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Aliases for GPR83 Gene

Aliases for GPR83 Gene

  • G Protein-Coupled Receptor 83 2 3 5
  • G-Protein Coupled Receptor 72 3 4
  • GPR72 3 4
  • Probable G-Protein Coupled Receptor 83 3
  • Glucocorticoid Induced Receptor 3
  • G Protein-Coupled Receptor 72 2
  • KIAA1540 4
  • GIR 3

External Ids for GPR83 Gene

Previous HGNC Symbols for GPR83 Gene

  • GPR72

Previous GeneCards Identifiers for GPR83 Gene

  • GC11U990275
  • GC11M093798
  • GC11M093750
  • GC11M094110
  • GC11M090176

Summaries for GPR83 Gene

GeneCards Summary for GPR83 Gene

GPR83 (G Protein-Coupled Receptor 83) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is PRLHR.

UniProtKB/Swiss-Prot for GPR83 Gene

  • Orphan receptor. Could be a neuropeptide Y receptor.

Gene Wiki entry for GPR83 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR83 Gene

Genomics for GPR83 Gene

Regulatory Elements for GPR83 Gene

Enhancers for GPR83 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F094199 0.8 Ensembl ENCODE 22.3 +200.8 200774 2.2 TBP ATF1 MLX RARA YY1 FOS CREM MIXL1 EGR2 THAP11 GPR83 PANX1 LOC105369435 GC11P094202
GH11F094177 0.2 ENCODE 18.2 +222.9 222905 1.7 GPR83 PANX1 ANKRD49 MRE11 ENSG00000255893 LOC105369435 GC11P094183 PIR47114
GH11F094185 0.4 ENCODE 9.2 +215.4 215413 2.1 JUND POLR2A LOC105369435 GPR83 GC11M094189 GC11P094183
GH11F094183 1 Ensembl ENCODE 8.3 +217.3 217321 0.7 CTCF CBX3 WRNIP1 TEAD4 MAX RAD21 TEAD3 POLR2A ZNF143 SMC3 GPR83 PANX1 GC11M094189 GC11P094183
GH11F094303 1.1 Ensembl ENCODE 8.3 +97.1 97131 2.2 CTCF REST MNT RAD21 GPR83 MRE11 ENSG00000255893 LOC105369435 IZUMO1R GC11P094202
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR83 on UCSC Golden Path with GeneCards custom track

Promoters for GPR83 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001771139 119 201 MAZ GLIS2 ZBTB26 ZBTB20 EZH2

Genomic Location for GPR83 Gene

Chromosome:
11
Start:
94,377,311 bp from pter
End:
94,401,419 bp from pter
Size:
24,109 bases
Orientation:
Minus strand

Genomic View for GPR83 Gene

Genes around GPR83 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR83 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR83 Gene

Proteins for GPR83 Gene

  • Protein details for GPR83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYM4-GPR83_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 83
    Protein Accession:
    Q9NYM4
    Secondary Accessions:
    • B0M0K5
    • Q6NWR4
    • Q9P1Y8

    Protein attributes for GPR83 Gene

    Size:
    423 amino acids
    Molecular mass:
    48339 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA96064.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR83 Gene

Post-translational modifications for GPR83 Gene

  • Glycosylation at Asn 37, Asn 46, and Asn 134
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR83 Gene

No data available for DME Specific Peptides for GPR83 Gene

Domains & Families for GPR83 Gene

Gene Families for GPR83 Gene

Protein Domains for GPR83 Gene

Suggested Antigen Peptide Sequences for GPR83 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYM4

UniProtKB/Swiss-Prot:

GPR83_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR83: view

Function for GPR83 Gene

Molecular function for GPR83 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Could be a neuropeptide Y receptor.

Gene Ontology (GO) - Molecular Function for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS 10760605
GO:0004983 neuropeptide Y receptor activity IEA --
genes like me logo Genes that share ontologies with GPR83: view
genes like me logo Genes that share phenotypes with GPR83: view

Animal Models for GPR83 Gene

MGI Knock Outs for GPR83:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR83

miRNA for GPR83 Gene

miRTarBase miRNAs that target GPR83

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR83

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR83 Gene

Localization for GPR83 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR83 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR83 Gene COMPARTMENTS Subcellular localization image for GPR83 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0097730 non-motile cilium IEA --
genes like me logo Genes that share ontologies with GPR83: view

Pathways & Interactions for GPR83 Gene

genes like me logo Genes that share pathways with GPR83: view

Pathways by source for GPR83 Gene

Interacting Proteins for GPR83 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000243673%0d%0a9606.ENSP00000349238%0d%0a
Selected Interacting proteins: Q9NYM4-GPR83_HUMAN ENSP00000243673 for GPR83 Gene via IID STRING

Gene Ontology (GO) - Biological Process for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0051384 response to glucocorticoid IEA --
genes like me logo Genes that share ontologies with GPR83: view

No data available for SIGNOR curated interactions for GPR83 Gene

Drugs & Compounds for GPR83 Gene

(2) Drugs for GPR83 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Candesartan Approved Pharma Antagonist Angiotensin II receptor 1 (AT1) antagonist 156
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibition, Inhibitor 405
genes like me logo Genes that share compounds with GPR83: view

Transcripts for GPR83 Gene

mRNA/cDNA for GPR83 Gene

Unigene Clusters for GPR83 Gene

G protein-coupled receptor 83:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR83

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR83 Gene

No ASD Table

Relevant External Links for GPR83 Gene

GeneLoc Exon Structure for
GPR83
ECgene alternative splicing isoforms for
GPR83

Expression for GPR83 Gene

mRNA expression in normal human tissues for GPR83 Gene

mRNA differential expression in normal tissues according to GTEx for GPR83 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.3), Brain - Cerebellum (x10.7), and Brain - Hypothalamus (x4.4).

Protein differential expression in normal tissues from HIPED for GPR83 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR83 Gene



Protein tissue co-expression partners for GPR83 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR83 Gene:

GPR83

SOURCE GeneReport for Unigene cluster for GPR83 Gene:

Hs.272385

mRNA Expression by UniProt/SwissProt for GPR83 Gene:

Q9NYM4-GPR83_HUMAN
Tissue specificity: Brain specific.
genes like me logo Genes that share expression patterns with GPR83: view

Primer Products

Orthologs for GPR83 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR83 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR83 34 35
  • 99.21 (n)
cow
(Bos Taurus)
Mammalia GPR83 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR83 34 35
  • 89.95 (n)
mouse
(Mus musculus)
Mammalia Gpr83 34 16 35
  • 86.06 (n)
rat
(Rattus norvegicus)
Mammalia Gpr83 34
  • 86.03 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR83 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR83 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR83 34 35
  • 74.94 (n)
lizard
(Anolis carolinensis)
Reptilia GPR83 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486806 34
  • 71.87 (n)
zebrafish
(Danio rerio)
Actinopterygii GPR83 35
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NepYr 35
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npr-22 35
  • 22 (a)
OneToOne
Species where no ortholog for GPR83 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR83 Gene

ENSEMBL:
Gene Tree for GPR83 (if available)
TreeFam:
Gene Tree for GPR83 (if available)

Paralogs for GPR83 Gene

(18) SIMAP similar genes for GPR83 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GPR83 Gene

genes like me logo Genes that share paralogs with GPR83: view

Variants for GPR83 Gene

Sequence variations from dbSNP and Humsavar for GPR83 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10466369 -- 94,388,736(+) gaaaa(C/T)ggcca intron-variant
rs10741488 -- 94,396,033(+) TGGCC(A/G)ACATG intron-variant
rs10831218 -- 94,388,013(+) GGCTG(A/G)TTCAA intron-variant
rs10831219 -- 94,391,893(+) GTTCA(A/G)CCATT intron-variant
rs10831222 -- 94,398,252(+) TCCTG(C/T)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR83 Gene

Variant ID Type Subtype PubMed ID
esv2671948 CNV deletion 23128226
esv3627321 CNV loss 21293372
nsv523083 CNV gain 19592680
nsv832233 CNV gain 17160897

Variation tolerance for GPR83 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR83 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR83

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR83 Gene

Disorders for GPR83 Gene

Relevant External Links for GPR83

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR83

No disorders were found for GPR83 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR83 Gene

Publications for GPR83 Gene

  1. Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. (PMID: 10760605) Parker R. … Herzog H. (Biochim. Biophys. Acta 2000) 2 3 4 64
  2. Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83). (PMID: 11060465) De Moerlooze L. … Parmentier M. (Cytogenet. Cell Genet. 2000) 2 3 22 64
  3. Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells. (PMID: 20200545) Hansen W. … Buer J. (Genes Immun. 2010) 3 22 64
  4. G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. (PMID: 16785516) Hansen W. … Buer J. (J. Immunol. 2006) 3 22 64
  5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64

Products for GPR83 Gene

Sources for GPR83 Gene

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