Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR75 Gene

Aliases for GPR75 Gene

  • G Protein-Coupled Receptor 75 2 3
  • GPRchr2 3
  • WI31133 3

External Ids for GPR75 Gene

Previous GeneCards Identifiers for GPR75 Gene

  • GC02M054118
  • GC02M054266
  • GC02M054037
  • GC02M054054
  • GC02M053991
  • GC02M054080
  • GC02M053814

Summaries for GPR75 Gene

Entrez Gene Summary for GPR75 Gene

  • GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]

GeneCards Summary for GPR75 Gene

GPR75 (G Protein-Coupled Receptor 75) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity.

UniProtKB/Swiss-Prot for GPR75 Gene

  • G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Gene Wiki entry for GPR75 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR75 Gene

Genomics for GPR75 Gene

Regulatory Elements for GPR75 Gene

Genomic Location for GPR75 Gene

Chromosome:
2
Start:
53,852,913 bp from pter
End:
53,860,033 bp from pter
Size:
7,121 bases
Orientation:
Minus strand

Genomic View for GPR75 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR75 Gene

Proteins for GPR75 Gene

  • Protein details for GPR75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95800-GPR75_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 75
    Protein Accession:
    O95800
    Secondary Accessions:
    • B2RC02
    • Q6NWR2

    Protein attributes for GPR75 Gene

    Size:
    540 amino acids
    Molecular mass:
    59359 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR75 Gene

Proteomics data for GPR75 Gene at MOPED

Post-translational modifications for GPR75 Gene

  • Glycosylation at Asn 2, Asn 12, and Asn 25

Other Protein References for GPR75 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR75 Gene

Domains & Families for GPR75 Gene

Gene Families for GPR75 Gene

Protein Domains for GPR75 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR75 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95800

UniProtKB/Swiss-Prot:

GPR75_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR75: view

Function for GPR75 Gene

Molecular function for GPR75 Gene

GENATLAS Biochemistry:
G protein-coupled receptor 75,expressed in the retinal pigment epithelium and in the brain,G protein-coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Gene Ontology (GO) - Molecular Function for GPR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity ISS --
GO:0016493 C-C chemokine receptor activity ISS --
genes like me logo Genes that share ontologies with GPR75: view
genes like me logo Genes that share phenotypes with GPR75: view

Animal Model Products

miRNA for GPR75 Gene

miRTarBase miRNAs that target GPR75

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR75

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR75 Gene

Localization for GPR75 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR75 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR75 Gene COMPARTMENTS Subcellular localization image for GPR75 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for GPR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10381362
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR75: view

Pathways & Interactions for GPR75 Gene

SuperPathways for GPR75 Gene

genes like me logo Genes that share pathways with GPR75: view

Pathways by source for GPR75 Gene

1 BioSystems pathway for GPR75 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Interacting Proteins for GPR75 Gene

Gene Ontology (GO) - Biological Process for GPR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway ISS --
GO:0070098 chemokine-mediated signaling pathway ISS --
GO:1901214 regulation of neuron death ISS --
genes like me logo Genes that share ontologies with GPR75: view

No data available for SIGNOR curated interactions for GPR75 Gene

Drugs & Compounds for GPR75 Gene

(1) Drugs for GPR75 Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL5 Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with GPR75: view

Transcripts for GPR75 Gene

mRNA/cDNA for GPR75 Gene

(1) REFSEQ mRNAs :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR75

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR75 Gene

No ASD Table

Relevant External Links for GPR75 Gene

GeneLoc Exon Structure for
GPR75
ECgene alternative splicing isoforms for
GPR75

Expression for GPR75 Gene

mRNA expression in normal human tissues for GPR75 Gene

mRNA Expression by UniProt/SwissProt for GPR75 Gene

O95800-GPR75_HUMAN
Tissue specificity: Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).
genes like me logo Genes that share expression patterns with GPR75: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR75 Gene

Orthologs for GPR75 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR75 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR75 35
  • 90.06 (n)
  • 93.7 (a)
GPR75 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr75 35
  • 85.43 (n)
  • 87.96 (a)
Gpr75 16
Gpr75 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR75 35
  • 99.51 (n)
  • 99.44 (a)
GPR75 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr75 35
  • 85.12 (n)
  • 87.96 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR75 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR75 35
  • 76.66 (n)
  • 81.37 (a)
GPR75 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR75 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr75 35
  • 74.04 (n)
  • 82.69 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100538001 35
  • 66.02 (n)
  • 68.74 (a)
gpr75 36
  • 65 (a)
OneToOne
Species with no ortholog for GPR75:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR75 Gene

ENSEMBL:
Gene Tree for GPR75 (if available)
TreeFam:
Gene Tree for GPR75 (if available)

Paralogs for GPR75 Gene

No data available for Paralogs for GPR75 Gene

Variants for GPR75 Gene

Sequence variations from dbSNP and Humsavar for GPR75 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_033471 -
VAR_033472 -
VAR_033473 -
VAR_071258 -
VAR_071259 -

Variation tolerance for GPR75 Gene

Residual Variation Intolerance Score: 30.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR75 Gene

HapMap Linkage Disequilibrium report
GPR75
Human Gene Mutation Database (HGMD)
GPR75

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR75 Gene

Disorders for GPR75 Gene

Relevant External Links for GPR75

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR75
genes like me logo Genes that share disorders with GPR75: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR75 Gene

Publications for GPR75 Gene

  1. RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75. (PMID: 17001303) Ignatov A. … Schaller H.C. (Br. J. Pharmacol. 2006) 23 67
  2. Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration. (PMID: 11466257) Sauer C.G. … Weber B.H. (Br J Ophthalmol 2001) 23 67
  3. Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16. (PMID: 10381362) Tarttelin E.E. … Gregory-Evans C.Y. (Biochem. Biophys. Res. Commun. 1999) 2 67
  4. The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis. (PMID: 23979485) Liu B. … Persaud S.J. (Diabetologia 2013) 67
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67

Products for GPR75 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GPR75
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GPR75
    • Block miRNA regulation of GPR75 using miScript Target Protectors

    Sources for GPR75 Gene

    Back to Top

    Content