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Aliases for GPR87 Gene

Aliases for GPR87 Gene

  • G Protein-Coupled Receptor 87 2 3 5
  • G-Protein Coupled Receptor 95 3 4
  • GPR95 3 4
  • G-Protein Coupled Receptor 87 3
  • Orphan GPCR 87 3
  • KPG_002 3
  • FKSG78 3

External Ids for GPR87 Gene

Previous HGNC Symbols for GPR87 Gene

  • GPR95

Previous GeneCards Identifiers for GPR87 Gene

  • GC03M147953
  • GC03M151844
  • GC03M152293
  • GC03M152332
  • GC03M152494
  • GC03M151012
  • GC03M148385

Summaries for GPR87 Gene

Entrez Gene Summary for GPR87 Gene

  • This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]

GeneCards Summary for GPR87 Gene

GPR87 (G Protein-Coupled Receptor 87) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY14.

UniProtKB/Swiss-Prot for GPR87 Gene

  • Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.

Gene Wiki entry for GPR87 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR87 Gene

Genomics for GPR87 Gene

Regulatory Elements for GPR87 Gene

Enhancers for GPR87 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F151274 1.2 FANTOM5 ENCODE 19.8 +39.1 39112 6.1 SCRT2 JUNB ETV6 MAFK SPI1 RELA GPR87 P2RY13 P2RY14 EIF2A GC03P151277
GH03F151349 1.1 Ensembl 19.4 -32.7 -32749 1.0 CTCF ZNF654 RAD21 MIXL1 GPR87 P2RY13 ERICH6 P2RY12
GH03F151345 1.1 FANTOM5 Ensembl ENCODE 19.2 -29.9 -29949 2.6 MAX MYC P2RY13 GPR87 P2RY14 P2RY12 CLRN1
GH03F151264 1.8 FANTOM5 Ensembl ENCODE 18.2 +51.2 51151 2.4 RFX1 MXI1 BMI1 EBF1 EP300 SPI1 P2RY14 GPR87 SETP11 GC03P151250
GH03F151350 0.7 FANTOM5 Ensembl 17.1 -34.8 -34849 2.8 ZFP64 EED TCF7 SPI1 GPR87 P2RY13 P2RY12 P2RY14
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR87 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR87 Gene

Chromosome:
3
Start:
151,294,086 bp from pter
End:
151,316,952 bp from pter
Size:
22,867 bases
Orientation:
Minus strand

Genomic View for GPR87 Gene

Genes around GPR87 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR87 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR87 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR87 Gene

Proteins for GPR87 Gene

  • Protein details for GPR87 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY21-GPR87_HUMAN
    Recommended name:
    G-protein coupled receptor 87
    Protein Accession:
    Q9BY21
    Secondary Accessions:
    • Q5KU35
    • Q96JZ8
    • Q9BXC2

    Protein attributes for GPR87 Gene

    Size:
    358 amino acids
    Molecular mass:
    41436 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK29069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR87 Gene

Post-translational modifications for GPR87 Gene

  • Glycosylation at Asn 4, Asn 25, and Asn 33
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR87 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR87 Gene

Domains & Families for GPR87 Gene

Gene Families for GPR87 Gene

Protein Domains for GPR87 Gene

Suggested Antigen Peptide Sequences for GPR87 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY21

UniProtKB/Swiss-Prot:

GPR87_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR87: view

Function for GPR87 Gene

Molecular function for GPR87 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.
UniProtKB/Swiss-Prot Induction:
By expression of p53/TP53 and by DNA damage in a TP53-dependent manner.

Gene Ontology (GO) - Molecular Function for GPR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA --
genes like me logo Genes that share ontologies with GPR87: view
genes like me logo Genes that share phenotypes with GPR87: view

Animal Models for GPR87 Gene

MGI Knock Outs for GPR87:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR87

miRNA for GPR87 Gene

miRTarBase miRNAs that target GPR87

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR87

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR87 Gene

Localization for GPR87 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR87 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR87 Gene COMPARTMENTS Subcellular localization image for GPR87 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR87: view

Pathways & Interactions for GPR87 Gene

SuperPathways for GPR87 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with GPR87: view

Pathways by source for GPR87 Gene

1 BioSystems pathway for GPR87 Gene

Interacting Proteins for GPR87 Gene

Gene Ontology (GO) - Biological Process for GPR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007194 negative regulation of adenylate cyclase activity IEA --
GO:0008150 biological_process ND --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR87: view

No data available for SIGNOR curated interactions for GPR87 Gene

Drugs & Compounds for GPR87 Gene

(3) Drugs for GPR87 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ki16425 Pharma Antagonist LPA receptor antagonist, LPA1 and LPA3 receptor antagonist 0
LPA Pharma Agonist 0
DIOCTANOY​LGLYCEROL​ PYROPHOS​PHATE Pharma 0

(1) Additional Compounds for GPR87 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dioctanoy?aelglycerol?ae pyrophos?aephate
Antagonist
genes like me logo Genes that share compounds with GPR87: view

Transcripts for GPR87 Gene

mRNA/cDNA for GPR87 Gene

Unigene Clusters for GPR87 Gene

G protein-coupled receptor 87:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR87

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR87 Gene

No ASD Table

Relevant External Links for GPR87 Gene

GeneLoc Exon Structure for
GPR87
ECgene alternative splicing isoforms for
GPR87

Expression for GPR87 Gene

mRNA expression in normal human tissues for GPR87 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR87 Gene

This gene is overexpressed in Esophagus - Mucosa (x12.7), Skin - Sun Exposed (Lower leg) (x10.1), Skin - Not Sun Exposed (Suprapubic) (x9.6), Vagina (x7.0), and Minor Salivary Gland (x4.3).

Protein differential expression in normal tissues from HIPED for GPR87 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR87 Gene



Protein tissue co-expression partners for GPR87 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR87 Gene:

GPR87

SOURCE GeneReport for Unigene cluster for GPR87 Gene:

Hs.591292

mRNA Expression by UniProt/SwissProt for GPR87 Gene:

Q9BY21-GPR87_HUMAN
Tissue specificity: Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.
genes like me logo Genes that share expression patterns with GPR87: view

Primer Products

Orthologs for GPR87 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR87 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR87 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia GPR87 34 35
  • 90.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR87 35
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR87 34 35
  • 87.8 (n)
mouse
(Mus musculus)
Mammalia Gpr87 34 16 35
  • 85.35 (n)
rat
(Rattus norvegicus)
Mammalia Gpr87 34
  • 84.09 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR87 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR87 34 35
  • 72.85 (n)
lizard
(Anolis carolinensis)
Reptilia GPR87 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr87 34
  • 65.53 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-83h2.2 35
  • 29 (a)
ManyToMany
CR626884.1 35
  • 26 (a)
ManyToMany
si:ch73-309g22.1 35
  • 21 (a)
ManyToMany
Species where no ortholog for GPR87 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR87 Gene

ENSEMBL:
Gene Tree for GPR87 (if available)
TreeFam:
Gene Tree for GPR87 (if available)

Paralogs for GPR87 Gene

Paralogs for GPR87 Gene

(10) SIMAP similar genes for GPR87 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR87: view

Variants for GPR87 Gene

Sequence variations from dbSNP and Humsavar for GPR87 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_035760 A colorectal cancer sample
rs1016629 -- 151,313,365(+) AGTCT(A/G)TATCA intron-variant
rs1048408 -- 151,294,181(-) GATTA(C/T)ACTGA intron-variant, reference, synonymous-codon
rs10513392 -- 151,297,453(+) AAATC(A/G)GAATA intron-variant
rs10553433 -- 151,309,118(+) ATACA(-/CG)cacac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR87 Gene

Variant ID Type Subtype PubMed ID
esv2726054 CNV deletion 23290073
esv2726055 CNV deletion 23290073
esv3598173 CNV loss 21293372
nsv592045 CNV gain 21841781
nsv954492 CNV duplication 24416366

Variation tolerance for GPR87 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR87 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR87

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR87 Gene

Disorders for GPR87 Gene

Relevant External Links for GPR87

Genetic Association Database (GAD)
GPR87
Human Genome Epidemiology (HuGE) Navigator
GPR87
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR87

No disorders were found for GPR87 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR87 Gene

Publications for GPR87 Gene

  1. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. (PMID: 19602589) Zhang Y. … Chen X. (Cancer Res. 2009) 3 4 22 64
  2. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PMID: 11273702) Wittenberger T. … Hellebrand S. (J. Mol. Biol. 2001) 2 3 4 64
  3. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. (PMID: 17905198) Tabata K. … Fujita N. (Biochem. Biophys. Res. Commun. 2007) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for GPR87 Gene

Sources for GPR87 Gene

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