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Aliases for GPR87 Gene

Aliases for GPR87 Gene

  • G Protein-Coupled Receptor 87 2 3
  • G-Protein Coupled Receptor 95 3 4
  • GPR95 3 4
  • G Protein-Coupled Receptor 95 3
  • G-Protein Coupled Receptor 87 3
  • Orphan GPCR 87 3
  • KPG_002 3
  • FKSG78 3

External Ids for GPR87 Gene

Previous HGNC Symbols for GPR87 Gene

  • GPR95

Previous GeneCards Identifiers for GPR87 Gene

  • GC03M147953
  • GC03M151844
  • GC03M152293
  • GC03M152332
  • GC03M152494
  • GC03M151012
  • GC03M148385

Summaries for GPR87 Gene

Entrez Gene Summary for GPR87 Gene

  • This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]

GeneCards Summary for GPR87 Gene

GPR87 (G Protein-Coupled Receptor 87) is a Protein Coding gene. Diseases associated with GPR87 include lung squamous cell carcinoma and oral squamous cell carcinoma. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY14.

UniProtKB/Swiss-Prot for GPR87 Gene

  • Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.

Gene Wiki entry for GPR87 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR87 Gene

Genomics for GPR87 Gene

Regulatory Elements for GPR87 Gene

Genomic Location for GPR87 Gene

Start:
151,294,086 bp from pter
End:
151,316,952 bp from pter
Size:
22,867 bases
Orientation:
Minus strand

Genomic View for GPR87 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR87 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR87 Gene

Proteins for GPR87 Gene

  • Protein details for GPR87 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY21-GPR87_HUMAN
    Recommended name:
    G-protein coupled receptor 87
    Protein Accession:
    Q9BY21
    Secondary Accessions:
    • Q5KU35
    • Q96JZ8
    • Q9BXC2

    Protein attributes for GPR87 Gene

    Size:
    358 amino acids
    Molecular mass:
    41436 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK29069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR87 Gene

Proteomics data for GPR87 Gene at MOPED

Post-translational modifications for GPR87 Gene

  • Glycosylation at Asn4, Asn25, and Asn33
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR87 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR87 Gene

Domains for GPR87 Gene

Gene Families for GPR87 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for GPR87 Gene

Suggested Antigen Peptide Sequences for GPR87 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY21

UniProtKB/Swiss-Prot:

GPR87_HUMAN :
  • Q9BY21
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR87: view

Function for GPR87 Gene

Molecular function for GPR87 Gene

UniProtKB/Swiss-Prot Function: Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.
UniProtKB/Swiss-Prot Induction: By expression of p53/TP53 and by DNA damage in a TP53-dependent manner.

Gene Ontology (GO) - Molecular Function for GPR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA --
genes like me logo Genes that share ontologies with GPR87: view

Phenotypes for GPR87 Gene

genes like me logo Genes that share phenotypes with GPR87: view

Animal Models for GPR87 Gene

MGI Knock Outs for GPR87:

Animal Model Products

CRISPR Products

miRNA for GPR87 Gene

miRTarBase miRNAs that target GPR87

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR87

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GPR87 Gene

Localization for GPR87 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR87 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR87 Gene COMPARTMENTS Subcellular localization image for GPR87 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR87: view

Pathways for GPR87 Gene

SuperPathways for GPR87 Gene

genes like me logo Genes that share pathways with GPR87: view

Pathways by source for GPR87 Gene

1 BioSystems pathway for GPR87 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR87 Gene

Gene Ontology (GO) - Biological Process for GPR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007194 negative regulation of adenylate cyclase activity IEA --
GO:0008150 biological_process ND --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR87: view

Compounds for GPR87 Gene

(3) IUPHAR Ligand for GPR87 Gene

Ligand Type Action Affinity Pubmed IDs
dioctanoy?aelglycerol?ae pyrophos?aephate Antagonist Antagonist 7
LPA Agonist Agonist 5.6
Ki16425 Antagonist Antagonist 5.25
genes like me logo Genes that share compounds with GPR87: view

Transcripts for GPR87 Gene

mRNA/cDNA for GPR87 Gene

(12) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR87 Gene

G protein-coupled receptor 87:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR87

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR87 Gene

No ASD Table

Relevant External Links for GPR87 Gene

GeneLoc Exon Structure for
GPR87
ECgene alternative splicing isoforms for
GPR87

Expression for GPR87 Gene

mRNA expression in normal human tissues for GPR87 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR87 Gene

This gene is overexpressed in Esophagus - Mucosa (12.7), Skin - Sun Exposed (Lower leg) (10.1), Skin - Not Sun Exposed (Suprapubic) (9.6), Vagina (7.0), and Minor Salivary Gland (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GPR87 Gene

SOURCE GeneReport for Unigene cluster for GPR87 Gene Hs.591292

mRNA Expression by UniProt/SwissProt for GPR87 Gene

Q9BY21-GPR87_HUMAN
Tissue specificity: Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.
genes like me logo Genes that share expressions with GPR87: view

In Situ Assay Products

Orthologs for GPR87 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR87 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR87 35
  • 99.35 (n)
  • 99.44 (a)
GPR87 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR87 35
  • 87.8 (n)
  • 92.74 (a)
GPR87 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR87 35
  • 90.5 (n)
  • 94.13 (a)
GPR87 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr87 35
  • 85.35 (n)
  • 89.86 (a)
Gpr87 16
Gpr87 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR87 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR87 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr87 35
  • 84.09 (n)
  • 88.98 (a)
chicken
(Gallus gallus)
Aves GPR87 35
  • 72.85 (n)
  • 82.02 (a)
GPR87 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR87 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr87 35
  • 65.53 (n)
  • 65.24 (a)
zebrafish
(Danio rerio)
Actinopterygii CR626884.1 36
  • 26 (a)
ManyToMany
si:ch73-309g22.1 36
  • 21 (a)
ManyToMany
si:dkey-83h2.2 36
  • 29 (a)
ManyToMany
Species with no ortholog for GPR87:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR87 Gene

ENSEMBL:
Gene Tree for GPR87 (if available)
TreeFam:
Gene Tree for GPR87 (if available)

Paralogs for GPR87 Gene

Paralogs for GPR87 Gene

Selected SIMAP similar genes for GPR87 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR87: view

Variants for GPR87 Gene

Sequence variations from dbSNP and Humsavar for GPR87 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_035760 A colorectal cancer sample
VAR_055921 -

Structural Variations from Database of Genomic Variants (DGV) for GPR87 Gene

Variant ID Type Subtype PubMed ID
esv2726054 CNV Deletion 23290073
esv2726055 CNV Deletion 23290073

Relevant External Links for GPR87 Gene

HapMap Linkage Disequilibrium report
GPR87

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR87 Gene

Disorders for GPR87 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for GPR87 Gene including...

Search for GPR87 Gene in MalaCards »

Relevant External Links for GPR87

Genetic Association Database (GAD)
GPR87
Human Genome Epidemiology (HuGE) Navigator
GPR87
genes like me logo Genes that share disorders with GPR87: view

No data available for UniProtKB/Swiss-Prot for GPR87 Gene

Publications for GPR87 Gene

  1. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. (PMID: 19602589) Zhang Y. … Chen X. (Cancer Res. 2009) 3 4 23
  2. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PMID: 11273702) Wittenberger T. … Hellebrand S. (J. Mol. Biol. 2001) 2 3 4
  3. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee D.K. … O'Dowd B.F. (Gene 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GPR87 Gene

Sources for GPR87 Gene

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