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Aliases for GPR84 Gene

Aliases for GPR84 Gene

  • G Protein-Coupled Receptor 84 2 3 5
  • Inflammation-Related G-Protein Coupled Receptor EX33 3 4
  • EX33 3 4
  • Inflammation-Related G Protein-Coupled Receptor EX33 3
  • GPCR4 3

External Ids for GPR84 Gene

Previous GeneCards Identifiers for GPR84 Gene

  • GC12M054882
  • GC12M054472
  • GC12M053042
  • GC12M054756
  • GC12M051796

Summaries for GPR84 Gene

GeneCards Summary for GPR84 Gene

GPR84 (G Protein-Coupled Receptor 84) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR84 Gene

  • Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.

Gene Wiki entry for GPR84 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR84 Gene

Genomics for GPR84 Gene

Regulatory Elements for GPR84 Gene

Promoters for GPR84 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR84 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR84 Gene

Chromosome:
12
Start:
54,350,784 bp from pter
End:
54,365,253 bp from pter
Size:
14,470 bases
Orientation:
Minus strand

Genomic View for GPR84 Gene

Genes around GPR84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR84 Gene

Proteins for GPR84 Gene

  • Protein details for GPR84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQS5-GPR84_HUMAN
    Recommended name:
    G-protein coupled receptor 84
    Protein Accession:
    Q9NQS5
    Secondary Accessions:
    • B6V9G7

    Protein attributes for GPR84 Gene

    Size:
    396 amino acids
    Molecular mass:
    43705 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR84 Gene

Proteomics data for GPR84 Gene at MOPED

Post-translational modifications for GPR84 Gene

  • Glycosylation at Asn 3 and Asn 8
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR84 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR84 Gene

Domains & Families for GPR84 Gene

Gene Families for GPR84 Gene

Protein Domains for GPR84 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR84 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQS5

UniProtKB/Swiss-Prot:

GPR84_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR84: view

Function for GPR84 Gene

Molecular function for GPR84 Gene

UniProtKB/Swiss-Prot Function:
Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.
UniProtKB/Swiss-Prot Induction:
By bacterial lipopolysaccharides (LPS) in the monocytic leukemia cell line THP-1.
genes like me logo Genes that share phenotypes with GPR84: view

Animal Models for GPR84 Gene

MGI Knock Outs for GPR84:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR84 Gene

Localization for GPR84 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR84 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR84 Gene COMPARTMENTS Subcellular localization image for GPR84 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GPR84: view

Pathways & Interactions for GPR84 Gene

genes like me logo Genes that share pathways with GPR84: view

Pathways by source for GPR84 Gene

1 BioSystems pathway for GPR84 Gene

Interacting Proteins for GPR84 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000267015%0d%0a9606.ENSP00000349238%0d%0a9606.ENSP00000386444%0d%0a9606.ENSP00000381339%0d%0a
Selected Interacting proteins: ENSP00000267015 for GPR84 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR84 Gene

None

No data available for SIGNOR curated interactions for GPR84 Gene

Drugs & Compounds for GPR84 Gene

(8) Drugs for GPR84 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
decanoic acid Experimental Pharma Full agonist, Agonist 118
2-hydroxy capric acid Pharma Full agonist, Agonist 0
3-hydroxy capric acid Pharma Full agonist, Agonist 0
6-n-octylaminouracil Pharma Full agonist, Agonist 0
lauric acid Pharma Agonist 0

(2) Additional Compounds for GPR84 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-hydroxy lauric acid
Full agonist, Agonist
3-hydroxy lauric acid
Full agonist, Agonist
genes like me logo Genes that share compounds with GPR84: view

Transcripts for GPR84 Gene

Unigene Clusters for GPR84 Gene

G protein-coupled receptor 84:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR84 Gene

No ASD Table

Relevant External Links for GPR84 Gene

GeneLoc Exon Structure for
GPR84
ECgene alternative splicing isoforms for
GPR84

Expression for GPR84 Gene

mRNA expression in normal human tissues for GPR84 Gene

mRNA differential expression in normal tissues according to GTEx for GPR84 Gene

This gene is overexpressed in Whole Blood (x32.4).

Protein differential expression in normal tissues from HIPED for GPR84 Gene

This gene is overexpressed in Cervix (56.5) and Peripheral blood mononuclear cells (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR84 Gene



SOURCE GeneReport for Unigene cluster for GPR84 Gene Hs.306199

mRNA Expression by UniProt/SwissProt for GPR84 Gene

Q9NQS5-GPR84_HUMAN
Tissue specificity: Expressed predominantly in hematopoietic tissues. High levels detected in the bone marrow and lower levels in the peripheral leukocytes and lung. Also expressed in brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta and intestine. Within the leukocyte population expression is higher in neutrophils and eosinophils relative to T- or B-lymphocytes.
genes like me logo Genes that share expression patterns with GPR84: view

Protein tissue co-expression partners for GPR84 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GPR84 Gene

Orthologs for GPR84 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR84 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR84 35
  • 99.49 (n)
  • 98.99 (a)
GPR84 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR84 36
  • 90 (a)
OneToOne
GPR84 35
  • 88.47 (n)
  • 89.65 (a)
dog
(Canis familiaris)
Mammalia GPR84 35
  • 84.48 (n)
  • 82.95 (a)
GPR84 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr84 16
Gpr84 36
  • 85 (a)
OneToOne
Gpr84 35
  • 84.01 (n)
  • 85.35 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR84 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr84 35
  • 83 (n)
  • 83.84 (a)
lizard
(Anolis carolinensis)
Reptilia GPR84 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr84 35
  • 61.69 (n)
  • 60.5 (a)
zebrafish
(Danio rerio)
Actinopterygii gpr84 35
  • 54.7 (n)
  • 53.46 (a)
gpr84 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004930 35
  • 42.16 (n)
  • 29.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4313 36
  • 16 (a)
OneToMany
moody 36
  • 14 (a)
OneToMany
Tre1 36
  • 23 (a)
OneToMany
EG:22E5.11 37
  • 26 (a)
Tre1 35
  • 46.61 (n)
  • 30.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
Species with no ortholog for GPR84:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR84 Gene

ENSEMBL:
Gene Tree for GPR84 (if available)
TreeFam:
Gene Tree for GPR84 (if available)

Paralogs for GPR84 Gene

No data available for Paralogs for GPR84 Gene

Variants for GPR84 Gene

Sequence variations from dbSNP and Humsavar for GPR84 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_049397 -
VAR_069393 -

Variation tolerance for GPR84 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR84 Gene

HapMap Linkage Disequilibrium report
GPR84

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR84 Gene

Disorders for GPR84 Gene

Relevant External Links for GPR84

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR84

No disorders were found for GPR84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR84 Gene

Publications for GPR84 Gene

  1. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PMID: 11273702) Wittenberger T. … Hellebrand S. (J. Mol. Biol. 2001) 2 3 4 67
  2. Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes. (PMID: 11404393) Yousefi S. … Jarai G. (J. Leukoc. Biol. 2001) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. GPR84 sustains aberrant I^-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis. (PMID: 25293777) Dietrich P.A. … Wang J.Y. (Blood 2014) 3
  5. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3

Products for GPR84 Gene

Sources for GPR84 Gene

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