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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR87 Gene

protein-coding   GIFtS: 50
GCID: GC03M151012

G Protein-Coupled Receptor 87


(Previous symbol: GPR95)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor 871 2     G Protein-Coupled Receptor 952
GPR951 2 3     G-Protein Coupled Receptor 872
G-Protein Coupled Receptor 952 3     Orphan GPCR 872
KPG_0022     

External Ids:    HGNC: 45381   Entrez Gene: 538362   Ensembl: ENSG000001382717   OMIM: 6063795   UniProtKB: Q9BY213   

Export aliases for GPR87 gene to outside databases

Previous GC identifers: GC03M147953 GC03M151844 GC03M152293 GC03M152332 GC03M152494 GC03M148385


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPR87 Gene:
This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on
chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma
(PMID:18057535) and regulated by p53 (PMID:19602589). (provided by RefSeq, Nov 2011)

GeneCards Summary for GPR87 Gene: 
GPR87 (G protein-coupled receptor 87) is a protein-coding gene. Diseases associated with GPR87 include lung squamous cell carcinoma, and squamous cell carcinoma, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors). GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is GPR82.

UniProtKB/Swiss-Prot: GPR87_HUMAN, Q9BY21
Function: Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA
damage

Gene Wiki entry for GPR87 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR87 gene promoter:
         GR   E2F-4   E2F-3a   E2F-5   GR-beta   E2F-2   PPAR-alpha   E2F   E2F-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR87 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPR87

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR87


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q24

GPR87 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR87 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M151012:  view genomic region     (about GC identifiers)

Start:
151,011,874 bp from pter      End:
151,034,740 bp from pter
Size:
22,867 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPR87_HUMAN, Q9BY21 (See protein sequence)
Recommended Name: G-protein coupled receptor 87  
Size: 358 amino acids; 41436 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAK29069.1; Type=Erroneous initiation;
Secondary accessions: Q5KU35 Q96JZ8 Q9BXC2

Explore the universe of human proteins at neXtProt for GPR87: NX_Q9BY21

Explore proteomics data for GPR87 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BY21

  • GPR87 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPR87 Protein Expression
    REFSEQ proteins: NP_076404.3  
    ENSEMBL proteins: 
     ENSP00000260843  

    Human Recombinant Protein Products for GPR87: 
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    Novus Biologicals GPR87 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPR87 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane NAS--

    GPR87 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for GPR87 
    Cloud-Clone Corp. CLIAs for GPR87


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR87 
    Class A Orphans

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR002286 purinergic_P2Y_rcpt
     IPR008109 P2Y13_purnocptor

    Graphical View of Domain Structure for InterPro Entry Q9BY21

    ProtoNet protein and cluster: Q9BY21

    UniProtKB/Swiss-Prot: GPR87_HUMAN, Q9BY21
    Similarity: Belongs to the G-protein coupled receptor 1 family


    GPR87 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPR87_HUMAN, Q9BY21
    Function: Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA
    damage
    Induction: By expression of p53/TP53 and by DNA damage in a TP53-dependent manner

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0045028G-protein coupled purinergic nucleotide receptor activity IEA--
         
    GPR87 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR87:
     Increased homologous recombina 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gpr87):
     limbs/digits/tail  skeleton 

    GPR87 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gpr87tm1Lex for GPR87

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GPR87 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR87


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPR87 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    GPCRs, Class A Rhodopsin-like0.41


    1 BioSystems Pathway for GPR87
        GPCRs, Class A Rhodopsin-like


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR87

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007194negative regulation of adenylate cyclase activity IEA--
    GO:0008150biological_process ND--

    GPR87 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPR87

    3 IUPHAR Ligands for GPR87 (GPR87)    About this table 
    LigandTypeActionAffinityPubmed IDs
    LPA
    AgonistAgonist7.4417905198 18466763
    Ki16425
    AntagonistAntagonist7.4417905198
    dioctanoy?aelglycerol?ae pyrophos?aephate
    AntagonistAntagonist7.4417905198

    Search CenterWatch for drugs/clinical trials and news about GPR87

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPR87 gene: 
    NM_023915.3  

    Unigene Cluster for GPR87:

    G protein-coupled receptor 87
    Hs.591292  [show with all ESTs]
    Unigene Representative Sequence: NM_023915
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260843(uc003eyt.2)
    miRNA
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    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR87
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR87

    Additional mRNA sequence: 

    AB031548.1 AF086432.1 AF237763.1 AF345566.1 AF411114.1 AK027784.1 BC009540.1 BC112941.1 
    BC117565.1 BC132888.1 BC132890.1 EU883576.1 

    2 DOTS entries:

    DT.203012  DT.40124685 

    24/29 AceView cDNA sequences (see all 29):

    BM976299 AF411114 W79123 AF086432 BU683700 BM695531 AF345566 W79920 
    NM_023915 AF237763 BU679920 BG286447 BE879604 BG676453 AK027784 AI659657 
    BG677820 BU684220 BC009540 BU728943 AW873727 BE563611 BX284030 AI611298 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPR87 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GPR87 Expression
    About this image


    See GPR87 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPR87

    SOURCE GeneReport for Unigene cluster: Hs.591292

    UniProtKB/Swiss-Prot: GPR87_HUMAN, Q9BY21
    Tissue specificity: Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus,
    hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung

        SABiosciences Expression via Pathway-Focused PCR Array including GPR87: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR87

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GPR87 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr871 , 5 G protein-coupled receptor 871, 5 85.35(n)1
    89.86(a)1
      3 (29.00 cM)5
    841111  NM_032399.11  NP_115775.11 
     591790065 
    chicken
    (Gallus gallus)
    Aves GPR871 G protein-coupled receptor 87 72.94(n)
    82.02(a)
      425038  XM_422840.2  XP_422840.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR876
    G protein-coupled receptor 87
    70(a)
    1 ↔ 1
    3(18070932-18088614)
    zebrafish
    (Danio rerio)
    Actinopterygii CR626884.26
    CR626884.16
    (see all 3)
    Uncharacterized protein
    (see all 3)
    29(a)
    25(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    15(3884031-3885272)
    15(3925592-3929550)


    ENSEMBL Gene Tree for GPR87 (if available)
    TreeFam Gene Tree for GPR87 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPR87 gene
    GPR822  P2RY132  GPR1712  GPR342  P2RY142  P2RY122  
    10 SIMAP similar genes for GPR87 using alignment to 1 protein entry:     GPR87_HUMAN:
    P2RY14    P2RY13    P2RY12    GPR171    F2RL2    GPR34
    GPR183    CYSLTR2    KPG_011    PTAFR

    GPR87 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in GPR87 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357604
    A colorectal cancer sample4--see VAR_0357602 D Y mis40--------
    VAR_0559214
    ----see VAR_0559212 T M mis40--------

    HapMap Linkage Disequilibrium report for GPR87 (151011874 - 151034740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GPR87:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726054CNV Deletion23290073
    esv2726055CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR87
    DNA2.0 Custom Variant and Variant Library Synthesis for GPR87

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606379    OMIM disorders: --

    4 diseases for GPR87:    About MalaCards
    lung squamous cell carcinoma    squamous cell carcinoma    oral squamous cell carcinoma    prostatitis


    GPR87 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GPR87
    Human Genome Epidemiology (HuGE) Navigator: GPR87 (1 document)

    Export disorders for GPR87 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPR87 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with GPR87)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PubMed id 11273702)1, 2, 3 Wittenberger T.... Hellebrand S. (2001)
    2. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. (PubMed id 19602589)1, 2, 9 Zhang Y.... Chen X. (2009)
    3. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. (PubMed id 17905198)1, 2 Tabata K.... Fujita N. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155)1, 2 Lee D.K....O'Dowd B.F. (2001)
    7. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)4 Yokoyama K....Hosoya T. (2010)
    8. GPR87 is an overexpressed G-protein coupled receptor in squamous cell carcinoma of the lung. (PubMed id 18057535)1 Gugger M....Reubi J.C. (2008)
    9. hGPR87 contributes to viability of human tumor cells. (PubMed id 18183596)1 Glatt S....Sommergruber W. (2008)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53836 HGNC: 4538 AceView: GPR87 Ensembl:ENSG00000138271 euGenes: HUgn53836
    ECgene: GPR87 H-InvDB: GPR87

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPR87 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPR87 gene:
    Search GeneIP for patents involving GPR87

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 27 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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