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Aliases for GPR87 Gene

Aliases for GPR87 Gene

  • G Protein-Coupled Receptor 87 2 3 5
  • G-Protein Coupled Receptor 95 3 4
  • GPR95 3 4
  • G Protein-Coupled Receptor 95 3
  • Orphan GPCR 87 3
  • KPG_002 3
  • FKSG78 3

External Ids for GPR87 Gene

Previous HGNC Symbols for GPR87 Gene

  • GPR95

Previous GeneCards Identifiers for GPR87 Gene

  • GC03M147953
  • GC03M151844
  • GC03M152293
  • GC03M152332
  • GC03M152494
  • GC03M151012
  • GC03M148385

Summaries for GPR87 Gene

Entrez Gene Summary for GPR87 Gene

  • This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]

GeneCards Summary for GPR87 Gene

GPR87 (G Protein-Coupled Receptor 87) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY14.

UniProtKB/Swiss-Prot for GPR87 Gene

  • Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.

Gene Wiki entry for GPR87 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR87 Gene

Genomics for GPR87 Gene

Regulatory Elements for GPR87 Gene

Promoters for GPR87 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR87 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR87 Gene

Chromosome:
3
Start:
151,294,086 bp from pter
End:
151,316,952 bp from pter
Size:
22,867 bases
Orientation:
Minus strand

Genomic View for GPR87 Gene

Genes around GPR87 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR87 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR87 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR87 Gene

Proteins for GPR87 Gene

  • Protein details for GPR87 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY21-GPR87_HUMAN
    Recommended name:
    G-protein coupled receptor 87
    Protein Accession:
    Q9BY21
    Secondary Accessions:
    • Q5KU35
    • Q96JZ8
    • Q9BXC2

    Protein attributes for GPR87 Gene

    Size:
    358 amino acids
    Molecular mass:
    41436 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK29069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR87 Gene

Proteomics data for GPR87 Gene at MOPED

Post-translational modifications for GPR87 Gene

  • Glycosylation at Asn 4, Asn 25, and Asn 33
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR87 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GPR87

No data available for DME Specific Peptides for GPR87 Gene

Domains & Families for GPR87 Gene

Gene Families for GPR87 Gene

Protein Domains for GPR87 Gene

Suggested Antigen Peptide Sequences for GPR87 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY21

UniProtKB/Swiss-Prot:

GPR87_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR87: view

Function for GPR87 Gene

Molecular function for GPR87 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.
UniProtKB/Swiss-Prot Induction:
By expression of p53/TP53 and by DNA damage in a TP53-dependent manner.

Gene Ontology (GO) - Molecular Function for GPR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA --
genes like me logo Genes that share ontologies with GPR87: view
genes like me logo Genes that share phenotypes with GPR87: view

Animal Models for GPR87 Gene

MGI Knock Outs for GPR87:

Animal Model Products

miRNA for GPR87 Gene

miRTarBase miRNAs that target GPR87

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR87 Gene

Localization for GPR87 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR87 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR87 Gene COMPARTMENTS Subcellular localization image for GPR87 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for GPR87 Gene

Pathways & Interactions for GPR87 Gene

SuperPathways for GPR87 Gene

genes like me logo Genes that share pathways with GPR87: view

Pathways by source for GPR87 Gene

1 BioSystems pathway for GPR87 Gene

Interacting Proteins for GPR87 Gene

Gene Ontology (GO) - Biological Process for GPR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GPR87: view

No data available for SIGNOR curated interactions for GPR87 Gene

Drugs & Compounds for GPR87 Gene

(3) Drugs for GPR87 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ki16425 Pharma Antagonist LPA receptor antagonist 0
LPA Pharma Agonist 0
DIOCTANOY​LGLYCEROL​ PYROPHOS​PHATE Pharma 0

(1) Additional Compounds for GPR87 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dioctanoy?aelglycerol?ae pyrophos?aephate
Antagonist
genes like me logo Genes that share compounds with GPR87: view

Transcripts for GPR87 Gene

mRNA/cDNA for GPR87 Gene

Unigene Clusters for GPR87 Gene

G protein-coupled receptor 87:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR87 Gene

No ASD Table

Relevant External Links for GPR87 Gene

GeneLoc Exon Structure for
GPR87
ECgene alternative splicing isoforms for
GPR87

Expression for GPR87 Gene

mRNA expression in normal human tissues for GPR87 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR87 Gene

This gene is overexpressed in Esophagus - Mucosa (x12.7), Skin - Sun Exposed (Lower leg) (x10.1), Skin - Not Sun Exposed (Suprapubic) (x9.6), Vagina (x7.0), and Minor Salivary Gland (x4.3).

Protein differential expression in normal tissues from HIPED for GPR87 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR87 Gene



SOURCE GeneReport for Unigene cluster for GPR87 Gene Hs.591292

mRNA Expression by UniProt/SwissProt for GPR87 Gene

Q9BY21-GPR87_HUMAN
Tissue specificity: Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.
genes like me logo Genes that share expression patterns with GPR87: view

Protein tissue co-expression partners for GPR87 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for GPR87 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR87 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR87 35
  • 87.8 (n)
  • 92.74 (a)
GPR87 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR87 35
  • 90.5 (n)
  • 94.13 (a)
GPR87 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr87 35
  • 85.35 (n)
  • 89.86 (a)
Gpr87 16
Gpr87 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR87 35
  • 99.35 (n)
  • 99.44 (a)
GPR87 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr87 35
  • 84.09 (n)
  • 88.98 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR87 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR87 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR87 35
  • 72.85 (n)
  • 82.02 (a)
GPR87 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR87 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr87 35
  • 65.53 (n)
  • 65.24 (a)
zebrafish
(Danio rerio)
Actinopterygii CR626884.1 36
  • 26 (a)
ManyToMany
si:ch73-309g22.1 36
  • 21 (a)
ManyToMany
si:dkey-83h2.2 36
  • 29 (a)
ManyToMany
Species with no ortholog for GPR87:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR87 Gene

ENSEMBL:
Gene Tree for GPR87 (if available)
TreeFam:
Gene Tree for GPR87 (if available)

Paralogs for GPR87 Gene

Paralogs for GPR87 Gene

(10) SIMAP similar genes for GPR87 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR87: view

Variants for GPR87 Gene

Sequence variations from dbSNP and Humsavar for GPR87 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_035760 A colorectal cancer sample
VAR_055921 -

Structural Variations from Database of Genomic Variants (DGV) for GPR87 Gene

Variant ID Type Subtype PubMed ID
esv2726054 CNV Deletion 23290073
esv2726055 CNV Deletion 23290073

Variation tolerance for GPR87 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR87 Gene

HapMap Linkage Disequilibrium report
GPR87

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR87 Gene

Disorders for GPR87 Gene

Relevant External Links for GPR87

Genetic Association Database (GAD)
GPR87
Human Genome Epidemiology (HuGE) Navigator
GPR87
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR87

No disorders were found for GPR87 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR87 Gene

Publications for GPR87 Gene

  1. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PMID: 11273702) Wittenberger T. … Hellebrand S. (J. Mol. Biol. 2001) 2 3 4 67
  2. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. (PMID: 19602589) Zhang Y. … Chen X. (Cancer Res. 2009) 3 23
  3. G protein-coupled receptor 87 (GPR87) promotes the growth and metastasis of CD133a8_ cancer stem-like cells in hepatocellular carcinoma. (PMID: 23593389) Yan M. … Li J. (PLoS ONE 2013) 3
  4. Expression and role of GPR87 in urothelial carcinoma of the bladder. (PMID: 23752273) Okazoe H. … Kakehi Y. (Int J Mol Sci 2013) 3
  5. Early effects of FOLFOX treatment of colorectal tumour in an animal model: assessment of changes in gene expression and FDG kinetics. (PMID: 19280186) Strauss L.G. … Dimitrakopoulou-Strauss A. (Eur. J. Nucl. Med. Mol. Imaging 2009) 23

Products for GPR87 Gene

Sources for GPR87 Gene

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