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Aliases for GPR68 Gene

Aliases for GPR68 Gene

  • G Protein-Coupled Receptor 68 2 3 5
  • Sphingosylphosphorylcholine Receptor 3 4
  • GPR12A 3 4
  • OGR1 3 4
  • Ovarian Cancer G Protein-Coupled Receptor, 1 3
  • Ovarian Cancer G-Protein Coupled Receptor 1 3
  • G-Protein Coupled Receptor 68 4
  • AI2A6 3
  • OGR-1 4

External Ids for GPR68 Gene

Previous GeneCards Identifiers for GPR68 Gene

  • GC14M089206
  • GC14M085516
  • GC14M089690
  • GC14M090769
  • GC14M091699
  • GC14M071875

Summaries for GPR68 Gene

Entrez Gene Summary for GPR68 Gene

  • The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017]

GeneCards Summary for GPR68 Gene

GPR68 (G Protein-Coupled Receptor 68) is a Protein Coding gene. Diseases associated with GPR68 include Amelogenesis Imperfecta, Hypomaturation Type, 2A6 and Amelogenesis Imperfecta Hypomaturation Type. Among its related pathways are RET signaling and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR4.

UniProtKB/Swiss-Prot for GPR68 Gene

  • Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).

Gene Wiki entry for GPR68 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR68 Gene

Genomics for GPR68 Gene

Regulatory Elements for GPR68 Gene

Enhancers for GPR68 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G091264 0.8 FANTOM5 dbSUPER 22.7 +7.3 7270 0.1 BCOR SMARCA5 PTBP1 HDAC2 ZMYM3 KDM1A GPR68 ENSG00000260810
GH14G091201 1.2 FANTOM5 ENCODE 12.4 +68.5 68467 1.3 PKNOX1 CREB3L1 ARNT TCF12 ZNF766 CBX5 ELK1 KLF13 NCOA1 ZNF592 GPR68 C14orf159 PPP4R3A GC14P091227 GC14P091148
GH14G091226 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.9 +41.0 40962 7.3 HDGF PKNOX1 FOXA2 WRNIP1 GATA2 ELK1 ZNF207 ZNF143 FOS JUNB CCDC88C PPP4R3A GPR68 RPS6KA5 C14orf159 GC14P091227 ENSG00000258875
GH14G091303 0.8 ENCODE dbSUPER 12.3 -32.8 -32840 0.8 HDGF PKNOX1 KLF1 POLR2A TEAD4 RBBP5 FOS GPR68 CCDC88C PIR51395 GC14M091427 GC14M091392 PIR52737
GH14G091302 0.4 dbSUPER 12.3 -31.6 -31609 0.5 JUNB ETV6 GPR68 CCDC88C PIR51395 GC14M091427 PIR52737 GC14M091392
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR68 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR68 Gene

Chromosome:
14
Start:
91,232,532 bp from pter
End:
91,270,790 bp from pter
Size:
38,259 bases
Orientation:
Minus strand

Genomic View for GPR68 Gene

Genes around GPR68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR68 Gene

Proteins for GPR68 Gene

  • Protein details for GPR68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15743-OGR1_HUMAN
    Recommended name:
    Ovarian cancer G-protein coupled receptor 1
    Protein Accession:
    Q15743
    Secondary Accessions:
    • Q13334
    • Q4VBB4
    • Q6IX34

    Protein attributes for GPR68 Gene

    Size:
    365 amino acids
    Molecular mass:
    41077 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH96071.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH96072.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH96073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH96074.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98567.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAT38917.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ACG60649.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW81447.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR68 Gene

Post-translational modifications for GPR68 Gene

  • Glycosylation at isoforms=3 and isoforms=8
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR68 Gene

Domains & Families for GPR68 Gene

Gene Families for GPR68 Gene

Suggested Antigen Peptide Sequences for GPR68 Gene

Graphical View of Domain Structure for InterPro Entry

Q15743

UniProtKB/Swiss-Prot:

OGR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR68: view

Function for GPR68 Gene

Molecular function for GPR68 Gene

GENATLAS Biochemistry:
G protein coupled receptor 68,with strong homology to GPR4,expressed in spleen,testis,small intestine,peripheral blood leucocytes,brain,heart,lung,placenta,kidney
UniProtKB/Swiss-Prot Function:
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).

Gene Ontology (GO) - Molecular Function for GPR68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS,IEA --
genes like me logo Genes that share ontologies with GPR68: view
genes like me logo Genes that share phenotypes with GPR68: view

Animal Models for GPR68 Gene

MGI Knock Outs for GPR68:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR68

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR68

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR68 Gene

Localization for GPR68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR68 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR68 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for GPR68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8661159
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR68: view

Pathways & Interactions for GPR68 Gene

genes like me logo Genes that share pathways with GPR68: view

Gene Ontology (GO) - Biological Process for GPR68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 7498459
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0032024 positive regulation of insulin secretion IEA --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
genes like me logo Genes that share ontologies with GPR68: view

No data available for SIGNOR curated interactions for GPR68 Gene

Drugs & Compounds for GPR68 Gene

(3) Drugs for GPR68 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GPR68: view

Transcripts for GPR68 Gene

Unigene Clusters for GPR68 Gene

G protein-coupled receptor 68:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR68

Alternative Splicing Database (ASD) splice patterns (SP) for GPR68 Gene

No ASD Table

Relevant External Links for GPR68 Gene

GeneLoc Exon Structure for
GPR68
ECgene alternative splicing isoforms for
GPR68

Expression for GPR68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR68 Gene

mRNA differential expression in normal tissues according to GTEx for GPR68 Gene

This gene is overexpressed in Pituitary (x5.4).

Protein differential expression in normal tissues from HIPED for GPR68 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR68 Gene



Protein tissue co-expression partners for GPR68 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR68 Gene:

GPR68

SOURCE GeneReport for Unigene cluster for GPR68 Gene:

Hs.8882

mRNA Expression by UniProt/SwissProt for GPR68 Gene:

Q15743-OGR1_HUMAN
Tissue specificity: Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.

Evidence on tissue expression from TISSUES for GPR68 Gene

  • Lung(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GPR68: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR68 Gene

Orthologs for GPR68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR68 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia GPR68 34 35
  • 91.16 (n)
cow
(Bos Taurus)
Mammalia GPR68 34 35
  • 91.04 (n)
rat
(Rattus norvegicus)
Mammalia Gpr68 34
  • 88.22 (n)
mouse
(Mus musculus)
Mammalia Gpr68 34 16 35
  • 87.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR68 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR68 34 35
  • 62.96 (n)
lizard
(Anolis carolinensis)
Reptilia GPR68 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733637 34
  • 61.38 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC799203 34
  • 60.08 (n)
GPR68 35
  • 52 (a)
OneToOne
Species where no ortholog for GPR68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR68 Gene

ENSEMBL:
Gene Tree for GPR68 (if available)
TreeFam:
Gene Tree for GPR68 (if available)

Paralogs for GPR68 Gene

Paralogs for GPR68 Gene

genes like me logo Genes that share paralogs with GPR68: view

Variants for GPR68 Gene

Sequence variations from dbSNP and Humsavar for GPR68 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_077874 Amelogenesis imperfecta, hypomaturation type, 2A6 (AI2A6) [MIM:617217]
rs1057517671 Pathogenic 91,234,383(-) GCCGC(-/AA)GGACC reference, frameshift-variant
rs1057517672 Pathogenic 91,234,830(-) CTCGC(C/T)GCCCT reference, missense
rs1000039073 -- 91,261,805(+) AGGTT(C/G)AATCA intron-variant
rs1000128738 -- 91,235,167(+) CTGGT(A/G)GTGGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR68 Gene

Variant ID Type Subtype PubMed ID
dgv141n21 CNV gain 19592680
nsv1046924 CNV gain 25217958
nsv819108 CNV loss 19587683
nsv832857 CNV loss 17160897
nsv952882 CNV deletion 24416366

Variation tolerance for GPR68 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR68 Gene

Human Gene Mutation Database (HGMD)
GPR68
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR68 Gene

Disorders for GPR68 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GPR68 Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
amelogenesis imperfecta, hypomaturation type, 2a6
  • amelogenesis imperfecta, hypomaturation type, iia6
amelogenesis imperfecta hypomaturation type
  • aih
amelogenesis imperfecta
  • ai
ovarian cancer
  • malignant ovarian tumor
rectal prolapse
  • procidentia, rectum
- elite association - COSMIC cancer census association via MalaCards
Search GPR68 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

OGR1_HUMAN
  • Amelogenesis imperfecta, hypomaturation type, 2A6 (AI2A6) [MIM:617217]: A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. {ECO:0000269 PubMed:27693231}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GPR68

Human Genome Epidemiology (HuGE) Navigator
GPR68
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR68
genes like me logo Genes that share disorders with GPR68: view

No data available for Genatlas for GPR68 Gene

Publications for GPR68 Gene

  1. Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14. (PMID: 8661159) Xu Y. … Casey G. (Genomics 1996) 2 3 4 22 64
  2. Proton-sensing G-protein-coupled receptors. (PMID: 12955148) Ludwig M.-G. … Seuwen K. (Nature 2003) 3 4 22 64
  3. Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta. (PMID: 27693231) Parry D.A. … Mighell A.J. (Am. J. Hum. Genet. 2016) 3 4 64
  4. Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer. (PMID: 17728215) Singh L.S. … Xu Y. (J. Natl. Cancer Inst. 2007) 3 22 64
  5. Retraction. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. (PMID: 16508674) (Nat. Cell Biol. 2006) 4 22 64

Products for GPR68 Gene

  • Addgene plasmids for GPR68

Sources for GPR68 Gene

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