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Aliases for GPR78 Gene

Aliases for GPR78 Gene

  • G Protein-Coupled Receptor 78 2 3 5

External Ids for GPR78 Gene

Previous GeneCards Identifiers for GPR78 Gene

  • GC04P008571
  • GC04P008762
  • GC04P008775
  • GC04P008776
  • GC04P008700
  • GC04P008501

Summaries for GPR78 Gene

Entrez Gene Summary for GPR78 Gene

  • The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for GPR78 Gene

GPR78 (G Protein-Coupled Receptor 78) is a Protein Coding gene. Diseases associated with GPR78 include Schizophrenia. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR26.

UniProtKB/Swiss-Prot for GPR78 Gene

  • Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Gene Wiki entry for GPR78 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR78 Gene

Genomics for GPR78 Gene

Regulatory Elements for GPR78 Gene

Enhancers for GPR78 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F008303 1.3 Ensembl ENCODE 14.1 -254.9 -254885 1.6 HDGF ATF1 PKNOX1 ARNT CREB3L1 YBX1 GATA2 FOS ZNF263 MCM3 GPR78 HTRA3 GMPSP1 SH3TC1 ENPP7P10 GC04M008288 ENSG00000249145
GH04F007936 0.9 ENCODE 13.8 -619.4 -619395 5.5 SIN3A ZNF48 RAD21 RARA ZEB1 ZNF335 GATA4 GLIS2 RCOR1 EGR2 AFAP1 GPR78 LOC389199
GH04F008559 0.7 FANTOM5 ENCODE 16.6 +2.2 2213 3.1 ZKSCAN1 GPR78 CPZ
GH04F007977 1 Ensembl ENCODE 11 -579.9 -579877 2.9 KLF1 ZFP64 ZNF266 KLF17 ZNF140 ZNF101 ZNF335 ZNF354C ZNF433 TCF7L2 GMPSP1 GPR78 LOC389199 AFAP1 PIR60893 PIR56008
GH04F008438 1.1 ENCODE 9.9 -118.5 -118466 3.7 PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TRMT44 HTRA3 LOC389199 ENSG00000251615 GPR78 ACOX3 LOC105374376
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR78 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR78 Gene

Chromosome:
4
Start:
8,558,725 bp from pter
End:
8,619,761 bp from pter
Size:
61,037 bases
Orientation:
Plus strand

Genomic View for GPR78 Gene

Genes around GPR78 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR78 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR78 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR78 Gene

Proteins for GPR78 Gene

  • Protein details for GPR78 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P69-GPR78_HUMAN
    Recommended name:
    G-protein coupled receptor 78
    Protein Accession:
    Q96P69
    Secondary Accessions:
    • Q8NGV3

    Protein attributes for GPR78 Gene

    Size:
    363 amino acids
    Molecular mass:
    39332 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR78 Gene

Post-translational modifications for GPR78 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR78 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR78 Gene

Domains & Families for GPR78 Gene

Gene Families for GPR78 Gene

Protein Domains for GPR78 Gene

Graphical View of Domain Structure for InterPro Entry

Q96P69

UniProtKB/Swiss-Prot:

GPR78_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR78: view

Function for GPR78 Gene

Molecular function for GPR78 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Gene Ontology (GO) - Molecular Function for GPR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 17363172
genes like me logo Genes that share ontologies with GPR78: view
genes like me logo Genes that share phenotypes with GPR78: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR78

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR78 Gene

Localization for GPR78 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR78 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR78 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR78: view

Pathways & Interactions for GPR78 Gene

SuperPathways for GPR78 Gene

No Data Available

Interacting Proteins for GPR78 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371927%0d%0a9606.ENSP00000349238%0d%0a
Selected Interacting proteins: Q96P69-GPR78_HUMAN ENSP00000371927 for GPR78 Gene via IID STRING

Gene Ontology (GO) - Biological Process for GPR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA 17363172
genes like me logo Genes that share ontologies with GPR78: view

No data available for Pathways by source and SIGNOR curated interactions for GPR78 Gene

Transcripts for GPR78 Gene

mRNA/cDNA for GPR78 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR78 Gene

G protein-coupled receptor 78:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR78

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR78 Gene

No ASD Table

Relevant External Links for GPR78 Gene

GeneLoc Exon Structure for
GPR78
ECgene alternative splicing isoforms for
GPR78

Expression for GPR78 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR78 Gene

mRNA differential expression in normal tissues according to GTEx for GPR78 Gene

This gene is overexpressed in Esophagus - Mucosa (x31.8) and Vagina (x7.5).

NURSA nuclear receptor signaling pathways regulating expression of GPR78 Gene:

GPR78

SOURCE GeneReport for Unigene cluster for GPR78 Gene:

Hs.740355

mRNA Expression by UniProt/SwissProt for GPR78 Gene:

Q96P69-GPR78_HUMAN
Tissue specificity: High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.
genes like me logo Genes that share expression patterns with GPR78: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR78 Gene

Orthologs for GPR78 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR78 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR78 34 35
  • 99.08 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR78 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR78 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR78 34 35
  • 62.64 (n)
zebrafish
(Danio rerio)
Actinopterygii GPR78 (2 of 2) 35
  • 49 (a)
OneToMany
gpr78 35
  • 45 (a)
OneToMany
Species where no ortholog for GPR78 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR78 Gene

ENSEMBL:
Gene Tree for GPR78 (if available)
TreeFam:
Gene Tree for GPR78 (if available)

Paralogs for GPR78 Gene

Paralogs for GPR78 Gene

(1) SIMAP similar genes for GPR78 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR78: view

Variants for GPR78 Gene

Sequence variations from dbSNP and Humsavar for GPR78 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000720 -- 8,582,368(+) CCTAC(C/T)CCTTG intron-variant
rs10006769 -- 8,584,035(+) gtgtg(C/T)ccatg intron-variant
rs10662031 -- 8,584,222(+) CAGCC(-/ATG)ATATT intron-variant
rs10662033 -- 8,584,224(+) GCCAT(-/GAT)ATTAT intron-variant
rs10938724 -- 8,587,479(+) GAGCT(A/G)AGGCT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR78 Gene

Variant ID Type Subtype PubMed ID
esv2759222 CNV gain+loss 17122850
esv34196 OTHER inversion 12058347
nsv1005698 CNV gain 25217958
nsv1014219 CNV gain 25217958
nsv4225 CNV insertion 18451855
nsv428437 CNV gain 18775914
nsv470015 CNV loss 18288195

Variation tolerance for GPR78 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR78 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR78

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR78 Gene

Disorders for GPR78 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR78 Gene - From: GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search GPR78 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR78

Genetic Association Database (GAD)
GPR78
Human Genome Epidemiology (HuGE) Navigator
GPR78
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR78
genes like me logo Genes that share disorders with GPR78: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR78 Gene

Publications for GPR78 Gene

  1. Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia. (PMID: 16389273) Underwood S.L. … Evans K.L. (Mol. Psychiatry 2006) 3 22 46 64
  2. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee D.K. … O'Dowd B.F. (Gene 2001) 2 3 4 64
  3. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PMID: 19328558) Yosifova A. … Nakamura Y. (J Affect Disord 2009) 3 46 64
  4. Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78. (PMID: 17363172) Jones P.G. … Pausch M.H. (Biochim. Biophys. Acta 2007) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for GPR78 Gene

Sources for GPR78 Gene

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