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LPAR5 Gene

protein-coding   GIFtS: 46

GC12M006599
lysophosphatidic acid receptor 5
(Previous name: G protein-coupled receptor 92 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: GPR93, GPR92)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
GPR92 2, 3, 5
GPR93 2, 3, 5
KPG_010 1, 2
LPA-5 3
LPA5 1, 2, 5
Descriptions
G protein-coupled receptor 92 1, 2
G-protein coupled receptor 92 3
G-protein coupled receptor 93 2, 3
LPA receptor 5 3
lysophosphatidic acid receptor 5 2
External Ids
HGNC: 133071
Entrez Gene: 571212
UniProtKB: Q9H1C03
Ensembl: ENSG000001845747
Search outside databases for aliases for LPAR5 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LPAR5:
This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors.
This protein transmits extracellular signals from lysophosphatidic acid to cells through
heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve
as targets for pharmaceutical drugs. Transcript variants of this gene have been
described.[provided by RefSeq]

UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities

Gene Wiki entry for LPAR5 (GPR92)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

LPAR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006599:     (about GC identifiers)

Start:
6,598,262 bp from pter
End:
6,615,548 bp from pter
Size:
17,287 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000012.10  NT_009759.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0 (See protein sequence)
Recommended Name: Lysophosphatidic acid receptor 5  
Size: 372 amino acids; 41347 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

REFSEQ proteins (2 alternative transcripts): 
NP_001136433.1  NP_065133.1  


ENSEMBL proteins: 
ENSP00000327875 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (GPCR GPR92)
Human Recombinant Proteins from Abnova (GPR92)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005575 cellular_component ND--
GO:0005886 plasma membrane IEA--
GO:0016021 integral to membrane IEA--
About this table

Antibodies for LPAR5: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for LPAR5
Browse R&D Systems for Antibodies
Antibodies from Abcam (GPCR GPR92), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Novus Biologicals Antibody for LPAR5

Assays for LPAR5: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_supfam
 IPR000276 7TM_GPCR_Rhodpsn
 IPR002286 P2_purnocptor


   GeneDecks  LPAR5 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9H1C0

ProtoNet protein and cluster: Q9H1C0

UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0
Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (LPAR5)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (GPR92)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020400

              Applied Biosystems Silencer® siRNAs for LPAR5

              Sigma-Aldrich siRNA and siRNA Panels for LPAR5  
                     Sigma-Aldrich shRNA Panels and shRNA for LPAR5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for LPAR5
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142961
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142961
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001142961 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001142961

UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003674 molecular_function ND--
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity IEA--
GO:0045028 purinergic nucleotide receptor activity, G-protein coupled IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



3 Interacting proteins for LPAR5 (ENSP000003278753) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
LPAR1ENSP000003635533STRING (score=.77)
S1PR1ENSP000003054163STRING (score=.753)
S1PR5ENSP000003284723STRING (score=.75)
About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007165 signal transduction IEA--
GO:0007186 G-protein coupled receptor protein signaling pathway IEA--
GO:0008150 biological_process ND--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LPAR5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (LPAR5)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (GPR92)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020400

              Sigma-Aldrich siRNA and siRNA Panels for LPAR5  
                     Sigma-Aldrich shRNA Panels and shRNA for LPAR5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001142961  NM_020400  

REFSEQ mRNAs for LPAR5 gene (2 alternative transcripts): 

NM_001142961.1   NM_020400.5   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001142961  NM_020400  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142961
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142961
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001142961 

Additional cDNA sequence: 

AB041943.1 AJ272207.1 AK313127.1 BC033571.2 BC072394.1 

4 DOTS entries:

DT.431181  DT.121122091  DT.100758350  DT.91755582 

24/139 AceView cDNA sequences (see all 139 ):

BI520382 BM560468 BC072394 BI825892 AI024421 NM_020400 NM_032489 BC033010 
AF085884 BM553910 BI832341 BI828527 BI829134 BI830966 AJ272207 H91857 
BI828365 BI829508 BI520377 BI830306 BI826973 BM553134 BI829361 BI828510 

Unigene Cluster for LPAR5:

Lysophosphatidic acid receptor 5
Hs.155538  [show with all ESTs]
Unigene Representative Sequence: BC072394


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000329858  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LPAR5 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for LPAR5

1 / 2

6 probe-sets matching LPAR5 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
61975_at2 U95-C 1 1.00 1.00 0.93 0.59 -- -- -- -- --
90985_at2 U95-D 1 1.00 1.00 0.84 1.46 -- -- -- -- --

231788_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

230252_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

231788_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

230252_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  LPAR5 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TCTAACTTCT

SOURCE GeneReport for Unigene cluster: Hs.155538

UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0
Tissue specificity: Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or
hippocampus

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for LPAR5 gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LPAR51   -- lysophosphatidic acid receptor 5 86.26(n)
81.59(a)
486724  XM_543851.1  XP_543851.1 
chimpanzee
(Pan troglodytes)
LPAR51   -- lysophosphatidic acid receptor 5 98.75(n)
99.19(a)
747759  XM_001162521.1  XP_001162521.1 
rat
(Rattus norvegicus)
Lpar51   -- lysophosphatidic acid receptor 5 81.24(n)
80.33(a)
500317  XM_575667.2  XP_575667.1 
mouse
(Mus musculus)
Lpar51, 5 65
lysophosphatidic acid receptor 51, 5 80.78(n)1
81.42(a)1
3818101  XM_355812.41  XP_355812.21 
 AK1318635  AY2556215  (see all 7)
chicken
(Gallus gallus)
GPR921   -- G protein-coupled receptor 92 57.84(n)
54.17(a)
418279  XM_416504.2  XP_416504.2 
About this table        Species with no ortholog for LPAR5

ENSEMBL Gene Tree for LPAR5
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for LPAR5 gene
LPAR42  P2RY52  GPR1742  P2RY102  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/84 NCBI SNPs in LPAR5 are shown (see all 84 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 20)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs10570691,2
C,H6598567(-) acacaT/Gtacat 2 -- ut31 ese35Minor allele frequency- G:0.00MN EU EA WA 596
--
rs116121,2
F6598426(+) TCCACG/AAGGTC 2 -- ut311Minor allele frequency- A:0.22MN 184
--
rs110642891,2
C6598010(+) CCAGCA/GTGCTG 1 -- ng510--------
--
rs21418791,2
C6616884(+) aaaatA/Ttaaaa 1 -- ng310--------
--
rs72989891,2
C6615428(+) CTCCCA/GGGGCG 1 -- ut51 ese30--------
--
rs21418801,2
C6616901(+) caggcG/Ttagtg 1 -- ng310--------
rs37419241,2
C6600217(+) GGCACG/AGCAAA 2 A/A syn1 ese32Minor allele frequency- A:0.03EA NA 1558
rs64897261,2
A,C,F,H6612248(+) AGGGTA/GGGCGG 1 -- int17Minor allele frequency- G:0.27NA EU EA WA 522
rs43769591,2
A,C,F,H6612077(+) CTCAGT/CCCAAA 1 -- int18Minor allele frequency- C:0.24EU EA WA 834
--
rs28862711,2
C,F,H6604574(+) TAggcC/Tgggcg 1 -- int14Minor allele frequency- T:0.18EU EA WA 420
About this table

HapMap Linkage Disequilibrium images for LPAR5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606926

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

9 PubMed articles for LPAR5 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57121 HGNC: 13307 AceView: GPR92andACRBP Ensembl:ENSG00000184574 euGenes: HUgn57121
ECgene: LPAR5 H-InvDB: LPAR5
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for LPAR5:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for LPAR5 Antibodies for LPAR5
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for LPAR5 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(GPCR GPR92)
 Antibodies (GPCR GPR92)
 Search OriGene for LPAR5
 Search Tocris compounds for LPAR5




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for LPAR5

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