GPR61 Gene
protein-coding GIFtS: 46
GCID: GC01P110082
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|
G protein-coupled receptor 61
| |
Aliases
for GPR61 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Protein-Coupled Receptor 611 2 | | BALGR1 2 3 | | Biogenic Amine Receptor-Like G-Protein Coupled Receptor2 3 | | GPCR32 | | Biogenic Amine Receptor-Like GPCR2 | | Probable G-Protein Coupled Receptor 612 |
Export aliases for GPR61 gene to outside databasesPrevious GC identifers: GC01P110561 GC01P109011 GC01P109185 GC01P109381 GC01P109794 GC01P107975 |
Summaries
for GPR61 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GPR61:
This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembranedomains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene ismost closely related to biogenic amine receptors. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GPR61_HUMAN, Q9BZJ8Function: Orphan receptor
Gene Wiki entry for GPR61
|
Genomic Views
for GPR61 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPR61 gene promoter:
ER-alpha AP-2gamma HEN1 SRY Ik-2 AP-2beta Chx10 Pax-4a AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPR61
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR61 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3GPR61 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P110082: view genomic region
(about GC identifiers)
Start:
|
110,082,494 bp from pter |
End:
|
110,091,028 bp from pter |
Size:
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8,535 bases |
Orientation:
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plus strand |
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Proteins
for GPR61 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GPR61_HUMAN, Q9BZJ8 (See
protein sequence)Recommended Name: Probable G-protein coupled receptor 61 Size: 451 amino acids; 49292 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAK12637.1; Type=Frameshift; Positions=415;
Secondary accessions: A8K1W2 Q6NWS0 Q8TDV4 Q96PR4Explore the universe of human proteins at neXtProt for GPR61: NX_Q9BZJ8
GPR61 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_114142.3
ENSEMBL proteins: ENSP00000385422 ENSP00000432456 ENSP00000433661
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
GPR61 for ontologies About GeneDecksing
GPR61 Antibody Products:
Assay Products for GPR61: |
Protein
Domains /
Families
for GPR61 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPR61 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BZJ8ProtoNet protein and cluster: Q9BZJ8 UniProtKB/Swiss-Prot: GPR61_HUMAN, Q9BZJ8Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for GPR61 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GPR61_HUMAN, Q9BZJ8Function: Orphan receptor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR61 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR61 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR61 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- |
GPR61 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for GPR61:
|
Pathways & Interactions
for GPR61 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | GPCRs, Other | |
1  BioSystems Pathway for GPR61
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR61
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
GPR61 for ontologies About GeneDecksing
|
Drugs & Compounds
for GPR61 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GPR61
Search CenterWatch for drugs/clinical trials and news about GPR61
|
Transcripts
for GPR61 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPR61 gene: NM_031936.4 Unigene Cluster for GPR61: G protein-coupled receptor 61 Hs.709782 [show with all ESTs]Unigene Representative Sequence: NM_0319365 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000404129(uc001dxy.2) ENST00000527748 ENST00000469383 ENST00000533959
ENST00000526744
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR61 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR61 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GPR61 (NM_031936) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPR61 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR61 |
Additional cDNA sequence: AF317652.1 AK290027.1 BC067464.1 BC095507.1 JF810889.1 4 DOTS entries: DT.100657210 DT.100651278 DT.121349735 DT.100745303 24/185 AceView cDNA sequences (see all 185): CD633398 CD633318 AA213669 CD633291 CD633350 CD633341 CD633314 CD633308 CD633323 CD633392 CD633319 CD633391 AI370211 CD633322 CD633353 CD633417 CD633359 CD633269 CD633381 CD633389 CD633358 CD633356 CD633297 CD633312
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for GPR61 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | - | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GPR61
|
Expression
for GPR61 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPR61 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAGGGTGG
About this image
Genevestigator expression for GPR61
SOURCE GeneReport for Unigene cluster: Hs.709782
UniProtKB/Swiss-Prot: GPR61_HUMAN, Q9BZJ8Tissue specificity: Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala andhippocampus. Also expressed in testis. Low expression in many other tissues
SABiosciences Expression via Pathway-Focused PCR Array including GPR61:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR61
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPR61 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR61 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR61 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR61 |
Orthologs
for GPR61 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GPR61 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for GPR61 (if available)
TreeFam Gene Tree for GPR61 (if available) |
Paralogs
for GPR61 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GPR61 gene
- GPR622 GPR1012 GPR1612
GPR61 for paralogs About GeneDecksing
|
Genomic Variants
for GPR61 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPR61 (110082494 - 110091028 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GPR61: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR61 |
|
Disorders
/ Diseases
for GPR61 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 GPR61 for disorders About MalaCards
GPR61 for disorders About GeneDecksing
OMIM gene information: 606916
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: GPR61 (1 document)
Export disorders for GPR61 gene to outside databases
|
Publications
for GPR61 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPR61 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with GPR61) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain. (PubMed id 11690637)1, 2, 3, 9 Cikos S.... Koppel J. (2001)
- Identification of four novel human G protein-coupled receptors expressed in the brain. (PubMed id 11165367)1, 2, 3 Lee D.K.... O'Dowd B.F. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1 Wheeler H.E....Kim S.K. (2009)
- The N-terminal domain of GPR61, an orphan G-protein-coupled receptor, is essential for its constitutive activity. (PubMed id 19025769)1 Toyooka M....Takeda S. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors. (PubMed id 15615699)1 Conner A.C....Poyner D.R. (2005)
|
External Searches for GPR61 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPR61 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPR61 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPR61 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPR61 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GPR61 gene:
Search GeneIP for patents involving GPR61
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPR61 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GPR61 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPR61 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR61 | | | OriGene Protein Over-expression Lysate for GPR61 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPR61 | | OriGene 3'-UTR Clone for GPR61 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR61 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR61 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPR61 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR61 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR61 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPR61 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR61 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR61 |
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| |  |  |  |  | | | | |
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 | | | GPR61 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR61 |
|  |  |  | | | | ThermoFisher Antibodies for GPR61 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR61 |
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