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GPR63 Gene

protein-coding   GIFtS: 55
GCID: GC06M097242

G Protein-Coupled Receptor 63

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 631 2     PSP24(beta)2
PSP24-22 3     Brain Expressed G-Protein-Coupled Receptor PSP24 Beta2
PSP24-beta2 3     Probable G-Protein Coupled Receptor 632
PSP24B2 3     

External Ids:    HGNC: 133021   Entrez Gene: 814912   Ensembl: ENSG000001122187   OMIM: 6069155   UniProtKB: Q9BZJ63   

Export aliases for GPR63 gene to outside databases

Previous GC identifers: GC06M097114 GC06M097262 GC06M097291 GC06M097352 GC06M094680


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPR63 Gene:
This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same
protein, have been identified. (provided by RefSeq, Dec 2011)

GeneCards Summary for GPR63 Gene:
GPR63 (G protein-coupled receptor 63) is a protein-coding gene. Diseases associated with GPR63 include gilles de la tourette syndrome. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR45.

UniProtKB/Swiss-Prot: GPR63_HUMAN, Q9BZJ6
Function: Orphan receptor. May play a role in brain function

Gene Wiki entry for GPR63 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR63 gene promoter:
         JunB   NCX/Ncx   FosB   Fra-1   CUTL1   LCR-F1   JunD   HSF2   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR63 promoter sequence
   Search Chromatin IP Primers for GPR63

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR63


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.1-q16.3   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.1-q16.3

GPR63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR63 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M097242:  view genomic region     (about GC identifiers)

Start:
97,242,002 bp from pter      End:
97,285,353 bp from pter
Size:
43,352 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GPR63_HUMAN, Q9BZJ6 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 63  
Size: 419 amino acids; 47578 Da
Secondary accessions: Q9UJH3

Explore the universe of human proteins at neXtProt for GPR63: NX_Q9BZJ6

Explore proteomics data for GPR63 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn16, Asn28, Asn62

  • See GPR63 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137429.1  NP_110411.1  

    ENSEMBL proteins: 
     ENSP00000229955   ENSP00000393170  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR63
    Class A Orphans

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9BZJ6

    ProtoNet protein and cluster: Q9BZJ6

    UniProtKB/Swiss-Prot: GPR63_HUMAN, Q9BZJ6
    Similarity: Belongs to the G-protein coupled receptor 1 family


    GPR63 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPR63_HUMAN, Q9BZJ6
    Function: Orphan receptor. May play a role in brain function

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004930G-protein coupled receptor activity IEA--
         
    GPR63 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR63
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    miRTarBase miRNAs that target GPR63:
    hsa-mir-10a-5p (MIRT025588), hsa-let-7d-5p (MIRT032107), hsa-mir-26b-5p (MIRT030295)

    Block miRNA regulation of human, mouse, rat GPR63 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate GPR63:
    hsa-miR-424 hsa-miR-15a hsa-miR-503 hsa-miR-195 hsa-miR-497 hsa-miR-16 hsa-miR-15b hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidGPR63 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GPR63

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR63


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPR63_HUMAN, Q9BZJ6: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0043235receptor complex IDA--

    GPR63 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPR63 About    
    See pathways by source

    SuperPathContained pathways About
    1Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    2Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    1 BioSystems Pathway for GPR63
        GPCRs, Class A Rhodopsin-like


        Pathway & Disease-focused RT2 Profiler PCR Array including GPR63: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPR63

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for GPR63 (Q9BZJ62, 3 ENSP000002299554) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8111271 I2D: score=3 STRING: ENSP00000357656
    --P310162MINT-8109090
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0008150biological_process ND--

    GPR63 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR63

    3 IUPHAR Ligands for GPR63 (GPR63)    About this table
    LigandTypeActionAffinityPubmed IDs
    dioleoyl phosphatidic acid
    AgonistFull agonist6.312618218
    sphingosine 1-phosphate
    AgonistFull agonist6.1 - 6.1812618218
    dihydrosp?aehingosine?ae-1-phosph?aeate
    AgonistFull agonist6.1712618218



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GPR63 gene (2 alternative transcripts): 
    NM_001143957.2  NM_030784.3  

    Unigene Cluster for GPR63:

    G protein-coupled receptor 63
    Hs.221364  [show with all ESTs]
    Unigene Representative Sequence: NM_001143957
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229955(uc003pou.3) ENST00000417980(uc010kcl.3)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate GPR63:
    hsa-miR-424 hsa-miR-15a hsa-miR-503 hsa-miR-195 hsa-miR-497 hsa-miR-16 hsa-miR-15b hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidGPR63 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat GPR63
      QuantiFast Probe-based Assays in human, mouse, rat GPR63

    Additional mRNA sequence: 

    AB030566.1 AB209347.1 AK289839.1 AK313535.1 BC067465.1 BC067466.1 BC067467.1 BC067468.1 
    BC067469.1 FJ348260.1 

    4 DOTS entries:

    DT.91819571  DT.40118096  DT.75184583  DT.40227114 

    14 AceView cDNA sequences:

    BC067466 AB030566 BQ230164 NM_030784 BC067465 CD559538 BC067467 BC067468 
    CD559537 BC067469 CD559540 CF147781 CD559539 CD559541 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GPR63    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
    SP1:                          -               
    SP2:                    -     -               
    SP3:                                          


    ECgene alternative splicing isoforms for GPR63

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR63 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCCTAAGT
    GPR63 Expression
    About this image

    GPR63 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR63 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.221364

    UniProtKB/Swiss-Prot: GPR63_HUMAN, Q9BZJ6
    Tissue specificity: Expressed in brain; detected in the frontal cortex, with lower levels in the thalamus,
    caudate, hypothalamus and midbrain

        Pathway & Disease-focused RT2 Profiler PCR Array including GPR63: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPR63 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr631 , 5 G protein-coupled receptor 631, 5 87.39(n)1
    92.53(a)1
      4 (10.53 cM)5
    810061  NM_030733.31  NP_109658.21 
     249664075 
    chicken
    (Gallus gallus)
    Aves GPR631 G protein-coupled receptor 63 77.09(n)
    80.19(a)
      100857561  XM_003641015.2  XP_003641063.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR636
    G protein-coupled receptor 63
    76(a)
    1 ↔ 1
    1(173642972-173644267)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gpr631 G protein-coupled receptor 63 71.76(n)
    75.89(a)
      100485628  XM_002934868.2  XP_002934914.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.64592 Transcribed sequence with weak similarity to protein more 79.66(n)    AW154394.1 


    ENSEMBL Gene Tree for GPR63 (if available)
    TreeFam Gene Tree for GPR63 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPR63 gene
    GPR452  GPR1352  
    3 SIMAP similar genes for GPR63 using alignment to 5 protein entries:     GPR63_HUMAN (see all proteins):
    GPR45    DRD2    GIR

    GPR63 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPR63 (see all 812)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1908544891,2
    --94721547(+) GGACCA/GAGTAG 2 -- us2k10--------
    rs624130521,2
    C,F--94721548(+) GACCGA/CGTAGA 2 -- us2k12Minor allele frequency- C:0.05NA 122
    rs2138421,2
    C,F,O,A,H--97241562(+) ATAAAT/CGATGT 2 -- ds500117Minor allele frequency- C:0.35NA NS EA WA CSA 920
    rs1856711681,2
    --97241649(+) TAGAAA/GCAGAC 2 -- ds50010--------
    rs1905285111,2
    --97241693(+) TTTAAA/TTAATT 2 -- ds50010--------
    rs801025311,2
    C,F--97242059(+) ATAAGA/TATATG 2 -- ut313Minor allele frequency- T:0.06WA CSA 122
    rs1489450481,2
    --97242065(+) ATATGC/TACAAA 2 -- ut310--------
    rs2010302081,2
    --97242118(+) AAGGT-/TGTTTTT 2 -- ut310--------
    rs2021934061,2
    C--97242119(+) AAGGT-/GTTTTT 2 -- ut310--------
    rs9774561,2
    C,F--97242156(+) taaaaT/Caaatt 2 -- ut311Minor allele frequency- C:0.07NA 120

    HapMap Linkage Disequilibrium report for GPR63 (97242002 - 97285353 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GPR63:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv886425CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR63
    DNA2.0 Custom Variant and Variant Library Synthesis for GPR63

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606915    OMIM disorders: --

    1 disease for GPR63:    
    About MalaCards
    gilles de la tourette syndrome

    1 disease from the University of Copenhagen DISEASES database for GPR63:
    Gilles de la Tourette syndrome

    GPR63 for disorders           About GeneDecksing


    Export disorders for GPR63 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR63 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with GPR63)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PubMed id 11165367)1, 2, 9 Lee D.K.... O'Dowd B.F. (Brain Res. Mol. Brain Res. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. (PubMed id 11027574)1, 2 Kawasawa Y.... Shimizu T. (Biochem. Biophys. Res. Commun. 2000)
    5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    6. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)
    7. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (Nature 2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. (PubMed id 12618218)1 Niedernberg A....Kostenis E. (Cell. Signal. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81491 HGNC: 13302 AceView: GPR63 Ensembl:ENSG00000112218 euGenes: HUgn81491
    ECgene: GPR63 H-InvDB: GPR63

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPR63 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPR63 gene:
    Search GeneIP for patents involving GPR63

    GeneCards and IP:
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