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GPR62 Gene

protein-coding   GIFtS: 48
GCID: GC03P051964

G Protein-Coupled Receptor 62

  Search for GPR62
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 621 2     GPCR82
G-Protein Coupled Receptor GPCR82 3     KPG_0052
G-Protein Coupled Receptor KPG_0052 3     Probable G-Protein Coupled Receptor 622
hGPCR82 3     

External Ids:    HGNC: 133011   Entrez Gene: 1184422   Ensembl: ENSG000001809297   OMIM: 6069175   UniProtKB: Q9BZJ73   

Export aliases for GPR62 gene to outside databases

Previous GC identifers: GC03P051082 GC03P051243 GC03P051845 GC03P051948


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GPR62 Gene:
GPR62 (G protein-coupled receptor 62) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR61.

UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7
Function: Orphan receptor

Gene Wiki entry for GPR62 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR62 gene promoter:
         PPAR-alpha   GR   Max1   HOXA3   NRSF form 1   Lmo2   GR-alpha   NRSF form 2   C/EBPalpha   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR62 promoter sequence
   Search Chromatin IP Primers for GPR62

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR62


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.1

GPR62 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR62 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P051964:  view genomic region     (about GC identifiers)

Start:
51,989,330 bp from pter      End:
51,991,520 bp from pter
Size:
2,191 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 62  
Size: 368 amino acids; 37614 Da
Secondary accessions: F1DAM4 Q5KU27

Explore the universe of human proteins at neXtProt for GPR62: NX_Q9BZJ7

Explore proteomics data for GPR62 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3, Asn8

  • See GPR62 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_543141.3  
    ENSEMBL proteins: 
     ENSP00000319250  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR62
    Class A Orphans

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9BZJ7

    ProtoNet protein and cluster: Q9BZJ7

    UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7
    Similarity: Belongs to the G-protein coupled receptor 1 family


    GPR62 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPR62_HUMAN, Q9BZJ7
    Function: Orphan receptor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    GPR62 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR62:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidGPR62 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPR62_HUMAN, Q9BZJ7: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0043235receptor complex IDA--

    GPR62 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPR62 About    
    See pathways by source

    SuperPathContained pathways About
    1GPCRs, Other
    GPCRs, Other


    1 BioSystems Pathway for GPR62
        GPCRs, Other


        Pathway & Disease-focused RT2 Profiler PCR Array including GPR62: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPR62

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0008150biological_process ND--

    GPR62 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR62



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GPR62 gene: 
    NM_080865.3  

    Unigene Cluster for GPR62:

    G protein-coupled receptor 62
    Hs.232213  [show with all ESTs]
    Unigene Representative Sequence: NM_080865
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000322241(uc003dca.4)
    miRNA
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    hsa-miR-1226 hsa-miR-4328 hsa-miR-1237 hsa-miR-339-5p hsa-miR-1911* hsa-miR-1305 hsa-miR-370 hsa-miR-582-5p
    SwitchGear 3'UTR luciferase reporter plasmidGPR62 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat GPR62

    Additional mRNA sequence: 

    AB032600.1 BC026357.1 HQ709188.1 

    3 DOTS entries:

    DT.75155412  DT.40129726  DT.95350995 

    10 AceView cDNA sequences:

    NM_080865 BI550945 AI951672 BF940605 AI083852 BI820558 BC026357 AI991916 
    BG700144 AI678943 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR62 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGGGGC
    GPR62 Expression
    About this image


    GPR62 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    GPR62 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR62 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.232213

    UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7
    Tissue specificity: Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen,
    thalamus and hippocampus

        Pathway & Disease-focused RT2 Profiler PCR Array including GPR62: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPR62 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr621 , 5 G protein-coupled receptor 621, 5 83.33(n)1
    83.62(a)1
      9 (57.56 cM)5
    4360901  NM_001159652.11  NP_001153124.11 
     1064639735 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    many ↔ many
    2(152963975-152965135)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-111e5.46
    si:dkeyp-111e5.4
    29(a)
    many ↔ many
    6(41962700-41967549) ENSDARG00000003900


    ENSEMBL Gene Tree for GPR62 (if available)
    TreeFam Gene Tree for GPR62 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPR62 gene
    GPR612  

    GPR62 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPR62 (see all 64)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1442033691,2
    --51987368(+) AAAAGA/GTAGAT 1 -- us2k10--------
    rs1823616841,2
    --51987466(+) AAGCTC/GTTGGA 1 -- us2k10--------
    rs729640031,2
    C--51987515(+) TTAGCG/AGGATC 1 -- us2k12Minor allele frequency- A:0.06WA 120
    rs1869794981,2
    --51987774(+) CAGGAC/GCCAGA 1 -- us2k10--------
    rs1912328761,2
    --51988012(+) ACAAGA/GTGCAG 1 -- us2k10--------
    rs1834846881,2
    --51988106(+) ATGGTA/GAGAAA 1 -- us2k10--------
    rs1152953761,2
    C,F--51988135(+) CTCAGA/C/TGGACT 1 -- us2k11WA 118
    rs1884660831,2
    --51988156(+) CGTGGA/GGGAGA 1 -- us2k10--------
    rs1465756771,2
    --51988217(+) AGGTTA/GTCGGG 1 -- us2k10--------
    rs1932198161,2
    --51988220(+) TTGTCA/GGGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPR62 (51989330 - 51991520 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GPR62:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508922CNV Insertion20534489
    dgv5134n71CNV Loss21882294
    nsv876780CNV Loss21882294
    dgv5135n71CNV Loss21882294
    nsv520211CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606917    OMIM disorders: --


    GPR62 for disorders           About GeneDecksing


    Export disorders for GPR62 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR62 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with GPR62)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PubMed id 11165367)1, 2, 3 Lee D.K.... O'Dowd B.F. (Brain Res. Mol. Brain Res. 2001)
    2. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    3. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 118442 HGNC: 13301 AceView: GPR62 Ensembl:ENSG00000180929 euGenes: HUgn118442
    ECgene: GPR62 H-InvDB: GPR62

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPR62 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPR62 gene:
    Search GeneIP for patents involving GPR62

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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