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Aliases for GPR62 Gene

Aliases for GPR62 Gene

  • G Protein-Coupled Receptor 62 2 3 5
  • G-Protein Coupled Receptor KPG_005 3 4
  • G-Protein Coupled Receptor GPCR8 3 4
  • HGPCR8 3 4
  • Probable G-Protein Coupled Receptor 62 3
  • KPG_005 3
  • GPCR8 3

External Ids for GPR62 Gene

Previous GeneCards Identifiers for GPR62 Gene

  • GC03P051082
  • GC03P051243
  • GC03P051845
  • GC03P051948
  • GC03P051964

Summaries for GPR62 Gene

GeneCards Summary for GPR62 Gene

GPR62 (G Protein-Coupled Receptor 62) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR61.

UniProtKB/Swiss-Prot for GPR62 Gene

  • Orphan receptor.

Gene Wiki entry for GPR62 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR62 Gene

Genomics for GPR62 Gene

Regulatory Elements for GPR62 Gene

Enhancers for GPR62 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F052044 1.8 FANTOM5 Ensembl ENCODE 23.4 +96.3 96309 14.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF416 ZNF143 GPR62 NT5DC2 RPL29 DUSP7 PCBP4 RAD54L2 WDR82 TWF2 ACY1 LOC105377089
GH03F052039 1.4 FANTOM5 Ensembl ENCODE 19.9 +85.2 85233 2.1 DMAP1 RAD21 RARA CREM THAP11 SP5 NFYC CEBPB MIER2 PPARG GPR62 RPL29 PCBP4 LOC105377088 LOC105377089
GH03F052085 1.5 FANTOM5 Ensembl ENCODE 14.6 +133.9 133908 6.8 ARID4B ZSCAN9 RAD21 EGR1 SCRT2 ZNF143 ETV6 FOS CREM ZNF654 GPR62 DUSP7 PCBP4 ABHD14B ALAS1 PPM1M GLYCTK LINC00696 POC1A
GH03F051980 1.1 ENCODE 15.1 +28.9 28891 6.8 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 GPR62 NEK4 PARP3 RPL29 ABHD14B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR62 on UCSC Golden Path with GeneCards custom track

Promoters for GPR62 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GPR62 Gene

51,955,314 bp from pter
51,957,504 bp from pter
2,191 bases
Plus strand

Genomic View for GPR62 Gene

Genes around GPR62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR62 Gene

Proteins for GPR62 Gene

  • Protein details for GPR62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 62
    Protein Accession:
    Secondary Accessions:
    • F1DAM4
    • Q5KU27

    Protein attributes for GPR62 Gene

    368 amino acids
    Molecular mass:
    37614 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR62 Gene

Post-translational modifications for GPR62 Gene

  • Glycosylation at Asn 3 and Asn 8
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR62 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR62 Gene

Domains & Families for GPR62 Gene

Gene Families for GPR62 Gene

Protein Domains for GPR62 Gene

Suggested Antigen Peptide Sequences for GPR62 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR62: view

Function for GPR62 Gene

Molecular function for GPR62 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR62: view
genes like me logo Genes that share phenotypes with GPR62: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR62

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR62 Gene

Localization for GPR62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR62 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR62 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR62: view

Pathways & Interactions for GPR62 Gene

SuperPathways for GPR62 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR62: view

Pathways by source for GPR62 Gene

1 BioSystems pathway for GPR62 Gene

Interacting Proteins for GPR62 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9BZJ7-GPR62_HUMAN ENSP00000319250 for GPR62 Gene via IID STRING

Gene Ontology (GO) - Biological Process for GPR62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GPR62: view

No data available for SIGNOR curated interactions for GPR62 Gene

Transcripts for GPR62 Gene

mRNA/cDNA for GPR62 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR62 Gene

G protein-coupled receptor 62:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR62

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR62 Gene

No ASD Table

Relevant External Links for GPR62 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR62 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of GPR62 Gene:


SOURCE GeneReport for Unigene cluster for GPR62 Gene:


mRNA Expression by UniProt/SwissProt for GPR62 Gene:

Tissue specificity: Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.
genes like me logo Genes that share expression patterns with GPR62: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR62 Gene

Orthologs for GPR62 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR62 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR62 34
  • 99.18 (n)
(Bos Taurus)
Mammalia GPR62 34 35
  • 86.42 (n)
(Canis familiaris)
Mammalia GPR62 34 35
  • 86.05 (n)
(Mus musculus)
Mammalia Gpr62 34 16 35
  • 83.33 (n)
(Rattus norvegicus)
Mammalia Gpr62 34
  • 82.52 (n)
(Monodelphis domestica)
Mammalia GPR62 35
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
(Danio rerio)
Actinopterygii si:dkeyp-111e5.4 35
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
Species where no ortholog for GPR62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR62 Gene

Gene Tree for GPR62 (if available)
Gene Tree for GPR62 (if available)

Paralogs for GPR62 Gene

Paralogs for GPR62 Gene

genes like me logo Genes that share paralogs with GPR62: view

Variants for GPR62 Gene

Sequence variations from dbSNP and Humsavar for GPR62 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1045656 -- 51,957,575(-) CCAAA(A/G)AGGGG downstream-variant-500B, utr-variant-3-prime
rs1045671 -- 51,957,523(-) CAGTT(C/T)TCAGC downstream-variant-500B, utr-variant-3-prime
rs111973853 -- 51,954,749(+) AAAAA(-/A)GGAAA upstream-variant-2KB
rs112596491 -- 51,955,948(+) TCTGC(A/T)GCCGG reference, missense
rs112738567 -- 51,955,966(+) GCTCG(C/G)GGTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GPR62 Gene

Variant ID Type Subtype PubMed ID
nsv1003453 CNV gain 25217958
nsv1126647 CNV deletion 24896259
nsv508922 CNV insertion 20534489
nsv520211 CNV gain 19592680
nsv954857 CNV deletion 24416366

Variation tolerance for GPR62 Gene

Gene Damage Index Score: 4.49; 64.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR62 Gene

Disorders for GPR62 Gene

Relevant External Links for GPR62

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR62 Gene

Publications for GPR62 Gene

  1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PMID: 11165367) Lee D.K. … O'Dowd B.F. (Brain Res. Mol. Brain Res. 2001) 2 3 4 64
  2. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4 64
  3. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 64
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for GPR62 Gene

Sources for GPR62 Gene

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