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Aliases & Descriptions for GPR85
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ50993 2 | | FLJ51159 2 | | FLJ99433 2 | | SREB 2 | | SREB2 1, 2, 3, 5 |
| | | Descriptions |
|---|
| G protein-coupled receptor 85 2 | | Super conserved receptor expressed in brain 2 2, 3 | | seven transmembrane helix receptor 2 |
|
| | Search outside databases for aliases for GPR85 genePrevious GC identifers: GC07M111205 GC07M112267 GC07M112280 GC07M112314 |
Summaries for GPR85(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GPR85: Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM] UniProtKB/Swiss-Prot: GPR85_HUMAN, P60893Function: Orphan receptorGene Wiki entry for GPR85 |
Genomic Location for GPR85
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GPR85 gene 
Entrez Gene cytogenetic band: 7q31 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q31GPR85 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M112507:
(about GC identifiers)
Start:
|
112,507,704 bp from pter |
End:
|
112,515,069 bp from pter |
Size:
|
7,366 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 112,088,951-112,096,319 |
RefSeq DNA sequence:- NC_000007.12 NT_007933.14 NT_079596.2
| Proteins for GPR85
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GPR85_HUMAN, P60893 (See
protein sequence)Recommended Name: Probable G-protein coupled receptor 85 Size: 370 amino acids; 41995 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q9JHI6 Q9NPD1Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (4 alternative transcripts):
NP_001139737.1 NP_001139738.1 NP_001139739.1 NP_061843.3
ENSEMBL proteins: ENSP00000297146
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for GPR85: Assays for GPR85: | Protein
Domains/ Families for GPR85(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P60893
ProtoNet protein and cluster: P60893 UniProtKB/Swiss-Prot: GPR85_HUMAN, P60893Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for GPR85
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018970
Applied Biosystems Silencer® siRNAs for GPR85
Sigma-Aldrich siRNA and siRNA Panels for GPR85  Sigma-Aldrich shRNA Panels and shRNA for GPR85  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018970                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018970                                  untagged cDNA clone in CMV expression vector: NM_018970 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018970
UniProtKB/Swiss-Prot: GPR85_HUMAN, P60893Function: Orphan receptor3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Gpr85):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for GPR85
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/37 Interacting proteins for GPR85 (ENSP000002971463) via UniProtKB, MINT, and/or STRING (see all 37
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
TAS | 10833454 | | GO:0007186 | G-protein coupled receptor protein signaling pathway |
IEA | -- | About this table
|
Drugs & Compounds for GPR85(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for GPR85
|
Transcripts for GPR85(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018970
Sigma-Aldrich siRNA and siRNA Panels for GPR85  Sigma-Aldrich shRNA Panels and shRNA for GPR85  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018970 REFSEQ mRNAs for GPR85 gene (4 alternative transcripts): NM_001146265.1 NM_001146266.1 NM_001146267.1 NM_018970.6
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018970               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018970                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018970                                  untagged cDNA clone in CMV expression vector: NM_018970  Additional cDNA sequence: AB040800.1 AF250237.2 AK297464.1 AK302769.1 AK309392.1 AK312587.1 AL161959.1 BC030577.1 CR609708.1 5 DOTS entries: DT.70100926 DT.307158 DT.121106438 DT.121106435 DT.95146749 24/34 AceView cDNA sequences (see all 34
):CR609708 BI915894 AW513647 AL540052 BG719824 NM_018970 AL161959 T06908 AW148538 AI673342 AI910962 AI631153 BC030577 BQ771598 BX453573 AF250237 AB040800 CD246165 AA732890 BX431250 AI200800 AL540051 AA883367 N62306
highest scoring ESTs for GPR85:AI631153 AF250237 AI200800 AI673342 AI910962 AL540052 BC030577 BG719824 AA332611 AA732890 Unigene Cluster for GPR85: G protein-coupled receptor 85 Hs.152009 [show with all ESTs]Unigene Representative Sequence: NM_018970
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GPR85 (see all 6
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | |
| SP1: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for GPR85
1 Ensembl transcript including schematic representation: ENST00000297146
|
Expression for GPR85
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GPR85 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GPR85
1 / 2 / 3 5 probe-sets matching GPR85 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTTTGAAACT
SOURCE GeneReport for Unigene cluster: Hs.152009 UniProtKB/Swiss-Prot: GPR85_HUMAN, P60893Tissue specificity: Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord |
Orthologs for GPR85
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GPR85 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for GPR85
ENSEMBL Gene Tree for GPR85 | Paralogs for GPR85(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GPR85 gene
- GPR1732 GPR272
|
SNPs/Variants for GPR85(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GPR85 (up to first 250kb)
|
Disorders & Mutations for GPR85
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605188
|
Medical News for GPR85(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GPR85 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for GPR85 gene (see all 16
):- An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PubMed id 10833454)1, 2, 3, 4 Matsumoto M....Furuichi K. (2000)
- The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31. (PubMed id 10978537)2, 3, 4 Hellebrand S.... Wittenberger T. (2000)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. (PubMed id 15893849)1, 3 Matsumoto M....Kleinman J.E. (2005)
- Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)3 Anney R.J....Gill M. (2008)
- The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. (PubMed id 18413613)3 Matsumoto M....Weinberger D.R. (2008)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)3 Wiemann S....Poustka A. (2004)
|
Search for GPR85
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GPR85
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GPR85
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPR85(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GPR85(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GPR85:

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Incremental update: 13 Oct 2009
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