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Aliases for GPR63 Gene

Aliases for GPR63 Gene

  • G Protein-Coupled Receptor 63 2 3
  • PSP24-Beta 3 4
  • PSP24-2 3 4
  • PSP24B 3 4
  • Brain Expressed G-Protein-Coupled Receptor PSP24 Beta 3
  • Probable G-Protein Coupled Receptor 63 3
  • PSP24(Beta) 3

External Ids for GPR63 Gene

Summaries for GPR63 Gene

Entrez Gene Summary for GPR63 Gene

  • This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for GPR63 Gene

GPR63 (G Protein-Coupled Receptor 63) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR45.

UniProtKB/Swiss-Prot for GPR63 Gene

  • Orphan receptor. May play a role in brain function

Gene Wiki entry for GPR63 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR63 Gene

Genomics for GPR63 Gene

Genomic Location for GPR63 Gene

Start:
96,794,122 bp from pter
End:
96,837,477 bp from pter
Size:
43,356 bases
Orientation:
Minus strand

Genomic View for GPR63 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR63 Gene

Regulatory Elements for GPR63 Gene

Proteins for GPR63 Gene

  • Protein details for GPR63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZJ6-GPR63_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 63
    Protein Accession:
    Q9BZJ6
    Secondary Accessions:
    • Q9UJH3

    Protein attributes for GPR63 Gene

    Size:
    419 amino acids
    Molecular mass:
    47578 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR63 Gene

Proteomics data for GPR63 Gene at MOPED

Post-translational modifications for GPR63 Gene

  • Glycosylation at Asn16, Asn28, and Asn62

Other Protein References for GPR63 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR63 Gene

Domains for GPR63 Gene

Gene Families for GPR63 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for GPR63 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

GPR63_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9BZJ6
genes like me logo Genes that share domains with GPR63: view

Function for GPR63 Gene

Molecular function for GPR63 Gene

UniProtKB/Swiss-Prot Function: Orphan receptor. May play a role in brain function

Gene Ontology (GO) - Molecular Function for GPR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR63: view

miRNA for GPR63 Gene

miRTarBase miRNAs that target GPR63

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GPR63 Gene

Localization for GPR63 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR63 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR63 Gene COMPARTMENTS Subcellular localization image for GPR63 gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR63: view

Pathways for GPR63 Gene

SuperPathways for GPR63 Gene

genes like me logo Genes that share pathways with GPR63: view

Pathways by source for GPR63 Gene

1 BioSystems pathway for GPR63 Gene

Interacting Proteins for GPR63 Gene

Gene Ontology (GO) - Biological Process for GPR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GPR63: view

Compounds for GPR63 Gene

(3) IUPHAR Ligand for GPR63 Gene

Ligand Type Action Affinity Pubmed IDs
sphingosine 1-phosphate Agonist Agonist 8.96
dihydrosp?aehingosine?ae-1-phosph?aeate Agonist Agonist 8
dioleoyl phosphatidic acid Agonist Full agonist 6.3
genes like me logo Genes that share compounds with GPR63: view

Transcripts for GPR63 Gene

mRNA/cDNA for GPR63 Gene

(11) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR63 Gene

G protein-coupled receptor 63:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR63 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -
SP3:

Relevant External Links for GPR63 Gene

GeneLoc Exon Structure for
GPR63
ECgene alternative splicing isoforms for
GPR63

Expression for GPR63 Gene

mRNA expression in normal human tissues for GPR63 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPR63 Gene

SOURCE GeneReport for Unigene cluster for GPR63 Gene Hs.221364

mRNA Expression by UniProt/SwissProt for GPR63 Gene

Q9BZJ6-GPR63_HUMAN
Tissue specificity: Expressed in brain; detected in the frontal cortex, with lower levels in the thalamus, caudate, hypothalamus and midbrain
genes like me logo Genes that share expressions with GPR63: view

Orthologs for GPR63 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR63 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR63 36
  • 99.68 (n)
  • 99.76 (a)
GPR63 37
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR63 36
  • 91.41 (n)
  • 93.79 (a)
GPR63 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR63 36
  • 91.89 (n)
  • 94.51 (a)
GPR63 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr63 36
  • 87.39 (n)
  • 92.53 (a)
Gpr63 16
Gpr63 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR63 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr63 36
  • 87.63 (n)
  • 92.29 (a)
chicken
(Gallus gallus)
Aves GPR63 36
  • 77.09 (n)
  • 80.19 (a)
GPR63 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR63 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr63 36
  • 71.76 (n)
  • 75.89 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.6459 36
gpr63 36
  • 68.13 (n)
  • 71.91 (a)
gpr63 37
  • 69 (a)
OneToOne
Species with no ortholog for GPR63:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR63 Gene

ENSEMBL:
Gene Tree for GPR63 (if available)
TreeFam:
Gene Tree for GPR63 (if available)

Paralogs for GPR63 Gene

Paralogs for GPR63 Gene

Selected SIMAP similar genes for GPR63 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GPR63: view

Variants for GPR63 Gene

Sequence variations from dbSNP and Humsavar for GPR63 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs213842 -- 96,793,686(+) ATAAA(C/T)GATGT downstream-variant-500B
rs213843 -- 96,796,736(+) ACTTA(C/G)AACTA utr-variant-3-prime
rs392127 -- 96,799,690(+) TTGGA(A/T)GTCCC reference, synonymous-codon
rs392242 -- 96,799,992(+) TGACC(A/G)TTTAA intron-variant
rs850433 -- 96,797,328(+) AAGGC(C/T)AATTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR63 Gene

Variant ID Type Subtype PubMed ID
nsv886425 CNV Loss 21882294

Relevant External Links for GPR63 Gene

HapMap Linkage Disequilibrium report
GPR63

Disorders for GPR63 Gene

(1) University of Copenhagen DISEASES for GPR63 Gene

genes like me logo Genes that share disorders with GPR63: view

No data available for UniProtKB/Swiss-Prot for GPR63 Gene

Publications for GPR63 Gene

  1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PMID: 11165367) Lee D.K. … O'Dowd B.F. (Brain Res. Mol. Brain Res. 2001) 3 4 23
  2. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. (PMID: 11027574) Kawasawa Y. … Shimizu T. (Biochem. Biophys. Res. Commun. 2000) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for GPR63 Gene

Sources for GPR63 Gene

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