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Aliases for GPR88 Gene

Aliases for GPR88 Gene

  • G Protein-Coupled Receptor 88 2 3 5
  • Striatum-Specific G-Protein Coupled Receptor 3 4
  • G-Protein Coupled Receptor 88 2 3
  • G Protein Coupled Receptor 88 2 3
  • STRG 3 4

External Ids for GPR88 Gene

Previous GeneCards Identifiers for GPR88 Gene

  • GC01P101794
  • GC01P100184
  • GC01P100294
  • GC01P100715
  • GC01P100776
  • GC01P101003
  • GC01P099128

Summaries for GPR88 Gene

GeneCards Summary for GPR88 Gene

GPR88 (G Protein-Coupled Receptor 88) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR88 Gene

  • Orphan receptor.

Gene Wiki entry for GPR88 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR88 Gene

Genomics for GPR88 Gene

Regulatory Elements for GPR88 Gene

Promoters for GPR88 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR88 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR88 Gene

Chromosome:
1
Start:
100,538,137 bp from pter
End:
100,542,027 bp from pter
Size:
3,891 bases
Orientation:
Plus strand

Genomic View for GPR88 Gene

Genes around GPR88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR88 Gene

Proteins for GPR88 Gene

  • Protein details for GPR88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZN0-GPR88_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 88
    Protein Accession:
    Q9GZN0
    Secondary Accessions:
    • Q29S24
    • Q6VN48

    Protein attributes for GPR88 Gene

    Size:
    384 amino acids
    Molecular mass:
    40246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR88 Gene

Proteomics data for GPR88 Gene at MOPED

Post-translational modifications for GPR88 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR88 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR88 Gene

Domains & Families for GPR88 Gene

Gene Families for GPR88 Gene

Protein Domains for GPR88 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR88 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZN0

UniProtKB/Swiss-Prot:

GPR88_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR88: view

Function for GPR88 Gene

Molecular function for GPR88 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes for GPR88 Gene

genes like me logo Genes that share phenotypes with GPR88: view

Animal Model Products

miRNA for GPR88 Gene

miRTarBase miRNAs that target GPR88

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR88 Gene

Localization for GPR88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR88 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR88 Gene COMPARTMENTS Subcellular localization image for GPR88 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with GPR88: view

Pathways & Interactions for GPR88 Gene

SuperPathways for GPR88 Gene

Superpath Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR88: view

Pathways by source for GPR88 Gene

1 BioSystems pathway for GPR88 Gene

Interacting Proteins for GPR88 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000314223%0d%0a9606.ENSP00000349238%0d%0a9606.ENSP00000343027%0d%0a9606.ENSP00000358867%0d%0a
Selected Interacting proteins: ENSP00000314223 for GPR88 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0019228 neuronal action potential IEA --
genes like me logo Genes that share ontologies with GPR88: view

No data available for SIGNOR curated interactions for GPR88 Gene

Drugs & Compounds for GPR88 Gene

(1) Drugs for GPR88 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
COMPOUND 2 [PMID: 24793972] Pharma 0
genes like me logo Genes that share compounds with GPR88: view

Transcripts for GPR88 Gene

mRNA/cDNA for GPR88 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR88 Gene

G protein-coupled receptor 88:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR88 Gene

No ASD Table

Relevant External Links for GPR88 Gene

GeneLoc Exon Structure for
GPR88
ECgene alternative splicing isoforms for
GPR88

Expression for GPR88 Gene

mRNA expression in normal human tissues for GPR88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR88 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x18.9), Brain - Caudate (basal ganglia) (x15.2), and Brain - Nucleus accumbens (basal ganglia) (x11.5).

SOURCE GeneReport for Unigene cluster for GPR88 Gene Hs.170053

mRNA Expression by UniProt/SwissProt for GPR88 Gene

Q9GZN0-GPR88_HUMAN
Tissue specificity: Expressed almost exclusively in striatum.
genes like me logo Genes that share expression patterns with GPR88: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR88 Gene

Orthologs for GPR88 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR88 36
  • 100 (a)
OneToOne
GPR88 35
  • 99.83 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia GPR88 36
  • 97 (a)
OneToOne
GPR88 35
  • 93.13 (n)
  • 97.21 (a)
dog
(Canis familiaris)
Mammalia GPR88 35
  • 92.83 (n)
  • 95.81 (a)
GPR88 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr88 16
Gpr88 36
  • 96 (a)
OneToOne
Gpr88 35
  • 90.28 (n)
  • 95.57 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR88 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr88 35
  • 88.45 (n)
  • 95.31 (a)
chicken
(Gallus gallus)
Aves GPR88 35
  • 74.88 (n)
  • 74.31 (a)
GPR88 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR88 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr88 35
  • 57.04 (n)
  • 53.43 (a)
zebrafish
(Danio rerio)
Actinopterygii gpr88 36
  • 50 (a)
OneToOne
gpr88 35
  • 54.87 (n)
  • 48.74 (a)
Species with no ortholog for GPR88:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR88 Gene

ENSEMBL:
Gene Tree for GPR88 (if available)
TreeFam:
Gene Tree for GPR88 (if available)

Paralogs for GPR88 Gene

No data available for Paralogs for GPR88 Gene

Variants for GPR88 Gene

Sequence variations from dbSNP and Humsavar for GPR88 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2809819 - 100,539,534(-) GTGGA(C/T)TCGCG reference, missense
rs3001995 - 100,539,920(+) GTGCA(C/G)GCGGC reference, missense
rs2030048 -- 100,541,021(+) GTACT(A/G)TAATG utr-variant-3-prime
rs2036212 -- 100,538,103(+) CCTGG(A/G)TGATG upstream-variant-2KB
rs2518418 -- 100,541,192(+) GAAGC(A/G)ATACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR88 Gene

Variant ID Type Subtype PubMed ID
nsv830826 CNV Gain 17160897
nsv823653 CNV Loss 20364138
esv22185 CNV Loss 19812545

Variation tolerance for GPR88 Gene

Gene Damage Index Score: 8.18; 84.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR88 Gene

HapMap Linkage Disequilibrium report
GPR88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR88 Gene

Disorders for GPR88 Gene

Relevant External Links for GPR88

Genetic Association Database (GAD)
GPR88
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR88

No disorders were found for GPR88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR88 Gene

Publications for GPR88 Gene

  1. A novel G-protein-coupled receptor gene expressed in striatum. (PMID: 11056049) Mizushima K. … Ito T. (Genomics 2000) 3 4 67
  2. Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine. (PMID: 17033635) Conti B. … Bartfai T. (Mol. Psychiatry 2007) 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for GPR88 Gene

Sources for GPR88 Gene

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