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Aliases for GPR89A Gene

Aliases for GPR89A Gene

  • G Protein-Coupled Receptor 89A 2 3 5
  • Putative NF-Kappa-B-Activating Protein 90 3 4
  • Putative MAPK-Activating Protein PM01 3 4
  • GPR89 3 4
  • SH120 3 4
  • Golgi PH Regulator A 3
  • Protein GPR89A 4
  • Protein GPR89 3
  • GPR89B 3
  • UNQ192 3
  • GPHRA 4
  • GPHR 3

External Ids for GPR89A Gene

Previous GeneCards Identifiers for GPR89A Gene

  • GC01P145867
  • GC01M144476
  • GC01M145764

Summaries for GPR89A Gene

Entrez Gene Summary for GPR89A Gene

  • GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]

GeneCards Summary for GPR89A Gene

GPR89A (G Protein-Coupled Receptor 89A) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and voltage-gated anion channel activity. An important paralog of this gene is GPR89B.

UniProtKB/Swiss-Prot for GPR89A Gene

  • Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Additional gene information for GPR89A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR89A Gene

Genomics for GPR89A Gene

Regulatory Elements for GPR89A Gene

Enhancers for GPR89A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H146034 1.5 ENCODE dbSUPER 37.6 +429.6 429592 5.6 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZFP41 MEF2D SSRP1 PIAS3 POLR3C NBPF20 GPR89A GNRHR2 NUDT17 ENSG00000213240 ANKRD35 TXNIP PEX11B
GH01H144997 1.6 Ensembl ENCODE dbSUPER 31.3 -608.4 -608439 4.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF766 PIAS3 POLR3C NBPF20 GPR89A PFN1P6 ENSG00000224363 NBPF25P NUDT17 LOC645166 LIX1L-AS1
GH01H144994 1.5 Ensembl ENCODE dbSUPER 21.2 -612.3 -612279 2.7 PKNOX1 FEZF1 ZNF48 FOS ZNF548 YY2 ZNF662 REST KAT8 GLIS1 PIAS3 POLR3C NBPF20 PFN1P6 GPR89A LOC645166 NUDT17 LIX1L-AS1 GNRHR2 ENSG00000271644
GH01H146226 1.4 ENCODE dbSUPER 21.1 +620.1 620076 3.3 HDGF ARNT SIN3A FEZF1 ZNF2 ZBTB7B ZNF302 ZNF143 ZNF548 SP3 PIAS3 POLR3C NBPF20 GPR89A NBPF25P ENSG00000234225 PEX11B RBM8A ENSG00000213240 PIR33330
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR89A on UCSC Golden Path with GeneCards custom track

Promoters for GPR89A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000012903 341 1800 HDGF ATF1 SIN3A GLI4 ZNF2 ZBTB7B ZNF121 GLIS2 FOS ATF7

Transcription factor binding sites by QIAGEN in the GPR89A gene promoter:

Genomic Locations for GPR89A Gene

Genomic Locations for GPR89A Gene
63,018 bases
Plus strand

Genomic View for GPR89A Gene

Genes around GPR89A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR89A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR89A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR89A Gene

Proteins for GPR89A Gene

  • Protein details for GPR89A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi pH regulator A
    Protein Accession:
    Secondary Accessions:
    • A6NN37
    • B2RUV3
    • B3KMN3
    • B4DLT3
    • B4DXE7
    • Q53FQ9
    • Q5T2V8
    • Q5T5P5
    • Q659E2
    • Q6NVY5
    • Q9P0S4
    • Q9Y302

    Protein attributes for GPR89A Gene

    455 amino acids
    Molecular mass:
    52917 Da
    Quaternary structure:
    • Homotrimer.
    • Does not seem to be able to bind GTP.

    Alternative splice isoforms for GPR89A Gene


neXtProt entry for GPR89A Gene

Post-translational modifications for GPR89A Gene

  • Glycosylation at isoforms=2, 3180 and isoforms=2, 3243
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR89A Gene

Domains & Families for GPR89A Gene

Gene Families for GPR89A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GPR89A Gene

Suggested Antigen Peptide Sequences for GPR89A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
genes like me logo Genes that share domains with GPR89A: view

Function for GPR89A Gene

Molecular function for GPR89A Gene

UniProtKB/Swiss-Prot Function:
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Phenotypes From GWAS Catalog for GPR89A Gene

Gene Ontology (GO) - Molecular Function for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005244 voltage-gated ion channel activity IEA --
GO:0008308 voltage-gated anion channel activity IDA 18794847
genes like me logo Genes that share ontologies with GPR89A: view

Phenotypes for GPR89A Gene

GenomeRNAi human phenotypes for GPR89A:
genes like me logo Genes that share phenotypes with GPR89A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89A Gene

Localization for GPR89A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR89A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030660 Golgi-associated vesicle membrane IDA 18794847
GO:0032580 Golgi cisterna membrane IDA 18794847
genes like me logo Genes that share ontologies with GPR89A: view

No data available for Subcellular locations from COMPARTMENTS for GPR89A Gene

Pathways & Interactions for GPR89A Gene

SuperPathways for GPR89A Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GPR89A: view

No data available for Pathways by source and SIGNOR curated interactions for GPR89A Gene

Drugs & Compounds for GPR89A Gene

No Compound Related Data Available

Transcripts for GPR89A Gene

mRNA/cDNA for GPR89A Gene

(8) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR89A Gene

G protein-coupled receptor 89A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR89A Gene

No ASD Table

Relevant External Links for GPR89A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR89A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR89A Gene

Protein differential expression in normal tissues from HIPED for GPR89A Gene

This gene is overexpressed in Nasal epithelium (60.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR89A Gene

Protein tissue co-expression partners for GPR89A Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR89A Gene:


SOURCE GeneReport for Unigene cluster for GPR89A Gene:


mRNA Expression by UniProt/SwissProt for GPR89A Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for GPR89A Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with GPR89A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR89A Gene

Orthologs for GPR89A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR89B 33 34
  • 99.71 (n)
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
LOC483157 33
  • 93.7 (n)
(Bos Taurus)
Mammalia GPR89 33 34
  • 94.09 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
(Rattus norvegicus)
Mammalia Gpr89b 33
  • 89.16 (n)
(Mus musculus)
Mammalia Gpr89 33 34
  • 88.42 (n)
(Gallus gallus)
Aves GPR89 34
  • 95 (a)
GPR89B 33
  • 83.19 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490107 33
  • 79.07 (n)
(Danio rerio)
Actinopterygii GPR89A 34
  • 90 (a)
si:ch73-390b10.2 33
  • 77.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011252 33
  • 60.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8090 33 34
  • 59.14 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.16 33
  • 58.11 (n)
Y75B8A.16 34
  • 55 (a)
C11H1.2 34
  • 53 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GTG2 33
  • 54.38 (n)
(Oryza sativa)
Liliopsida Os04g0600800 33
  • 56.76 (n)
Species where no ortholog for GPR89A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR89A Gene

Gene Tree for GPR89A (if available)
Gene Tree for GPR89A (if available)

Paralogs for GPR89A Gene

Paralogs for GPR89A Gene

(2) SIMAP similar genes for GPR89A Gene using alignment to 4 proteins: Pseudogenes for GPR89A Gene

genes like me logo Genes that share paralogs with GPR89A: view

Variants for GPR89A Gene

Sequence variations from dbSNP and Humsavar for GPR89A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10910846 -- 145,659,481(-) taggc(C/T)ggtcg intron-variant
rs111338698 -- 145,659,066(-) GGCAT(G/T)GTGGC intron-variant
rs111383109 -- 145,619,259(-) GTTTT(G/T)CTTTT intron-variant
rs111488177 -- 145,641,195(-) TTTTT(G/T)TGTGT intron-variant
rs111533600 -- 145,630,557(-) TTAAT(A/T)ATTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR89A Gene

Variant ID Type Subtype PubMed ID
nsv998178 CNV loss 25217958
nsv946272 CNV duplication 23825009
nsv946271 CNV duplication 23825009
nsv831392 CNV gain 17160897
nsv469752 CNV loss 16826518
nsv1015025 CNV gain 25217958
nsv1005055 CNV loss 25217958
esv3587422 CNV gain 21293372
esv3587421 CNV loss 21293372
esv3572342 CNV gain 25503493
dgv95e212 CNV gain 25503493
dgv532n54 CNV gain 21841781
dgv332n100 CNV gain+loss 25217958
dgv331n100 CNV gain 25217958

Variation tolerance for GPR89A Gene

Gene Damage Index Score: 0.79; 16.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR89A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR89A Gene

Disorders for GPR89A Gene

Relevant External Links for GPR89A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR89A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR89A Gene

Publications for GPR89A Gene

  1. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 4 60
  2. Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. (PMID: 19135895) Pandey S … Assmann SM (Cell 2009) 3 4 60
  3. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PMID: 18794847) Maeda Y … Kinoshita T (Nature cell biology 2008) 3 4 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for GPR89A Gene

Sources for GPR89A Gene

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