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GPR87 Gene

protein-coding   GIFtS: 51
GCID: GC03M151012

G Protein-Coupled Receptor 87


(Previous symbol: GPR95)
  See GPR87-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 871 2     G Protein-Coupled Receptor 952
GPR951 2 3     G-Protein Coupled Receptor 872
G-Protein Coupled Receptor 952 3     Orphan GPCR 872
KPG_0022     

External Ids:    HGNC: 45381   Entrez Gene: 538362   Ensembl: ENSG000001382717   OMIM: 6063795   UniProtKB: Q9BY213   

Export aliases for GPR87 gene to outside databases

Previous GC identifers: GC03M147953 GC03M151844 GC03M152293 GC03M152332 GC03M152494 GC03M148385


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPR87 Gene:
This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on
chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma
(PMID:18057535) and regulated by p53 (PMID:19602589). (provided by RefSeq, Nov 2011)

GeneCards Summary for GPR87 Gene:
GPR87 (G protein-coupled receptor 87) is a protein-coding gene. Diseases associated with GPR87 include lung squamous cell carcinoma, and oral squamous cell carcinoma. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is GPR82.

UniProtKB/Swiss-Prot: GPR87_HUMAN, Q9BY21
Function: Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA
damage

Gene Wiki entry for GPR87 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR87 gene promoter:
         GR   E2F-4   E2F-3a   E2F-5   GR-beta   E2F-2   PPAR-alpha   E2F   E2F-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR87 promoter sequence
   Search Chromatin IP Primers for GPR87

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR87


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q24

GPR87 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR87 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M151012:  view genomic region     (about GC identifiers)

Start:
151,011,874 bp from pter      End:
151,034,740 bp from pter
Size:
22,867 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GPR87_HUMAN, Q9BY21 (See protein sequence)
Recommended Name: G-protein coupled receptor 87  
Size: 358 amino acids; 41436 Da
Sequence caution: Sequence=AAK29069.1; Type=Erroneous initiation;
Secondary accessions: Q5KU35 Q96JZ8 Q9BXC2

Explore the universe of human proteins at neXtProt for GPR87: NX_Q9BY21

Explore proteomics data for GPR87 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4, Asn25, Asn33

  • See GPR87 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076404.3  
    ENSEMBL proteins: 
     ENSP00000260843  

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    antibodies-online peptides for GPR87

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    antibodies-online antibodies for GPR87 (36 products) 

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    antibodies-online kits for GPR87 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR87
    Class A Orphans

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR008109 P2Y13_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9BY21

    ProtoNet protein and cluster: Q9BY21

    UniProtKB/Swiss-Prot: GPR87_HUMAN, Q9BY21
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GPR87           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPR87_HUMAN, Q9BY21
    Function: Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA
    damage
    Induction: By expression of p53/TP53 and by DNA damage in a TP53-dependent manner

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0045028G-protein coupled purinergic nucleotide receptor activity IEA--
         
    Find genes that share ontologies with GPR87           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR87:
     Increased homologous recombina 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gpr87):
     limbs/digits/tail  skeleton 

    Find genes that share phenotypes with GPR87           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gpr87tm1Lex for GPR87

       genOway: Develop your customized and physiologically relevant rodent model for GPR87

    miRNA
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    miRTarBase miRNAs that target GPR87:
    hsa-mir-335-5p (MIRT018778)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPR87_HUMAN, Q9BY21: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GPR87           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPR87 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    1 BioSystems Pathway for GPR87
        GPCRs, Class A Rhodopsin-like


        Pathway & Disease-focused RT2 Profiler PCR Array including GPR87: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPR87

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007194negative regulation of adenylate cyclase activity IEA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with GPR87           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR87

    3 IUPHAR Ligands for GPR87 (GPR87)    About this table
    LigandTypeActionAffinityPubmed IDs
    LPA
    AgonistAgonist7.4417905198 18466763
    Ki16425
    AntagonistAntagonist7.4417905198
    dioctanoy?aelglycerol?ae pyrophos?aephate
    AntagonistAntagonist7.4417905198



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPR87 gene: 
    NM_023915.3  

    Unigene Cluster for GPR87:

    G protein-coupled receptor 87
    Hs.591292  [show with all ESTs]
    Unigene Representative Sequence: NM_023915
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260843(uc003eyt.2)
    miRNA
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13642) for GPR87 

    Additional mRNA sequence: 

    AB031548.1 AF086432.1 AF237763.1 AF345566.1 AF411114.1 AK027784.1 BC009540.1 BC112941.1 
    BC117565.1 BC132888.1 BC132890.1 EU883576.1 

    2 DOTS entries:

    DT.203012  DT.40124685 

    Selected AceView cDNA sequences (see all 29):

    AF345566 AF411114 BU683700 W79123 BM695531 BM976299 AF086432 AF237763 
    BC009540 AK027784 BG286447 BG677820 NM_023915 BG676453 BU679920 BU728943 
    W79920 BE879604 BU684220 AI659657 AI611298 BE563611 BX284030 AW873727 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR87 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GPR87 Expression
    About this image


    GPR87 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Epidermis (Integumentary System)
    GPR87 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR87 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591292

    UniProtKB/Swiss-Prot: GPR87_HUMAN, Q9BY21
    Tissue specificity: Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus,
    hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung

        Pathway & Disease-focused RT2 Profiler PCR Array including GPR87: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPR87 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr871 , 5 G protein-coupled receptor 871, 5 85.35(n)1
    89.86(a)1
      3 (29.00 cM)5
    841111  NM_032399.11  NP_115775.11 
     591790065 
    chicken
    (Gallus gallus)
    Aves GPR871 G protein-coupled receptor 87 72.85(n)
    82.02(a)
      425038  XM_422840.3  XP_422840.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR876
    G protein-coupled receptor 87
    70(a)
    1 ↔ 1
    3(18070932-18088614)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gpr871 G protein-coupled receptor 87 65.53(n)
    65.24(a)
      100493843  XM_002941105.2  XP_002941151.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-83h2.26
    CR626884.16
    (see all 3)
    Uncharacterized protein
    (see all 3)
    29(a)
    26(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    15(3883672-3885344) ENSDARG00000076698
    15(3925592-3929550) ENSDARG00000015974


    ENSEMBL Gene Tree for GPR87 (if available)
    TreeFam Gene Tree for GPR87 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPR87 gene
    GPR822  P2RY132  GPR1712  GPR342  P2RY142  P2RY122  
    10 SIMAP similar genes for GPR87 using alignment to 1 protein entry:     GPR87_HUMAN:
    P2RY14    P2RY13    P2RY12    GPR171    F2RL2    GPR34
    GPR183    CYSLTR2    KPG_011    PTAFR

    Find genes that share paralogs with GPR87           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for GPR87    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357604
    A colorectal cancer sample4--see VAR_0357602 D Y mis40--------
    rs355211041,2,4
    ----see VAR_0559212 mis40--------

    HapMap Linkage Disequilibrium report for GPR87 (151011874 - 151034740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GPR87:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726054CNV Deletion23290073
    esv2726055CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR87
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606379    OMIM disorders: --

    3 diseases for GPR87:    
    About MalaCards
    lung squamous cell carcinoma    oral squamous cell carcinoma    breast and colorectal cancer


    Find genes that share disorders with GPR87           About GenesLikeMe

    Genetic Association Database (GAD): GPR87
    Human Genome Epidemiology (HuGE) Navigator: GPR87 (1 document)

    Export disorders for GPR87 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR87 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with GPR87)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PubMed id 11273702)1, 2, 3 Wittenberger T.... Hellebrand S. (J. Mol. Biol. 2001)
    2. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. (PubMed id 19602589)1, 2, 9 Zhang Y.... Chen X. (Cancer Res. 2009)
    3. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. (PubMed id 17905198)1, 2 Tabata K.... Fujita N. (Biochem. Biophys. Res. Commun. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155)1, 2 Lee D.K.... O'Dowd B.F. (Gene 2001)
    7. G protein-coupled receptor 87 (GPR87) promotes the growth and metastasis of CD133a8_ cancer stem-like cells in hepatocellular carcinoma. (PubMed id 23593389)1 Yan M....Li J. (PLoS ONE 2013)
    8. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    9. GPR87 is an overexpressed G-protein coupled receptor in squamous cell carcinoma of the lung. (PubMed id 18057535)1 Gugger M....Reubi J.C. (Dis. Markers 2008)
    10. hGPR87 contributes to viability of human tumor cells. (PubMed id 18183596)1 Glatt S....Sommergruber W. (Int. J. Cancer 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 53836 HGNC: 4538 AceView: GPR87 Ensembl:ENSG00000138271 euGenes: HUgn53836
    ECgene: GPR87 H-InvDB: GPR87

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPR87 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPR87 gene:
    Search GeneIP for patents involving GPR87

    GeneCards and IP:
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