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Aliases for GPR63 Gene

Aliases for GPR63 Gene

  • G Protein-Coupled Receptor 63 2 3 5
  • PSP24-Beta 3 4
  • PSP24-2 3 4
  • PSP24B 3 4
  • Brain Expressed G-Protein-Coupled Receptor PSP24 Beta 3
  • PSP24(Beta) 3

External Ids for GPR63 Gene

Previous GeneCards Identifiers for GPR63 Gene

  • GC06M097114
  • GC06M097262
  • GC06M097291
  • GC06M097352
  • GC06M094680
  • GC06M097242

Summaries for GPR63 Gene

Entrez Gene Summary for GPR63 Gene

  • This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for GPR63 Gene

GPR63 (G Protein-Coupled Receptor 63) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR45.

UniProtKB/Swiss-Prot for GPR63 Gene

  • Orphan receptor. May play a role in brain function.

Gene Wiki entry for GPR63 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR63 Gene

Genomics for GPR63 Gene

Regulatory Elements for GPR63 Gene

Enhancers for GPR63 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR63 on UCSC Golden Path with GeneCards custom track

Promoters for GPR63 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR63 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR63 Gene

96,794,122 bp from pter
96,837,492 bp from pter
43,371 bases
Minus strand

Genomic View for GPR63 Gene

Genes around GPR63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR63 Gene

Proteins for GPR63 Gene

  • Protein details for GPR63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 63
    Protein Accession:
    Secondary Accessions:
    • Q9UJH3

    Protein attributes for GPR63 Gene

    419 amino acids
    Molecular mass:
    47578 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR63 Gene

Proteomics data for GPR63 Gene at MOPED

Post-translational modifications for GPR63 Gene

  • Glycosylation at Asn 16, Asn 28, and Asn 62
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR63 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR63 Gene

Domains & Families for GPR63 Gene

Gene Families for GPR63 Gene

Protein Domains for GPR63 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR63: view

Function for GPR63 Gene

Molecular function for GPR63 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. May play a role in brain function.

Gene Ontology (GO) - Molecular Function for GPR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GPR63: view
genes like me logo Genes that share phenotypes with GPR63: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR63

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR63 Gene

Localization for GPR63 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR63 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR63 Gene COMPARTMENTS Subcellular localization image for GPR63 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with GPR63: view

Pathways & Interactions for GPR63 Gene

SuperPathways for GPR63 Gene

genes like me logo Genes that share pathways with GPR63: view

Pathways by source for GPR63 Gene

1 BioSystems pathway for GPR63 Gene

Interacting Proteins for GPR63 Gene

Gene Ontology (GO) - Biological Process for GPR63 Gene


No data available for SIGNOR curated interactions for GPR63 Gene

Drugs & Compounds for GPR63 Gene

(3) Drugs for GPR63 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0

(2) Additional Compounds for GPR63 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
dioleoyl phosphatidic acid
Full agonist, Agonist
genes like me logo Genes that share compounds with GPR63: view

Transcripts for GPR63 Gene

mRNA/cDNA for GPR63 Gene

(11) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR63 Gene

G protein-coupled receptor 63:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR63 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -

Relevant External Links for GPR63 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR63 Gene

mRNA expression in normal human tissues for GPR63 Gene

Protein differential expression in normal tissues from HIPED for GPR63 Gene

This gene is overexpressed in Islet of Langerhans (44.9) and Heart (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR63 Gene

SOURCE GeneReport for Unigene cluster for GPR63 Gene Hs.221364

mRNA Expression by UniProt/SwissProt for GPR63 Gene

Tissue specificity: Expressed in brain; detected in the frontal cortex, with lower levels in the thalamus, caudate, hypothalamus and midbrain.
genes like me logo Genes that share expression patterns with GPR63: view

Protein tissue co-expression partners for GPR63 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GPR63 Gene

Orthologs for GPR63 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR63 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR63 35
  • 91.41 (n)
  • 93.79 (a)
GPR63 36
  • 89 (a)
(Canis familiaris)
Mammalia GPR63 35
  • 91.89 (n)
  • 94.51 (a)
GPR63 36
  • 89 (a)
(Mus musculus)
Mammalia Gpr63 35
  • 87.39 (n)
  • 92.53 (a)
Gpr63 16
Gpr63 36
  • 90 (a)
(Pan troglodytes)
Mammalia GPR63 35
  • 99.68 (n)
  • 99.76 (a)
GPR63 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Gpr63 35
  • 87.63 (n)
  • 92.29 (a)
(Monodelphis domestica)
Mammalia GPR63 36
  • 84 (a)
(Gallus gallus)
Aves GPR63 35
  • 77.09 (n)
  • 80.19 (a)
GPR63 36
  • 80 (a)
(Anolis carolinensis)
Reptilia GPR63 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr63 35
  • 71.76 (n)
  • 75.89 (a)
(Danio rerio)
Actinopterygii Dr.6459 35
gpr63 35
  • 68.13 (n)
  • 71.91 (a)
gpr63 36
  • 69 (a)
Species with no ortholog for GPR63:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR63 Gene

Gene Tree for GPR63 (if available)
Gene Tree for GPR63 (if available)

Paralogs for GPR63 Gene

Paralogs for GPR63 Gene

(3) SIMAP similar genes for GPR63 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GPR63: view

Variants for GPR63 Gene

Sequence variations from dbSNP and Humsavar for GPR63 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs35358396 - 96,799,671(-) TTGTC(A/G)TGTAT reference, missense
rs1206072 -- 96,795,134(+) TCTGG(A/G)GGCCC utr-variant-3-prime
rs1206073 -- 96,795,165(+) agctc(C/T)cttgg utr-variant-3-prime
rs1328123 -- 96,811,522(-) AGAAC(A/G)TGATG intron-variant, upstream-variant-2KB
rs1328125 -- 96,823,821(+) TGTGC(C/T)ACAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR63 Gene

Variant ID Type Subtype PubMed ID
nsv886425 CNV Loss 21882294

Variation tolerance for GPR63 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR63 Gene

Disorders for GPR63 Gene

Relevant External Links for GPR63

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR63 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR63 Gene

Publications for GPR63 Gene

  1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PMID: 11165367) Lee D.K. … O'Dowd B.F. (Brain Res. Mol. Brain Res. 2001) 3 4 23 67
  2. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  3. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  4. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for GPR63 Gene

Sources for GPR63 Gene