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Aliases for GPR83 Gene

Aliases for GPR83 Gene

  • G Protein-Coupled Receptor 83 2 3
  • GPR72 3 4 6
  • G Protein-Coupled Receptor 72 2 3
  • G-Protein Coupled Receptor 72 3 4
  • GIR 3 6
  • Probable G-Protein Coupled Receptor 83 3
  • Glucocorticoid Induced Receptor 3
  • KIAA1540 4

External Ids for GPR83 Gene

Previous HGNC Symbols for GPR83 Gene

  • GPR72

Previous GeneCards Identifiers for GPR83 Gene

  • GC11U990275
  • GC11M093798
  • GC11M093750
  • GC11M094110
  • GC11M090176

Summaries for GPR83 Gene

GeneCards Summary for GPR83 Gene

GPR83 (G Protein-Coupled Receptor 83) is a Protein Coding gene. Diseases associated with GPR83 include dissecting aortic aneurysm. Among its related pathways are Peptide ligand-binding receptors and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for GPR83 Gene

  • Orphan receptor. Could be a neuropeptide Y receptor

Gene Wiki entry for GPR83 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR83 Gene

Genomics for GPR83 Gene

Regulatory Elements for GPR83 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPR83 Gene

Start:
94,377,311 bp from pter
End:
94,401,419 bp from pter
Size:
24,109 bases
Orientation:
Minus strand

Genomic View for GPR83 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR83 Gene

Proteins for GPR83 Gene

  • Protein details for GPR83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYM4-GPR83_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 83
    Protein Accession:
    Q9NYM4
    Secondary Accessions:
    • B0M0K5
    • Q6NWR4
    • Q9P1Y8

    Protein attributes for GPR83 Gene

    Size:
    423 amino acids
    Molecular mass:
    48339 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA96064.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR83 Gene

Proteomics data for GPR83 Gene at MOPED

Post-translational modifications for GPR83 Gene

  • Glycosylation at Asn37, Asn46, and Asn134
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR83 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR83 Gene

Domains for GPR83 Gene

Gene Families for GPR83 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for GPR83 Gene

Suggested Antigen Peptide Sequences for GPR83 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYM4

UniProtKB/Swiss-Prot:

GPR83_HUMAN :
  • Q9NYM4
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR83: view

Function for GPR83 Gene

Molecular function for GPR83 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Could be a neuropeptide Y receptor

Gene Ontology (GO) - Molecular Function for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10760605
GO:0004983 neuropeptide Y receptor activity IEA --
genes like me logo Genes that share ontologies with GPR83: view
genes like me logo Genes that share phenotypes with GPR83: view

Animal Models for GPR83 Gene

MGI Knock Outs for GPR83:

Animal Model Products

miRNA for GPR83 Gene

miRTarBase miRNAs that target GPR83

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GPR83 Gene

Localization for GPR83 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR83 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR83 Gene COMPARTMENTS Subcellular localization image for GPR83 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031513 nonmotile primary cilium IEA --
genes like me logo Genes that share ontologies with GPR83: view

Pathways for GPR83 Gene

genes like me logo Genes that share pathways with GPR83: view

Pathways by source for GPR83 Gene

2 BioSystems pathways for GPR83 Gene
1 KEGG pathway for GPR83 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR83 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000243673%0d%0a9606.ENSP00000349238%0d%0a
Selected Interacting proteins: ENSP00000243673 for GPR83 Gene via STRING

Symbol External ID(s) Details
CCDC88B

Gene Ontology (GO) - Biological Process for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0051384 response to glucocorticoid IEA --
genes like me logo Genes that share ontologies with GPR83: view

Transcripts for GPR83 Gene

mRNA/cDNA for GPR83 Gene

Unigene Clusters for GPR83 Gene

G protein-coupled receptor 83:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR83

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR83 Gene

No ASD Table

Relevant External Links for GPR83 Gene

GeneLoc Exon Structure for
GPR83
ECgene alternative splicing isoforms for
GPR83

Expression for GPR83 Gene

mRNA expression in normal human tissues for GPR83 Gene

mRNA differential expression in normal tissues according to GTEx for GPR83 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (12.3), Brain - Cerebellum (10.7), and Brain - Hypothalamus (4.4).

Protein differential expression in normal tissues for GPR83 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPR83 Gene

SOURCE GeneReport for Unigene cluster for GPR83 Gene Hs.272385

mRNA Expression by UniProt/SwissProt for GPR83 Gene

Q9NYM4-GPR83_HUMAN
Tissue specificity: Brain specific
genes like me logo Genes that share expressions with GPR83: view

Expression partners for GPR83 Gene

In Situ Assay Products

Orthologs for GPR83 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR83 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GPR83 35
  • 89.95 (n)
  • 92.89 (a)
GPR83 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr83 35
  • 86.06 (n)
  • 89.55 (a)
Gpr83 16
Gpr83 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR83 35
  • 99.21 (n)
  • 99.29 (a)
GPR83 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr83 35
  • 86.03 (n)
  • 89.29 (a)
cow
(Bos Taurus)
Mammalia GPR83 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR83 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR83 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR83 35
  • 74.94 (n)
  • 73.46 (a)
GPR83 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR83 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486806 35
  • 71.87 (n)
  • 77.07 (a)
zebrafish
(Danio rerio)
Actinopterygii GPR83 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NepYr 36
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npr-22 36
  • 22 (a)
OneToOne
Species with no ortholog for GPR83:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR83 Gene

ENSEMBL:
Gene Tree for GPR83 (if available)
TreeFam:
Gene Tree for GPR83 (if available)

Paralogs for GPR83 Gene

Selected SIMAP similar genes for GPR83 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GPR83 Gene

genes like me logo Genes that share paralogs with GPR83: view

Variants for GPR83 Gene

Sequence variations from dbSNP and Humsavar for GPR83 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1097 -- 94,377,508(+) AAAAG(C/G)GTTTT utr-variant-3-prime
rs546439 -- 94,402,189(+) CTTCT(C/T)CAGGA upstream-variant-2KB
rs547289 -- 94,402,260(+) GTCCT(C/T)TGCCA upstream-variant-2KB
rs550255 -- 94,402,617(+) CAGTT(C/T)TCCAC upstream-variant-2KB
rs581449 -- 94,402,995(-) GCGCT(C/T)GCCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR83 Gene

Variant ID Type Subtype PubMed ID
nsv523083 CNV Gain 19592680
nsv832233 CNV Gain 17160897
esv2671948 CNV Deletion 23128226

Relevant External Links for GPR83 Gene

HapMap Linkage Disequilibrium report
GPR83

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR83 Gene

Disorders for GPR83 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for GPR83 Gene in MalaCards »

(1) Diseases for GPR83 Gene including...

(2) University of Copenhagen DISEASES for GPR83 Gene

genes like me logo Genes that share disorders with GPR83: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for GPR83 Gene

Publications for GPR83 Gene

  1. Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. (PMID: 10760605) Parker R. … Herzog H. (Biochim. Biophys. Acta 2000) 2 3 4
  2. Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83). (PMID: 11060465) De Moerlooze L. … Parmentier M. (Cytogenet. Cell Genet. 2000) 2 3 23
  3. G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. (PMID: 16785516) Hansen W. … Buer J. (J. Immunol. 2006) 3 23
  4. Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells. (PMID: 20200545) Hansen W. … Buer J. (Genes Immun. 2010) 3 23
  5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4

Products for GPR83 Gene

Sources for GPR83 Gene

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