GPR83 Gene
protein-coding GIFtS: 52
GCID: GC11M094110
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|
G protein-coupled receptor 83(Previous name: G protein-coupled receptor 72 )
(Previous symbol: GPR72)
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Aliases
for GPR83 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Protein-Coupled Receptor 831 2 | | GIR2 5 | | GPR721 2 3 5 | | Glucocorticoid Induced Receptor2 | | G Protein-Coupled Receptor 721 2 | | Probable G-Protein Coupled Receptor 832 | | G-Protein Coupled Receptor 722 3 | | KIAA15403 |
Export aliases for GPR83 gene to outside databasesPrevious GC identifers: GC11U990275 GC11M094295 GC11M093798 GC11M093750 GC11M090176 |
Summaries
for GPR83 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GPR83_HUMAN, Q9NYM4Function: Orphan receptor. Could be a neuropeptide Y receptor
Gene Wiki entry for GPR83
|
Genomic Views
for GPR83 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPR83 gene promoter:
CUTL1 Meis-1b MZF-1 Pax-3 PPAR-gamma1 SREBP-1a FOXO4 PPAR-gamma2 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPR83
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR83 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q21 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21GPR83 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M094110: view genomic region
(about GC identifiers)
Start:
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94,110,477 bp from pter |
End:
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94,134,585 bp from pter |
Size:
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24,109 bases |
Orientation:
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minus strand |
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Proteins
for GPR83 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GPR83_HUMAN, Q9NYM4 (See
protein sequence)Recommended Name: Probable G-protein coupled receptor 83 precursor Size: 423 amino acids; 48339 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA96064.1; Type=Erroneous initiation;
Secondary accessions: B0M0K5 Q6NWR4 Q9P1Y8Explore the universe of human proteins at neXtProt for GPR83: NX_Q9NYM4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NYM4
GPR83 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057624.3
ENSEMBL proteins: ENSP00000243673 ENSP00000441550
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
GPR83 for ontologies About GeneDecksing
GPR83 Antibody Products:
Assay Products for GPR83: |
Protein
Domains /
Families
for GPR83 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPR83 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NYM4ProtoNet protein and cluster: Q9NYM4 1 Blocks protein family: IPB000611 Neuropeptide Y receptor signature
UniProtKB/Swiss-Prot: GPR83_HUMAN, Q9NYM4Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for GPR83 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GPR83_HUMAN, Q9NYM4Function: Orphan receptor. Could be a neuropeptide Y receptor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR83 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR83
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for GPR83 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR83 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR83 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
TAS | 10760605 | | GO:0004983 | neuropeptide Y receptor activity |
IEA | -- |
GPR83 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for GPR83:
Animal Models:
Mouse knock-outs for GPR83: Gpr83tm1.1Ayr Gpr83tm1.1Fpow
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Gpr83):
GPR83 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GPR83 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | GPCRs, Other | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for GPR83
1 
Kegg Pathway (Kegg details for GPR83):
GPR83 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR83
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
-- | -- | | GO:0051384 | response to glucocorticoid stimulus |
IEA | -- |
GPR83 for ontologies About GeneDecksing
|
Drugs & Compounds
for GPR83 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GPR83
Search CenterWatch for drugs/clinical trials and news about GPR83
|
Transcripts
for GPR83 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPR83 gene: NM_016540.3 Unigene Cluster for GPR83: G protein-coupled receptor 83 Hs.272385 [show with all ESTs]Unigene Representative Sequence: NM_0165402 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000243673(uc001pet.2) ENST00000539203
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR83 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR83
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GPR83 (NM_016540) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPR83 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR83 |
Additional cDNA sequence: AB040973.1 AF236081.1 AK315161.1 BC067473.1 BC067474.1 EU432120.1 1 DOTS entry: DT.95258201 24/27 AceView cDNA sequences (see all 27): AA324654 Z41671 AB040973 AF236081 CK002718 BQ716232 R39688 AA297170 AA326425 BX280108 CD559637 BC067474 NM_016540 CD559636 BC067473 AA297171 AI914177 BE670361 AI884371 R25904 CN479705 AW964735 R62461 H19165
GeneLoc Exon Structure
|
Expression
for GPR83 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPR83 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATTTATTG
About this image
See GPR83 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPR83
SOURCE GeneReport for Unigene cluster: Hs.272385
UniProtKB/Swiss-Prot: GPR83_HUMAN, Q9NYM4Tissue specificity: Brain specific
SABiosciences Expression via Pathway-Focused PCR Array including GPR83:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR83
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPR83 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR83 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR83 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR83 |
Orthologs
for GPR83 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GPR83 gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GPR831 |
G protein-coupled receptor 83 |
74.58(n)
72.88(a) |
|
428093 XM_425651.2 XP_425651.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GPR836 |
-- |
59(a) |
1 ↔ 1 |
GL343465.1(715552-720709) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-27p18.26 |
si:dkey-27p18.2 |
61(a) |
1 ↔ 1 |
5(24146343-24153244) |
ENSEMBL Gene Tree for GPR83 (if available)
TreeFam Gene Tree for GPR83 (if available) |
Paralogs
for GPR83 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GPR83 gene
- HCRTR22 PRLHR2 NPFFR22 PPYR12 NPY5R2 TACR12 TACR32 NPY1R2
- NPFFR12 QRFPR2 NPY2R2 HCRTR12 TACR22
18 SIMAP similar genes for GPR83 using alignment to 3 protein entries: GPR83_HUMAN (see all proteins):GIR ADORA2A DRD3 NPY2R FKSG35 TACR1
NPFFR2 PRLHR hA2aR BRS3 NPY1R PPYR1
TACR3 DRD2 NPFFR1 NPY6R OPRM1 TACR2
GPR83 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for GPR83
PGOHUM00000241820
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Genomic Variants
for GPR83 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPR83 (94110477 - 94134585 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GPR83: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR83 |
|
Disorders
/ Diseases
for GPR83 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPR83 for disorders About GeneDecksing
OMIM gene information: 605569
OMIM disorders: --
4  diseases for GPR83: About MalaCardsdissecting aortic aneurysm aortic aneurysm hyperinsulinism hyperglycemia
1 disease from the University of Copenhagen DISEASES database for GPR83:Diabetes mellitus Export disorders for GPR83 gene to outside databases
|
Publications
for GPR83 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPR83 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with GPR83) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. (PubMed id 10760605)1, 2, 3 Parker R.... Herzog H. (2000)
- Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83). (PubMed id 11060465)1, 3, 9 De Moerlooze L.... Parmentier M. (2000)
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
- G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. (PubMed id 16785516)1, 9 Hansen W....Buer J. (2006)
- Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells. (PubMed id 20200545)1, 9 Hansen W....Buer J. (2010)
- Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PubMed id 22566498)1 Turner S.T....Boerwinkle E. (2012)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for GPR83 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPR83 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPR83 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing GPR83 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPR83 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GPR83 gene:
Search GeneIP for patents involving GPR83
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPR83 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPR83 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR83 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR83 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPR83 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR83 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR83 |
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| |  |  |  |  | | | | |
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 | | | GPR83 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR83 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR83 |
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