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Aliases for GPR65 Gene

Aliases for GPR65 Gene

  • G Protein-Coupled Receptor 65 2 3 5
  • T-Cell Death-Associated Gene 8 Protein 3 4
  • TDAG8 3 4
  • G-Protein Coupled Receptor 65 4
  • Psychosine Receptor 3
  • HTDAG8 3

External Ids for GPR65 Gene

Previous GeneCards Identifiers for GPR65 Gene

  • GC14P085976
  • GC14P082288
  • GC14P086461
  • GC14P087541
  • GC14P088471
  • GC14P068641

Summaries for GPR65 Gene

GeneCards Summary for GPR65 Gene

GPR65 (G Protein-Coupled Receptor 65) is a Protein Coding gene. Diseases associated with GPR65 include Rectal Prolapse. Among its related pathways are Signaling by GPCR and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR4.

UniProtKB/Swiss-Prot for GPR65 Gene

  • Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation-induced cell death or differentiation of T-cells.

Gene Wiki entry for GPR65 Gene

Additional gene information for GPR65 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR65 Gene

Genomics for GPR65 Gene

Regulatory Elements for GPR65 Gene

Enhancers for GPR65 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H088004 1.8 FANTOM5 Ensembl ENCODE dbSUPER 38.9 +2.5 2475 6 PKNOX1 TBL1XR1 SIN3A BMI1 BATF RFX5 ATF7 ETV6 RUNX3 CREM GPR65 GALC ENSG00000258407
GH14H087989 1.7 FANTOM5 ENCODE dbSUPER 33.9 -11.8 -11774 8 HDGF FOXA2 SIN3A YY1 CBX5 ZNF143 ZNF207 SP3 JUNB REST GPR65 GALC FAM35CP ZC3H14
GH14H088001 1.5 FANTOM5 Ensembl ENCODE dbSUPER 30.2 -2.3 -2335 2 REST SP1 IKZF1 EED ETV6 IKZF2 CREM RUNX3 SPI1 GALC GPR65 RNU6-835P
GH14H088043 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.8 +40.0 40019 3 FOXA2 MLX ARID4B YY1 SLC30A9 FOS ATF7 SP5 MXD4 JUNB GALC GPR65 LOC101928791 GC14P088067
GH14H088022 1.5 Ensembl ENCODE dbSUPER 5.9 +20.1 20123 5 FOXA2 ARNT DMAP1 YY1 TCF12 CAVIN1 MXD4 NCOA1 ZNF592 KAT8 GALC GPR65 LINC01146 LOC101928791
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR65 on UCSC Golden Path with GeneCards custom track

Promoters for GPR65 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000071686 676 1601 PKNOX1 TBL1XR1 SIN3A BMI1 BATF RAD21 RFX5 ATF7 ETV6 RUNX3

Genomic Location for GPR65 Gene

Chromosome:
14
Start:
88,005,124 bp from pter
End:
88,014,811 bp from pter
Size:
9,688 bases
Orientation:
Plus strand

Genomic View for GPR65 Gene

Genes around GPR65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR65 Gene

Proteins for GPR65 Gene

  • Protein details for GPR65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYL9-PSYR_HUMAN
    Recommended name:
    Psychosine receptor
    Protein Accession:
    Q8IYL9
    Secondary Accessions:
    • O75819

    Protein attributes for GPR65 Gene

    Size:
    337 amino acids
    Molecular mass:
    39333 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR65 Gene

Post-translational modifications for GPR65 Gene

  • Glycosylation at posLast=22, posLast=7979, and isoforms=166
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR65 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR65 Gene

Domains & Families for GPR65 Gene

Gene Families for GPR65 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR65 Gene

Suggested Antigen Peptide Sequences for GPR65 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYL9

UniProtKB/Swiss-Prot:

PSYR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR65: view

Function for GPR65 Gene

Molecular function for GPR65 Gene

GENATLAS Biochemistry:
G protein coupled receptor 65,predominantly expressed in lymphoid tissues,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation-induced cell death or differentiation of T-cells.

Phenotypes From GWAS Catalog for GPR65 Gene

Gene Ontology (GO) - Molecular Function for GPR65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 15618224
genes like me logo Genes that share ontologies with GPR65: view
genes like me logo Genes that share phenotypes with GPR65: view

Animal Models for GPR65 Gene

MGI Knock Outs for GPR65:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR65

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR65
  • Applied Biological Materials Clones for GPR65
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR65 Gene

Localization for GPR65 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR65 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR65 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPR65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 9655242
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR65: view

Pathways & Interactions for GPR65 Gene

genes like me logo Genes that share pathways with GPR65: view

Gene Ontology (GO) - Biological Process for GPR65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS,IEA --
GO:0006955 immune response TAS 9655242
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 15618224
GO:0007275 multicellular organism development TAS 9655242
genes like me logo Genes that share ontologies with GPR65: view

No data available for SIGNOR curated interactions for GPR65 Gene

Drugs & Compounds for GPR65 Gene

(1) Drugs for GPR65 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GPR65 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPR65: view

Transcripts for GPR65 Gene

mRNA/cDNA for GPR65 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(33) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR65 Gene

G protein-coupled receptor 65:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR65
  • Applied Biological Materials Clones for GPR65
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GPR65 Gene

No ASD Table

Relevant External Links for GPR65 Gene

GeneLoc Exon Structure for
GPR65
ECgene alternative splicing isoforms for
GPR65

Expression for GPR65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR65 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR65 Gene

This gene is overexpressed in Whole Blood (x15.1) and Spleen (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of GPR65 Gene:

GPR65

SOURCE GeneReport for Unigene cluster for GPR65 Gene:

Hs.443243

mRNA Expression by UniProt/SwissProt for GPR65 Gene:

Q8IYL9-PSYR_HUMAN
Tissue specificity: Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for GPR65 Gene

  • Blood(4.4)
  • Nervous system(4.3)
  • Spleen(2)
genes like me logo Genes that share expression patterns with GPR65: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR65 Gene

Orthologs for GPR65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR65 33 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia GPR65 33 34
  • 86.84 (n)
cow
(Bos Taurus)
Mammalia GPR65 33 34
  • 84.27 (n)
rat
(Rattus norvegicus)
Mammalia Gpr65 33
  • 79.4 (n)
mouse
(Mus musculus)
Mammalia Gpr65 33 16 34
  • 78.21 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR65 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR65 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR65 33 34
  • 63.26 (n)
lizard
(Anolis carolinensis)
Reptilia GPR65 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr65 33
  • 56.51 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr65 34
  • 33 (a)
OneToOne
Species where no ortholog for GPR65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR65 Gene

ENSEMBL:
Gene Tree for GPR65 (if available)
TreeFam:
Gene Tree for GPR65 (if available)

Paralogs for GPR65 Gene

Paralogs for GPR65 Gene

(10) SIMAP similar genes for GPR65 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR65: view

Variants for GPR65 Gene

Sequence variations from dbSNP and Humsavar for GPR65 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000069220 -- 88,013,798(+) GAAAA(A/T)GGATC utr-variant-3-prime
rs1000427539 -- 88,004,935(+) TAATA(C/T)CAGTA upstream-variant-2KB
rs1000460088 -- 88,005,235(+) TAAGA(A/T)TAAAA intron-variant
rs1000530192 -- 88,010,509(+) TCTAT(A/G)TACAC upstream-variant-2KB, utr-variant-5-prime
rs1000596884 -- 88,012,310(+) ATTAA(C/T)AAATC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR65 Gene

Variant ID Type Subtype PubMed ID
dgv673e212 CNV loss 25503493
nsv1389 CNV deletion 18451855
nsv952879 CNV duplication 24416366

Variation tolerance for GPR65 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.54; 77.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR65 Gene

Human Gene Mutation Database (HGMD)
GPR65
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR65 Gene

Disorders for GPR65 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR65 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
rectal prolapse
  • procidentia, rectum
- elite association - COSMIC cancer census association via MalaCards
Search GPR65 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR65

Genetic Association Database (GAD)
GPR65
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR65
genes like me logo Genes that share disorders with GPR65: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR65 Gene

Publications for GPR65 Gene

  1. Cloning, characterization, and mapping of human homolog of mouse T-cell death-associated gene. (PMID: 9655242) Kyaw H … Li Y (DNA and cell biology 1998) 2 3 4 22 60
  2. Identification of a molecular target of psychosine and its role in globoid cell formation. (PMID: 11309421) Im DS … Lynch KR (The Journal of cell biology 2001) 3 4 22 60
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 45 60
  4. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A … Parkes M (Nature genetics 2010) 3 45 60
  5. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. (PMID: 15665078) Radu CG … Witte ON (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 22 60

Products for GPR65 Gene

  • Addgene plasmids for GPR65

Sources for GPR65 Gene

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