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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR63 Gene

protein-coding   GIFtS: 54
GCID: GC06M097242

G Protein-Coupled Receptor 63

  Search for GPR63
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor 631 2     PSP24(beta)2
PSP24-22 3     Brain Expressed G-Protein-Coupled Receptor PSP24 Beta2
PSP24-beta2 3     Probable G-Protein Coupled Receptor 632
PSP24B2 3     

External Ids:    HGNC: 133021   Entrez Gene: 814912   Ensembl: ENSG000001122187   OMIM: 6069155   UniProtKB: Q9BZJ63   

Export aliases for GPR63 gene to outside databases

Previous GC identifers: GC06M097114 GC06M097262 GC06M097291 GC06M097352 GC06M094680


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPR63 Gene:
This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same
protein, have been identified. (provided by RefSeq, Dec 2011)

GeneCards Summary for GPR63 Gene: 
GPR63 (G protein-coupled receptor 63) is a protein-coding gene. Among its related super-pathways are Peptide GPCRs and Class A/1 (Rhodopsin-like receptors). GO annotations related to this gene include G-protein coupled receptor activity and molecular_function. An important paralog of this gene is GPR45.

UniProtKB/Swiss-Prot: GPR63_HUMAN, Q9BZJ6
Function: Orphan receptor. May play a role in brain function

Gene Wiki entry for GPR63 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR63 gene promoter:
         JunB   NCX/Ncx   FosB   Fra-1   CUTL1   LCR-F1   JunD   HSF2   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR63 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPR63

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR63


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.1-q16.3   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.1-q16.3

GPR63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR63 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M097242:  view genomic region     (about GC identifiers)

Start:
97,242,002 bp from pter      End:
97,285,353 bp from pter
Size:
43,352 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPR63_HUMAN, Q9BZJ6 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 63  
Size: 419 amino acids; 47578 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q9UJH3

Explore the universe of human proteins at neXtProt for GPR63: NX_Q9BZJ6

Explore proteomics data for GPR63 at MOPED 

GPR63 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

GPR63 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001137429.1  NP_110411.1  

ENSEMBL proteins: 
 ENSP00000229955   ENSP00000393170  

Human Recombinant Protein Products for GPR63: 
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Cloud-Clone Corp. Proteins for GPR63 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016020membrane NAS--
GO:0016021integral to membrane IEA--

GPR63 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for GPR63


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
GPCRAO: GPCR / Class A : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: GPR63 
Class A Orphans

2 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9BZJ6

ProtoNet protein and cluster: Q9BZJ6

UniProtKB/Swiss-Prot: GPR63_HUMAN, Q9BZJ6
Similarity: Belongs to the G-protein coupled receptor 1 family


GPR63 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: GPR63_HUMAN, Q9BZJ6
Function: Orphan receptor. May play a role in brain function

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0004930G-protein coupled receptor activity IEA--
     
GPR63 for ontologies           About GeneDecksing


Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidGPR63 3' UTR sequence
Inhib. RNA
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Gene Editing
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for GPR63 About                                                                                                See pathways by source

SuperPathContained pathways About
1Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
2Class A/1 (Rhodopsin-like receptors)
GPCRs, Class A Rhodopsin-like0.41

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for GPR63
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


1 BioSystems Pathway for GPR63
    GPCRs, Class A Rhodopsin-like



GPR63 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR63

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for GPR63 (Q9BZJ62, 3 ENSP000002299554) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
FYNP062412, 3, ENSP000003576564MINT-8111271 I2D: score=3 STRING: ENSP00000357656
--P310162MINT-8109090
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0008150biological_process ND--

GPR63 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GPR63

3 IUPHAR Ligands for GPR63 (GPR63)    About this table 
LigandTypeActionAffinityPubmed IDs
dioleoyl phosphatidic acid
AgonistFull agonist6.312618218
sphingosine 1-phosphate
AgonistFull agonist6.1 - 6.1812618218
dihydrosp?aehingosine?ae-1-phosph?aeate
AgonistFull agonist6.1712618218

Search CenterWatch for drugs/clinical trials and news about GPR63

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GPR63 gene (2 alternative transcripts): 
NM_001143957.2  NM_030784.3  

Unigene Cluster for GPR63:

G protein-coupled receptor 63
Hs.221364  [show with all ESTs]
Unigene Representative Sequence: NM_001143957
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000229955(uc003pou.3) ENST00000417980(uc010kcl.3)
miRNA
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hsa-miR-424 hsa-miR-15a hsa-miR-503 hsa-miR-195 hsa-miR-497 hsa-miR-16 hsa-miR-15b hsa-miR-646
SwitchGear 3'UTR luciferase reporter plasmidGPR63 3' UTR sequence
Inhib. RNA
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR63
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR63

Additional mRNA sequence: 

AB030566.1 AB209347.1 AK289839.1 AK313535.1 BC067465.1 BC067466.1 BC067467.1 BC067468.1 
BC067469.1 FJ348260.1 

4 DOTS entries:

DT.91819571  DT.40118096  DT.75184583  DT.40227114 

14 AceView cDNA sequences:

AB030566 BQ230164 BC067466 NM_030784 CD559540 CD559539 BC067467 BC067469 
CD559537 CD559541 CD559538 BC067468 BC067465 CF147781 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GPR63    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1:                          -               
SP2:                    -     -               
SP3:                                          


ECgene alternative splicing isoforms for GPR63

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GPR63 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATGCCTAAGT
GPR63 Expression
About this image


See GPR63 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPR63

SOURCE GeneReport for Unigene cluster: Hs.221364

UniProtKB/Swiss-Prot: GPR63_HUMAN, Q9BZJ6
Tissue specificity: Expressed in brain; detected in the frontal cortex, with lower levels in the thalamus,
caudate, hypothalamus and midbrain

    SABiosciences Expression via Pathway-Focused PCR Array including GPR63: 
          G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GPR63 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gpr631 , 5 G protein-coupled receptor 631, 5 87.39(n)1
92.53(a)1
  4 (10.53 cM)5
810061  NM_030733.31  NP_109658.21 
 249664075 
chicken
(Gallus gallus)
Aves LOC1008575611 probable G-protein coupled receptor 63-like 77.09(n)
80.19(a)
  100857561  XM_003641015.1  XP_003641063.1 
lizard
(Anolis carolinensis)
Reptilia GPR636
Uncharacterized protein
76(a)
1 ↔ 1
1(173642972-173644267)
zebrafish
(Danio rerio)
Actinopterygii Dr.64592 Transcribed sequence with weak similarity to protein more 79.66(n)    AW154394.1 


ENSEMBL Gene Tree for GPR63 (if available)
TreeFam Gene Tree for GPR63 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for GPR63 gene
GPR452  GPR1352  
3 SIMAP similar genes for GPR63 using alignment to 5 protein entries:     GPR63_HUMAN (see all proteins):
GPR45    DRD2    GIR

GPR63 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/812 SNPs in GPR63 are shown (see all 812)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1908544891,2
--94721547(+) GGACCA/GAGTAG 2 -- us2k10--------
rs624130521,2
C,F--94721548(+) GACCGA/CGTAGA 2 -- us2k12Minor allele frequency- C:0.05NA 122
rs2138421,2
C,F,O,A,H--97241562(+) ATAAAT/CGATGT 2 -- ds500117Minor allele frequency- C:0.35NA NS EA WA CSA 920
rs1856711681,2
--97241649(+) TAGAAA/GCAGAC 2 -- ds50010--------
rs1905285111,2
--97241693(+) TTTAAA/TTAATT 2 -- ds50010--------
rs801025311,2
C,F--97242059(+) ATAAGA/TATATG 2 -- ut313Minor allele frequency- T:0.06WA CSA 122
rs1489450481,2
--97242065(+) ATATGC/TACAAA 2 -- ut310--------
rs2010302081,2
--97242118(+) AAGGT-/TGTTTTT 2 -- ut310--------
rs2021934061,2
C--97242119(+) AAGGT-/GTTTTT 2 -- ut310--------
rs9774561,2
C,F--97242156(+) taaaaT/Caaatt 2 -- ut311Minor allele frequency- C:0.07NA 120

HapMap Linkage Disequilibrium report for GPR63 (97242002 - 97285353 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for GPR63:    About this table     
Variant IDTypeSubtypePubMed ID
nsv886425CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GPR63 for disorders           About MalaCards
OMIM gene information: 606915    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for GPR63:
Gilles de la Tourette syndrome

GPR63 for disorders           About GeneDecksing


Export disorders for GPR63 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for GPR63 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with GPR63)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PubMed id 11165367)1, 2, 9 Lee D.K.... O'Dowd B.F. (2001)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
  4. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. (PubMed id 11027574)1, 2 Kawasawa Y.... Shimizu T. (2000)
  5. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
  6. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
  7. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  9. Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. (PubMed id 12618218)1 Niedernberg A....Kostenis E. (2003)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 81491 HGNC: 13302 AceView: GPR63 Ensembl:ENSG00000112218 euGenes: HUgn81491
ECgene: GPR63 H-InvDB: GPR63

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for GPR63 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for GPR63 gene:
Search GeneIP for patents involving GPR63

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 27 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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