Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR85 Gene

Aliases for GPR85 Gene

  • G Protein-Coupled Receptor 85 2 3 5
  • Super Conserved Receptor Expressed In Brain 2 3 4
  • SREB2 3 4
  • Probable G-Protein Coupled Receptor 85 3
  • Seven Transmembrane Helix Receptor 3
  • SREB 3

External Ids for GPR85 Gene

Previous GeneCards Identifiers for GPR85 Gene

  • GC07M111205
  • GC07M112267
  • GC07M112280
  • GC07M112314
  • GC07M112507
  • GC07M112720
  • GC07M107088

Summaries for GPR85 Gene

Entrez Gene Summary for GPR85 Gene

  • Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]

GeneCards Summary for GPR85 Gene

GPR85 (G Protein-Coupled Receptor 85) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR173.

UniProtKB/Swiss-Prot for GPR85 Gene

  • Orphan receptor.

Gene Wiki entry for GPR85 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR85 Gene

Genomics for GPR85 Gene

Regulatory Elements for GPR85 Gene

Enhancers for GPR85 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G112448 1.2 ENCODE 10.1 +636.5 636526 6.0 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF610 GLIS1 IFRD1 LSMEM1 GPR85 ENSG00000180019 GC07P112458
GH07G113117 1.1 ENCODE 7 -30.4 -30425 2.1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 KLF13 LINC00998 GPR85 ENSG00000225457
GH07G113085 1 ENCODE 5.5 +0.5 540 2.7 PKNOX1 ATF1 SIN3A ZNF2 TCF12 ZNF766 GLIS2 GATA2 FOS SP3 LINC00998 GPR85 ENSG00000279288
GH07G113460 0.7 FANTOM5 1.9 -372.5 -372480 0.3 HDAC1 PKNOX1 ZSCAN4 YY1 CBX5 HNF4G MAFK EP300 NR2F2 JUND GPR85 GC07P113463 GC07M113450
GH07G113100 0.7 ENCODE 0.4 -12.5 -12527 0.9 PKNOX1 ZSCAN4 RBBP5 EP300 ATF2 NFIC ZNF316 ZNF318 CBX5 SMARCA4 LINC00998 ENSG00000225457 GPR85
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR85 on UCSC Golden Path with GeneCards custom track

Promoters for GPR85 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216893 978 2001 PKNOX1 ATF1 SIN3A ZNF2 TCF12 ZNF766 GLIS2 GATA2 FOS MCM3

Genomic Location for GPR85 Gene

Chromosome:
7
Start:
113,078,331 bp from pter
End:
113,087,778 bp from pter
Size:
9,448 bases
Orientation:
Minus strand

Genomic View for GPR85 Gene

Genes around GPR85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR85 Gene

Proteins for GPR85 Gene

  • Protein details for GPR85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60893-GPR85_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 85
    Protein Accession:
    P60893
    Secondary Accessions:
    • Q9JHI6
    • Q9NPD1

    Protein attributes for GPR85 Gene

    Size:
    370 amino acids
    Molecular mass:
    41995 Da
    Quaternary structure:
    • Interacts with DLG4 AND DLG3.

neXtProt entry for GPR85 Gene

Post-translational modifications for GPR85 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GPR85 Gene

Domains & Families for GPR85 Gene

Gene Families for GPR85 Gene

Protein Domains for GPR85 Gene

Graphical View of Domain Structure for InterPro Entry

P60893

UniProtKB/Swiss-Prot:

GPR85_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR85: view

Function for GPR85 Gene

Molecular function for GPR85 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS,IEA 10833454
GO:0005515 protein binding IPI 25780553
genes like me logo Genes that share ontologies with GPR85: view
genes like me logo Genes that share phenotypes with GPR85: view

Animal Models for GPR85 Gene

MGI Knock Outs for GPR85:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR85

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR85 Gene

Localization for GPR85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR85 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR85 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA,IEA 25780553
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR85: view

Pathways & Interactions for GPR85 Gene

genes like me logo Genes that share pathways with GPR85: view

Pathways by source for GPR85 Gene

1 BioSystems pathway for GPR85 Gene

Interacting Proteins for GPR85 Gene

Gene Ontology (GO) - Biological Process for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10833454
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR85: view

No data available for SIGNOR curated interactions for GPR85 Gene

Transcripts for GPR85 Gene

Unigene Clusters for GPR85 Gene

G protein-coupled receptor 85:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR85

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR85 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for GPR85 Gene

GeneLoc Exon Structure for
GPR85
ECgene alternative splicing isoforms for
GPR85

Expression for GPR85 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR85 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR85 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.0), Brain - Caudate (basal ganglia) (x4.8), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR85 Gene



NURSA nuclear receptor signaling pathways regulating expression of GPR85 Gene:

GPR85

SOURCE GeneReport for Unigene cluster for GPR85 Gene:

Hs.152009

mRNA Expression by UniProt/SwissProt for GPR85 Gene:

P60893-GPR85_HUMAN
Tissue specificity: Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord.

Evidence on tissue expression from TISSUES for GPR85 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with GPR85: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR85 Gene

Orthologs for GPR85 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR85 34 35
  • 99.64 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR85 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR85 34 35
  • 97.48 (n)
dog
(Canis familiaris)
Mammalia GPR85 34 35
  • 97.21 (n)
rat
(Rattus norvegicus)
Mammalia Gpr85 34
  • 95.59 (n)
mouse
(Mus musculus)
Mammalia Gpr85 34 16 35
  • 94.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR85 35
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR85 34 35
  • 91.17 (n)
lizard
(Anolis carolinensis)
Reptilia GPR85 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr85 34
  • 87.39 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr85 34 35
  • 77.66 (n)
sreb2 34
Species where no ortholog for GPR85 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR85 Gene

ENSEMBL:
Gene Tree for GPR85 (if available)
TreeFam:
Gene Tree for GPR85 (if available)

Paralogs for GPR85 Gene

Paralogs for GPR85 Gene

(7) SIMAP similar genes for GPR85 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GPR85: view

Variants for GPR85 Gene

Sequence variations from dbSNP and Humsavar for GPR85 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000158609 -- 113,089,657(+) TTAGA(A/C)ATGAA upstream-variant-2KB
rs1000858246 -- 113,081,920(+) TAGAA(C/T)CCCAA utr-variant-3-prime
rs1000938943 -- 113,086,843(+) TGACG(C/T)CCGCC intron-variant, upstream-variant-2KB
rs1001531956 -- 113,089,203(+) TGTGC(A/G)TTGTT upstream-variant-2KB
rs1002157413 -- 113,085,032(+) ATATT(A/T)TTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR85 Gene

Variant ID Type Subtype PubMed ID
esv2759556 CNV gain 17122850
nsv435847 CNV deletion 17901297
nsv464689 CNV gain 19166990
nsv5907 CNV insertion 18451855
nsv608226 CNV gain 21841781
nsv7405 OTHER inversion 18451855

Variation tolerance for GPR85 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR85 Gene

Human Gene Mutation Database (HGMD)
GPR85
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR85 Gene

Disorders for GPR85 Gene

Relevant External Links for GPR85

Genetic Association Database (GAD)
GPR85
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR85

No disorders were found for GPR85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR85 Gene

Publications for GPR85 Gene

  1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PMID: 10833454) Matsumoto M. … Furuichi K. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  2. The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31. (PMID: 10978537) Hellebrand S. … Wittenberger T. (Biochim. Biophys. Acta 2000) 2 3 4 64
  3. The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis. (PMID: 25780553) Fujita-Jimbo E. … Momoi T. (Mol Autism 2015) 3 4 64
  4. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64
  5. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. (PMID: 15893849) Matsumoto M. … Kleinman J.E. (Brain Res. Mol. Brain Res. 2005) 3 22 64

Products for GPR85 Gene

Sources for GPR85 Gene

Content
Loading form....