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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GPR89A Gene

protein-coding GIFtS: 44
GCID: GC01M145764

G protein-coupled receptor 89A

Search for GPR89A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
G Protein-Coupled Receptor 89A¹ ²		Protein GPR89²
UNQ192¹ ²		GPHRA³
Putative MAPK-Activating Protein PM01² ³		GPR89³
Putative NF-Kappa-B-Activating Protein 90² ³		SH120³
GPR89B²		Protein GPR89A³
Golgi PH Regulator A²

External Ids:	HGNC: 31984¹	Entrez Gene: 653519²	Ensembl: ENSG00000117262⁷	OMIM: 612821⁵	UniProtKB: B7ZAQ6³

ORGUL members:
	NONCODE:n410110

Export aliases for GPR89A gene to outside databases

Previous GC identifers: GC01P145867 GC01M144476

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPR89A:

GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).(supplied by OMIM, Jun 2009)

UniProtKB/Swiss-Prot: GPHRA_HUMAN, B7ZAQ6

Function: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may

function in counter-ion conductance (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167185.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GPR89A gene promoter:
Pax-6 ZID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GPR89A promoter sequence

Search SABiosciences Chromatin IP Primers for GPR89A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR89A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1

GPR89A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR89A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M145764: view genomic region (about GC identifiers)

Start:	145,764,411 bp from pter	End:	145,827,103 bp from pter
Size:	62,693 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GPHRA_HUMAN, B7ZAQ6 (See protein sequence)

Recommended Name: Golgi pH regulator A

Size: 455 amino acids; 52917 Da

Subunit: Homotrimer (By similarity)

Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein (By similarity)

Miscellaneous: Does not seem to be able to bind GTP

Secondary accessions: A6NN37 B2RUV3 B3KMN3 B4DXE7 Q53FQ9 Q5T2V8 Q5T5P5 Q659E2 Q6NVY5 Q9P0S4 Q9Y302

Alternative splicing: 3 isoforms: B7ZAQ6-1 B7ZAQ6-2 B7ZAQ6-3

Explore the universe of human proteins at neXtProt for GPR89A: NX_B7ZAQ6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_B7ZAQ6

GPR89A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001091081.1 NP_001091082.2

ENSEMBL proteins:

ENSP00000319673 ENSP00000436705 ENSP00000434495 ENSP00000432248 ENSP00000433482

ENSP00000434108 ENSP00000432212 ENSP00000410203

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	Uscn Proteins for GPR89A

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	--	--
GO:0016021	integral to membrane	IEA	--
GO:0030660	Golgi-associated vesicle membrane	IDA	18794847
GO:0032580	Golgi cisterna membrane	IDA	18794847

GPR89A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GPR89A for domains About GeneDecksing

3 InterPro domains/families:

IPR015672 GPCR89-rel

IPR022535 Golgi_pH-regulator_cons_dom

IPR025969 ABA_GPCR_dom

Graphical View of Domain Structure for InterPro Entry B7ZAQ6

ProtoNet protein and cluster: B7ZAQ6

UniProtKB/Swiss-Prot: GPHRA_HUMAN, B7ZAQ6

Similarity: Belongs to the Golgi pH regulator (TC 1.A.38) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GPHRA_HUMAN, B7ZAQ6

Function: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may

function in counter-ion conductance (By similarity)

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In Situ Assay
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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IMP	12761501
GO:0005244	voltage-gated ion channel activity	--	--
GO:0008308	voltage-gated anion channel activity	IDA	18794847

GPR89A for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for GPR89A:

Synthetic lethal with c-Myc af

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GPR89A

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for GPR89A (B7ZAQ6³ ENSP00000319673⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CLN3	Q13286³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IMP	12761501
GO:0015031	protein transport	IEA	--
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP	12761501
GO:0044070	regulation of anion transport	IDA	18794847
GO:0051452	intracellular pH reduction	IDA	18794847

GPR89A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GPR89A
Search CenterWatch for drugs/clinical trials and news about GPR89A / GPHRA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for GPR89A gene (2 alternative transcripts):

NM_001097612.1 NM_001097613.2

Unigene Clusters for GPR89A:

G protein-coupled receptor 89A

Hs.504320 [show with all ESTs], Hs.559115 [show with all ESTs]

Unigene Representative Sequences: NM_001097613, AK001354

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000313835(uc010ozb.1) ENST00000465185(uc001eop.2) ENST00000460277

ENST00000493684(uc001eoq.2) ENST00000534502 ENST00000462900 ENST00000478703

ENST00000466593 ENST00000528944 ENST00000492401 ENST00000527989 ENST00000532574

ENST00000524525 ENST00000454423(uc010ozc.1 uc001eos.2 uc001eot.2 uc010ozd.1 uc010oze.1)

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Additional cDNA sequence:

AK001354.1 AK094228.1

24/32 DOTS entries (see all 32):

DT.91680583 DT.95287144 DT.416281 DT.92435818 DT.121363265 DT.100810208 DT.121355550 DT.121341871

DT.95287146 DT.100035994 DT.100810206 DT.100706587 DT.121355541 DT.121363294 DT.100810210 DT.121341865

DT.121341876 DT.92435810 DT.95287178 DT.100659441 DT.121355498 DT.121355500 DT.121363227 DT.121363237

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GPR89A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAAGGTTA

About this image
See GPR89A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPR89A

SOURCE GeneReport for Unigene clusters: Hs.504320 Hs.559115

UniProtKB/Swiss-Prot: GPHRA_HUMAN, B7ZAQ6

Tissue specificity: Ubiquitous

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR89A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89A gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GPR89B¹	G protein-coupled receptor 89B	83.19(n) 95.15(a)		418459 NM_001030791.1 NP_001025962.1
lizard (Anolis carolinensis)	Reptilia	--	--	94(a)	1 → many	3(161957686-161981402)
zebrafish (Danio rerio)	Actinopterygii	gpr89b¹	G protein-coupled receptor 89B	77.68(n) 90.31(a)		100331395 XM_002663314.1 XP_002663360.1
fruit fly (Drosophila melanogaster)	Insecta	CG8090¹	CG8090	59.14(n) 57.56(a)		36682 NM_137172.3 NP_611016.2
worm (Caenorhabditis elegans)	Secernentea	CELE_Y75B8A.16¹	Protein Y75B8A.16	58.3(n) 58.22(a)		176650 NM_067187.3 NP_499588.1
thale cress (Arabidopsis thaliana)	eudicotyledons	GTG2¹	GPCR-type G protein 2	54.05(n) 45.87(a)		828874 NM_118899.3 NP_194493.2
rice (Oryza sativa)	Liliopsida	Os04g0600800¹	hypothetical protein	56.76(n) 46.62(a)		4336878 NM_001060297.2 NP_001053762.2

ENSEMBL Gene Tree for GPR89A (if available)
TreeFam Gene Tree for GPR89A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GPR89A gene

GPR89B¹ ² GPR89C²

2 SIMAP similar genes for GPR89A using alignment to 4 protein entries: GPHRA_HUMAN (see all proteins):

GPR89C GPR89B

GPR89A for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for GPR89A
PGOHUM00000258098 PGOHUM00000243096 PGOHUM00000263287

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144407605^1,2		--	145764852(+)	`TACTCA/GTGGTC`	3	--	nc-transcript-variantut3¹		0	--	--	--	--
rs148803813^1,2		--	145764872(+)	`CCTGAC/GGGGGA`	3	--	nc-transcript-variantut3¹		0	--	--	--	--
rs199877619^1,2	C	--	145765206(+)	`GCACAG/CAGGAG`	5	/S /C	nc-transcript-variantmis¹		1		EU	935
rs201038597^1,2		--	145765341(+)	`GCTGTA/CAACAT`	3	--	int¹		0	--	--	--	--
rs200110171^1,2		--	145765424(+)	`AGATGA/GCATAA`	5	A V	nc-transcript-variantmis¹		0	--	--	--	--
rs202060570^1,2		--	145765425(+)	`GATGGC/TATAAA`	5	T A	nc-transcript-variantmis¹		0	--	--	--	--
rs147689241^1,2		--	145766318(+)	`TGGGAC/TGTATC`	3	--	int¹		0	--	--	--	--
rs141361982^1,2		--	145766430(+)	`TGCCCA/TCTCCC`	3	--	int¹		0	--	--	--	--
rs1284295^1,2	C,H,	--	145766876(+)	`AATCAA/GTATCA`	3	--	int¹		0	--	--	--	--
rs78206316^1,2	C	--	145767715(+)	`ATGCTC/GATCAT`	3	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GPR89A (145764411 - 145827103 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for GPR89A
4 CNVs: 8923 3311 6783 2325

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GPR89A for disorders About MalaCards

GPR89A for disorders About GeneDecksing

OMIM gene information: 612821 OMIM disorders: --

Export disorders for GPR89A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GPR89A gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with GPR89A)

Utopia: connect your pdf to the dynamic
world of online information

Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. (PubMed id 19135895)^{1, 2} Pandey S.... Assmann S.M. (2009)
GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PubMed id 18794847)^{1, 2} Maeda Y....Kinoshita T. (2008)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)^{1, 2} Matsuda A....Sugano S. (2003)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2} Lai C.H....Lin W. (2000)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 653519	HGNC: 31984	Ensembl:ENSG00000117262	euGenes: HUgn653519	ECgene: GPR89A
H-InvDB: GPR89A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GPR89A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GPR89A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GPR89A gene:
Search GeneIP for patents involving GPR89A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GPR89A Gene

G protein-coupled receptor 89A

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GPR89A Gene

G protein-coupled receptor 89A

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for GPR89A gene

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for GPR89A gene

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for GPR89A gene

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Orthologs
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Genomic Variants
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Disorders / Diseases
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Intellectual Property
for GPR89A gene

Products
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