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GPR89A Gene

protein-coding   GIFtS: 45
GCID: GC01M145764

G Protein-Coupled Receptor 89A

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 89A1 2     Protein GPR892
Putative MAPK-Activating Protein PM012 3     GPHRA3
Putative NF-Kappa-B-Activating Protein 902 3     GPR893
GPR89B2     SH1203
UNQ1922     Protein GPR89A3
Golgi PH Regulator A2     

External Ids:    HGNC: 319841   Entrez Gene: 6535192   Ensembl: ENSG000001172627   OMIM: 6128215   UniProtKB: B7ZAQ63   

Export aliases for GPR89A gene to outside databases

Previous GC identifers: GC01P145867 GC01M144476


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPR89A Gene:
GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).(supplied by OMIM, Jun 2009)

GeneCards Summary for GPR89A Gene:
GPR89A (G protein-coupled receptor 89A) is a protein-coding gene. Diseases associated with GPR89A include malaria. GO annotations related to this gene include voltage-gated anion channel activity and signal transducer activity. An important paralog of this gene is GPR89C.

UniProtKB/Swiss-Prot: GPHRA_HUMAN, B7ZAQ6
Function: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may
function in counter-ion conductance (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR89A gene promoter:
         Pax-6   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR89A promoter sequence
   Search Chromatin IP Primers for GPR89A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR89A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21.1

GPR89A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR89A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M145764:  view genomic region     (about GC identifiers)

Start:
145,764,411 bp from pter      End:
145,827,103 bp from pter
Size:
62,693 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GPHRA_HUMAN, B7ZAQ6 (See protein sequence)
Recommended Name: Golgi pH regulator A  
Size: 455 amino acids; 52917 Da
Subunit: Homotrimer (By similarity)
Miscellaneous: Does not seem to be able to bind GTP
Secondary accessions: A6NN37 B2RUV3 B3KMN3 B4DXE7 Q53FQ9 Q5T2V8 Q5T5P5 Q659E2 Q6NVY5 Q9P0S4
Q9Y302
Alternative splicing: 3 isoforms:  B7ZAQ6-1   B7ZAQ6-2   B7ZAQ6-3   

Explore the universe of human proteins at neXtProt for GPR89A: NX_B7ZAQ6

Explore proteomics data for GPR89A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys272
  • Glycosylation2 at Asn180, Asn243
  • Modification sites at PhosphoSitePlus

  • See GPR89A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091081.1  NP_001091082.2  

    ENSEMBL proteins: 
     ENSP00000319673   ENSP00000436705   ENSP00000434495   ENSP00000432248   ENSP00000433482  
     ENSP00000434108   ENSP00000432212   ENSP00000410203  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR015672 GPCR89-rel
     IPR022535 Golgi_pH-regulator_cons_dom
     IPR025969 ABA_GPCR_dom

    Graphical View of Domain Structure for InterPro Entry B7ZAQ6

    ProtoNet protein and cluster: B7ZAQ6

    UniProtKB/Swiss-Prot: GPHRA_HUMAN, B7ZAQ6
    Similarity: Belongs to the Golgi pH regulator (TC 1.A.38) family


    GPR89A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPHRA_HUMAN, B7ZAQ6
    Function: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may
    function in counter-ion conductance (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005244voltage-gated ion channel activity ----
    GO:0008308voltage-gated anion channel activity IDA18794847
         
    GPR89A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR89A:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR89A
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    hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-622 hsa-miR-29a* hsa-miR-223*
    SwitchGear 3'UTR luciferase reporter plasmidGPR89A 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPHRA_HUMAN, B7ZAQ6: Golgi apparatus membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0030660Golgi-associated vesicle membrane IDA18794847
    GO:0032580Golgi cisterna membrane IDA18794847

    GPR89A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPR89A
    Interactions:

        Search GeneGlobe Interaction Network for GPR89A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for GPR89A (B7ZAQ63 ENSP000003196734) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLN3Q132863I2D: score=1 
    CASP3ENSP000003110324STRING: ENSP00000311032
    BIRC2ENSP000002277584STRING: ENSP00000227758
    BIRC3ENSP000002634644STRING: ENSP00000263464
    BIRC7ENSP000002171694STRING: ENSP00000217169
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IMP12761501
    GO:0015031protein transport IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501
    GO:0044070regulation of anion transport IDA18794847
    GO:0051452intracellular pH reduction IDA18794847

    GPR89A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR89A (GPHRA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GPR89A gene (2 alternative transcripts): 
    NM_001097612.1  NM_001097613.2  

    Unigene Clusters for GPR89A:

    G protein-coupled receptor 89A
    Hs.504320  [show with all ESTs], Hs.559115  [show with all ESTs]
    Unigene Representative Sequences: NM_001097613, AK001354
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313835(uc010ozb.1) ENST00000465185(uc001eop.2) ENST00000460277
    ENST00000493684(uc001eoq.2) ENST00000534502 ENST00000462900 ENST00000478703
    ENST00000466593 ENST00000528944 ENST00000492401 ENST00000527989 ENST00000532574
    ENST00000524525 ENST00000454423(uc010ozc.1 uc001eos.2 uc001eot.2 uc010ozd.1 uc010oze.1)

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    hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-622 hsa-miR-29a* hsa-miR-223*
    SwitchGear 3'UTR luciferase reporter plasmidGPR89A 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat GPR89A

    Additional mRNA sequence: 

    AK001354.1 AK094228.1 

    Selected DOTS entries (see all 32):

    DT.91680583  DT.95287144  DT.416281  DT.92435818  DT.121363265  DT.100810208  DT.121355550  DT.121341871 
    DT.95287146  DT.100035994  DT.100810206  DT.100706587  DT.121355541  DT.121363294  DT.100810210  DT.121341865 
    DT.121341876  DT.92435810  DT.95287178  DT.100659441  DT.121355498  DT.121355500  DT.121363227  DT.121363237 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR89A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAGGTTA
    GPR89A Expression
    About this image

    GPR89A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR89A Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.504320 Hs.559115

    UniProtKB/Swiss-Prot: GPHRA_HUMAN, B7ZAQ6
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GPR89A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr891 G protein-coupled receptor 89 88.42(n)
    96.92(a)
      67549  NM_026229.4  NP_080505.1 
    chicken
    (Gallus gallus)
    Aves GPR89B1 G protein-coupled receptor 89B 83.19(n)
    95.15(a)
      418459  NM_001030791.1  NP_001025962.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    94(a)
    1 → many
    3(161957661-161981564)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004901071 Golgi pH regulator-like 79.07(n)
    92.95(a)
      100490107  XM_004918220.1  XP_004918277.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-390b10.21 si:ch73-390b10.2 77.68(n)
    90.31(a)
      100331395  XM_002663314.2  XP_002663360.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80901 CG8090 59.14(n)
    57.56(a)
      36682  NM_137172.3  NP_611016.2 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y75B8A.161 CELE_Y75B8A.16 58.11(n)
    57.95(a)
      176650  NM_067187.4  NP_499588.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GTG21 GTG2 54.38(n)
    46.48(a)
      828874  NM_118899.3  NP_194493.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g06008001 Os04g0600800 56.76(n)
    46.62(a)
      4336878  NM_001060297.2  NP_001053762.2 


    ENSEMBL Gene Tree for GPR89A (if available)
    TreeFam Gene Tree for GPR89A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPR89A gene
    GPR89B1 2  GPR89C2  
    2 SIMAP similar genes for GPR89A using alignment to 4 protein entries:     GPHRA_HUMAN (see all proteins):
    GPR89C    GPR89B

    GPR89A for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for GPR89A
    PGOHUM00000258098 PGOHUM00000243096 PGOHUM00000263287


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPR89A (see all 495)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444076051,2
    --145764852(+) TACTCA/GTGGTC 3 -- ut31 nc-transcript-variant0--------
    rs1488038131,2
    --145764872(+) CCTGAC/GGGGGA 3 -- ut31 nc-transcript-variant0--------
    rs1998776191,2
    C--145765206(+) GCACAG/CAGGAG 5 /S /C mis11Minor allele frequency- C:0.00EU 935
    rs2010385971,2
    --145765341(+) GCTGTA/CAACAT 3 -- int10--------
    rs2001101711,2
    --145765424(+) AGATGA/GCATAA 5 A V mis10--------
    rs2020605701,2
    --145765425(+) GATGGC/TATAAA 5 T A mis10--------
    rs1476892411,2
    C--145766318(+) TGGGAC/TGTATC 3 -- int10--------
    rs1413619821,2
    --145766430(+) TGCCCA/TCTCCC 3 -- int10--------
    rs12842951,2
    C,H--145766876(+) aatcaA/Gtatca 3 -- int10--------
    rs782063161,2
    C--145767715(+) ATGCTC/GATCAT 3 -- int10--------

    HapMap Linkage Disequilibrium report for GPR89A (145764411 - 145827103 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GPR89A (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv15n16CNV Deletion17901297
    dgv46e201CNV Deletion23290073
    dgv349n71CNV Loss21882294
    nsv469752CNV Loss16826518
    esv33868CNV Loss17666407
    nsv831392CNV Gain17160897
    nsv428224CNV Gain18775914
    dgv350n71CNV Gain21882294
    dgv352n71CNV Gain21882294
    nsv872241CNV Gain+Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612821    OMIM disorders: --

    1 disease for GPR89A:    
    About MalaCards
    malaria


    GPR89A for disorders           About GeneDecksing


    Export disorders for GPR89A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR89A gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with GPR89A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. (PubMed id 19135895)1, 2 Pandey S.... Assmann S.M. (Cell 2009)
    2. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PubMed id 18794847)1, 2 Maeda Y.... Kinoshita T. (Nat. Cell Biol. 2008)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (Oncogene 2003)
    8. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 653519 HGNC: 31984 Ensembl:ENSG00000117262 euGenes: HUgn653519 ECgene: GPR89A
    H-InvDB: GPR89A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPR89A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPR89A gene:
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    GeneCards and IP:
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