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Aliases for GPR89A Gene

Aliases for GPR89A Gene

  • G Protein-Coupled Receptor 89A 2 3 5
  • Putative NF-Kappa-B-Activating Protein 90 3 4
  • Putative MAPK-Activating Protein PM01 3 4
  • GPR89 3 4
  • SH120 3 4
  • Protein GPR89A 4
  • Protein GPR89 3
  • GPR89B 3
  • UNQ192 3
  • GPHRA 4
  • GPHR 3

External Ids for GPR89A Gene

Previous GeneCards Identifiers for GPR89A Gene

  • GC01P145867
  • GC01M144476
  • GC01M145764

Summaries for GPR89A Gene

Entrez Gene Summary for GPR89A Gene

  • GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]

GeneCards Summary for GPR89A Gene

GPR89A (G Protein-Coupled Receptor 89A) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and voltage-gated anion channel activity. An important paralog of this gene is GPR89B.

UniProtKB/Swiss-Prot for GPR89A Gene

  • Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR89A Gene

Genomics for GPR89A Gene

Regulatory Elements for GPR89A Gene

Promoters for GPR89A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR89A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GPR89A gene promoter:

Genomic Location for GPR89A Gene

Chromosome:
1
Start:
145,607,960 bp from pter
End:
145,670,977 bp from pter
Size:
63,018 bases
Orientation:
Plus strand

Genomic View for GPR89A Gene

Genes around GPR89A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR89A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR89A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR89A Gene

Proteins for GPR89A Gene

  • Protein details for GPR89A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B7ZAQ6-GPHRA_HUMAN
    Recommended name:
    Golgi pH regulator A
    Protein Accession:
    B7ZAQ6
    Secondary Accessions:
    • A6NN37
    • B2RUV3
    • B3KMN3
    • B4DLT3
    • B4DXE7
    • Q53FQ9
    • Q5T2V8
    • Q5T5P5
    • Q659E2
    • Q6NVY5
    • Q9P0S4
    • Q9Y302

    Protein attributes for GPR89A Gene

    Size:
    455 amino acids
    Molecular mass:
    52917 Da
    Quaternary structure:
    • Homotrimer.
    Miscellaneous:
    • Does not seem to be able to bind GTP.

    Alternative splice isoforms for GPR89A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR89A Gene

Proteomics data for GPR89A Gene at MOPED

Post-translational modifications for GPR89A Gene

  • Glycosylation at Asn 180 and Asn 243
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR89A Gene

Domains & Families for GPR89A Gene

Protein Domains for GPR89A Gene

Suggested Antigen Peptide Sequences for GPR89A Gene

Graphical View of Domain Structure for InterPro Entry

B7ZAQ6

UniProtKB/Swiss-Prot:

GPHRA_HUMAN :
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
Family:
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
genes like me logo Genes that share domains with GPR89A: view

No data available for Gene Families for GPR89A Gene

Function for GPR89A Gene

Molecular function for GPR89A Gene

UniProtKB/Swiss-Prot Function:
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Phenotypes for GPR89A Gene

GenomeRNAi human phenotypes for GPR89A:
genes like me logo Genes that share phenotypes with GPR89A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR89A

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89A Gene

Localization for GPR89A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR89A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030660 Golgi-associated vesicle membrane IDA 18794847
genes like me logo Genes that share ontologies with GPR89A: view

No data available for Subcellular locations from COMPARTMENTS for GPR89A Gene

Pathways & Interactions for GPR89A Gene

SuperPathways for GPR89A Gene

No Data Available

Interacting Proteins for GPR89A Gene

Gene Ontology (GO) - Biological Process for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with GPR89A: view

No data available for Pathways by source and SIGNOR curated interactions for GPR89A Gene

Drugs & Compounds for GPR89A Gene

No Compound Related Data Available

Transcripts for GPR89A Gene

mRNA/cDNA for GPR89A Gene

(8) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR89A Gene

G protein-coupled receptor 89A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR89A Gene

No ASD Table

Relevant External Links for GPR89A Gene

GeneLoc Exon Structure for
GPR89A
ECgene alternative splicing isoforms for
GPR89A

Expression for GPR89A Gene

mRNA expression in normal human tissues for GPR89A Gene

Protein differential expression in normal tissues from HIPED for GPR89A Gene

This gene is overexpressed in Nasal epithelium (60.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR89A Gene



SOURCE GeneReport for Unigene cluster for GPR89A Gene Hs.504320

mRNA Expression by UniProt/SwissProt for GPR89A Gene

B7ZAQ6-GPHRA_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with GPR89A: view

Protein tissue co-expression partners for GPR89A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GPR89A Gene

Orthologs for GPR89A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR89 35
  • 94.09 (n)
  • 99.05 (a)
GPR89 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC483157 35
  • 93.7 (n)
  • 98.46 (a)
-- 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gpr89 35
  • 88.42 (n)
  • 96.92 (a)
Gpr89 36
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GPR89B 35
  • 99.71 (n)
  • 100 (a)
GPR89B 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gpr89b 35
  • 89.16 (n)
  • 96.92 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPR89B 35
  • 83.19 (n)
  • 95.15 (a)
GPR89 36
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490107 35
  • 79.07 (n)
  • 92.95 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-390b10.2 35
  • 77.68 (n)
  • 90.31 (a)
GPR89A 36
  • 90 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011252 35
  • 60.94 (n)
  • 63.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8090 35
  • 59.14 (n)
  • 57.56 (a)
CG8090 36
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.16 35
  • 58.11 (n)
  • 57.95 (a)
C11H1.2 36
  • 53 (a)
ManyToMany
Y75B8A.16 36
  • 55 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GTG2 35
  • 54.38 (n)
  • 46.48 (a)
rice
(Oryza sativa)
Liliopsida Os04g0600800 35
  • 56.76 (n)
  • 46.62 (a)
Species with no ortholog for GPR89A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR89A Gene

ENSEMBL:
Gene Tree for GPR89A (if available)
TreeFam:
Gene Tree for GPR89A (if available)

Paralogs for GPR89A Gene

Paralogs for GPR89A Gene

(2) SIMAP similar genes for GPR89A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GPR89A Gene

genes like me logo Genes that share paralogs with GPR89A: view

Variants for GPR89A Gene

Sequence variations from dbSNP and Humsavar for GPR89A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1471631 -- 145,627,000(-) AAAGA(A/T)AATCT intron-variant
rs1531793 -- 145,627,236(-) agtat(A/C/G/T)tacaa intron-variant
rs1284295 -- 145,668,183(+) aatca(A/G)tatca intron-variant
rs1871934 -- 145,625,202(+) ATAAC(A/G)TTAAA intron-variant
rs2262354 -- 145,653,390(+) ttcca(A/G)ttatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR89A Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
esv529 CNV CNV 17122850
dgv349n71 CNV Loss 21882294
dgv350n71 CNV Gain 21882294
nsv428224 CNV Gain 18775914
nsv872241 CNV Gain+Loss 21882294
nsv831392 CNV Gain 17160897
esv33868 CNV Loss 17666407
essv3464 CNV CNV 17122850
nsv469752 CNV Loss 16826518
dgv352n71 CNV Gain 21882294

Variation tolerance for GPR89A Gene

Gene Damage Index Score: 0.79; 16.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR89A Gene

HapMap Linkage Disequilibrium report
GPR89A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR89A Gene

Disorders for GPR89A Gene

Relevant External Links for GPR89A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR89A

No disorders were found for GPR89A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR89A Gene

Publications for GPR89A Gene

  1. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. (PMID: 19135895) Pandey S. … Assmann S.M. (Cell 2009) 3
  4. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PMID: 18794847) Maeda Y. … Kinoshita T. (Nat. Cell Biol. 2008) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for GPR89A Gene

Sources for GPR89A Gene

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