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Aliases for GPR89A Gene

Aliases for GPR89A Gene

  • G Protein-Coupled Receptor 89A 2 3 5
  • Putative NF-Kappa-B-Activating Protein 90 3 4
  • Putative MAPK-Activating Protein PM01 3 4
  • GPR89 3 4
  • SH120 3 4
  • Golgi PH Regulator A 3
  • Protein GPR89A 4
  • Protein GPR89 3
  • GPR89B 3
  • UNQ192 3
  • GPHRA 4
  • GPHR 3

External Ids for GPR89A Gene

Previous GeneCards Identifiers for GPR89A Gene

  • GC01P145867
  • GC01M144476
  • GC01M145764

Summaries for GPR89A Gene

Entrez Gene Summary for GPR89A Gene

  • GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]

GeneCards Summary for GPR89A Gene

GPR89A (G Protein-Coupled Receptor 89A) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and voltage-gated anion channel activity. An important paralog of this gene is GPR89B.

UniProtKB/Swiss-Prot for GPR89A Gene

  • Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR89A Gene

Genomics for GPR89A Gene

Regulatory Elements for GPR89A Gene

Enhancers for GPR89A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G145609 1.1 ENCODE 0.7 +2.4 2432 1.9 HDGF PKNOX1 CREB3L1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 POLR3C ENSG00000213240 GPR89A PDZK1
GH01G145688 1.1 Ensembl ENCODE 0.2 +82.1 82124 3.5 HDAC1 FOXA2 RAD21 SCRT2 FOS RELB IKZF2 HMG20B CEBPB REST ENSG00000213240 PIAS3 PDZK1 GPR89A
GH01G145705 1.2 Ensembl ENCODE 0.1 +99.3 99300 3.4 FOXA2 MLX ARID4B SIN3A YBX1 DMAP1 ZNF48 YY1 TCF12 FOS CD160 PDZK1 GPR89A
GH01G145676 0.5 Ensembl 0.2 +68.1 68141 0.2 JUND GATA3 EGR1 NFE2L1 FOS PDZK1 GPR89A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR89A on UCSC Golden Path with GeneCards custom track

Promoters for GPR89A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000012903 341 1800 HDGF ATF1 SIN3A GLI4 ZNF2 ZBTB7B ZNF121 GLIS2 GATA2 FOS

Transcription factor binding sites by QIAGEN in the GPR89A gene promoter:

Genomic Location for GPR89A Gene

Chromosome:
1
Start:
145,607,960 bp from pter
End:
145,670,977 bp from pter
Size:
63,018 bases
Orientation:
Plus strand

Genomic View for GPR89A Gene

Genes around GPR89A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR89A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR89A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR89A Gene

Proteins for GPR89A Gene

  • Protein details for GPR89A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B7ZAQ6-GPHRA_HUMAN
    Recommended name:
    Golgi pH regulator A
    Protein Accession:
    B7ZAQ6
    Secondary Accessions:
    • A6NN37
    • B2RUV3
    • B3KMN3
    • B4DLT3
    • B4DXE7
    • Q53FQ9
    • Q5T2V8
    • Q5T5P5
    • Q659E2
    • Q6NVY5
    • Q9P0S4
    • Q9Y302

    Protein attributes for GPR89A Gene

    Size:
    455 amino acids
    Molecular mass:
    52917 Da
    Quaternary structure:
    • Homotrimer.
    Miscellaneous:
    • Does not seem to be able to bind GTP.

    Alternative splice isoforms for GPR89A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR89A Gene

Post-translational modifications for GPR89A Gene

  • Glycosylation at posLast=180180 and posLast=243243
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR89A Gene

Domains & Families for GPR89A Gene

Protein Domains for GPR89A Gene

Suggested Antigen Peptide Sequences for GPR89A Gene

Graphical View of Domain Structure for InterPro Entry

B7ZAQ6

UniProtKB/Swiss-Prot:

GPHRA_HUMAN :
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
Family:
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
genes like me logo Genes that share domains with GPR89A: view

No data available for Gene Families for GPR89A Gene

Function for GPR89A Gene

Molecular function for GPR89A Gene

UniProtKB/Swiss-Prot Function:
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Gene Ontology (GO) - Molecular Function for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005244 voltage-gated ion channel activity IEA --
GO:0008308 voltage-gated anion channel activity IDA 18794847
genes like me logo Genes that share ontologies with GPR89A: view

Phenotypes for GPR89A Gene

GenomeRNAi human phenotypes for GPR89A:
genes like me logo Genes that share phenotypes with GPR89A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR89A

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89A Gene

Localization for GPR89A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR89A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030660 Golgi-associated vesicle membrane IDA 18794847
GO:0032580 Golgi cisterna membrane IDA 18794847
genes like me logo Genes that share ontologies with GPR89A: view

No data available for Subcellular locations from COMPARTMENTS for GPR89A Gene

Pathways & Interactions for GPR89A Gene

SuperPathways for GPR89A Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GPR89A: view

No data available for Pathways by source and SIGNOR curated interactions for GPR89A Gene

Drugs & Compounds for GPR89A Gene

No Compound Related Data Available

Transcripts for GPR89A Gene

mRNA/cDNA for GPR89A Gene

(8) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR89A Gene

G protein-coupled receptor 89A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR89A Gene

No ASD Table

Relevant External Links for GPR89A Gene

GeneLoc Exon Structure for
GPR89A
ECgene alternative splicing isoforms for
GPR89A

Expression for GPR89A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR89A Gene

Protein differential expression in normal tissues from HIPED for GPR89A Gene

This gene is overexpressed in Nasal epithelium (60.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR89A Gene



Protein tissue co-expression partners for GPR89A Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR89A Gene:

GPR89A

SOURCE GeneReport for Unigene cluster for GPR89A Gene:

Hs.504320

mRNA Expression by UniProt/SwissProt for GPR89A Gene:

B7ZAQ6-GPHRA_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for GPR89A Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with GPR89A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR89A Gene

Orthologs for GPR89A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR89B 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 98 (a)
OneToMany
LOC483157 34
  • 93.7 (n)
cow
(Bos Taurus)
Mammalia GPR89 34 35
  • 94.09 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gpr89b 34
  • 89.16 (n)
mouse
(Mus musculus)
Mammalia Gpr89 34 35
  • 88.42 (n)
chicken
(Gallus gallus)
Aves GPR89 35
  • 95 (a)
OneToMany
GPR89B 34
  • 83.19 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490107 34
  • 79.07 (n)
zebrafish
(Danio rerio)
Actinopterygii GPR89A 35
  • 90 (a)
OneToMany
si:ch73-390b10.2 34
  • 77.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011252 34
  • 60.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8090 34 35
  • 59.14 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.16 34
  • 58.11 (n)
Y75B8A.16 35
  • 55 (a)
ManyToMany
C11H1.2 35
  • 53 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GTG2 34
  • 54.38 (n)
rice
(Oryza sativa)
Liliopsida Os04g0600800 34
  • 56.76 (n)
Species where no ortholog for GPR89A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR89A Gene

ENSEMBL:
Gene Tree for GPR89A (if available)
TreeFam:
Gene Tree for GPR89A (if available)

Paralogs for GPR89A Gene

Paralogs for GPR89A Gene

(2) SIMAP similar genes for GPR89A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GPR89A Gene

genes like me logo Genes that share paralogs with GPR89A: view

Variants for GPR89A Gene

Sequence variations from dbSNP and Humsavar for GPR89A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10910846 -- 145,659,481(-) taggc(C/T)ggtcg intron-variant
rs111338698 -- 145,659,066(-) GGCAT(G/T)GTGGC intron-variant
rs111383109 -- 145,619,259(-) GTTTT(G/T)CTTTT intron-variant
rs111488177 -- 145,641,195(-) TTTTT(G/T)TGTGT intron-variant
rs111533600 -- 145,630,557(-) TTAAT(A/T)ATTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR89A Gene

Variant ID Type Subtype PubMed ID
dgv331n100 CNV gain 25217958
dgv332n100 CNV gain+loss 25217958
dgv532n54 CNV gain 21841781
dgv95e212 CNV gain 25503493
esv3572342 CNV gain 25503493
esv3587421 CNV loss 21293372
esv3587422 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv469752 CNV loss 16826518
nsv831392 CNV gain 17160897
nsv946271 CNV duplication 23825009
nsv946272 CNV duplication 23825009
nsv998178 CNV loss 25217958

Variation tolerance for GPR89A Gene

Gene Damage Index Score: 0.79; 16.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR89A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR89A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR89A Gene

Disorders for GPR89A Gene

Relevant External Links for GPR89A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR89A

No disorders were found for GPR89A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR89A Gene

Publications for GPR89A Gene

  1. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 4 64
  2. Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. (PMID: 19135895) Pandey S. … Assmann S.M. (Cell 2009) 3 4 64
  3. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PMID: 18794847) Maeda Y. … Kinoshita T. (Nat. Cell Biol. 2008) 3 4 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for GPR89A Gene

Sources for GPR89A Gene

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