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Aliases for GPR65 Gene

Aliases for GPR65 Gene

  • G Protein-Coupled Receptor 65 2 3 5
  • T-Cell Death-Associated Gene 8 Protein 3 4
  • G-Protein Coupled Receptor 65 3 4
  • TDAG8 3 4
  • HTDAG8 3

External Ids for GPR65 Gene

Previous GeneCards Identifiers for GPR65 Gene

  • GC14P085976
  • GC14P082288
  • GC14P086461
  • GC14P087541
  • GC14P088471
  • GC14P068641

Summaries for GPR65 Gene

GeneCards Summary for GPR65 Gene

GPR65 (G Protein-Coupled Receptor 65) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for GPR65 Gene

  • Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation-induced cell death or differentiation of T-cells.

Gene Wiki entry for GPR65 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR65 Gene

Genomics for GPR65 Gene

Regulatory Elements for GPR65 Gene

Enhancers for GPR65 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR65 on UCSC Golden Path with GeneCards custom track

Promoters for GPR65 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR65 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR65 Gene

88,005,124 bp from pter
88,014,811 bp from pter
9,688 bases
Plus strand

Genomic View for GPR65 Gene

Genes around GPR65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR65 Gene

Proteins for GPR65 Gene

  • Protein details for GPR65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Psychosine receptor
    Protein Accession:
    Secondary Accessions:
    • O75819

    Protein attributes for GPR65 Gene

    337 amino acids
    Molecular mass:
    39333 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR65 Gene

Proteomics data for GPR65 Gene at MOPED

Post-translational modifications for GPR65 Gene

  • Glycosylation at Asn 2, Asn 79, and Asn 166
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR65 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR65 Gene

Domains & Families for GPR65 Gene

Gene Families for GPR65 Gene

Protein Domains for GPR65 Gene

Suggested Antigen Peptide Sequences for GPR65 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR65: view

Function for GPR65 Gene

Molecular function for GPR65 Gene

GENATLAS Biochemistry:
G protein coupled receptor 65,predominantly expressed in lymphoid tissues,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation-induced cell death or differentiation of T-cells.
genes like me logo Genes that share phenotypes with GPR65: view

Animal Models for GPR65 Gene

MGI Knock Outs for GPR65:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR65

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR65 Gene

Localization for GPR65 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR65 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR65 Gene COMPARTMENTS Subcellular localization image for GPR65 gene
Compartment Confidence
plasma membrane 5
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for GPR65 Gene

Pathways & Interactions for GPR65 Gene

genes like me logo Genes that share pathways with GPR65: view

Interacting Proteins for GPR65 Gene

Gene Ontology (GO) - Biological Process for GPR65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,IDA 15618224
GO:0010447 response to acidic pH IDA 15618224
GO:0030819 positive regulation of cAMP biosynthetic process IDA 15618224
GO:0031532 actin cytoskeleton reorganization IDA 15618224
genes like me logo Genes that share ontologies with GPR65: view

No data available for SIGNOR curated interactions for GPR65 Gene

Drugs & Compounds for GPR65 Gene

(1) Drugs for GPR65 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GPR65 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPR65: view

Transcripts for GPR65 Gene

mRNA/cDNA for GPR65 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(33) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR65 Gene

G protein-coupled receptor 65:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR65 Gene

No ASD Table

Relevant External Links for GPR65 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR65 Gene

mRNA expression in normal human tissues for GPR65 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR65 Gene

This gene is overexpressed in Whole Blood (x15.1) and Spleen (x5.6).

SOURCE GeneReport for Unigene cluster for GPR65 Gene Hs.443243

mRNA Expression by UniProt/SwissProt for GPR65 Gene

Tissue specificity: Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with GPR65: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR65 Gene

Orthologs for GPR65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR65 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR65 35
  • 84.27 (n)
  • 79.82 (a)
GPR65 36
  • 79 (a)
(Canis familiaris)
Mammalia GPR65 35
  • 86.84 (n)
  • 84.27 (a)
GPR65 36
  • 83 (a)
(Mus musculus)
Mammalia Gpr65 35
  • 78.21 (n)
  • 79.4 (a)
Gpr65 16
Gpr65 36
  • 79 (a)
(Pan troglodytes)
Mammalia GPR65 35
  • 99.6 (n)
  • 99.11 (a)
GPR65 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Gpr65 35
  • 79.4 (n)
  • 80.9 (a)
(Monodelphis domestica)
Mammalia GPR65 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia GPR65 36
  • 56 (a)
(Gallus gallus)
Aves GPR65 35
  • 63.26 (n)
  • 57.43 (a)
GPR65 36
  • 52 (a)
(Anolis carolinensis)
Reptilia GPR65 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr65 35
  • 56.51 (n)
  • 46.98 (a)
(Danio rerio)
Actinopterygii gpr65 36
  • 33 (a)
Species with no ortholog for GPR65:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR65 Gene

Gene Tree for GPR65 (if available)
Gene Tree for GPR65 (if available)

Paralogs for GPR65 Gene

Paralogs for GPR65 Gene

(10) SIMAP similar genes for GPR65 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR65: view

Variants for GPR65 Gene

Sequence variations from dbSNP and Humsavar for GPR65 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs3742704 - 88,011,538(-) TGTGA(G/T)GCTGA reference, missense
rs1372363 -- 88,006,834(+) GCATC(G/T)CAGAC intron-variant
rs1372364 -- 88,006,955(+) cttgc(C/T)ctggt intron-variant
rs1441809 -- 88,008,047(+) AATAA(A/G)ATCAG intron-variant
rs8004567 -- 88,013,267(+) GTCTC(A/G)ATCGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR65 Gene

Variant ID Type Subtype PubMed ID
nsv1389 CNV Loss 18451855

Variation tolerance for GPR65 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.54; 77.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR65 Gene

Disorders for GPR65 Gene

Relevant External Links for GPR65

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR65 Gene

Publications for GPR65 Gene

  1. Cloning, characterization, and mapping of human homolog of mouse T- cell death-associated gene. (PMID: 9655242) Kyaw H. … Li Y. (DNA Cell Biol. 1998) 2 3 4 23 67
  2. Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. (PMID: 15618224) Ishii S. … Shimizu T. (J. Biol. Chem. 2005) 3 23
  3. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. (PMID: 15665078) Radu C.G. … Witte O.N. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23
  4. G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers. (PMID: 15221007) Sin W.C. … Yang J. (Oncogene 2004) 3 23
  5. Identification of a molecular target of psychosine and its role in globoid cell formation. (PMID: 11309421) Im D.-S. … Lynch K.R. (J. Cell Biol. 2001) 3 23

Products for GPR65 Gene

Sources for GPR65 Gene