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Aliases for GPR85 Gene

Aliases for GPR85 Gene

  • G Protein-Coupled Receptor 85 2 3 5
  • Super Conserved Receptor Expressed In Brain 2 3 4
  • SREB2 3 4
  • Probable G-Protein Coupled Receptor 85 3
  • Seven Transmembrane Helix Receptor 3
  • SREB 3

External Ids for GPR85 Gene

Previous GeneCards Identifiers for GPR85 Gene

  • GC07M111205
  • GC07M112267
  • GC07M112280
  • GC07M112314
  • GC07M112507
  • GC07M112720
  • GC07M107088

Summaries for GPR85 Gene

Entrez Gene Summary for GPR85 Gene

  • Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]

GeneCards Summary for GPR85 Gene

GPR85 (G Protein-Coupled Receptor 85) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR173.

UniProtKB/Swiss-Prot for GPR85 Gene

  • Orphan receptor.

Gene Wiki entry for GPR85 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR85 Gene

Genomics for GPR85 Gene

Regulatory Elements for GPR85 Gene

Enhancers for GPR85 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F113117 1.1 ENCODE 7 -30.4 -30425 2.1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3 LINC00998 TMEM168 ZNF277 GPR85 ENSG00000225457
GH07F113085 1 ENCODE 5.5 +0.5 540 2.7 PKNOX1 ATF1 SIN3A ZNF2 GLIS2 GATA2 FOS MCM3 SP3 YY2 LINC00998 GPR85 ENSG00000279288
GH07F113460 0.7 FANTOM5 1.9 -372.5 -372480 0.3 HDAC1 PKNOX1 NR2F2 YY1 ATF3 CBX5 HNF4G ZBTB33 FOXP2 MAFK GPR85 GC07P113463 GC07M113450
GH07F113099 0.6 ENCODE 0.4 -11.7 -11703 0.2 RFX1 TEAD4 HMBOX1 DPF2 ZKSCAN1 ENSG00000225457 GPR85
GH07F113100 0.6 ENCODE 0.4 -12.5 -12527 0.9 ZNF316 PKNOX1 ZNF318 SMARCA4 EMSY MAFK ATF2 LINC00998 ENSG00000225457 GPR85
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR85 on UCSC Golden Path with GeneCards custom track

Promoters for GPR85 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000312591 1077 2600 ATF1 SIN3A ZNF2 GLIS2 GATA2 FOS MCM3 SP3 YY2 ZNF623

Genomic Location for GPR85 Gene

113,078,331 bp from pter
113,087,778 bp from pter
9,448 bases
Minus strand

Genomic View for GPR85 Gene

Genes around GPR85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR85 Gene

Proteins for GPR85 Gene

  • Protein details for GPR85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 85
    Protein Accession:
    Secondary Accessions:
    • Q9JHI6
    • Q9NPD1

    Protein attributes for GPR85 Gene

    370 amino acids
    Molecular mass:
    41995 Da
    Quaternary structure:
    • Interacts with DLG4 AND DLG3.

neXtProt entry for GPR85 Gene

Post-translational modifications for GPR85 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GPR85 Gene

Domains & Families for GPR85 Gene

Gene Families for GPR85 Gene

Protein Domains for GPR85 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR85: view

Function for GPR85 Gene

Molecular function for GPR85 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS 10833454
GO:0005515 protein binding IPI 25780553
genes like me logo Genes that share ontologies with GPR85: view
genes like me logo Genes that share phenotypes with GPR85: view

Animal Models for GPR85 Gene

MGI Knock Outs for GPR85:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR85 Gene

Localization for GPR85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR85 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR85 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 25780553
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR85: view

Pathways & Interactions for GPR85 Gene

genes like me logo Genes that share pathways with GPR85: view

Pathways by source for GPR85 Gene

1 BioSystems pathway for GPR85 Gene

Interacting Proteins for GPR85 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000297146 P60893-GPR85_HUMAN for GPR85 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10833454
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR85: view

No data available for SIGNOR curated interactions for GPR85 Gene

Transcripts for GPR85 Gene

Unigene Clusters for GPR85 Gene

G protein-coupled receptor 85:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR85 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - -

Relevant External Links for GPR85 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR85 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR85 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR85 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.0), Brain - Caudate (basal ganglia) (x4.8), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR85 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR85 Gene:


SOURCE GeneReport for Unigene cluster for GPR85 Gene:


mRNA Expression by UniProt/SwissProt for GPR85 Gene:

Tissue specificity: Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord.
genes like me logo Genes that share expression patterns with GPR85: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for GPR85 Gene

Orthologs for GPR85 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR85 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR85 34 35
  • 99.64 (n)
(Monodelphis domestica)
Mammalia GPR85 35
  • 99 (a)
(Bos Taurus)
Mammalia GPR85 34 35
  • 97.48 (n)
(Canis familiaris)
Mammalia GPR85 34 35
  • 97.21 (n)
(Rattus norvegicus)
Mammalia Gpr85 34
  • 95.59 (n)
(Mus musculus)
Mammalia Gpr85 34 16 35
  • 94.95 (n)
(Ornithorhynchus anatinus)
Mammalia GPR85 35
  • 94 (a)
(Gallus gallus)
Aves GPR85 34 35
  • 91.17 (n)
(Anolis carolinensis)
Reptilia GPR85 35
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr85 34
  • 87.39 (n)
(Danio rerio)
Actinopterygii gpr85 34 35
  • 77.66 (n)
sreb2 34
Species where no ortholog for GPR85 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR85 Gene

Gene Tree for GPR85 (if available)
Gene Tree for GPR85 (if available)

Paralogs for GPR85 Gene

Paralogs for GPR85 Gene

(7) SIMAP similar genes for GPR85 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GPR85: view

Variants for GPR85 Gene

Sequence variations from dbSNP and Humsavar for GPR85 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1056588 -- 113,086,060(-) GAGGA(A/G)TATCA intron-variant, utr-variant-5-prime
rs111446312 -- 113,089,679(+) TGCCT(A/T)TGTCC upstream-variant-2KB
rs111742019 -- 113,087,946(+) ATTTG(A/T)TCTTG upstream-variant-2KB
rs112218049 -- 113,083,913(+) ATAGC(-/CTT)CTTCT cds-indel
rs112395723 -- 113,085,443(+) GATTT(A/G)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR85 Gene

Variant ID Type Subtype PubMed ID
esv2759556 CNV gain 17122850
nsv435847 CNV deletion 17901297
nsv464689 CNV gain 19166990
nsv5907 CNV insertion 18451855
nsv608226 CNV gain 21841781
nsv7405 OTHER inversion 18451855

Variation tolerance for GPR85 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR85 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR85 Gene

Disorders for GPR85 Gene

Relevant External Links for GPR85

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR85 Gene

Publications for GPR85 Gene

  1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PMID: 10833454) Matsumoto M. … Furuichi K. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  2. The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31. (PMID: 10978537) Hellebrand S. … Wittenberger T. (Biochim. Biophys. Acta 2000) 2 3 4 64
  3. The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis. (PMID: 25780553) Fujita-Jimbo E. … Momoi T. (Mol Autism 2015) 3 4 64
  4. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64
  5. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. (PMID: 15893849) Matsumoto M. … Kleinman J.E. (Brain Res. Mol. Brain Res. 2005) 3 22 64

Products for GPR85 Gene

Sources for GPR85 Gene

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