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Aliases for GPR61 Gene

Aliases for GPR61 Gene

  • G Protein-Coupled Receptor 61 2 3
  • Biogenic Amine Receptor-Like G-Protein Coupled Receptor 3 4
  • BALGR 3 4
  • Biogenic Amine Receptor-Like GPCR 3
  • GPCR3 3

External Ids for GPR61 Gene

Previous GeneCards Identifiers for GPR61 Gene

  • GC01P110561
  • GC01P109011
  • GC01P109185
  • GC01P109381
  • GC01P109794
  • GC01P110082
  • GC01P107975

Summaries for GPR61 Gene

Entrez Gene Summary for GPR61 Gene

  • This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR61 Gene

GPR61 (G Protein-Coupled Receptor 61) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR62.

UniProtKB/Swiss-Prot for GPR61 Gene

  • Orphan receptor

Gene Wiki entry for GPR61 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR61 Gene

Genomics for GPR61 Gene

Regulatory Elements for GPR61 Gene

Genomic Location for GPR61 Gene

109,539,872 bp from pter
109,548,406 bp from pter
8,535 bases
Plus strand

Genomic View for GPR61 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR61 Gene

Proteins for GPR61 Gene

  • Protein details for GPR61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 61
    Protein Accession:
    Secondary Accessions:
    • A8K1W2
    • Q6NWS0
    • Q8TDV4
    • Q96PR4

    Protein attributes for GPR61 Gene

    451 amino acids
    Molecular mass:
    49292 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK12637.1; Type=Frameshift; Positions=415; Evidence={ECO:0000305};

neXtProt entry for GPR61 Gene

Proteomics data for GPR61 Gene at MOPED

Post-translational modifications for GPR61 Gene

Other Protein References for GPR61 Gene

Antibody Products

No data available for DME Specific Peptides for GPR61 Gene

Domains & Families for GPR61 Gene

Gene Families for GPR61 Gene

Protein Domains for GPR61 Gene


Suggested Antigen Peptide Sequences for GPR61 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR61: view

Function for GPR61 Gene

Molecular function for GPR61 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor

Gene Ontology (GO) - Molecular Function for GPR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR61: view
genes like me logo Genes that share phenotypes with GPR61: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR61 Gene

Localization for GPR61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR61 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR61 Gene COMPARTMENTS Subcellular localization image for GPR61 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GPR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR61: view

Pathways & Interactions for GPR61 Gene

SuperPathways for GPR61 Gene

Superpath Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR61: view

Pathways by source for GPR61 Gene

1 BioSystems pathway for GPR61 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR61 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000385422 for GPR61 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GPR61: view

No data available for SIGNOR curated interactions for GPR61 Gene

Drugs & Compounds for GPR61 Gene

No Compound Related Data Available

Transcripts for GPR61 Gene

Unigene Clusters for GPR61 Gene

G protein-coupled receptor 61:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR61

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR61 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5
SP1: - -
SP2: - -

Relevant External Links for GPR61 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR61 Gene

mRNA expression in normal human tissues for GPR61 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR61 Gene

This gene is overexpressed in Pituitary (x6.2), Brain - Cortex (x5.9), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR61 Gene

SOURCE GeneReport for Unigene cluster for GPR61 Gene Hs.709782

mRNA Expression by UniProt/SwissProt for GPR61 Gene

Tissue specificity: Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus. Also expressed in testis. Low expression in many other tissues
genes like me logo Genes that share expression patterns with GPR61: view

Protein tissue co-expression partners for GPR61 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues for GPR61 Gene

Orthologs for GPR61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR61 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR61 35
  • 92.31 (n)
  • 96.23 (a)
GPR61 36
  • 97 (a)
(Canis familiaris)
Mammalia GPR61 35
  • 89.95 (n)
  • 95.34 (a)
GPR61 36
  • 86 (a)
(Mus musculus)
Mammalia Gpr61 35
  • 91 (n)
  • 96.65 (a)
Gpr61 16
Gpr61 36
  • 96 (a)
(Pan troglodytes)
Mammalia GPR61 35
  • 99.56 (n)
  • 100 (a)
GPR61 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr61 35
  • 91 (n)
  • 97.1 (a)
(Monodelphis domestica)
Mammalia GPR61 36
  • 89 (a)
(Gallus gallus)
Aves GPR61 35
  • 72.4 (n)
  • 72.21 (a)
GPR61 36
  • 42 (a)
(Anolis carolinensis)
Reptilia GPR61 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr61 35
  • 65.82 (n)
  • 67.85 (a)
(Danio rerio)
Actinopterygii LOC571338 35
  • 64.26 (n)
  • 62.89 (a)
gpr61 36
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
Species with no ortholog for GPR61:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR61 Gene

Gene Tree for GPR61 (if available)
Gene Tree for GPR61 (if available)

Paralogs for GPR61 Gene

Paralogs for GPR61 Gene

genes like me logo Genes that share paralogs with GPR61: view

Variants for GPR61 Gene

Sequence variations from dbSNP and Humsavar for GPR61 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs552101 -- 109,539,851(+) TTGCC(G/T)GCTGC upstream-variant-2KB
rs1434285 -- 109,538,187(+) TGTAC(G/T)CAGGT upstream-variant-2KB
rs7550711 -- 109,540,264(+) TGGGC(C/T)CTTCA intron-variant
rs12023963 -- 109,542,205(+) CTCAG(C/T)TTCAT intron-variant
rs12044778 -- 109,541,786(+) AGTGG(A/G)TGGAG intron-variant

Variation tolerance for GPR61 Gene

Residual Variation Intolerance Score: 7.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR61 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR61 Gene

Disorders for GPR61 Gene

Relevant External Links for GPR61

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR61: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR61 Gene

Publications for GPR61 Gene

  1. Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain. (PMID: 11690637) Cikos S. … Koppel J. (Biochim. Biophys. Acta 2001) 2 23 67
  2. Identification of four novel human G protein-coupled receptors expressed in the brain. (PMID: 11165367) Lee D.K. … O'Dowd B.F. (Brain Res. Mol. Brain Res. 2001) 2 67
  3. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 67
  4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 67
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67

Products for GPR61 Gene

Sources for GPR61 Gene

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