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Aliases for GPR6 Gene

Aliases for GPR6 Gene

  • G Protein-Coupled Receptor 6 2 3 5
  • Sphingosine 1-Phosphate Receptor GPR6 4

External Ids for GPR6 Gene

Previous GeneCards Identifiers for GPR6 Gene

  • GC06P110135
  • GC06P110323
  • GC06P110345
  • GC06P110406
  • GC06P107866

Summaries for GPR6 Gene

GeneCards Summary for GPR6 Gene

GPR6 (G Protein-Coupled Receptor 6) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for GPR6 Gene

  • Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).

Gene Wiki entry for GPR6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR6 Gene

Genomics for GPR6 Gene

Regulatory Elements for GPR6 Gene

Enhancers for GPR6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR6 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR6 Gene

109,978,256 bp from pter
109,980,720 bp from pter
2,465 bases
Plus strand

Genomic View for GPR6 Gene

Genes around GPR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR6 Gene

Proteins for GPR6 Gene

  • Protein details for GPR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 6
    Protein Accession:
    Secondary Accessions:
    • B4DHS9
    • J3KQR3
    • Q17RJ7
    • Q5SYL0

    Protein attributes for GPR6 Gene

    362 amino acids
    Molecular mass:
    37881 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR6 Gene


neXtProt entry for GPR6 Gene

Proteomics data for GPR6 Gene at MOPED

Post-translational modifications for GPR6 Gene

  • Glycosylation at Asn 2, Asn 9, and Asn 51
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR6 Gene

Domains & Families for GPR6 Gene

Gene Families for GPR6 Gene

Suggested Antigen Peptide Sequences for GPR6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR6: view

Function for GPR6 Gene

Molecular function for GPR6 Gene

GENATLAS Biochemistry:
G protein coupled receptor 6,with close homology to GPR3,predominantly expressed in the putamen
UniProtKB/Swiss-Prot Function:
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).
genes like me logo Genes that share phenotypes with GPR6: view

Animal Models for GPR6 Gene

MGI Knock Outs for GPR6:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR6 Gene

Localization for GPR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR6 Gene

Cell membrane; Multi-pass membrane protein. Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor.

Subcellular locations from

Jensen Localization Image for GPR6 Gene COMPARTMENTS Subcellular localization image for GPR6 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for GPR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with GPR6: view

Pathways & Interactions for GPR6 Gene

SuperPathways for GPR6 Gene

genes like me logo Genes that share pathways with GPR6: view

Pathways by source for GPR6 Gene

1 BioSystems pathway for GPR6 Gene

Interacting Proteins for GPR6 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000275169 for GPR6 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 7832990
genes like me logo Genes that share ontologies with GPR6: view

No data available for SIGNOR curated interactions for GPR6 Gene

Drugs & Compounds for GPR6 Gene

(2) Drugs for GPR6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
calcium Nutra 0
genes like me logo Genes that share compounds with GPR6: view

Transcripts for GPR6 Gene

mRNA/cDNA for GPR6 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR6 Gene

G protein-coupled receptor 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR6 Gene

No ASD Table

Relevant External Links for GPR6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR6 Gene

mRNA expression in normal human tissues for GPR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR6 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x17.0), Brain - Putamen (basal ganglia) (x15.9), and Brain - Caudate (basal ganglia) (x10.9).

SOURCE GeneReport for Unigene cluster for GPR6 Gene Hs.46332

genes like me logo Genes that share expression patterns with GPR6: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR6 Gene

Orthologs for GPR6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR6 35
  • 86.92 (n)
  • 93.09 (a)
GPR6 36
  • 93 (a)
(Canis familiaris)
Mammalia GPR6 35
  • 91.16 (n)
  • 94.48 (a)
GPR6 36
  • 94 (a)
(Mus musculus)
Mammalia Gpr6 35
  • 86.65 (n)
  • 93.37 (a)
Gpr6 16
Gpr6 36
  • 94 (a)
(Pan troglodytes)
Mammalia GPR6 35
  • 99.36 (n)
  • 100 (a)
GPR6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr6 35
  • 86.74 (n)
  • 93.37 (a)
(Monodelphis domestica)
Mammalia GPR6 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
(Gallus gallus)
Aves GPR6 35
  • 71.93 (n)
  • 77.63 (a)
GPR6 36
  • 74 (a)
(Anolis carolinensis)
Reptilia GPR6 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr6 35
  • 67.66 (n)
  • 72.94 (a)
(Danio rerio)
Actinopterygii LOC100538060 35
  • 69.44 (n)
  • 71.33 (a)
si:ch73-362m14.3 36
  • 49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7224 35
Species with no ortholog for GPR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR6 Gene

Gene Tree for GPR6 (if available)
Gene Tree for GPR6 (if available)

Paralogs for GPR6 Gene

Paralogs for GPR6 Gene

(2) SIMAP similar genes for GPR6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR6: view

Variants for GPR6 Gene

Sequence variations from dbSNP and Humsavar for GPR6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6568622 -- 109,977,104(+) AGCTG(A/C)GTTAT upstream-variant-2KB
rs12207084 -- 109,977,593(+) ccagc(C/T)tgacc upstream-variant-2KB
rs12207222 -- 109,977,865(+) GGTAG(A/C)TACTT upstream-variant-2KB
rs7759173 -- 109,978,393(+) TCTGT(C/T)TGCGC utr-variant-5-prime
rs71551391 -- 109,978,289(+) CCTTT(-/T)CTGCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR6 Gene

Variant ID Type Subtype PubMed ID
nsv823821 CNV Gain 20364138

Variation tolerance for GPR6 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR6 Gene

Disorders for GPR6 Gene

Relevant External Links for GPR6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR6 Gene

Publications for GPR6 Gene

  1. Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. (PMID: 8530049) Song Z.-H. … Bonner T.I. (Genomics 1995) 2 3 4 67
  2. Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. (PMID: 12649592) Uhlenbrock K. … Kostenis E. (Cell. Physiol. Biochem. 2003) 3 23
  3. How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis. (PMID: 22487033) Collins A.G. … Frank M.J. (Eur. J. Neurosci. 2012) 3
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3
  5. Lipid G protein-coupled receptor ligand identification using beta- arrestin PathHunter assay. (PMID: 19286662) Yin H. … Chen Y.A. (J. Biol. Chem. 2009) 23

Products for GPR6 Gene

Sources for GPR6 Gene