for GPRASP1 Gene

Unigene Clusters for GPRASP1 Gene

G protein-coupled receptor associated sorting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPRASP1 Gene

No ASD Table

Relevant External Links for GPRASP1 Gene

GeneLoc Exon Structure for
GPRASP1
ECgene alternative splicing isoforms for
GPRASP1

Expression for GPRASP1 Gene

mRNA expression in normal human tissues for GPRASP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPRASP1 Gene

SOURCE GeneReport for Unigene cluster for GPRASP1 Gene Hs.729265

mRNA Expression by UniProt/SwissProt for GPRASP1 Gene

Q5JY77-GASP1_HUMAN
Tissue specificity: Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.
genes like me logo Genes that share expressions with GPRASP1: view

No data available for mRNA differential expression in normal tissues for GPRASP1 Gene

Orthologs for GPRASP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRASP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPRASP1 35
  • 96.13 (n)
  • 94.04 (a)
GPRASP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GPRASP1 35
  • 81.1 (n)
  • 69.28 (a)
GPRASP1 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gprasp1 35
  • 74.94 (n)
  • 60.27 (a)
Gprasp1 16
Gprasp1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gprasp1 35
  • 74.77 (n)
  • 59.79 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ARMCX3 36
  • 18 (a)
OneToMany
Species with no ortholog for GPRASP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRASP1 Gene

ENSEMBL:
Gene Tree for GPRASP1 (if available)
TreeFam:
Gene Tree for GPRASP1 (if available)

Paralogs for GPRASP1 Gene

Paralogs for GPRASP1 Gene

Selected SIMAP similar genes for GPRASP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPRASP1: view

Variants for GPRASP1 Gene

Sequence variations from dbSNP and Humsavar for GPRASP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_026579 -
VAR_049263 -
VAR_049264 -

Structural Variations from Database of Genomic Variants (DGV) for GPRASP1 Gene

Variant ID Type Subtype PubMed ID
nsv526716 CNV Gain 19592680

Relevant External Links for GPRASP1 Gene

HapMap Linkage Disequilibrium report
GPRASP1
Locus Specific Mutation Databases (LSDB)
GPRASP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRASP1 Gene

Disorders for GPRASP1 Gene

Relevant External Links for GPRASP1

Genetic Association Database (GAD)
GPRASP1
Human Genome Epidemiology (HuGE) Navigator
GPRASP1
genes like me logo Genes that share disorders with GPRASP1: view

No data available for UniProtKB/Swiss-Prot for GPRASP1 Gene

Publications for GPRASP1 Gene

  1. Modulation of postendocytic sorting of G protein-coupled receptors. (PMID: 12142540) Whistler J.L. … Von Zastrow M. (Science 2002) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4
  3. Identification of a novel family of G protein-coupled receptor associated sorting proteins. (PMID: 15086532) Simonin F. … Kieffer B.L. (J. Neurochem. 2004) 2 3 4
  4. Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort. (PMID: 19237393) Blakey J.D. … Hall I.P. (Thorax 2009) 3 48
  5. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. (PMID: 23954414) He C. … Levine B. (Cell 2013) 3 4

Products for GPRASP1 Gene

Sources for GPRASP1 Gene

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