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Aliases for GPR75 Gene

Aliases for GPR75 Gene

  • G Protein-Coupled Receptor 75 2 3 5
  • Probable G-Protein Coupled Receptor 75 3
  • GPRchr2 3
  • WI31133 3

External Ids for GPR75 Gene

Previous GeneCards Identifiers for GPR75 Gene

  • GC02M054118
  • GC02M054266
  • GC02M054037
  • GC02M054054
  • GC02M053991
  • GC02M054080
  • GC02M053814

Summaries for GPR75 Gene

Entrez Gene Summary for GPR75 Gene

  • GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]

GeneCards Summary for GPR75 Gene

GPR75 (G Protein-Coupled Receptor 75) is a Protein Coding gene. Diseases associated with GPR75 include Doyne Honeycomb Retinal Dystrophy. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity.

UniProtKB/Swiss-Prot for GPR75 Gene

  • G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Gene Wiki entry for GPR75 Gene

Additional gene information for GPR75 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR75 Gene

Genomics for GPR75 Gene

GeneHancer (GH) Regulatory Elements for GPR75 Gene

Promoters and enhancers for GPR75 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I053859 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 +0.2 174 0.9 SSRP1 SIN3A EZH2 GPR75-ASB3 GPR75 ACYP2 MIR3682
GH02I053785 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.4 +73.0 73048 3 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ASB3 ERLEC1 ACYP2 GPR75 GPR75-ASB3
GH02I054041 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.8 -183.6 -183610 3.6 FOXA2 MLX ARID4B DMAP1 ZNF48 SLC30A9 CBX5 ATF7 FOS SP5 ACYP2 RNU7-172P EML6 TSPYL6 HMGB1P31 GPR75 RPL21P30
GH02I053791 Enhancer 0.3 FANTOM5 8.3 +68.0 67963 0.3 GPR75 ACYP2 ASB3 ERLEC1 PIR55664 GPR75-ASB3
GH02I053738 Enhancer 0.4 FANTOM5 5.2 +120.9 120919 0.4 HNF4A GPR75 PSME4 GC02P053747 ASB3 GC02M053662 GPR75-ASB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR75 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR75 gene promoter:

Genomic Locations for GPR75 Gene

Genomic Locations for GPR75 Gene
chr2:53,852,913-53,860,033
(GRCh38/hg38)
Size:
7,121 bases
Orientation:
Minus strand
chr2:54,080,050-54,087,170
(GRCh37/hg19)

Genomic View for GPR75 Gene

Genes around GPR75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR75 Gene

Proteins for GPR75 Gene

  • Protein details for GPR75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95800-GPR75_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 75
    Protein Accession:
    O95800
    Secondary Accessions:
    • B2RC02
    • Q6NWR2

    Protein attributes for GPR75 Gene

    Size:
    540 amino acids
    Molecular mass:
    59359 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR75 Gene

Post-translational modifications for GPR75 Gene

  • Glycosylation at posLast=22, posLast=1212, and isoforms=25

Other Protein References for GPR75 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR75 Gene

Domains & Families for GPR75 Gene

Gene Families for GPR75 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR75 Gene

Suggested Antigen Peptide Sequences for GPR75 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95800

UniProtKB/Swiss-Prot:

GPR75_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR75: view

Function for GPR75 Gene

Molecular function for GPR75 Gene

GENATLAS Biochemistry:
G protein-coupled receptor 75,expressed in the retinal pigment epithelium and in the brain,G protein-coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Gene Ontology (GO) - Molecular Function for GPR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity ISS --
GO:0016493 C-C chemokine receptor activity ISS,IEA --
genes like me logo Genes that share ontologies with GPR75: view
genes like me logo Genes that share phenotypes with GPR75: view

miRNA for GPR75 Gene

miRTarBase miRNAs that target GPR75

Clone Products

  • Addgene plasmids for GPR75

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR75 Gene

Localization for GPR75 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR75 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR75 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 10381362
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR75: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR75 Gene

Pathways & Interactions for GPR75 Gene

genes like me logo Genes that share pathways with GPR75: view

Pathways by source for GPR75 Gene

1 BioSystems pathway for GPR75 Gene

Interacting Proteins for GPR75 Gene

Gene Ontology (GO) - Biological Process for GPR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway ISS --
GO:0070098 chemokine-mediated signaling pathway ISS,IEA --
GO:1901214 regulation of neuron death IEA,ISS --
genes like me logo Genes that share ontologies with GPR75: view

No data available for SIGNOR curated interactions for GPR75 Gene

Drugs & Compounds for GPR75 Gene

(1) Drugs for GPR75 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL5 Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with GPR75: view

Transcripts for GPR75 Gene

mRNA/cDNA for GPR75 Gene

(1) REFSEQ mRNAs :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

  • Addgene plasmids for GPR75

Alternative Splicing Database (ASD) splice patterns (SP) for GPR75 Gene

No ASD Table

Relevant External Links for GPR75 Gene

GeneLoc Exon Structure for
GPR75
ECgene alternative splicing isoforms for
GPR75

Expression for GPR75 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR75 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR75 Gene:

GPR75

mRNA Expression by UniProt/SwissProt for GPR75 Gene:

O95800-GPR75_HUMAN
Tissue specificity: Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).

Evidence on tissue expression from TISSUES for GPR75 Gene

  • Nervous system(4.4)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with GPR75: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR75 Gene

Orthologs for GPR75 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR75 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR75 33 34
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia GPR75 33 34
  • 90.06 (n)
mouse
(Mus musculus)
Mammalia Gpr75 33 16 34
  • 85.43 (n)
rat
(Rattus norvegicus)
Mammalia Gpr75 33
  • 85.12 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR75 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR75 33 34
  • 76.66 (n)
lizard
(Anolis carolinensis)
Reptilia GPR75 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr75 33
  • 74.04 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100538001 33
  • 66.02 (n)
gpr75 34
  • 65 (a)
OneToOne
Species where no ortholog for GPR75 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR75 Gene

ENSEMBL:
Gene Tree for GPR75 (if available)
TreeFam:
Gene Tree for GPR75 (if available)

Paralogs for GPR75 Gene

No data available for Paralogs for GPR75 Gene

Variants for GPR75 Gene

Sequence variations from dbSNP and Humsavar for GPR75 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000066296 -- 53,859,651(-) A/T intron_variant
rs1000286325 -- 53,859,808(-) A/G intron_variant
rs1000484885 -- 53,860,097(-) C/G/T upstream_transcript_variant
rs1000703883 -- 53,859,064(-) A/G intron_variant
rs1000847586 -- 53,854,194(-) A/G coding_sequence_variant, missense_variant

Variation tolerance for GPR75 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR75 Gene

Human Gene Mutation Database (HGMD)
GPR75
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR75

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR75 Gene

Disorders for GPR75 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR75 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
doyne honeycomb retinal dystrophy
  • dhrd
- elite association - COSMIC cancer census association via MalaCards
Search GPR75 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR75

genes like me logo Genes that share disorders with GPR75: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR75 Gene

Publications for GPR75 Gene

  1. Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16. (PMID: 10381362) Tarttelin EE … Gregory-Evans CY (Biochemical and biophysical research communications 1999) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration. (PMID: 11466257) Sauer CG … Weber BH (The British journal of ophthalmology 2001) 4 22 58
  5. The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis. (PMID: 23979485) Liu B … Persaud SJ (Diabetologia 2013) 4 58

Products for GPR75 Gene

  • Addgene plasmids for GPR75

Sources for GPR75 Gene

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