GPR89B Gene
protein-coding GIFtS: 44
GCID: GC01P147400
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|
G protein-coupled receptor 89B(Previous name: G protein-coupled receptor 89 )
(Previous symbol: GPR89)
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Aliases
for GPR89B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Protein-Coupled Receptor 89B1 2 | | Golgi PH Regulator B2 | | GPR891 2 | | Protein GPR892 | | SH1201 2 | | Putative MAPK-Activating Protein PM012 | | GPHR2 5 | | Putative NF-Kappa-B-Activating Protein 902 | | G Protein-Coupled Receptor 891 | | GPHRB3 | | Golgi PH Regulator A2 | | Protein GPR89B3 |
Export aliases for GPR89B gene to outside databasesPrevious GC identifers: GC01U901427 GC01P145868 GC01M119728 |
Summaries
for GPR89B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GPHRB_HUMAN, P0CG08Function: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that mayfunction in counter-ion conductance (By similarity)
Gene Wiki entry for GPR89B
|
Genomic Views
for GPR89B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167185.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPR89B gene promoter:
ER-alpha Pax-6 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPR89B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR89B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21.1GPR89B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P147400: view genomic region
(about GC identifiers)
Start:
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147,400,506 bp from pter |
End:
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147,465,753 bp from pter |
Size:
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65,248 bases |
Orientation:
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plus strand |
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Proteins
for GPR89B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GPHRB_HUMAN, P0CG08 (See
protein sequence)Recommended Name: Golgi pH regulator B Size: 455 amino acids; 52917 Da
Subunit: Homotrimer (By similarity)
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein (By similarity)
Miscellaneous: Does not seem to be able to bind GTP
Sequence caution: Sequence=AAF36121.1; Type=Erroneous termination; Positions=297; Note=Translated as Cys;
Secondary accessions: A6NN37 B2RUV3 B3KMN3 Q53FQ9 Q5T2V8 Q5T5P5 Q659E2 Q6NVY5 Q9P0S4 Q9Y302Explore the universe of human proteins at neXtProt for GPR89B: NX_P0CG08
GPR89B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057418.1
ENSEMBL proteins: ENSP00000358233
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
GPR89B for ontologies About GeneDecksing
GPR89B Antibody Products:
Assay Products for GPR89B: |
Protein
Domains /
Families
for GPR89B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPR89B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0CG08ProtoNet protein and cluster: P0CG08 UniProtKB/Swiss-Prot: GPHRB_HUMAN, P0CG08Similarity: Belongs to the Golgi pH regulator (TC 1.A.38) family |
Function
for GPR89B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GPHRB_HUMAN, P0CG08Function: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that mayfunction in counter-ion conductance (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR89B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR89B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR89B |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004871 | signal transducer activity |
-- | -- | | GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0008308 | voltage-gated anion channel activity |
-- | -- |
GPR89B for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for GPR89B:
Animal Models:
Mouse knock-out Gpr89tm1Lex for GPR89B
10 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Gpr89):
GPR89B for phenotypes About GeneDecksing
|
Pathways & Interactions
for GPR89B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR89B
1 Interacting protein for GPR89B (P0CG083) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
-- | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade |
-- | -- | | GO:0044070 | regulation of anion transport |
-- | -- | | GO:0051452 | intracellular pH reduction |
-- | -- |
GPR89B for ontologies About GeneDecksing
|
Drugs & Compounds
for GPR89B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GPR89B
Search CenterWatch for drugs/clinical trials and news about GPR89B / GPHRB
|
Transcripts
for GPR89B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPR89B gene: NM_016334.3 Unigene Cluster for GPR89B: G protein-coupled receptor 89B Hs.645432 [show with all ESTs]Unigene Representative Sequence: NM_0163348 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000314163(uc010ozs.1) ENST00000488165 ENST00000478307(uc001epv.4 uc010ozt.2 uc010ozu.2 uc001epw.4 uc010ozv.2 uc009wjm.3 uc001epy.4)
ENST00000468618 ENST00000491975 ENST00000461786 ENST00000488603 ENST00000490955
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR89B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR89B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GPR89B (NM_016334) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPR89B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR89B |
Additional cDNA sequence: AF151035.1 AK302266.1 U78723.1 17 DOTS entries: DT.91680583 DT.121363265 DT.100663130 DT.92435818 DT.416281 DT.121355600 DT.95287152 DT.100810210 DT.100810215 DT.95287144 DT.100841343 DT.121355491 DT.92435820 DT.95287181 DT.100757464 DT.121363233 DT.92435810 24/189 AceView cDNA sequences (see all 189): AI383358 BQ014901 BG939128 BU190636 CA428806 BX117855 AW241473 AI479549 BM562802 BG110085 AW771327 BU737743 BE672682 BE041306 AI634397 BG116788 AI584111 AW241413 BI060800 AW771855 AA911620 BQ212944 AA825670 CD674946
GeneLoc Exon Structure
|
Expression
for GPR89B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPR89B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GPR89B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPR89B
SOURCE GeneReport for Unigene cluster: Hs.645432
UniProtKB/Swiss-Prot: GPHRB_HUMAN, P0CG08Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for GPR89B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR89B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat GPR89B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR89B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR89B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR89B |
Orthologs
for GPR89B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for GPR89B gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for GPR89B (if available)
TreeFam Gene Tree for GPR89B (if available) |
Paralogs
for GPR89B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GPR89B gene
- GPR89A1 2 GPR89C2
2 SIMAP similar genes for GPR89B using alignment to 1 protein entry: GPHRB_HUMAN:GPR89C GPR89A
GPR89B for paralogs About GeneDecksing
|
Genomic Variants
for GPR89B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPR89B (147400506 - 147465753 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GPR89B
1 CNV: 34420 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR89B |
|
Disorders
/ Diseases
for GPR89B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPR89B for disorders About GeneDecksing
OMIM gene information: 612806
OMIM disorders: --
1  disease for GPR89B: About MalaCardsovarian hyperstimulation syndrome
Export disorders for GPR89B gene to outside databases
|
Publications
for GPR89B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPR89B gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with GPR89B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PubMed id 18794847)1, 2 Maeda Y....Kinoshita T. (2008)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. (PubMed id 19135895)2 Pandey S.... Assmann S.M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1 Clark H.F.... Gray A.M. (2003)
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1 Matsuda A....Sugano S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for GPR89B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPR89B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPR89B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPR89B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPR89B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GPR89B gene:
Search GeneIP for patents involving GPR89B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPR89B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GPR89B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPR89B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR89B | | | OriGene Protein Over-expression Lysate for GPR89B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPR89B | | OriGene 3'-UTR Clone for GPR89B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR89B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR89B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GPR89B | | OriGene Custom Protein Services for GPR89B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPR89B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR89B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR89B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPR89B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR89B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR89B |
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 |  |  |  | |
| | | | Search Tocris compounds for GPR89B |
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 | | | GPR89B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR89B |
|  |  |  | | | | ThermoFisher Antibodies for GPR89B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR89B |
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