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GPR89B Gene

protein-coding   GIFtS: 46
GCID: GC01P147400

G Protein-Coupled Receptor 89B

(Previous name: G protein-coupled receptor 89)
(Previous symbol: GPR89)
  Search for GPR89B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 89B1 2     Golgi PH Regulator B2
GPR891 2     Protein GPR892
GPHR2 5     Putative MAPK-Activating Protein PM012
G Protein-Coupled Receptor 891     Putative NF-Kappa-B-Activating Protein 902
SH1202     GPHRB3
Golgi PH Regulator A2     Protein GPR89B3

External Ids:    HGNC: 138401   Entrez Gene: 514632   Ensembl: ENSG000001880927   OMIM: 6128065   UniProtKB: P0CG083   

Export aliases for GPR89B gene to outside databases

Previous GC identifers: GC01U901427 GC01P145868 GC01M119728


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GPR89B Gene:
GPR89B (G protein-coupled receptor 89B) is a protein-coding gene. GO annotations related to this gene include voltage-gated ion channel activity. An important paralog of this gene is GPR89A.

UniProtKB/Swiss-Prot: GPHRB_HUMAN, P0CG08
Function: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may
function in counter-ion conductance (By similarity)

Gene Wiki entry for GPR89B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR89B gene promoter:
         ER-alpha   Pax-6   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR89B promoter sequence
   Search Chromatin IP Primers for GPR89B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR89B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.1

GPR89B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR89B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P147400:  view genomic region     (about GC identifiers)

Start:
147,400,506 bp from pter      End:
147,465,753 bp from pter
Size:
65,248 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GPHRB_HUMAN, P0CG08 (See protein sequence)
Recommended Name: Golgi pH regulator B  
Size: 455 amino acids; 52917 Da
Subunit: Homotrimer (By similarity)
Miscellaneous: Does not seem to be able to bind GTP
Sequence caution: Sequence=AAF36121.1; Type=Erroneous termination; Positions=297; Note=Translated as Cys;
Secondary accessions: A6NN37 B2RUV3 B3KMN3 Q53FQ9 Q5T2V8 Q5T5P5 Q659E2 Q6NVY5 Q9P0S4 Q9Y302

Explore the universe of human proteins at neXtProt for GPR89B: NX_P0CG08

Explore proteomics data for GPR89B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys272
  • Glycosylation2 at Asn180, Asn243

  • See GPR89B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057418.1  
    ENSEMBL proteins: 
     ENSP00000358233   ENSP00000475253  

    GPR89B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR015672 GPCR89-rel
     IPR022535 Golgi_pH-regulator_cons_dom
     IPR025969 ABA_GPCR_dom

    Graphical View of Domain Structure for InterPro Entry P0CG08

    ProtoNet protein and cluster: P0CG08

    UniProtKB/Swiss-Prot: GPHRB_HUMAN, P0CG08
    Similarity: Belongs to the Golgi pH regulator (TC 1.A.38) family


    Find genes that share domains with GPR89B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPHRB_HUMAN, P0CG08
    Function: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may
    function in counter-ion conductance (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity ----
    GO:0005244voltage-gated ion channel activity IEA--
    GO:0008308voltage-gated anion channel activity ----
         
    Find genes that share ontologies with GPR89B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for GPR89B:
     Decreased circadian period len  Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gpr89):
     craniofacial  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism 
     immune system  integument  mortality/aging  pigmentation  reproductive system 

    Find genes that share phenotypes with GPR89B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gpr89tm1Lex for GPR89B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR89B
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    hsa-mir-107 (MIRT048310)

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    hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-622 hsa-miR-29a* hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidGPR89B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPHRB_HUMAN, P0CG08: Golgi apparatus membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0030660Golgi-associated vesicle membrane ----
    GO:0032580Golgi cisterna membrane ----

    Find genes that share ontologies with GPR89B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPR89B
    Interactions:

        Search GeneGlobe Interaction Network for GPR89B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for GPR89B (P0CG083 ENSP000003582334) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLN3Q132863I2D: score=1 
    CASP3ENSP000003110324STRING: ENSP00000311032
    BIRC2ENSP000002277584STRING: ENSP00000227758
    BIRC3ENSP000002634644STRING: ENSP00000263464
    BIRC7ENSP000002171694STRING: ENSP00000217169
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0015031protein transport IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling ----
    GO:0044070regulation of anion transport ----
    GO:0051452intracellular pH reduction ----

    Find genes that share ontologies with GPR89B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR89B (GPHRB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPR89B gene: 
    NM_016334.3  

    Unigene Cluster for GPR89B:

    G protein-coupled receptor 89B
    Hs.645432  [show with all ESTs]
    Unigene Representative Sequence: NM_016334
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314163(uc010ozs.1) ENST00000488165 ENST00000478307(uc001epv.4 uc010ozt.2 uc010ozu.2 uc001epw.4 uc010ozv.2 uc009wjm.3 uc001epy.4)
    ENST00000468618 ENST00000491975 ENST00000461786 ENST00000488603 ENST00000490955

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate GPR89B:
    hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-622 hsa-miR-29a* hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidGPR89B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GPR89B
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    OriGene qPCR primer pairs and template standards for GPR89B
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    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat GPR89B
      QuantiTect SYBR Green Assays in human, mouse, rat GPR89B
      QuantiFast Probe-based Assays in human, mouse, rat GPR89B

    Additional mRNA sequence: 

    AF151035.1 AK302266.1 U78723.1 

    17 DOTS entries:

    DT.91680583  DT.121363265  DT.100663130  DT.92435818  DT.416281  DT.121355600  DT.95287152  DT.100810210 
    DT.100810215  DT.95287144  DT.100841343  DT.121355491  DT.92435820  DT.95287181  DT.100757464  DT.121363233 
    DT.92435810 

    Selected AceView cDNA sequences (see all 189):

    CA428806 AW241473 BQ014901 BU190636 BG939128 AI479549 BM562802 AI383358 
    BX117855 BU737743 BE041306 AW771327 AI634397 BG110085 BE672682 BG116788 
    AI584111 AW241413 BI060800 AW771855 AA911620 CD674946 BQ212944 AA825670 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR89B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GPR89B Expression
    About this image

    GPR89B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR89B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645432

    UniProtKB/Swiss-Prot: GPHRB_HUMAN, P0CG08
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GPR89B gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr891 , 5 G protein-coupled receptor 891, 5 88.5(n)1
    96.92(a)1
      3 (42.01 cM)5
    675491  NM_026229.41  NP_080505.11 
     968682815 
    chicken
    (Gallus gallus)
    Aves GPR89B1 G protein-coupled receptor 89B 83.11(n)
    95.15(a)
      418459  NM_001030791.1  NP_001025962.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    94(a)
    1 → many
    3(161957661-161981564)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ063256.12   -- 79.27(n)    BJ063256.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-390b10.21 si:ch73-390b10.2 77.61(n)
    90.31(a)
      100331395  XM_002663314.2  XP_002663360.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80901 CG8090 59.22(n)
    57.56(a)
      36682  NM_137172.3  NP_611016.2 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y75B8A.161 CELE_Y75B8A.16 58.11(n)
    57.95(a)
      176650  NM_067187.4  NP_499588.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GTG21 GTG2 54.38(n)
    46.48(a)
      828874  NM_118899.3  NP_194493.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g06008001 Os04g0600800 56.76(n)
    46.62(a)
      4336878  NM_001060297.2  NP_001053762.2 


    ENSEMBL Gene Tree for GPR89B (if available)
    TreeFam Gene Tree for GPR89B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPR89B gene
    GPR89A1 2  GPR89C2  
    2 SIMAP similar genes for GPR89B using alignment to 2 protein entries:     GPHRB_HUMAN (see all proteins):
    GPR89C    GPR89A

    Find genes that share paralogs with GPR89B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPR89B (see all 82)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862357401,2
    C--147416986(+) ACAGGG/TTTCAT 1 -- int10--------
    rs1889968711,2
    --147417023(+) ATATAC/TACCTC 1 -- int10--------
    rs1820823491,2
    C--147417087(+) AATCTA/TCTGTA 1 -- int10--------
    rs1392724781,2
    --147417709(+) AAGGCC/TGGAAA 1 -- int10--------
    rs2009559571,2
    C--147417815(+) TTCTCC/TAGTCC 1 -- int10--------
    rs1873580621,2
    --147417838(+) TCAAGC/TTTCTT 1 -- int10--------
    rs1497399951,2
    --147418082(+) GGATCA/GACCCA 1 -- int10--------
    rs1162207761,2
    F--147418393(+) CATGTT/AATTTG 1 -- int11Minor allele frequency- A:0.07NA 120
    rs1475771731,2
    --147418576(+) TGTCAA/GTGGTC 1 -- int10--------
    rs1908222661,2
    --147418620(+) GTAGTA/GTAGTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for GPR89B (147400506 - 147465753 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GPR89B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv511130CNV Loss21212237
    nsv872268CNV Gain21882294
    nsv7181OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR89B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612806    OMIM disorders: --


    Find genes that share disorders with GPR89B           About GenesLikeMe


    Export disorders for GPR89B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR89B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with GPR89B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    2. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PubMed id 18794847)1, 2 Maeda Y.... Kinoshita T. (Nat. Cell Biol. 2008)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    6. Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. (PubMed id 19135895)2 Pandey S.... Assmann S.M. (Cell 2009)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51463 HGNC: 13840 AceView: GPR89 Ensembl:ENSG00000188092 euGenes: HUgn51463
    ECgene: GPR89B H-InvDB: GPR89B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPR89B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPR89B gene:
    Search GeneIP for patents involving GPR89B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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