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Aliases & Descriptions for LPAR5
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases GPR92 2 , 3 , 5 GPR93 2 , 3 , 5 KPG_010 1 , 2 LPA-5 3 LPA5 1 , 2 , 5
Descriptions G protein-coupled receptor 92 1 , 2 G-protein coupled receptor 92 3 G-protein coupled receptor 93 2 , 3 LPA receptor 5 3 lysophosphatidic acid receptor 5 2
Search outside databases for aliases for LPAR5 gene
Summaries for LPAR5 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for LPAR5 : This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors.This protein transmits extracellular signals from lysophosphatidic acid to cells throughheterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serveas targets for pharmaceutical drugs. Transcript variants of this gene have beendescribed.[provided by RefSeq] UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0 Function : Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities
Gene Wiki entry for LPAR5 (GPR92)
Genomic Location for LPAR5
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31 LPAR5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M006599:
(about GC identifiers )
Start:
6,598,262 bp from pter
End:
6,615,548 bp from pter
Size:
17,287 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000012.10 NT_009759.15 Proteins for LPAR5
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0 (See
protein sequence )Recommended Name: Lysophosphatidic acid receptor 5 Size : 372 amino acids; 41347 Da
Subcellular location : Cell membrane; Multi-pass membrane protein
REFSEQ proteins (2 alternative transcripts):
NP_001136433.1 NP_065133.1 ENSEMBL proteins: ENSP00000327875 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for LPAR5: Assays for LPAR5:
Protein
Domains/ Families for LPAR5(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9H1C0 ProtoNet protein and cluster: Q9H1C0
UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0 Similarity : Belongs to the G-protein coupled receptor 1 family
Gene Function for LPAR5
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Clones , and
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_020400 Applied Biosystems Silencer ® siRNAs for LPAR5 Sigma-Aldrich siRNA and siRNA Panels for LPAR5 Sigma-Aldrich shRNA Panels and shRNA for LPAR5 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142961                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142961                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001142961  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001142961 UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0 Function : Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities
4 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND -- GO:0004872 receptor activity
IEA -- GO:0004930 G-protein coupled receptor activity
IEA -- GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
IEA --
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Pathways & Interactions for LPAR5
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Interacting proteins for LPAR5 (ENSP00000327875 3 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007165 signal transduction
IEA -- GO:0007186 G-protein coupled receptor protein signaling pathway
IEA -- GO:0008150 biological_process
ND --
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Drugs & Compounds for LPAR5 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for LPAR5
Transcripts for LPAR5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_020400 Sigma-Aldrich siRNA and siRNA Panels for LPAR5 Sigma-Aldrich shRNA Panels and shRNA for LPAR5 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001142961 NM_020400
REFSEQ mRNAs for LPAR5 gene (2 alternative transcripts): NM_001142961.1 NM_020400.5
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001142961 NM_020400
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142961                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142961                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001142961  
Additional cDNA sequence: AB041943.1 AJ272207.1 AK313127.1 BC033571.2 BC072394.1
4 DOTS entries : DT.431181 DT.121122091 DT.100758350 DT.91755582
24/139 AceView cDNA sequences (see all 139
):BI520382 BM560468 BC072394 BI825892 AI024421 NM_020400 NM_032489 BC033010 AF085884 BM553910 BI832341 BI828527 BI829134 BI830966 AJ272207 H91857 BI828365 BI829508 BI520377 BI830306 BI826973 BM553134 BI829361 BI828510
Unigene Cluster for LPAR5: Lysophosphatidic acid receptor 5 Hs.155538 [show with all ESTs ] Unigene Representative Sequence: BC072394 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000329858
Expression for LPAR5
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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LPAR5 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for LPAR5 1 / 2
6 probe-sets matching LPAR5 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TCTAACTTCTSOURCE GeneReport for Unigene cluster: Hs.155538 UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0 Tissue specificity : Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, orhippocampus
Orthologs for LPAR5
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for LPAR5 gene from 5 species
About this table Species with no ortholog for LPAR5 ENSEMBL Gene Tree for LPAR5 Paralogs for LPAR5 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for LPAR5 gene LPAR4 2 P2RY5 2 GPR174 2 P2RY10 2
SNPs/Variants for LPAR5 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for LPAR5 (up to first 250kb)
Disorders & Mutations for LPAR5
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 606926
Medical News for LPAR5 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for LPAR5 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for LPAR5 gene : Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155) 2, 3, 4 Lee D.K....O'Dowd B.F. (2001) Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. (PubMed id 11062477) 2, 3, 4 White K.E.... Strom T.M. (2000) Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes. (PubMed id 16651401) 2, 3 Kotarsky K....Olde B. (2006) GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. (PubMed id 16774927) 2, 3 Lee C.W....Chun J. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878) 3, 4 Takeda S.... Mitaku S. (2002) Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. (PubMed id 18499677) 3 Oh d.a. .Y....Seong J.Y. (2008) Gene expression profiling for the identification of G-protein coupled receptors in human platelets. (PubMed id 17920662) 3 Amisten S....Erlinge D. (2008) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing LPAR5
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing LPAR5
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Specialized Databases showing LPAR5 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for LPAR5 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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