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Aliases for GPR89A Gene

Aliases for GPR89A Gene

  • G Protein-Coupled Receptor 89A 2 3
  • Putative NF-Kappa-B-Activating Protein 90 3 4
  • Putative MAPK-Activating Protein PM01 3 4
  • SH120 3 4
  • GPR89 3 4
  • Golgi PH Regulator A 3
  • Protein GPR89A 4
  • Protein GPR89 3
  • UNQ192 3
  • GPR89B 3
  • GPHRA 4
  • GPHR 3

External Ids for GPR89A Gene

Previous GeneCards Identifiers for GPR89A Gene

  • GC01P145867
  • GC01M144476
  • GC01M145764

Summaries for GPR89A Gene

Entrez Gene Summary for GPR89A Gene

  • GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]

GeneCards Summary for GPR89A Gene

GPR89A (G Protein-Coupled Receptor 89A) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and voltage-gated anion channel activity. An important paralog of this gene is GPR89B.

UniProtKB/Swiss-Prot for GPR89A Gene

  • Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR89A Gene

Genomics for GPR89A Gene

Regulatory Elements for GPR89A Gene

Transcription factor binding sites by QIAGEN in the GPR89A gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPR89A Gene

145,607,960 bp from pter
145,670,740 bp from pter
62,781 bases
Plus strand

Genomic View for GPR89A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR89A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR89A Gene

Proteins for GPR89A Gene

  • Protein details for GPR89A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi pH regulator A
    Protein Accession:
    Secondary Accessions:
    • A6NN37
    • B2RUV3
    • B3KMN3
    • B4DLT3
    • B4DXE7
    • Q53FQ9
    • Q5T2V8
    • Q5T5P5
    • Q659E2
    • Q6NVY5
    • Q9P0S4
    • Q9Y302

    Protein attributes for GPR89A Gene

    455 amino acids
    Molecular mass:
    52917 Da
    Quaternary structure:
    • Homotrimer.
    • Does not seem to be able to bind GTP

    Alternative splice isoforms for GPR89A Gene


neXtProt entry for GPR89A Gene

Proteomics data for GPR89A Gene at MOPED

Post-translational modifications for GPR89A Gene

  • Ubiquitination at Lys272
  • Glycosylation at Asn180 and Asn243
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GPR89A Gene

Domains for GPR89A Gene

Protein Domains for GPR89A Gene

Suggested Antigen Peptide Sequences for GPR89A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
genes like me logo Genes that share domains with GPR89A: view

No data available for Gene Families for GPR89A Gene

Function for GPR89A Gene

Molecular function for GPR89A Gene

UniProtKB/Swiss-Prot Function:
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Gene Ontology (GO) - Molecular Function for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005244 voltage-gated ion channel activity --
GO:0008308 voltage-gated anion channel activity IDA 18794847
genes like me logo Genes that share ontologies with GPR89A: view

Phenotypes for GPR89A Gene

GenomeRNAi human phenotypes for GPR89A:
genes like me logo Genes that share phenotypes with GPR89A: view

Animal Model Products

CRISPR Products

miRNA for GPR89A Gene

miRTarBase miRNAs that target GPR89A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89A Gene

Localization for GPR89A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR89A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR89A Gene COMPARTMENTS Subcellular localization image for GPR89A gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
GO:0030660 Golgi-associated vesicle membrane IDA 18794847
GO:0032580 Golgi cisterna membrane IDA 18794847
genes like me logo Genes that share ontologies with GPR89A: view

Pathways for GPR89A Gene

SuperPathways for GPR89A Gene

No Data Available

Interacting Proteins for GPR89A Gene

Gene Ontology (GO) - Biological Process for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IMP 12761501
GO:0015031 protein transport IEA --
GO:0034765 regulation of ion transmembrane transport --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with GPR89A: view

No data available for Pathways by source for GPR89A Gene

Transcripts for GPR89A Gene

mRNA/cDNA for GPR89A Gene

(8) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR89A Gene

G protein-coupled receptor 89A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR89A Gene

No ASD Table

Relevant External Links for GPR89A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR89A Gene

mRNA expression in normal human tissues for GPR89A Gene

Protein differential expression in normal tissues for GPR89A Gene

This gene is overexpressed in Nasal epithelium (60.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPR89A Gene

SOURCE GeneReport for Unigene cluster for GPR89A Gene Hs.504320

mRNA Expression by UniProt/SwissProt for GPR89A Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with GPR89A: view

Expression partners for GPR89A Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GPR89A Gene

Orthologs for GPR89A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR89 35
  • 94.09 (n)
  • 99.05 (a)
GPR89 36
  • 96 (a)
(Canis familiaris)
Mammalia LOC483157 35
  • 93.7 (n)
  • 98.46 (a)
-- 36
  • 98 (a)
(Mus musculus)
Mammalia Gpr89 35
  • 88.42 (n)
  • 96.92 (a)
Gpr89 36
  • 97 (a)
(Pan troglodytes)
Mammalia GPR89B 35
  • 99.71 (n)
  • 100 (a)
GPR89B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr89b 35
  • 89.16 (n)
  • 96.92 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
(Gallus gallus)
Aves GPR89B 35
  • 83.19 (n)
  • 95.15 (a)
GPR89 36
  • 95 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490107 35
  • 79.07 (n)
  • 92.95 (a)
(Danio rerio)
Actinopterygii si:ch73-390b10.2 35
  • 77.68 (n)
  • 90.31 (a)
GPR89A 36
  • 90 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011252 35
  • 60.94 (n)
  • 63.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8090 35
  • 59.14 (n)
  • 57.56 (a)
CG8090 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.16 35
  • 58.11 (n)
  • 57.95 (a)
C11H1.2 36
  • 53 (a)
Y75B8A.16 36
  • 55 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GTG2 35
  • 54.38 (n)
  • 46.48 (a)
(Oryza sativa)
Liliopsida Os04g0600800 35
  • 56.76 (n)
  • 46.62 (a)
Species with no ortholog for GPR89A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR89A Gene

Gene Tree for GPR89A (if available)
Gene Tree for GPR89A (if available)

Paralogs for GPR89A Gene

Paralogs for GPR89A Gene

(2) SIMAP similar genes for GPR89A Gene using alignment to 4 proteins: Pseudogenes for GPR89A Gene

genes like me logo Genes that share paralogs with GPR89A: view

Variants for GPR89A Gene

Sequence variations from dbSNP and Humsavar for GPR89A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1284295 -- 145,668,183(-) aatca(A/G)tatca intron-variant
rs1471631 -- 145,627,000(-) AAAGA(A/T)AATCT intron-variant
rs1871934 -- 145,625,202(+) ATAAC(A/G)TTAAA intron-variant
rs2128371 -- 145,654,484(-) cctcc(A/G)cctcc intron-variant
rs2624712 -- 145,663,130(-) CCTAT(G/T)TCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR89A Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
esv529 CNV CNV 17122850
dgv349n71 CNV Loss 21882294
dgv350n71 CNV Gain 21882294
nsv428224 CNV Gain 18775914
nsv872241 CNV Gain+Loss 21882294
nsv831392 CNV Gain 17160897
esv33868 CNV Loss 17666407
essv3464 CNV CNV 17122850
nsv469752 CNV Loss 16826518
dgv352n71 CNV Gain 21882294

Relevant External Links for GPR89A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR89A Gene

Disorders for GPR89A Gene

No disorders were found for GPR89A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GPR89A Gene

Publications for GPR89A Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for GPR89A Gene

Sources for GPR89A Gene

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