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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR62 Gene

protein-coding   GIFtS: 46
GCID: GC03P051964

G Protein-Coupled Receptor 62

  Search for GPR62
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor 621 2     GPCR82
G-Protein Coupled Receptor GPCR82 3     KPG_0052
G-Protein Coupled Receptor KPG_0052 3     Probable G-Protein Coupled Receptor 622
hGPCR82 3     

External Ids:    HGNC: 133011   Entrez Gene: 1184422   Ensembl: ENSG000001809297   OMIM: 6069175   UniProtKB: Q9BZJ73   

Export aliases for GPR62 gene to outside databases

Previous GC identifers: GC03P051082 GC03P051243 GC03P051845 GC03P051948


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GPR62 Gene: 
GPR62 (G protein-coupled receptor 62) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR61.

UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7
Function: Orphan receptor

Gene Wiki entry for GPR62 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR62 gene promoter:
         PPAR-alpha   GR   Max1   HOXA3   NRSF form 1   Lmo2   GR-alpha   NRSF form 2   C/EBPalpha   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR62 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPR62

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR62


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.1

GPR62 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR62 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P051964:  view genomic region     (about GC identifiers)

Start:
51,989,330 bp from pter      End:
51,991,520 bp from pter
Size:
2,191 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 62  
Size: 368 amino acids; 37614 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: F1DAM4 Q5KU27

Explore the universe of human proteins at neXtProt for GPR62: NX_Q9BZJ7

Explore proteomics data for GPR62 at MOPED 

GPR62 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

GPR62 Protein Expression

REFSEQ proteins: NP_543141.3  
ENSEMBL proteins: 
 ENSP00000319250  

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--

GPR62 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
GPCRAO: GPCR / Class A : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: GPR62 
Class A Orphans

2 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9BZJ7

ProtoNet protein and cluster: Q9BZJ7

UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7
Similarity: Belongs to the G-protein coupled receptor 1 family


GPR62 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: GPR62_HUMAN, Q9BZJ7
Function: Orphan receptor

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
     
GPR62 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for GPR62:
 Increased gamma-H2AX phosphory 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for GPR62 About                                                                                                See pathways by source

SuperPathContained pathways About
1GPCRs, Other
GPCRs, Other


1 BioSystems Pathway for GPR62
    GPCRs, Other


Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR62

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0008150biological_process ND--

GPR62 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GPR62

Search CenterWatch for drugs/clinical trials and news about GPR62

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GPR62 gene: 
NM_080865.3  

Unigene Cluster for GPR62:

G protein-coupled receptor 62
Hs.232213  [show with all ESTs]
Unigene Representative Sequence: NM_080865
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000322241(uc003dca.4)
miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AB032600.1 BC026357.1 HQ709188.1 

3 DOTS entries:

DT.75155412  DT.40129726  DT.95350995 

10 AceView cDNA sequences:

NM_080865 BI550945 BI820558 AI083852 AI951672 BF940605 BC026357 AI991916 
AI678943 BG700144 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GPR62 expression in normal human tissues (normalized intensities)      GPR62 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGAAGGGGC
GPR62 Expression
About this image


GPR62 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Brain (Nervous System)
         Myelinating Oligodendrocyte Cells Forebrain White Matter

See GPR62 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPR62

SOURCE GeneReport for Unigene cluster: Hs.232213

UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7
Tissue specificity: Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen,
thalamus and hippocampus

    SABiosciences Expression via Pathway-Focused PCR Array including GPR62: 
          G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR62

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GPR62 gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gpr621 , 5 G protein-coupled receptor 621, 5 83.33(n)1
83.62(a)1
  9 (57.56 cM)5
4360901  NM_001159652.11  NP_001153124.11 
 1064639735 
zebrafish
(Danio rerio)
Actinopterygii BX324188.16
Uncharacterized protein
18(a)
possible ortholog
13(39894052-39896820)


ENSEMBL Gene Tree for GPR62 (if available)
TreeFam Gene Tree for GPR62 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for GPR62 gene
GPR612  

GPR62 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/64 SNPs in GPR62 are shown (see all 64)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1442033691,2
--51987368(+) AAAAGA/GTAGAT 1 -- us2k10--------
rs1823616841,2
--51987466(+) AAGCTC/GTTGGA 1 -- us2k10--------
rs729640031,2
C--51987515(+) TTAGCG/AGGATC 1 -- us2k12Minor allele frequency- A:0.06WA 120
rs1869794981,2
--51987774(+) CAGGAC/GCCAGA 1 -- us2k10--------
rs1912328761,2
--51988012(+) ACAAGA/GTGCAG 1 -- us2k10--------
rs1834846881,2
--51988106(+) ATGGTA/GAGAAA 1 -- us2k10--------
rs1152953761,2
C,F--51988135(+) CTCAGA/C/TGGACT 1 -- us2k11WA 118
rs1884660831,2
--51988156(+) CGTGGA/GGGAGA 1 -- us2k10--------
rs1465756771,2
--51988217(+) AGGTTA/GTCGGG 1 -- us2k10--------
rs1932198161,2
--51988220(+) TTGTCA/GGGGAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for GPR62 (51989330 - 51991520 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for GPR62:    About this table     
Variant IDTypeSubtypePubMed ID
nsv508922CNV Insertion20534489
dgv5134n71CNV Loss21882294
nsv876780CNV Loss21882294
dgv5135n71CNV Loss21882294
nsv520211CNV Gain19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GPR62 for disorders           About MalaCards
OMIM gene information: 606917    OMIM disorders: --


GPR62 for disorders           About GeneDecksing


Export disorders for GPR62 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for GPR62 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GPR62)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PubMed id 11165367)1, 2, 3 Lee D.K.... O'Dowd B.F. (2001)
  2. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 118442 HGNC: 13301 AceView: GPR62 Ensembl:ENSG00000180929 euGenes: HUgn118442
ECgene: GPR62 H-InvDB: GPR62

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for GPR62 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for GPR62 gene:
Search GeneIP for patents involving GPR62

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Regulatory tfbs in GPR62 promoter
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for GPR62
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPR62
Customized:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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