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Aliases for GPR88 Gene

Aliases for GPR88 Gene

  • G Protein-Coupled Receptor 88 2 3 5
  • Striatum-Specific G-Protein Coupled Receptor 3 4
  • STRG 3 4
  • Probable G-Protein Coupled Receptor 88 3
  • G-Protein Coupled Receptor 88 2
  • G Protein Coupled Receptor 88 2
  • COCPMR 3

External Ids for GPR88 Gene

Previous GeneCards Identifiers for GPR88 Gene

  • GC01P101794
  • GC01P100184
  • GC01P100294
  • GC01P100715
  • GC01P100776
  • GC01P101003
  • GC01P099128

Summaries for GPR88 Gene

Entrez Gene Summary for GPR88 Gene

  • The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]

GeneCards Summary for GPR88 Gene

GPR88 (G Protein-Coupled Receptor 88) is a Protein Coding gene. Diseases associated with GPR88 include Choreatic Disease. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR88 Gene

  • Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.

Gene Wiki entry for GPR88 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR88 Gene

Genomics for GPR88 Gene

Regulatory Elements for GPR88 Gene

Enhancers for GPR88 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G100438 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -97.7 -97662 3.6 PKNOX1 ATF1 GATA2 ZNF263 MEF2D MBD2 SMARCA4 PBX2 KDM1A WT1 CDC14A ENSG00000228086 GPR88 MFSD14A SLC35A3 GC01M100458 BCAS2P2
GH01G100443 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -93.3 -93258 3.3 HDGF CTCF FOXA2 JUN ZBTB40 FOSL1 GATA2 EED ETV6 FOS CDC14A GPR88 MFSD14A SLC35A3 GC01M100458 BCAS2P2
GH01G100583 1.4 Ensembl ENCODE dbSUPER 11.8 +47.0 47049 2.4 ELF3 FOXA2 RARA TCF12 SCRT2 FOS MIXL1 CBFB JUNB PPARG GPR88 VCAM1 GC01M100588
GH01G100394 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -141.5 -141513 5.3 HDGF PKNOX1 ZNF266 ZNF394 ATF2 ARID1B ZNF316 SMARCA4 MAFK PRDM1 CDC14A GPR88 MFSD14A BCAS2P2 GC01M100458
GH01G100463 1.3 Ensembl ENCODE dbSUPER 11.1 -74.2 -74203 0.5 CTCF MAX FEZF1 ZNF2 RAD21 ZNF143 SMC3 RELB MIXL1 ZNF654 ENSG00000228086 GPR88 SASS6 TRMT13 GC01M100458
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR88 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR88 Gene

Chromosome:
1
Start:
100,538,137 bp from pter
End:
100,542,027 bp from pter
Size:
3,891 bases
Orientation:
Plus strand

Genomic View for GPR88 Gene

Genes around GPR88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR88 Gene

Proteins for GPR88 Gene

  • Protein details for GPR88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZN0-GPR88_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 88
    Protein Accession:
    Q9GZN0
    Secondary Accessions:
    • Q29S24
    • Q6VN48

    Protein attributes for GPR88 Gene

    Size:
    384 amino acids
    Molecular mass:
    40246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR88 Gene

Post-translational modifications for GPR88 Gene

  • Glycosylation at isoforms=3
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR88 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR88 Gene

Domains & Families for GPR88 Gene

Gene Families for GPR88 Gene

Protein Domains for GPR88 Gene

Suggested Antigen Peptide Sequences for GPR88 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZN0

UniProtKB/Swiss-Prot:

GPR88_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR88: view

Function for GPR88 Gene

Molecular function for GPR88 Gene

UniProtKB/Swiss-Prot Function:
Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.

Gene Ontology (GO) - Molecular Function for GPR88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity ISS --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR88: view
genes like me logo Genes that share phenotypes with GPR88: view

Animal Model Products

CRISPR Products

miRNA for GPR88 Gene

miRTarBase miRNAs that target GPR88

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR88

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR88 Gene

Localization for GPR88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR88 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Note=During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood. {ECO:0000250 UniProtKB:Q9ESP4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR88 gene
Compartment Confidence
plasma membrane 5
nucleus 4

Gene Ontology (GO) - Cellular Components for GPR88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GPR88: view

Pathways & Interactions for GPR88 Gene

SuperPathways for GPR88 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR88: view

Pathways by source for GPR88 Gene

1 BioSystems pathway for GPR88 Gene

Interacting Proteins for GPR88 Gene

Gene Ontology (GO) - Biological Process for GPR88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 11056049
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 chemical synaptic transmission IBA --
GO:0007626 locomotory behavior IEA --
genes like me logo Genes that share ontologies with GPR88: view

No data available for SIGNOR curated interactions for GPR88 Gene

Drugs & Compounds for GPR88 Gene

(1) Drugs for GPR88 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
COMPOUND 2 [PMID: 24793972] Pharma 0
genes like me logo Genes that share compounds with GPR88: view

Transcripts for GPR88 Gene

mRNA/cDNA for GPR88 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR88 Gene

G protein-coupled receptor 88:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR88

Alternative Splicing Database (ASD) splice patterns (SP) for GPR88 Gene

No ASD Table

Relevant External Links for GPR88 Gene

GeneLoc Exon Structure for
GPR88
ECgene alternative splicing isoforms for
GPR88

Expression for GPR88 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR88 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x18.9), Brain - Caudate (basal ganglia) (x15.2), and Brain - Nucleus accumbens (basal ganglia) (x11.5).

NURSA nuclear receptor signaling pathways regulating expression of GPR88 Gene:

GPR88

SOURCE GeneReport for Unigene cluster for GPR88 Gene:

Hs.170053

mRNA Expression by UniProt/SwissProt for GPR88 Gene:

Q9GZN0-GPR88_HUMAN
Tissue specificity: Expressed predominantly in the striatum.

Evidence on tissue expression from TISSUES for GPR88 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GPR88: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR88 Gene

Orthologs for GPR88 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR88 34 35
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia GPR88 34 35
  • 93.13 (n)
dog
(Canis familiaris)
Mammalia GPR88 34 35
  • 92.83 (n)
mouse
(Mus musculus)
Mammalia Gpr88 34 16 35
  • 90.28 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR88 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr88 34
  • 88.45 (n)
chicken
(Gallus gallus)
Aves GPR88 34 35
  • 74.88 (n)
lizard
(Anolis carolinensis)
Reptilia GPR88 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr88 34
  • 57.04 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr88 34 35
  • 54.87 (n)
Species where no ortholog for GPR88 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR88 Gene

ENSEMBL:
Gene Tree for GPR88 (if available)
TreeFam:
Gene Tree for GPR88 (if available)

Paralogs for GPR88 Gene

No data available for Paralogs for GPR88 Gene

Variants for GPR88 Gene

Sequence variations from dbSNP and Humsavar for GPR88 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs875989788 Pathogenic 100,539,839(+) TGCTG(A/C)GTCTT reference, stop-gained
rs1000719686 -- 100,539,203(+) CTCAG(C/T)GTCTG reference, synonymous-codon
rs1000962455 -- 100,539,779(+) CCCGC(G/T)CTGCA reference, synonymous-codon
rs1001214170 -- 100,538,768(+) GGCAC(C/T)TGTCA intron-variant
rs1001514344 -- 100,541,544(+) AGTGA(A/C)CAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR88 Gene

Variant ID Type Subtype PubMed ID
esv22185 CNV loss 19812545
nsv546889 CNV gain 21841781
nsv823653 CNV loss 20364138
nsv830826 CNV gain 17160897

Variation tolerance for GPR88 Gene

Gene Damage Index Score: 8.18; 84.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR88 Gene

Human Gene Mutation Database (HGMD)
GPR88
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR88 Gene

Disorders for GPR88 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR88 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
choreatic disease
  • chorea
- elite association - COSMIC cancer census association via MalaCards
Search GPR88 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GPR88_HUMAN
  • Chorea, childhood-onset, with psychomotor retardation (COCPMR) [MIM:616939]: An autosomal recessive neurodevelopmental disorder characterized by abnormal involuntary movements, marked speech delay, intellectual disability and learning difficulties. {ECO:0000269 PubMed:27123486}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GPR88

Genetic Association Database (GAD)
GPR88
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR88
genes like me logo Genes that share disorders with GPR88: view

No data available for Genatlas for GPR88 Gene

Publications for GPR88 Gene

  1. Deleterious mutation in GPR88 is associated with chorea, speech delay, and learning disabilities. (PMID: 27123486) Alkufri F. … Elpeleg O. (Neurol. Genet. 2016) 3 4 64
  2. A novel G-protein-coupled receptor gene expressed in striatum. (PMID: 11056049) Mizushima K. … Ito T. (Genomics 2000) 3 4 64
  3. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. (PMID: 24793972) Jin C. … Zhang X.P. (ACS Chem Neurosci 2014) 3 64
  4. Association study in three different populations between the GPR88 gene and major psychoses. (PMID: 24689078) Del Zompo M. … Meloni R. (Mol Genet Genomic Med 2014) 3 64
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 46 64

Products for GPR88 Gene

  • Addgene plasmids for GPR88

Sources for GPR88 Gene

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