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Aliases for GPR68 Gene

Aliases for GPR68 Gene

  • G Protein-Coupled Receptor 68 2 3
  • Sphingosylphosphorylcholine Receptor 3 4
  • G-Protein Coupled Receptor 68 3 4
  • GPR12A 3 4
  • OGR1 3 4
  • Ovarian Cancer G Protein-Coupled Receptor, 1 3
  • OGR-1 4

External Ids for GPR68 Gene

Previous GeneCards Identifiers for GPR68 Gene

  • GC14M089206
  • GC14M085516
  • GC14M089690
  • GC14M090769
  • GC14M091699
  • GC14M071875

Summaries for GPR68 Gene

GeneCards Summary for GPR68 Gene

GPR68 (G Protein-Coupled Receptor 68) is a Protein Coding gene. Diseases associated with GPR68 include rectal prolapse and ovarian cancer. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for GPR68 Gene

  • Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).

Gene Wiki entry for GPR68 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR68 Gene

Genomics for GPR68 Gene

Regulatory Elements for GPR68 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPR68 Gene

Chromosome:
14
Start:
91,232,532 bp from pter
End:
91,270,790 bp from pter
Size:
38,259 bases
Orientation:
Minus strand

Genomic View for GPR68 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR68 Gene

Proteins for GPR68 Gene

  • Protein details for GPR68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15743-OGR1_HUMAN
    Recommended name:
    Ovarian cancer G-protein coupled receptor 1
    Protein Accession:
    Q15743
    Secondary Accessions:
    • Q13334
    • Q4VBB4
    • Q6IX34

    Protein attributes for GPR68 Gene

    Size:
    365 amino acids
    Molecular mass:
    41077 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH96071.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH96072.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH96073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH96074.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98567.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAT38917.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ACG60649.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW81447.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR68 Gene

Proteomics data for GPR68 Gene at MOPED

Post-translational modifications for GPR68 Gene

  • Glycosylation at Asn 3 and Asn 8
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR68 Gene

Antibody Products

No data available for DME Specific Peptides for GPR68 Gene

Domains & Families for GPR68 Gene

Gene Families for GPR68 Gene

Protein Domains for GPR68 Gene

Suggested Antigen Peptide Sequences for GPR68 Gene

Graphical View of Domain Structure for InterPro Entry

Q15743

UniProtKB/Swiss-Prot:

OGR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR68: view

Function for GPR68 Gene

Molecular function for GPR68 Gene

GENATLAS Biochemistry:
G protein coupled receptor 68,with strong homology to GPR4,expressed in spleen,testis,small intestine,peripheral blood leucocytes,brain,heart,lung,placenta,kidney
UniProtKB/Swiss-Prot Function:
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).

Gene Ontology (GO) - Molecular Function for GPR68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR68: view
genes like me logo Genes that share phenotypes with GPR68: view

Animal Models for GPR68 Gene

MGI Knock Outs for GPR68:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GPR68 Gene

Localization for GPR68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR68 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR68 Gene COMPARTMENTS Subcellular localization image for GPR68 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for GPR68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8661159
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR68: view

Pathways & Interactions for GPR68 Gene

genes like me logo Genes that share pathways with GPR68: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR68 Gene

Gene Ontology (GO) - Biological Process for GPR68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 7498459
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0032024 positive regulation of insulin secretion --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0045656 negative regulation of monocyte differentiation IEA --
genes like me logo Genes that share ontologies with GPR68: view

No data available for SIGNOR curated interactions for GPR68 Gene

Drugs & Compounds for GPR68 Gene

(3) Drugs for GPR68 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lysophosphatidylcholine Pharma Activator 0
Sphingosylphosphorylcholine Pharma 0
Calcium Nutra 0
genes like me logo Genes that share compounds with GPR68: view

Transcripts for GPR68 Gene

Unigene Clusters for GPR68 Gene

G protein-coupled receptor 68:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR68 Gene

No ASD Table

Relevant External Links for GPR68 Gene

GeneLoc Exon Structure for
GPR68
ECgene alternative splicing isoforms for
GPR68

Expression for GPR68 Gene

mRNA expression in normal human tissues for GPR68 Gene

mRNA differential expression in normal tissues according to GTEx for GPR68 Gene

This gene is overexpressed in Pituitary (x5.4).

Protein differential expression in normal tissues from HIPED for GPR68 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR68 Gene



SOURCE GeneReport for Unigene cluster for GPR68 Gene Hs.8882

mRNA Expression by UniProt/SwissProt for GPR68 Gene

Q15743-OGR1_HUMAN
Tissue specificity: Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.
genes like me logo Genes that share expression patterns with GPR68: view

Protein tissue co-expression partners for GPR68 Gene

Primer Products

In Situ Assay Products

Orthologs for GPR68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR68 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR68 35
  • 91.04 (n)
  • 90.03 (a)
GPR68 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR68 35
  • 91.16 (n)
  • 87.9 (a)
GPR68 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr68 35
  • 87.58 (n)
  • 92.05 (a)
Gpr68 16
Gpr68 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR68 35
  • 99.45 (n)
  • 99.73 (a)
GPR68 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102553138 35
  • 88.22 (n)
  • 93.15 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR68 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR68 35
  • 62.96 (n)
  • 63.7 (a)
GPR68 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR68 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733637 35
  • 61.38 (n)
  • 64.02 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC799203 35
  • 60.08 (n)
  • 56.05 (a)
GPR68 36
  • 52 (a)
OneToOne
Species with no ortholog for GPR68:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR68 Gene

ENSEMBL:
Gene Tree for GPR68 (if available)
TreeFam:
Gene Tree for GPR68 (if available)

Paralogs for GPR68 Gene

Paralogs for GPR68 Gene

genes like me logo Genes that share paralogs with GPR68: view

Variants for GPR68 Gene

Sequence variations from dbSNP and Humsavar for GPR68 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs933527 -- 91,238,953(-) TGTTT(C/T)TTTTT intron-variant, upstream-variant-2KB
rs933528 -- 91,238,844(-) CCACT(C/T)GTAAA intron-variant, upstream-variant-2KB
rs933529 -- 91,238,759(-) GGGGG(A/C)GCCTG intron-variant, upstream-variant-2KB
rs933531 -- 91,241,903(-) CAAAA(C/T)CCTGC intron-variant, upstream-variant-2KB
rs1815252 -- 91,242,472(+) TGGGT(A/G)GACAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR68 Gene

Variant ID Type Subtype PubMed ID
dgv141n21 CNV Gain 19592680
nsv832857 CNV Loss 17160897
nsv819108 CNV Loss 19587683

Variation tolerance for GPR68 Gene

Residual Variation Intolerance Score: 17.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR68 Gene

HapMap Linkage Disequilibrium report
GPR68
Human Gene Mutation Database (HGMD)
GPR68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR68 Gene

Disorders for GPR68 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR68 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
rectal prolapse
  • procidentia, rectum
ovarian cancer
  • tumor of the ovary
- elite association
Search GPR68 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR68

Human Genome Epidemiology (HuGE) Navigator
GPR68
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR68
genes like me logo Genes that share disorders with GPR68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR68 Gene

Publications for GPR68 Gene

  1. Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14. (PMID: 8661159) Xu Y. … Casey G. (Genomics 1996) 2 23 67
  2. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. (PMID: 19479052) Li H. … Xu Y. (PLoS ONE 2009) 23 67
  3. Sphingosylphosphorylcholine activates dendritic cells, stimulating the production of interleukin-12. (PMID: 17371542) Ceballos A. … Geffner J. (Immunology 2007) 23 67
  4. Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer. (PMID: 17728215) Singh L.S. … Xu Y. (J. Natl. Cancer Inst. 2007) 23 67
  5. Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. (PMID: 16490345) Afrasiabi E. … TAPrnquist K. (Cell. Signal. 2006) 23 67

Products for GPR68 Gene

Sources for GPR68 Gene

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