Aliases for GPR68 Gene
External Ids for GPR68 Gene
Previous GeneCards Identifiers for GPR68 Gene
GeneCards Summary for GPR68 Gene
GPR68 (G Protein-Coupled Receptor 68) is a Protein Coding gene. Diseases associated with GPR68 include rectal prolapse and ovarian cancer. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR132.
UniProtKB/Swiss-Prot for GPR68 Gene
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).