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GPR56 Gene

protein-coding   GIFtS: 65
GCID: GC16P057653

G Protein-Coupled Receptor 56

  See GPR56-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 561 2     7-Transmembrane Protein With No EGF-Like N-Terminal Domains-12
TM7XN12 3 5     G-Protein Coupled Receptor 562
TM7LN42 3     Protein TM7XN13
BFPP2 5     

External Ids:    HGNC: 45121   Entrez Gene: 92892   Ensembl: ENSG000002053367   OMIM: 6041105   UniProtKB: Q9Y6533   

Export aliases for GPR56 gene to outside databases

Previous GC identifers: GC16P048070 GC16P057736 GC16P057388 GC16P057450 GC16P057429 GC16P056211 GC16P043521


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPR56 Gene:
This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The
encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an
inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as
bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Feb 2014)

GeneCards Summary for GPR56 Gene:
GPR56 (G protein-coupled receptor 56) is a protein-coding gene. Diseases associated with GPR56 include bilateral perisylvian polymicrogyria, and polymicrogyria. GO annotations related to this gene include extracellular matrix binding and G-protein coupled receptor activity. An important paralog of this gene is GPR97.

UniProtKB/Swiss-Prot: GPR56_HUMAN, Q9Y653
Function: Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural
precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical
development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination.
Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and
possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE)
transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and,
during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is
inhibiting and GPR56 NT is activating angiogenesis

Gene Wiki entry for GPR56 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR56 gene promoter:
         c-Fos   Bach1   AP-1   Pax-2a   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GPR56 promoter sequence
   Search Chromatin IP Primers for GPR56

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR56


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

GPR56 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR56 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057653:  view genomic region     (about GC identifiers)

Start:
57,644,564 bp from pter      End:
57,698,944 bp from pter
Size:
54,381 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GPR56_HUMAN, Q9Y653 (See protein sequence)
Recommended Name: G-protein coupled receptor 56 precursor  
Size: 693 amino acids; 77738 Da
Subunit: Predominantly non-covalently linked heterodimer of the N-terminal and the C-terminal fragment. GPR56 NT
self-associates in a trans-trans manner; the homophilic interaction enhances receptor signaling. GPR56 CT
interacts with ARRB2; the interaction is impaired by GPR56 NT. Interacts with TGM2; TGM2 probably is not a GPR56
ligand and the interaction is reported conflictingly (PubMed:16757564, PubMed:21349848). Part of a
GPCR-tetraspanin complex at least consisting of GPR56, CD81, eventually CD9, and GNA11 in which CD81 is enhancing
the association of GPR56 with GNA11
Secondary accessions: A6NIT7 A6NJV9 B0M0K4 B4DR54 O95966 Q6ZMP1 Q8NGB3 Q96HB4
Alternative splicing: 5 isoforms:  Q9Y653-1   Q9Y653-2   Q9Y653-3   Q9Y653-4   Q9Y653-5   (Has no predictable signal peptide)

Explore the universe of human proteins at neXtProt for GPR56: NX_Q9Y653

Explore proteomics data for GPR56 at MOPED

Post-translational modifications: 

  • Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment and the membrane-bound
    C-terminal fragment predominantly remain associated and non-covalently linked. Shedding to yield the secreted
    GPR56 N-terminal fragment seems to involve metalloprotease(s)1
  • N-glycosylated. Contains sialic acid residues1
  • Ubiquitinated. Undergoes polyubiquitination upon activation1
  • Glycosylation2 at Asn39, Thr51, Asn148, Asn171, Asn234, Asn303, Asn324, Asn341
  • Modification sites at PhosphoSitePlus

  • See GPR56 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (11 alternative transcripts): 
    NP_001139242.1  NP_001139243.1  NP_001139245.1  NP_001139246.1  NP_001277071.1  NP_001277072.1  NP_001277073.1  NP_005673.3  
    NP_958932.1  NP_958933.1  NP_001139244.1  

    ENSEMBL proteins: 
     ENSP00000456781   ENSP00000454321   ENSP00000456166   ENSP00000455812   ENSP00000456469  
     ENSP00000455245   ENSP00000457456   ENSP00000455215   ENSP00000456796   ENSP00000456238  
     ENSP00000456794   ENSP00000457979   ENSP00000454263   ENSP00000454607   ENSP00000458063  
     ENSP00000457307   ENSP00000454364   ENSP00000455600   ENSP00000456494   ENSP00000456002  
     ENSP00000455351   ENSP00000457073   ENSP00000457122   ENSP00000456787   ENSP00000456632  
     ENSP00000373465   ENSP00000454574   ENSP00000456620   ENSP00000454855   ENSP00000454879  
     ENSP00000455209   ENSP00000458014   ENSP00000456603   ENSP00000457657   ENSP00000455074  
     ENSP00000455226   ENSP00000455553   ENSP00000457143   ENSP00000456819   ENSP00000455176  
     ENSP00000454490   ENSP00000455965   ENSP00000454933   ENSP00000454779   ENSP00000457612  
     ENSP00000457063   ENSP00000457994   ENSP00000456256   ENSP00000444911   ENSP00000456682  
     ENSP00000457223   ENSP00000458087   ENSP00000456147   ENSP00000454233   ENSP00000456362  
     ENSP00000456263   ENSP00000454289   ENSP00000456544   ENSP00000457953   ENSP00000457806  
     ENSP00000456599   ENSP00000457635   ENSP00000457178   ENSP00000456731   ENSP00000373464  
     ENSP00000444415   ENSP00000398034   ENSP00000369016   ENSP00000369018   ENSP00000438006  

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    antibodies-online peptides for GPR56

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRBO: GPCR / Class B : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR56
    Adhesion Class GPCRs

    4 InterPro protein domains:
     IPR003910 GPCR_2_orphan_rcpt_GPR56
     IPR000832 GPCR_2_secretin-like
     IPR017981 GPCR_2-like
     IPR000203 GPS

    Graphical View of Domain Structure for InterPro Entry Q9Y653

    ProtoNet protein and cluster: Q9Y653

    3 Blocks protein domains:
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB003910 GPR56 orphan receptor signature


    UniProtKB/Swiss-Prot: GPR56_HUMAN, Q9Y653
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 1 GPS domain


    Find genes that share domains with GPR56           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPR56_HUMAN, Q9Y653
    Function: Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural
    precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical
    development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination.
    Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and
    possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE)
    transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and,
    during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is
    inhibiting and GPR56 NT is activating angiogenesis
    Enzyme regulation: GPR56 NT is proposed to inhibit receptor signaling; its interactions with extracellular ligands
    and /or homophilic GPR56 NT interactions may relieve the inhibition

         Genatlas biochemistry entry for GPR56:
    secretin-like G protein coupled receptor 56,widely expressed,with highest levels,in thyroid,brain and heart

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity ISS--
    GO:0005518collagen binding ISS--
    GO:0050840extracellular matrix binding ISS--
         
    Find genes that share ontologies with GPR56           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR56:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gpr56):
     behavior/neurological  cellular  integument  nervous system 

    Find genes that share phenotypes with GPR56           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR56
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPR56
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    miRNA
    Products:
        
    miRTarBase miRNAs that target GPR56:
    hsa-let-7b-5p (MIRT001629), hsa-mir-98-5p (MIRT027574)

    Block miRNA regulation of human, mouse, rat GPR56 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPR56 (see all 9):
    hsa-miR-4264 hsa-miR-1226 hsa-miR-1283 hsa-miR-139-5p hsa-miR-582-5p hsa-miR-889 hsa-miR-3662 hsa-miR-1264
    SwitchGear 3'UTR luciferase reporter plasmidGPR56 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR56


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPR56_HUMAN, Q9Y653: Cell membrane; Multi-pass membrane protein
    GPR56_HUMAN, Q9Y653: GPR56 N-terminal fragment: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane TAS10049584
    GO:0016020membrane ----
    GO:0016021integral component of membrane TAS15004227

    Find genes that share ontologies with GPR56           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPR56 About    
    See pathways by source

    SuperPathContained pathways About
    1GPCRs, Other
    GPCRs, Other


    1 BioSystems Pathway for GPR56
        GPCRs, Other



        Pathway & Disease-focused RT2 Profiler PCR Array including GPR56: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GPR56

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for GPR56 (Q9Y6533 ENSP000003690184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB2P321213, ENSP000002692604I2D: score=1 STRING: ENSP00000269260
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IDA--
    GO:0007155cell adhesion IEA--
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS10049584
    GO:0007218neuropeptide signaling pathway IEA--

    Find genes that share ontologies with GPR56           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for GPR56



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPR56 gene (11 alternative transcripts): 
    NM_001145770.2  NM_001145771.2  NM_001145773.2  NM_001145774.2  NM_001290142.1  NM_001290143.1  NM_001290144.1  NM_005682.6  
    NM_201524.3  NM_201525.3  NM_001145772.2  

    Unigene Cluster for GPR56:

    G protein-coupled receptor 56
    Hs.513633  [show with all ESTs]
    Unigene Representative Sequence: NM_001145774
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 82):
    ENST00000565587 ENST00000568791 ENST00000570044 ENST00000567553 ENST00000565314
    ENST00000564912 ENST00000562673 ENST00000564907(uc002ema.1) ENST00000568908(uc002emc.2 uc002emb.2)
    ENST00000568909 ENST00000566778 ENST00000562101 ENST00000561872 ENST00000561988
    ENST00000567835(uc002elz.1) ENST00000569372 ENST00000563548 ENST00000562003

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    hsa-miR-4264 hsa-miR-1226 hsa-miR-1283 hsa-miR-139-5p hsa-miR-582-5p hsa-miR-889 hsa-miR-3662 hsa-miR-1264
    SwitchGear 3'UTR luciferase reporter plasmidGPR56 3' UTR sequence
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    Additional mRNA sequence: 

    AF106858.1 AJ011001.1 AK074399.1 AK075270.1 AK075555.1 AK131550.1 AK297236.1 AK299110.1 
    AK311156.1 AK312405.1 AL137591.1 AY358400.1 BC008770.2 BC013207.1 BT007311.1 CR936747.1 
    EU432119.1 

    Selected DOTS entries (see all 58):

    DT.100828461  DT.102829807  DT.40261948  DT.120700158  DT.100703669  DT.40106998  DT.100839383  DT.120700101 
    DT.120700109  DT.95224953  DT.97856419  DT.100828453  DT.101984946  DT.91866185  DT.117472  DT.40130744 
    DT.120700143  DT.120700167  DT.100828467  DT.120700090  DT.120700146  DT.120700166  DT.95224951  DT.91987190 

    Selected AceView cDNA sequences (see all 501):

    BE909397 BQ684018 BI917073 BQ681051 AI339068 AL137591 BQ422555 BX386431 
    NM_201525 AL045034 AA478599 AI244106 AI282295 BQ940423 BF345756 BQ678891 
    BT007311 AI193397 BQ232308 BQ676571 BQ683897 F09191 AW024245 BE407124 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR56 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCATTGTAG
    GPR56 Expression
    About this image


    GPR56 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
             Floor plate-like cells
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
             N2/LSB/S/F8-induced cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    GPR56 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR56 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513633

    UniProtKB/Swiss-Prot: GPR56_HUMAN, Q9Y653
    Tissue specificity: Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a
    great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells

        Pathway & Disease-focused RT2 Profiler PCR Array including GPR56: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GPR56
    OriGene qSTAR qPCR primer pairs in human, mouse for GPR56
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPR56
    QuantiTect SYBR Green Assays in human, mouse, rat GPR56
    QuantiFast Probe-based Assays in human, mouse, rat GPR56
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR56

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for GPR56 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr561 , 5 G protein-coupled receptor 561, 5 81.64(n)1
    80.09(a)1
      8 (47.12 cM)5
    147661  NM_018882.31  NP_061370.21 
     949771095 
    chicken
    (Gallus gallus)
    Aves GPR561 G protein-coupled receptor 56 59.82(n)
    47.93(a)
      415633  XM_004944034.1  XP_004944091.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR566
    G protein-coupled receptor 56
    44(a)
    1 ↔ 1
    GL343677.1(121503-137573)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gpr561 G protein-coupled receptor 56 50.12(n)
    39.47(a)
      100490972  XM_002931653.2  XP_002931699.2 
    zebrafish
    (Danio rerio)
    Actinopterygii gpr566
    G protein-coupled receptor 56
    24(a)
    1 → many
    7(30006746-30032840) ENSDARG00000027222


    ENSEMBL Gene Tree for GPR56 (if available)
    TreeFam Gene Tree for GPR56 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GPR56 gene
    GPR972  CD972  ELTD12  LPHN22  LPHN12  GPR1142  EMR12  LPHN32  
    EMR22  GPR1332  GPR1122  GPR1442  EMR32  GPR1262  GPR642  
    3 SIMAP similar genes for GPR56 using alignment to 48 protein entries:     GPR56_HUMAN (see all proteins):
    GPR97    GPR114    KPG_006

    Find genes that share paralogs with GPR56           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for GPR56 (see all 1283)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0262464
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0262462 R W mis40--------
    VAR_0695844
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0695842 L R mis40--------
    VAR_0695834
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0695832 E K mis40--------
    VAR_0262444
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0262442 C S mis40--------
    VAR_0262434
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0262432 Y C mis40--------
    VAR_0262454
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0262452 C S mis40--------
    VAR_0695814
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0695812 R Q mis40--------
    VAR_0262424
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0262422 R W mis40--------
    VAR_0695824
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0695822 W S mis40--------
    rs1219084621,2
    Cpathogenic158698765(+) GCCAGC/TGGAAC 16 R W mis11Minor allele frequency- T:0.00NA 4552
    rs354088561,2
    C--43529234(+) TGCTC-/GGAGGAGG 14 -- int1 cds1 us2k10--------
    rs751493221,2
    C--43529234(+) TGCTC-/GGAGGAG 7 -- int1 us2k10--------
    rs758575861,2
    C--43529234(+) TGCTCG/AGAGGA 7 -- int1 us2k11Minor allele frequency- A:0.50NA 2
    rs1462969171,2
    C--43529234(+) TGCTC-/GGAGGAGG 2 -- int10--------
    rs283647261,2
    C--43529571(+) CCCCC-/AGGGGG 2 -- int11Minor allele frequency- A:0.50NA 2
    rs283647271,2
    C--43529641(+) ACCCG-/C/GCTCCC 2 -- int10--------
    rs561778931,2
    C--57652486(+) TACAG-/GCATCT 2 -- us2k10--------
    rs344106911,2
    C--57662837(+) AGTGT-/GAGAGTG 7 -- int10--------
    rs58171031,2
    C--57662959(+) gtgtg-/TGagtat 7 -- int10--------
    rs3679616591,2
    C--57662974(+) GTGTG-/GT/TG 
            
    AGTGT
    7 -- int10--------
    rs609860321,2
    C--57678404(+) CACAC-/ATATGCA 8 -- int10--------
    rs598825631,2
    C--57678748(+) CACAC-/AC/CA 
            
    TCATG
    8 -- int10--------
    rs606424641,2
    C--57678819(+) CATCA-/CTCTTCA 8 -- int10--------
    rs614334921,2
    C--57679033(+) CCCCCC/-TGGGC 8 -- int11Minor allele frequency- -:0.50CSA 2
    rs38423621,2
    C--57686143(+) AGGTA-/CCATGT 8 -- int10--------
    rs125977771,2
    C,F,H--57688333(+) CCCCCG/CGtttt 8 -- int1 trp33Minor allele frequency- C:0.25NA 8
    rs125976251,2
    C,F,H--57688334(+) CCCCCT/Gttttt 8 -- int13Minor allele frequency- G:0.20NA 10
    rs735487801,2
    C,F--58665531(+) AAGAGG/AGGCAA 2 -- us2k15Minor allele frequency- A:0.06WA CSA NA 244
    rs47839991,2
    C,F,A,H--58665592(+) ATGGAT/CCTGGG 2 -- us2k131Minor allele frequency- C:0.29NA NS EA WA CSA 2914
    rs133314031,2
    C,F,H--58665740(+) AGCTCC/TTTTGT 2 -- us2k113Minor allele frequency- T:0.29NS EA WA NA 1194
    rs1423559631,2
    C--58665802(+) CCCTGG/TTCTCA 2 -- us2k10--------
    rs1918898961,2
    --58665825(+) AAGGCC/TGCTTT 2 -- us2k10--------
    rs1161204921,2
    C,F--58666012(+) GTGTCG/AAAATC 2 -- us2k13Minor allele frequency- A:0.05WA NA EA 358
    rs1459277551,2
    C--58666020(+) ATCTCA/GGCTCA 2 -- us2k10--------
    rs64999011,2
    C,F,A--58666192(+) GGTGAT/GCCACC 2 -- us2k17Minor allele frequency- G:0.33NA CSA 12
    rs583991221,2
    C,F--58666221(+) CACTGG/TGATTA 2 -- us2k14Minor allele frequency- T:0.14WA CSA EA 126
    rs1163683891,2
    F--58666232(+) TAGGCG/ATCAGC 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1175742041,2
    F--58666243(+) CACTGC/TACTCC 2 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1841389061,2
    --58666295(+) TCTTGC/TCTCTC 2 -- us2k10--------
    rs1892575761,2
    --58666349(+) GGATCA/CCCCAT 2 -- us2k10--------
    rs748827681,2
    C,F--58666502(+) TTCTCG/AATCCC 2 -- us2k11Minor allele frequency- A:0.11EA 120
    rs133378851,2
    C,F--58666654(+) AGGGAA/GGGTTT 2 -- us2k111Minor allele frequency- G:0.46NA WA CSA EA 372
    rs1816103941,2
    --58666671(+) TGCATC/TGAGGT 2 -- us2k10--------
    rs747656191,2
    C,F--58666753(+) TTGCCC/TGGATG 2 -- us2k12Minor allele frequency- T:0.09CSA WA 120
    rs762670191,2
    C,F--58666901(+) ACAAGG/CAGTGA 2 -- us2k11Minor allele frequency- C:0.04WA 118
    rs118622101,2
    C,F,H--58666944(+) GGGGCG/AAGTGG 2 -- us2k19Minor allele frequency- A:0.12NS EA WA NA 736
    rs343155101,2
    C,F--58667047(+) CTGCCC/TCTTTG 2 -- us2k14Minor allele frequency- T:0.12NA EA 244
    rs118593701,2
    C,F,H--58667140(+) CTCGCT/GTCCCG 2 -- us2k18Minor allele frequency- G:0.13NA WA CSA EA 367
    rs1865821751,2
    --58667220(+) CCAGGC/TGGGGC 2 -- us2k10--------
    rs771176341,2
    C,F--58667229(+) GCCTGG/CACTGA 2 -- us2k13Minor allele frequency- C:0.08NA CSA 124
    rs752288621,2
    C,F--58667245(+) GAGGCA/CGGAAG 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1507919641,2
    --58667269(+) GTTGGC/TAGATC 2 -- us2k10--------
    rs1391648681,2
    --58667277(+) ATCACA/GGATGG 2 -- us2k10--------
    rs1907042491,2
    --58667292(+) CAGCAC/TCTCCC 2 -- us2k10--------
    rs1819909961,2
    --58667394(+) GTCCAC/TGAAGA 2 -- us2k10--------
    rs1457856031,2
    --58667476(+) GGTGGC/TGGCTG 2 -- us2k10--------
    rs24046901,2
    C,F,H--58667809(+) CTGGGC/AGTCTC 2 -- int111Minor allele frequency- A:0.07NS NA CSA WA 1050
    rs1862054111,2
    C--58667810(+) TGGGCA/GTCTCT 2 -- int10--------
    rs1175721001,2
    --58667884(+) GCATGG/ATGGTC 2 -- int11Minor allele frequency- A:0.01NA 120
    rs794550061,2
    C,F--58667971(+) GTGACG/ACCGCG 2 -- int11Minor allele frequency- A:0.04WA 118
    rs1140573771,2
    F--58667975(+) CGCCGC/TGGAGC 2 -- int11Minor allele frequency- T:0.01WA 118
    rs781330451,2
    C,F--58668033(+) GCTTTC/TCGCAG 2 -- int13Minor allele frequency- T:0.05WA NA EA 358
    rs1896642081,2
    --58668069(+) TCCCAC/TGGAAA 2 -- int10--------
    rs1153559371,2
    C,F--58668154(+) CAAATG/AGAAGG 2 -- int11Minor allele frequency- A:0.02WA 118
    rs118637091,2
    C,F,H--58668183(+) GGGGGC/TGTGCC 2 -- int15Minor allele frequency- T:0.05WA NA CSA 244
    rs1399250371,2
    --58668374(+) GAACTC/GTCGTG 2 -- int10--------
    rs1453540271,2
    --58668376(+) ACTGTC/GGTGGA 2 -- int10--------
    rs752819591,2
    C,F--58668377(+) CTGTCG/ATGGAA 2 -- int11Minor allele frequency- A:0.12EA 120
    rs1826876011,2
    --58668485(+) AGGGGC/TAGTGG 2 -- int10--------
    rs1854710971,2
    --58668527(+) CCTCCC/TCTGGT 2 -- int10--------
    rs1476580081,2
    --58668539(+) TCATGA/GGCCAC 2 -- int10--------
    rs1426541341,2
    --58668750(+) CTTAGC/GGGGAG 2 -- int10--------
    rs1148782201,2
    F--58668758(+) GAGACC/TCTGGG 2 -- int11Minor allele frequency- T:0.05WA 118
    rs118639331,2
    C,F,H--58668800(+) GAAGGC/TGGCAT 2 -- int15Minor allele frequency- T:0.01NS EA NA 412
    rs1405770061,2
    --58668828(+) GGGCTG/TGGTGC 2 -- int10--------
    rs1899365511,2
    --58668837(+) GCTCCA/GTGGGC 2 -- int10--------
    rs1837284441,2
    --58668865(+) CAACTA/GCAGCT 2 -- int10--------
    rs1504442771,2
    C--58668925(+) GAAACA/GGAGGC 2 -- int10--------
    rs766131701,2
    C--58668930(+) GGAGGC/TGCCCT 2 -- int12Minor allele frequency- T:0.08NA 122
    rs118645641,2
    C,F,H--58669027(+) AGGGAG/CTGGGG 2 -- int15Minor allele frequency- C:0.06NA CSA WA EA 364
    rs118647951,2
    C,F,H--58669088(+) GGCATC/TGAGTG 2 -- int119Minor allele frequency- T:0.05NS EA NA CSA WA 2344
    rs1882574241,2
    --58669184(+) CTCTGA/GGCCTC 2 -- int10--------
    rs80491761,2
    C,F,A,H--58669399(+) GGCTGA/GGACCC 2 -- int125Minor allele frequency- N:0.00EA NA NS WA 2562
    rs49963531,2
    H--58669535(+) tcctcG/Ctgagg 2 -- int14Minor allele frequency- C:0.00NS EA 402
    rs58171021,2
    C--58669642(+) tctct-/A/AAA 
            
    aaaaa
    4 -- int1 cds11NA 2
    rs1152438971,2
    F--58669702(+) AAACCA/GAAGAT 2 -- int11Minor allele frequency- G:0.01WA 118
    rs1932800601,2
    --58669745(+) TAGGCA/GGATAC 2 -- int10--------
    rs1838039751,2
    --58669817(+) GATTGG/TCTATT 2 -- int10--------
    rs1379414261,2
    --58669829(+) AGAGGA/GCTTCA 2 -- int10--------
    rs1119528191,2
    C--58669845(+) ATGCTG/AGGTGG 2 -- int12Minor allele frequency- A:0.08NA 122
    rs770419521,2
    F--58669928(+) CTGGGC/TGCCAG 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1424214941,2
    --58670005(+) GCAGAA/GGACAC 2 -- int10--------
    rs1114656321,2
    C,F--58670010(+) GGACAG/CCGTGA 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs1148196521,2
    C,F--58670021(+) CATGCA/GGGGAT 2 -- int11Minor allele frequency- G:0.03WA 118
    rs788296941,2
    C,F--58670085(+) GCAAGA/GGGGGC 2 -- int14Minor allele frequency- G:0.06NA CSA EA 244
    rs750189421,2
    C,F--58670088(+) AGAGGG/AGCCCA 2 -- int11Minor allele frequency- A:0.02EA 120
    rs129293601,2
    C,F,H--58670126(+) GAAGGG/ACTTAT 2 -- int115Minor allele frequency- A:0.09NS EA NA 1468
    rs1156725621,2
    C,F--58670129(+) GGGCTT/GATTAG 2 -- int11Minor allele frequency- G:0.06WA 118
    rs1385417941,2
    C--58670151(+) CCTTGC/TTCTGG 2 -- int10--------
    rs1161612621,2
    F--58670348(+) CTTCCC/TCGCTG 2 -- int11Minor allele frequency- T:0.01WA 118
    rs1162996431,2
    C,F--58670370(+) AGGCGG/TGGGTG 2 -- int12Minor allele frequency- T:0.07WA NA 238
    rs1880262311,2
    --58670382(+) ACCTTA/GGAGGC 2 -- int10--------
    rs133383551,2
    C,F,H--58670528(+) AGTTGC/TCATTG 2 -- int111Minor allele frequency- T:0.09NS EA NA WA 1312
    rs47840001,2
    C,F,A,H--58670559(+) AGGGGC/GAAAGC 2 -- int119Minor allele frequency- G:0.38NA NS EA WA CSA 1345
    rs1146800371,2
    F--58670607(+) GAGTCA/GGTCCC 2 -- int11Minor allele frequency- G:0.07WA 118
    rs1914138221,2
    --58670621(+) CCCTCC/TCTGAG 2 -- int10--------
    rs1836124561,2
    --58670751(+) TAGAAC/TCTTCC 2 -- int10--------
    rs1415132181,2
    --58670847(+) CCACAA/GGCTCC 2 -- int10--------
    rs129216711,2
    C,F,H--58671030(+) TCATCT/CGAGCT 2 -- int18Minor allele frequency- C:0.09NS EA NA 664
    rs1117465981,2
    C,F--58671056(+) ATCCTA/GAGGCT 2 -- int12Minor allele frequency- G:0.04CSA WA 119
    rs1887169021,2
    --58671071(+) CTGAAA/GCACCA 2 -- int10--------
    rs776809601,2
    F--58671201(+) GGGAAC/GCAGAC 2 -- int10--------
    rs1916656671,2
    --58671385(+) TTGGCC/TGCAAA 2 -- int10--------
    rs343064301,2
    C,F--58671728(+) ATACCC/TACCTC 2 -- int15Minor allele frequency- T:0.10NA EA 246
    rs1135303781,2
    C,F--58671744(+) CTGGGC/TGCAGT 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs1853763721,2
    --58671791(+) AGGTGA/GGAGGA 2 -- int10--------
    rs1417365891,2
    --58671944(+) GAGCCC/GAGGAG 2 -- int10--------
    rs1899091511,2
    --58671978(+) TTGCAC/TCACTA 2 -- int10--------
    rs346074921,2
    C,F--58672182(+) TCCTAG/ACCCTC 2 -- int17Minor allele frequency- A:0.09NA CSA EA 250
    rs1178470401,2
    C,F--58672199(+) CCACCA/GTGTCT 2 -- int11Minor allele frequency- G:0.02NA 120
    rs713871901,2
    C,F--58672308(+) CTCCCC/TGGCAG 2 -- int16Minor allele frequency- T:0.09NA CSA EA 248
    rs1505507751,2
    --58672319(+) CCTCCC/TCTCTA 2 -- int10--------
    rs1825460371,2
    --58672382(+) GCCCAC/TTGTCT 2 -- int10--------
    rs1855297051,2
    --58672468(+) ACTTGG/TCAGGC 2 -- int10--------
    rs341779651,2
    C,F--58672577(+) ACTCCG/AGGCTC 2 -- int14Minor allele frequency- A:0.08NA EA 244
    rs678115521,2
    C,F--58672591(+) GAGGGT/GGCAGC 2 -- int16Minor allele frequency- G:0.32WA NA EA 364
    rs1883500621,2
    --58672641(+) TTCCTG/TCACCT 2 -- int10--------
    rs343701211,2
    C,F--58672683(+) GACTCC/TGTCGC 2 -- int16Minor allele frequency- T:0.08NA EA 248
    rs1399918851,2
    C--58672729(+) GACCCC/TAGTCC 2 -- int10--------
    rs340281831,2
    C,F--58672818(+) GAGCTG/ACCCCC 2 -- int15Minor allele frequency- A:0.09NA EA 246
    rs1808648841,2
    C--58672824(+) CCCCCA/GTTCCA 2 -- int10--------
    rs1454183771,2
    --58672861(+) CCTTCC/TGGATC 2 -- int10--------
    rs342060311,2
    C,F--58672886(+) TGCCCC/TGATTC 2 -- int15Minor allele frequency- T:0.09NA EA 246
    rs1472662791,2
    --58672898(+) TCAGGA/GACGTT 2 -- int10--------
    rs1407565421,2
    --58672998(+) ACCAAA/TGTCTC 2 -- int10--------
    rs1471254391,2
    C--58673010(+) TCCCCA/C/TGCTCT 2 -- int10--------
    rs1132376381,2
    C,F--58673077(+) TGCCCA/GTCCCT 2 -- int12Minor allele frequency- G:0.04CSA WA 120
    rs1849339231,2
    --58673081(+) CATCCC/TTCCGC 2 -- int10--------
    rs1139216611,2
    C--58673124(+) CCAGGG/TCTTCT 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs133312011,2
    C,F,H--58673177(+) ACACAT/CTCAGA 2 -- int15Minor allele frequency- C:0.03NS EA WA 526
    rs1458688321,2
    --58673181(+) ATTCAG/TATTCA 2 -- int10--------
    rs355623451,2
    C,F--58673253(+) CTACCC/TAAACA 2 -- int15Minor allele frequency- T:0.09NA EA 246
    rs1489973521,2
    --58673308(+) CACTTC/TCAAAA 2 -- int10--------
    rs1901833711,2
    --58673381(+) GCCCTA/GCCTCT 2 -- int10--------
    rs1429318921,2
    --58673394(+) ACCTCA/GGCCAA 2 -- int10--------
    rs1811956681,2
    --58673451(+) TCGAAA/GCCCCC 2 -- int10--------
    rs1871074541,2
    --58673471(+) TTCAGG/TTCCCA 2 -- int10--------
    rs1162464721,2
    C,F--58673557(+) CTCGGT/CTCCCC 2 -- int13Minor allele frequency- C:0.04WA NA EA 358
    rs1126459261,2
    F--58673584(+) TAGACT/AGTTGT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs801621661,2
    F--58673753(+) ACCCAA/GCCCAC 2 -- int11Minor allele frequency- G:0.01NA 120
    rs1413388621,2
    C--58673801(+) CAGAGC/TATCTT 2 -- int10--------
    rs11098371,2
    C,F,H--58673831(-) CACCTG/ACTATG 2 -- int18Minor allele frequency- A:0.01NS EA NA CSA WA 539
    rs1447068511,2
    --58673862(+) CACTCA/TTAACA 2 -- int10--------
    rs1385827141,2
    --58673874(+) ATAGTC/GTTGTG 2 -- int10--------
    rs1401399611,2
    --58673884(+) GTTTAA/CCAAGT 2 -- int10--------
    rs129186791,2
    C,F,A,H--58673888(+) AACAAG/TTCATT 2 -- int110Minor allele frequency- T:0.05NS NA CSA WA EA 590
    rs11098361,2
    C,F,H--58673953(-) AGTAGC/TGATAC 2 -- int124Minor allele frequency- T:0.07NS EA NA CSA WA 2582
    rs118644871,2
    C,F,H--58674025(+) CTGCCC/TCTAGC 7 -- us2k1 int18Minor allele frequency- T:0.03NS EA CSA WA NA 742
    rs1502848381,2
    --58674054(+) AAGTCC/TGACGG 7 -- us2k1 int10--------
    rs735487931,2
    C,F--58674071(+) AGGCAG/AGCAGA 7 -- us2k1 int12Minor allele frequency- A:0.14WA 120
    rs344679931,2
    C,F--58674083(+) CTGGGC/AAGCCA 7 -- us2k1 int15Minor allele frequency- A:0.12NA EA 128
    rs1915393191,2
    --58674093(+) AACTCC/TGCCCA 7 -- us2k1 int10--------
    rs9357391,2
    C,F,A,H--58674098(+) CGCCCG/AGCCAG 7 -- us2k1 int118Minor allele frequency- A:0.41NS EA NA WA CSA 796
    rs42387941,2
    C,F,A,H--58674128(+) CTATGT/CGGCCA 7 -- us2k1 int127Minor allele frequency- C:0.46NS EA NA WA CSA 2368
    rs1380915301,2
    --58674215(+) TCTGGC/TCAGCA 7 -- us2k1 int10--------
    rs762401181,2
    C,F--58674222(+) AGCACG/ACTCTG 7 -- us2k1 int11Minor allele frequency- A:0.03WA 118
    rs2012421611,2
    --58674232(+) GTGGG-/GTGTGTG 7 -- us2k1 int10--------
    rs340854911,2
    C--58674239(+) GTGTG-/GTGGTG 7 -- us2k1 int10--------
    rs80472791,2
    C,F,A,H--58674316(+) TACCAA/GTTGAT 7 -- us2k1 int137Minor allele frequency- G:0.37EA NA NS WA CSA 3409
    rs1128967051,2
    C,F--58674333(+) CTGAAA/GGACTG 7 -- us2k1 int11Minor allele frequency- G:0.00CSA 1
    rs1471978151,2
    --58674383(+) GACAAC/GCCATC 7 -- us2k1 int10--------
    rs1388549821,2
    --58674391(+) ATCCTC/TCCCTA 7 -- us2k1 int10--------
    rs1842360331,2
    --58674444(+) GGCTGA/GCCTCT 7 -- us2k1 int10--------
    rs1428014531,2
    C--58674468(+) TAAGGC/GAGTTC 7 -- us2k1 int10--------
    rs1879084471,2
    C--58674486(+) AGCCCC/TGGGAG 7 -- us2k1 int10--------
    rs64999021,2
    C,F,A,H--58674562(+) GCCTGC/GACTGG 7 -- us2k1 int113Minor allele frequency- G:0.30NS EA WA NA CSA 770
    rs620361241,2
    C--58674616(+) TCACCT/CTATGG 7 -- us2k1 int12Minor allele frequency- C:0.05NA 122
    rs347890181,2
    C--58674638(+) CCCAC-/GGGGTG 7 -- us2k1 int10--------
    rs1126329211,2
    C,F--58674668(+) TGCAGC/TTTGAT 7 -- us2k1 int11Minor allele frequency- T:0.50CSA 2
    rs64999031,2
    C,F,H--58674678(+) TTTCAG/AGCAGG 7 -- us2k1 int122Minor allele frequency- A:0.24NS EA WA NA CSA 2348
    rs1823509751,2
    --58674696(+) GGAGTA/GCAGTT 7 -- us2k1 int10--------
    rs169584061,2
    C,F,H--58674734(+) TGCCCG/AAGACG 7 -- us2k1 int110Minor allele frequency- A:0.06NA NS EA WA 682
    rs749821141,2
    C--58674767(+) TGGCAT/CGGGGA 7 -- us2k1 int13Minor allele frequency- C:0.15CSA WA EA 240
    rs777693261,2
    C--58674814(+) CTACCG/TGAGAG 7 -- us2k1 int13Minor allele frequency- T:0.16CSA WA EA 240
    rs1866814191,2
    --58674906(+) AGACCC/TGCTAT 7 -- us2k1 int10--------
    rs1166440831,2
    C,F--58674934(+) GCTCCC/TGCCAT 7 -- us2k1 int11Minor allele frequency- T:0.03WA 118
    rs791905351,2
    F--58674948(+) AACTCG/AGGCAC 7 -- us2k1 int11Minor allele frequency- A:0.03WA 118
    rs1929714741,2
    --58675105(+) TTGACC/TTCTCT 7 -- us2k1 int10--------
    rs782924201,2
    C,F--58675157(+) TCAGCG/AAGTGT 7 -- us2k1 int11Minor allele frequency- A:0.03WA 118
    rs133374841,2
    C,F,A,H--58675206(+) TAAAAT/GCCTCC 7 -- us2k1 int130Minor allele frequency- G:0.33EA NA NS WA CSA 2983
    rs735488021,2
    C,F--58675220(+) CACATC/TTGACT 7 -- us2k1 int11Minor allele frequency- T:0.50WA 2
    rs722311291,2
    C--58675258(+) GGAGG-/AGGGCAGA 14 -- us2k1 cds1 int10--------
    rs1846925651,2
    --58675302(+) AGCCTC/TCTGAC 7 -- us2k1 int10--------
    rs116439521,2
    C,F,H--58675383(+) CATGGC/TCCATT 7 -- us2k1 int123Minor allele frequency- T:0.29MN EA NS NA WA CSA 3600
    rs1888295341,2
    --58675408(+) TCTGAA/GCTTTT 7 -- us2k1 int10--------
    rs679035071,2
    C--58675587(+) CCCCG-/AGGGGG 7 -- us2k1 int10--------
    rs2004970211,2
    C--58675587(-) CCCCCC/TGNNNN 7 -- us2k1 int10--------
    rs1929024771,2
    --58675614(+) CAGTCA/GTGCGT 7 -- us2k1 int10--------
    rs343599111,2
    C--58675655(+) CACCC-/GGCTCC 7 -- us2k1 int10--------
    rs1858609771,2
    --58675678(+) CTTCCA/GCTCTG 7 -- us2k1 int10--------
    rs1121801991,2
    F--58675884(+) ATCCCC/TGGCCC 7 -- us2k1 int12Minor allele frequency- T:0.02CSA WA 120
    rs735505061,2
    C,F--58675906(+) TGAACA/GCTGTC 7 -- us2k1 int11Minor allele frequency- G:0.11WA 118
    rs1888869241,2
    --58675954(+) CCGGCA/GCTGAG 7 -- us2k1 int10--------
    rs1816371901,2
    --58676014(+) CTCCTA/GGTCTC 7 -- us2k1 int10--------
    rs767376221,2
    C,F--58676053(+) TCGTCC/TGTCAT 7 -- ut51 int11Minor allele frequency- T:0.01WA 118
    rs129328681,2
    C,F--58676110(+) GAGGGG/TTGTCT 7 -- ut51 int17Minor allele frequency- T:0.12MN EA NA 1498
    rs1838845191,2
    --58676121(+) CCCCAC/GCAAAC 7 -- ut51 int10--------
    rs1886119101,2
    --58676143(+) CTCCCC/TCTCCG 7 -- ut51 int10--------
    rs283647821,2
    C,F--58676238(+) CAGGGC/GTGGCA 7 -- ut51 int11Minor allele frequency- G:0.23EA 120
    rs735505101,2
    C,F--58676349(+) CAGGTG/AGGAAG 7 -- int12Minor allele frequency- A:0.04WA 120
    rs766523411,2
    C,F--58676373(+) GTGTGA/TGAGTG 7 -- int15Minor allele frequency- T:0.20NA CSA WA EA 362
    rs2020339621,2
    --58676393(+) AGCGT-/GAGAGTG 7 -- int10--------
    rs22788071,2
    C--58676397(+) GTGAGA/TGTGTG 7 -- int10--------
    rs721026731,2
    C--58676402(+) TGTGT-/GAGAGTG 7 -- int10--------
    rs1150131381,2
    --58676418(+) TGTGTA/GAGTGT 7 -- int10--------
    rs1380307091,2
    C--58676444(+) GTGTG-/GAAGTGT 7 -- int10--------
    rs718554221,2
    C--58676446(+) GTGAG-/AG/GT 
            
    TGTGA
    7 -- int10--------
    rs1407505251,2
    C--58676496(+) TGTGA-/GAGT  
            
    GAGTG
    7 -- int10--------
    rs49930221,2
    C,F,H--58676539(+) CTGAGA/CGTTTG 7 -- int113Minor allele frequency- C:0.31NS EA NA WA CSA 763
    rs722058861,2
    C--58676550(+) AGTGT-/GAGAGTG 7 -- int10--------
    rs2007586701,2
    --58676577(+) GAGTA-/TGAGTG
            
    TGAGT
    7 -- int10--------
    rs1407869601,2
    C--58676579(+) TATGA-/GTGTGTG 7 -- int10--------
    rs10756711,2
    C,F,H--58676640(-) CCACCC/TGTGCA 7 -- int17Minor allele frequency- T:0.02NS EA NA WA 520
    rs10756701,2
    C,F,H--58676718(-) CCTGGA/GCTAGA 7 -- int122Minor allele frequency- G:0.10NA EA NS WA 1810
    rs18070211,2
    C,F--58676759(-) GGTCCG/ACCCCC 7 -- int14Minor allele frequency- A:0.02NA EA 248
    rs783960431,2
    C,F--58676807(+) GGAGCG/AACACC 7 -- int13Minor allele frequency- A:0.10WA CSA 122
    rs18070201,2
    C,F,H--58676837(-) CCAGCA/TACAAA 7 -- int19Minor allele frequency- T:0.06NA EA NS WA 692
    rs1171671531,2
    F--58676916(+) GATCAG/CTGCTC 7 -- int11Minor allele frequency- C:0.03NA 120
    rs783665591,2
    C--58677172(+) CTGAAC/TGTGGG 7 -- int10--------
    rs768812701,2
    C,F--58677216(+) GCAGAC/TGGGGA 7 -- int11Minor allele frequency- T:0.05WA 118
    rs121489861,2
    C,F,A,H--58677225(+) GAAGCA/GCAGGC 7 -- int121Minor allele frequency- G:0.46NS EA NA WA CSA 2214
    rs1142444631,2
    F--58677230(+) GCAGGC/TTGCGG 7 -- int11Minor allele frequency- T:0.02WA 118
    rs1807165741,2
    --58677251(+) CTGCCC/TGTTGC 7 -- int10--------
    rs1508155021,2
    C--58677257(+) GTTGCC/TACCAG 7 -- int10--------
    rs1147874621,2
    C,F--58677316(+) CCCCGC/TGGGGG 7 -- int11Minor allele frequency- T:0.02WA 118
    rs792836151,2
    C--58677343(+) AACCAA/GTGATT 7 -- int13Minor allele frequency- G:0.09NA EA 242
    rs1394226941,2
    C--58677358(+) TCCTCA/CCCCGT 7 -- int10--------
    rs788012231,2
    C,F--58677375(+) CCCACC/TTCCCC 7 -- int11Minor allele frequency- T:0.03WA 118
    rs1859703171,2
    C--58677377(+) CACCTC/TCCCTG 7 -- int10--------
    rs579028041,2
    C--58677379(+) CCTCCC/GCTGCG 7 -- int12Minor allele frequency- G:0.18CSA EA 122
    rs1500693091,2
    C--58677443(+) TACTGA/CGTAGG 7 -- int10--------
    rs173781091,2
    C,F,H--58677564(+) CCAAGA/GAAGTT 7 -- int123Minor allele frequency- G:0.12NA NS EA WA CSA 2488
    rs1912152991,2
    --58677618(+) TCTGTC/TGGGAA 7 -- int10--------
    rs20190141,2
    H--58677637(-) tgcctC/Aaccca 7 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1820598461,2
    --58677644(+) GGCAAA/TTAAGG 7 -- int10--------
    rs598989991,2
    --58677703(+) CCTCCC/TAGAGG 7 -- int10--------
    rs1114886291,2
    C,F--58677709(+) AGAGGA/GTAGCC 7 -- int12Minor allele frequency- G:0.10CSA WA 120
    rs8829381,2
    C,F,A,H--58677711(-) GGGGCT/CATCCT 7 -- int118Minor allele frequency- C:0.26NS EA NA WA 2326
    rs1413700851,2
    --58677800(+) AGTTGG/TCTCCC 7 -- int10--------
    rs121490181,2
    C,F--58677810(+) CCAGAG/ACCCAG 7 -- int111Minor allele frequency- A:0.42NA WA CSA EA 374
    rs20012031,2
    C,F,A,H--58677839(-) GGCAGG/AAAAGA 7 -- int123Minor allele frequency- A:0.26NS EA NA WA 2758
    rs1473454281,2
    C--58677900(+) CTGCA-/GGGGAC 7 -- int10--------
    rs124483581,2
    C,F,H--58677936(+) CAGCAT/CCACTG 7 -- int111Minor allele frequency- C:0.30NA WA CSA EA 374
    rs1437932321,2
    --58677969(+) CTCTCA/GCCTCA 7 -- int10--------
    rs1466960551,2
    --58677979(+) AGGAGC/TTCAGC 7 -- int10--------
    rs757484981,2
    C,F--58678075(+) AACGCC/TGCTCC 7 -- int11Minor allele frequency- T:0.04EA 120
    rs740220041,2
    C,F--58678078(+) GCCGCC/TCCAGG 7 -- int11Minor allele frequency- T:0.50WA 2
    rs727916801,2
    C--58678127(+) CACTGG/CGCAAG 7 -- int13Minor allele frequency- C:0.04CSA WA NA 239
    rs755901551,2
    --58678143(+) GTCAGC/TCTGGT 7 -- int10--------
    rs743415301,2
    F--58678309(+) GGGAGG/AGGAAG 7 -- int11Minor allele frequency- A:0.01WA 118
    rs786288131,2
    C--58678327(+) TGTCTG/ATATGA 7 -- int13Minor allele frequency- A:0.12NA EA 242
    rs1479729971,2
    --58678387(+) GGGAAC/TGATAC 7 -- int10--------
    rs1134514211,2
    C--58678487(+) GCTCTA/GTGGGG 7 -- int11Minor allele frequency- G:0.00CSA 1
    rs1865387001,2
    C--58678489(+) TCTGTA/G/TGGGGG 7 -- int10--------
    rs1406818451,2
    --58678491(+) TGTGGC/GGGGGA 7 -- int10--------
    rs1905461291,2
    --58678507(+) GGCAGA/GAGGAC 7 -- int10--------
    rs801465281,2
    C,F--58678515(+) GACTCG/ACCAGG 7 -- int11Minor allele frequency- A:0.01WA 118
    rs561542221,2
    C--58678576(+) GAGGGC/GCAGGA 7 -- int13Minor allele frequency- G:0.11CSA NA EA 242
    rs124485301,2
    C,H--58678589(+) GGTGTT/GCAGTG 7 -- int15Minor allele frequency- G:0.23WA CSA NA EA 361
    rs343792571,2
    C--58678626(+) CTGGC-/TGCTGG 7 -- int10--------
    rs559954251,2
    C--58678629(+) GCTGCC/TGGGTT 7 -- int10--------
    rs560649371,2
    C--58678630(+) CTGCTA/GGGTTA 7 -- int10--------
    rs1462234341,2
    --58678654(+) GGAGCA/CGCTTC 7 -- int10--------
    rs1389273661,2
    --58678675(+) GAGACA/GAGGGG 7 -- int10--------
    rs1428079801,2
    --58678697(+) CAGTCA/GAGGGG 7 -- int10--------
    rs1145954011,2
    F--58678716(+) GAGAGA/GGGTGG 7 -- int11Minor allele frequency- G:0.04WA 118
    rs558517941,2
    C,F--58678745(+) GGTGTG/AGGGGT 7 -- int18Minor allele frequency- A:0.48WA NA CSA EA 366
    rs1473947811,2
    --58678777(+) CATGAC/GAAAGG 7 -- int10--------
    rs133374161,2
    C,F--58678788(+) CAGGTG/AAGAGG 7 -- int16Minor allele frequency- A:0.50NA WA EA 364
    rs133374171,2
    C--58678789(+) AGGTAC/AGAGGA 7 -- int14Minor allele frequency- A:0.49WA NA EA 360
    rs133323591,2
    C,F,H--58678830(+) CGGACC/TGTCCT 7 -- int118Minor allele frequency- T:0.41EA NA NS WA CSA 1409
    rs735505221,2
    C,F--58678848(+) GACTGG/AGATGC 7 -- int15Minor allele frequency- A:0.11WA CSA NA 243
    rs749628921,2
    C,F--58678854(+) GATGCG/AGGTTC 7 -- int12Minor allele frequency- A:0.09NA EA 240
    rs1131188281,2
    F--58678865(+) CGCCAA/TCCTGT 7 -- int11Minor allele frequency- T:0.00CSA 1
    rs1493697741,2
    C--58678891(+) AGGTGG/TGGTCT 7 -- int10--------
    rs1447218401,2
    C--58678901(+) TGGGGA/GGCTGT 7 -- int10--------
    rs786440391,2
    C,F--58678934(+) GGCTTC/TCATGT 7 -- int11Minor allele frequency- T:0.02WA 118
    rs1912123721,2
    --58678967(+) TGGAGA/GAGGCC 7 -- int10--------
    rs1826058591,2
    --58679041(+) CACCAA/CCTCCT 7 -- int10--------
    rs133396011,2
    C,F--58679067(+) CTTGAG/TCAGGG 7 -- int110Minor allele frequency- T:0.22NA WA CSA EA 371
    rs755606891,2
    C--58679243(+) CAAACC/TGGGTG 7 -- int13Minor allele frequency- T:0.10CSA NA EA 241
    rs745380701,2
    C,F--58679252(+) TGGGGC/TGGGGC 7 -- int12Minor allele frequency- T:0.09NA EA 240
    rs1875756161,2
    --58679301(+) GAGCCA/GTCACT 7 -- int10--------
    rs1388648301,2
    --58679415(+) GGTAG-/AGG   
       GGCCA
    AGGGT
    7 -- int10--------
    rs560158901,2
    C--58679420(+) GGGGC-/AGGGG 
     
    /AGGGGT
    CAAGG
    14 -- int1 cds10--------
    rs558819771,2
    C--58679422(+) GGCCA-/G/G   
      GGGTAG
    AGGGT
    7 -- int10--------
    rs1485173131,2
    --58679438(+) AGTAGG/TAAGGG 7 -- int10--------
    rs71977351,2
    C,F,H--58679491(+) CAGGAG/AGTCAG 7 -- int111Minor allele frequency- A:0.06NS EA WA NA 1074
    rs1927895841,2
    --58679494(+) GAGGTC/TAGCTA 7 -- int10--------
    rs1846319461,2
    C--58679529(+) TGATGA/GCTCAG 7 -- int10--------
    rs3697778751,2
    C--58679669(+) CCCCAC/TTCTTT 7 -- int10--------
    rs1470204221,2
    --58679745(+) TGCTCA/GTGTCT 7 -- int10--------
    rs80566581,2
    C,F,A,H--58679805(+) GGCCCG/ATAGAG 7 -- int111Minor allele frequency- A:0.43NA WA CSA EA 377
    rs80566591,2
    C,F,A,H--58679808(+) CCGTAG/CAGACA 7 -- int111Minor allele frequency- C:0.43NA WA CSA EA 377
    rs80566981,2
    C,F,A,H--58679874(+) ACATGG/AGCCTG 7 -- int111Minor allele frequency- A:0.43NA WA CSA EA 377
    rs64999041,2
    C,F,A,H--58679962(+) TGATAG/TAGGAA 7 -- int128Minor allele frequency- T:0.38NS EA NA WA CSA 2783
    rs1919498361,2
    --58679976(+) ATATGA/GGAAAG 7 -- int1