Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GPR56 Gene

protein-coding   GIFtS: 65
GCID: GC16P057653

G Protein-Coupled Receptor 56

  See GPR56-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
G Protein-Coupled Receptor 561 2     7-Transmembrane Protein With No EGF-Like N-Terminal Domains-12
TM7XN12 3 5     G-Protein Coupled Receptor 562
TM7LN42 3     Protein TM7XN13
BFPP2 5     

External Ids:    HGNC: 45121   Entrez Gene: 92892   Ensembl: ENSG000002053367   OMIM: 6041105   UniProtKB: Q9Y6533   

Export aliases for GPR56 gene to outside databases

Previous GC identifers: GC16P048070 GC16P057736 GC16P057388 GC16P057450 GC16P057429 GC16P056211 GC16P043521


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GPR56 Gene:
This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The
encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an
inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as
bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Feb 2014)

GeneCards Summary for GPR56 Gene:
GPR56 (G protein-coupled receptor 56) is a protein-coding gene. Diseases associated with GPR56 include bilateral perisylvian polymicrogyria, and polymicrogyria. GO annotations related to this gene include extracellular matrix binding and G-protein coupled receptor activity. An important paralog of this gene is GPR97.

UniProtKB/Swiss-Prot: GPR56_HUMAN, Q9Y653
Function: Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural
precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical
development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination.
Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and
possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE)
transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and,
during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is
inhibiting and GPR56 NT is activating angiogenesis

Gene Wiki entry for GPR56 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR56 gene promoter:
         c-Fos   Bach1   AP-1   Pax-2a   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GPR56 promoter sequence
   Search Chromatin IP Primers for GPR56

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR56


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

GPR56 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR56 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057653:  view genomic region     (about GC identifiers)

Start:
57,644,564 bp from pter      End:
57,698,944 bp from pter
Size:
54,381 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GPR56_HUMAN, Q9Y653 (See protein sequence)
Recommended Name: G-protein coupled receptor 56 precursor  
Size: 693 amino acids; 77738 Da
Subunit: Predominantly non-covalently linked heterodimer of the N-terminal and the C-terminal fragment. GPR56 NT
self-associates in a trans-trans manner; the homophilic interaction enhances receptor signaling. GPR56 CT
interacts with ARRB2; the interaction is impaired by GPR56 NT. Interacts with TGM2; TGM2 probably is not a GPR56
ligand and the interaction is reported conflictingly (PubMed:16757564, PubMed:21349848). Part of a
GPCR-tetraspanin complex at least consisting of GPR56, CD81, eventually CD9, and GNA11 in which CD81 is enhancing
the association of GPR56 with GNA11
Secondary accessions: A6NIT7 A6NJV9 B0M0K4 B4DR54 O95966 Q6ZMP1 Q8NGB3 Q96HB4
Alternative splicing: 5 isoforms:  Q9Y653-1   Q9Y653-2   Q9Y653-3   Q9Y653-4   Q9Y653-5   (Has no predictable signal peptide)

Explore the universe of human proteins at neXtProt for GPR56: NX_Q9Y653

Explore proteomics data for GPR56 at MOPED

Post-translational modifications: 

  • Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment and the membrane-bound
    C-terminal fragment predominantly remain associated and non-covalently linked. Shedding to yield the secreted
    GPR56 N-terminal fragment seems to involve metalloprotease(s)1
  • N-glycosylated. Contains sialic acid residues1
  • Ubiquitinated. Undergoes polyubiquitination upon activation1
  • Glycosylation2 at Asn39, Thr51, Asn148, Asn171, Asn234, Asn303, Asn324, Asn341
  • Modification sites at PhosphoSitePlus

  • See GPR56 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (11 alternative transcripts): 
    NP_001139242.1  NP_001139243.1  NP_001139245.1  NP_001139246.1  NP_001277071.1  NP_001277072.1  NP_001277073.1  NP_005673.3  
    NP_958932.1  NP_958933.1  NP_001139244.1  

    ENSEMBL proteins: 
     ENSP00000456781   ENSP00000454321   ENSP00000456166   ENSP00000455812   ENSP00000456469  
     ENSP00000455245   ENSP00000457456   ENSP00000455215   ENSP00000456796   ENSP00000456238  
     ENSP00000456794   ENSP00000457979   ENSP00000454263   ENSP00000454607   ENSP00000458063  
     ENSP00000457307   ENSP00000454364   ENSP00000455600   ENSP00000456494   ENSP00000456002  
     ENSP00000455351   ENSP00000457073   ENSP00000457122   ENSP00000456787   ENSP00000456632  
     ENSP00000373465   ENSP00000454574   ENSP00000456620   ENSP00000454855   ENSP00000454879  
     ENSP00000455209   ENSP00000458014   ENSP00000456603   ENSP00000457657   ENSP00000455074  
     ENSP00000455226   ENSP00000455553   ENSP00000457143   ENSP00000456819   ENSP00000455176  
     ENSP00000454490   ENSP00000455965   ENSP00000454933   ENSP00000454779   ENSP00000457612  
     ENSP00000457063   ENSP00000457994   ENSP00000456256   ENSP00000444911   ENSP00000456682  
     ENSP00000457223   ENSP00000458087   ENSP00000456147   ENSP00000454233   ENSP00000456362  
     ENSP00000456263   ENSP00000454289   ENSP00000456544   ENSP00000457953   ENSP00000457806  
     ENSP00000456599   ENSP00000457635   ENSP00000457178   ENSP00000456731   ENSP00000373464  
     ENSP00000444415   ENSP00000398034   ENSP00000369016   ENSP00000369018   ENSP00000438006  

    GPR56 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for GPR56
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for GPR56
    OriGene Protein Over-expression Lysate for GPR56
    OriGene MassSpec for GPR56
    OriGene Custom Protein Services for GPR56
    GenScript Custom Purified and Recombinant Proteins Services for GPR56
    Novus Biologicals GPR56 Proteins
    Novus Biologicals GPR56 Lysates
    Sino Biological Recombinant Protein for GPR56
    Sino Biological Cell Lysate for GPR56
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPR56

     
    Search eBioscience for Proteins for GPR56 

    GPR56 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for GPR56
    OriGene Antibodies for GPR56
    OriGene Custom Antibody Services for GPR56
    Novus Biologicals GPR56 Antibodies
    Search for Antibodies for GPR56 at Abcam
    Cloud-Clone Corp. Antibodies for GPR56
    ThermoFisher Antibodies for GPR56
    LSBio Antibodies in human, mouse, rat for GPR56

    GPR56 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GPR56
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GPR56
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GPR56
    Cloud-Clone Corp. CLIAs for GPR56
    Search eBioscience for ELISAs for GPR56 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GPCRBO: GPCR / Class B : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR56
    Adhesion Class GPCRs

    4 InterPro protein domains:
     IPR003910 GPCR_2_orphan_rcpt_GPR56
     IPR000832 GPCR_2_secretin-like
     IPR017981 GPCR_2-like
     IPR000203 GPS

    Graphical View of Domain Structure for InterPro Entry Q9Y653

    ProtoNet protein and cluster: Q9Y653

    3 Blocks protein domains:
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB003910 GPR56 orphan receptor signature


    UniProtKB/Swiss-Prot: GPR56_HUMAN, Q9Y653
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 1 GPS domain


    Find genes that share domains with GPR56           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPR56_HUMAN, Q9Y653
    Function: Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural
    precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical
    development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination.
    Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and
    possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE)
    transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and,
    during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is
    inhibiting and GPR56 NT is activating angiogenesis
    Enzyme regulation: GPR56 NT is proposed to inhibit receptor signaling; its interactions with extracellular ligands
    and /or homophilic GPR56 NT interactions may relieve the inhibition

         Genatlas biochemistry entry for GPR56:
    secretin-like G protein coupled receptor 56,widely expressed,with highest levels,in thyroid,brain and heart

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity ISS--
    GO:0005518collagen binding ISS--
    GO:0050840extracellular matrix binding ISS--
         
    Find genes that share ontologies with GPR56           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR56:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gpr56):
     behavior/neurological  cellular  integument  nervous system 

    Find genes that share phenotypes with GPR56           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR56
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GPR56

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPR56
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPR56

    miRNA
    Products:
        
    miRTarBase miRNAs that target GPR56:
    hsa-let-7b-5p (MIRT001629), hsa-mir-98-5p (MIRT027574)

    Block miRNA regulation of human, mouse, rat GPR56 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPR56 (see all 9):
    hsa-miR-4264 hsa-miR-1226 hsa-miR-1283 hsa-miR-139-5p hsa-miR-582-5p hsa-miR-889 hsa-miR-3662 hsa-miR-1264
    SwitchGear 3'UTR luciferase reporter plasmidGPR56 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GPR56
    Predesigned siRNA for gene silencing in human, mouse, rat GPR56

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GPR56

    Clone
    Products:
         
    OriGene clones in human, mouse for GPR56 (see all 45)
    OriGene ORF clones in mouse, rat for GPR56
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): GPR56 (NM_001145770)
    Sino Biological Human cDNA Clone for GPR56
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR56
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR56
    Addgene plasmids for GPR56 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GPR56
    Browse ESI BIO Cell Lines and PureStem Progenitors for GPR56 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR56


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GPR56_HUMAN, Q9Y653: Cell membrane; Multi-pass membrane protein
    GPR56_HUMAN, Q9Y653: GPR56 N-terminal fragment: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane TAS10049584
    GO:0016020membrane ----
    GO:0016021integral component of membrane TAS15004227

    Find genes that share ontologies with GPR56           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GPR56 About    
    See pathways by source

    SuperPathContained pathways About
    1GPCRs, Other
    GPCRs, Other


    1 BioSystems Pathway for GPR56
        GPCRs, Other



        Pathway & Disease-focused RT2 Profiler PCR Array including GPR56: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GPR56

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for GPR56 (Q9Y6533 ENSP000003690184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB2P321213, ENSP000002692604I2D: score=1 STRING: ENSP00000269260
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IDA--
    GO:0007155cell adhesion IEA--
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS10049584
    GO:0007218neuropeptide signaling pathway IEA--

    Find genes that share ontologies with GPR56           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR56



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GPR56 gene (11 alternative transcripts): 
    NM_001145770.2  NM_001145771.2  NM_001145773.2  NM_001145774.2  NM_001290142.1  NM_001290143.1  NM_001290144.1  NM_005682.6  
    NM_201524.3  NM_201525.3  NM_001145772.2  

    Unigene Cluster for GPR56:

    G protein-coupled receptor 56
    Hs.513633  [show with all ESTs]
    Unigene Representative Sequence: NM_001145774
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 82):
    ENST00000565587 ENST00000568791 ENST00000570044 ENST00000567553 ENST00000565314
    ENST00000564912 ENST00000562673 ENST00000564907(uc002ema.1) ENST00000568908(uc002emc.2 uc002emb.2)
    ENST00000568909 ENST00000566778 ENST00000562101 ENST00000561872 ENST00000561988
    ENST00000567835(uc002elz.1) ENST00000569372 ENST00000563548 ENST00000562003

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GPR56 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPR56 (see all 9):
    hsa-miR-4264 hsa-miR-1226 hsa-miR-1283 hsa-miR-139-5p hsa-miR-582-5p hsa-miR-889 hsa-miR-3662 hsa-miR-1264
    SwitchGear 3'UTR luciferase reporter plasmidGPR56 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GPR56
    Predesigned siRNA for gene silencing in human, mouse, rat GPR56
    Clone
    Products:
         
    OriGene clones in human, mouse for GPR56 (see all 45)
    OriGene ORF clones in mouse, rat for GPR56
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): GPR56 (NM_001145770)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR56
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR56
    Addgene plasmids for GPR56 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GPR56
    OriGene qSTAR qPCR primer pairs in human, mouse for GPR56
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPR56
      QuantiTect SYBR Green Assays in human, mouse, rat GPR56
      QuantiFast Probe-based Assays in human, mouse, rat GPR56

    Additional mRNA sequence: 

    AF106858.1 AJ011001.1 AK074399.1 AK075270.1 AK075555.1 AK131550.1 AK297236.1 AK299110.1 
    AK311156.1 AK312405.1 AL137591.1 AY358400.1 BC008770.2 BC013207.1 BT007311.1 CR936747.1 
    EU432119.1 

    58 DOTS entries (see top 24):

    DT.100828461  DT.102829807  DT.40261948  DT.120700158  DT.100703669  DT.40106998  DT.100839383  DT.120700101 
    DT.120700109  DT.95224953  DT.97856419  DT.100828453  DT.101984946  DT.91866185  DT.117472  DT.40130744 
    DT.120700143  DT.120700167  DT.100828467  DT.120700090  DT.120700146  DT.120700166  DT.95224951  DT.91987190 
    DT.100732088  DT.100828454  DT.120700150  DT.120700218  DT.120700152  DT.120700161  DT.120700232  DT.100828456 
    DT.100828459  DT.100828462  DT.120700147  DT.120700198  DT.95249852  DT.100703668  DT.100828457  DT.120700052 
    DT.120700053  DT.120700058  DT.120700066  DT.120700082  DT.120700093  DT.120700110  DT.120700162  DT.120700191 
    DT.120700210  DT.120700245  DT.91763943  DT.91763945  DT.91958552  DT.95080418  DT.95187381  DT.100828460 
    DT.120700049  DT.91763965 

    Selected AceView cDNA sequences (see all 501):

    BE909397 BQ684018 BI917073 BQ681051 AI339068 AL137591 BQ422555 BX386431 
    NM_201525 AL045034 AA478599 AI244106 AI282295 BQ940423 BF345756 BQ678891 
    BT007311 AI193397 BQ232308 BQ676571 BQ683897 F09191 AW024245 BE407124 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GPR56 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCATTGTAG
    GPR56 Expression
    About this image


    GPR56 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
             Floor plate-like cells
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
             N2/LSB/S/F8-induced cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    GPR56 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR56 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513633

    UniProtKB/Swiss-Prot: GPR56_HUMAN, Q9Y653
    Tissue specificity: Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a
    great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells

        Pathway & Disease-focused RT2 Profiler PCR Array including GPR56: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GPR56
    OriGene qSTAR qPCR primer pairs in human, mouse for GPR56
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPR56
    QuantiTect SYBR Green Assays in human, mouse, rat GPR56
    QuantiFast Probe-based Assays in human, mouse, rat GPR56
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR56

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for GPR56 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr561 , 5 G protein-coupled receptor 561, 5 81.64(n)1
    80.09(a)1
      8 (47.12 cM)5
    147661  NM_018882.31  NP_061370.21 
     949771095 
    chicken
    (Gallus gallus)
    Aves GPR561 G protein-coupled receptor 56 59.82(n)
    47.93(a)
      415633  XM_004944034.1  XP_004944091.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR566
    G protein-coupled receptor 56
    44(a)
    1 ↔ 1
    GL343677.1(121503-137573)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gpr561 G protein-coupled receptor 56 50.12(n)
    39.47(a)
      100490972  XM_002931653.2  XP_002931699.2 
    zebrafish
    (Danio rerio)
    Actinopterygii gpr566
    G protein-coupled receptor 56
    24(a)
    1 → many
    7(30006746-30032840) ENSDARG00000027222


    ENSEMBL Gene Tree for GPR56 (if available)
    TreeFam Gene Tree for GPR56 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GPR56 gene
    GPR972  CD972  ELTD12  LPHN22  LPHN12  GPR1142  EMR12  LPHN32  
    EMR22  GPR1332  GPR1122  GPR1442  EMR32  GPR1262  GPR642  
    3 SIMAP similar genes for GPR56 using alignment to 48 protein entries:     GPR56_HUMAN (see all proteins):
    GPR97    GPR114    KPG_006

    Find genes that share paralogs with GPR56           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GPR56 (see all 1283)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0262464
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0262462 R W mis40--------
    VAR_0695844
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0695842 L R mis40--------
    VAR_0695834
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0695832 E K mis40--------
    VAR_0262444
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0262442 C S mis40--------
    VAR_0262434
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0262432 Y C mis40--------
    VAR_0262454
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0262452 C S mis40--------
    VAR_0695814
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0695812 R Q mis40--------
    VAR_0262424
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0262422 R W mis40--------
    VAR_0695824
    Polymicrogyria, bilateral frontoparietal (BFPP)4--see VAR_0695822 W S mis40--------
    rs1219084621,2
    Cpathogenic158698765(+) GCCAGC/TGGAAC 16 R W mis11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for GPR56 (57644564 - 57698944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for GPR56:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714531CNV Deletion23290073
    esv2714530CNV Deletion23290073
    esv2714532CNV Deletion23290073
    nsv833246CNV Loss17160897
    nsv906725CNV Loss21882294
    esv259737OTHER Complex20981092

    Human Gene Mutation Database (HGMD): GPR56
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR56
    DNA2.0 Custom Variant and Variant Library Synthesis for GPR56

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604110   
    OMIM disorders: 606854  
    UniProtKB/Swiss-Prot: GPR56_HUMAN, Q9Y653
  • Polymicrogyria, bilateral frontoparietal (BFPP) [MIM:606854]: A malformation of the cortex in which the
    brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination, most
    severe in the frontoparietal regions. BFPP clinical manifestations include developmental and psychomotor delay,
    cerebellar and pyramidal signs, truncal ataxia, seizures, hyperreflexia. Polymicrogyria is a heterogeneous
    disorder, considered to be the result of postmigratory abnormal cortical organization. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 6 diseases for GPR56:    
    About MalaCards
    bilateral perisylvian polymicrogyria    polymicrogyria    bilateral frontoparietal polymicrogyria    neuronal migration disorders
    lennox-gastaut syndrome    periventricular nodular heterotopia

    3 diseases from the University of Copenhagen DISEASES database for GPR56:
    Periventricular nodular heterotopia     Lissencephaly     Focal epilepsy

    Find genes that share disorders with GPR56           About GenesLikeMe

    2 Novoseek inferred disease relationships for GPR56 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 9 15674329 (3), 17575113 (1)
    cancer 0 7 17575113 (4), 18378689 (1)

    GeneTests: GPR56
    GeneReviews: GPR56
    Genetic Association Database (GAD): GPR56
    Human Genome Epidemiology (HuGE) Navigator: GPR56 (1 document)

    Export disorders for GPR56 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GPR56 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with GPR56)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TM7XN1, a novel human EGF-TM7 like protein, detected with mRNA differential display using human melanoma cell lines with different metastatic potential. (PubMed id 10100861)1, 2, 3 Zendman A.J.W....van Muijen G.N.P. (FEBS Lett. 1999)
    2. GPR56, a novel secretin-like human G-protein-coupled receptor gene. (PubMed id 10049584)1, 2, 3 Liu M.... Herzog H. (Genomics 1999)
    3. Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association. (PubMed id 15004227)1, 2, 9 Little K.D.... Stipp C.S. (Mol. Biol. Cell 2004)
    4. Disease-associated mutations prevent GPR56-collagen III interaction. (PubMed id 22238662)1, 2 Luo R.... Piao X. (PLoS ONE 2012)
    5. The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity. (PubMed id 21708946)1, 2 Paavola K.J.... Hall R.A. (J. Biol. Chem. 2011)
    6. Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms. (PubMed id 21349848)1, 2 Chiang N.Y.... Lin H.H. (J. Biol. Chem. 2011)
    7. GPR56 Regulates VEGF production and angiogenesis during melanoma progression. (PubMed id 21724588)1, 2 Yang L.... Xu L. (Cancer Res. 2011)
    8. A novel GPR56 mutation causes bilateral frontoparietal polymicrogyria. (PubMed id 21723461)1, 2 Luo R.... Piao X. (Pediatr. Neurol. 2011)
    9. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    10. Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis. (PubMed id 19572147)1, 2 Kim J.E....Hwang J.I. (J. Cancer Res. Clin. Oncol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9289 HGNC: 4512 AceView: GPR56 Ensembl:ENSG00000205336 euGenes: HUgn9289
    ECgene: GPR56 H-InvDB: GPR56

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GPR56 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPR56 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=GPR56[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GPR56 gene:
    Search GeneIP for patents involving GPR56

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for GPR56 (GPR56)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for GPR56 (GPR56)   Browse Stem Cell Products  
     cDNA Clones for GPR56 (GPR56)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GPR56   OriGene RNAi products in human, mouse, rat for GPR56  
     OriGene qPCR primer pairs and template standards for GPR56   OriGene Protein Over-expression Lysate for GPR56  
     OriGene MassSpec something-or-other for GPR56   OriGene clones in human, mouse for GPR56  
     OriGene qSTAR qPCR primer pairs in human, mouse for GPR56   OriGene Purified Protein for GPR56  
     OriGene ORF clones in mouse, rat for GPR56   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GPR56   OriGene Custom Protein Services for GPR56  

     
     
     Block miRNA regulation of human, mouse, rat GPR56 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GPR56
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR56 Predesigned siRNA for gene silencing in human, mouse, rat GPR56
     QuantiFast Probe-based Assays in human, mouse, rat GPR56 QuantiTect SYBR Green Assays in human, mouse, rat GPR56
     PCR Arrays including human, mouse, rat GPR56 Search Chromatin IP Primers for GPR56
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPR56  GeneGlobe Interaction Network for GPR56
     Regulatory tfbs in GPR56 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GPR56 GenScript cDNA clones with any tag delivered in your preferred vector for GPR56
     GenScript Custom Assay Services for GPR56 GenScript Custom overexpressing Cell Line Services for GPR56
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GPR56
     Proteins for GPR56
     Cell Lysates for GPR56
     cDNA Clones for GPR56
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GPR56 antibodies
     GPR56 proteins
     GPR56 lysates
     Search for Antibodies for GPR56 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for GPR56
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GPR56
     Antibodies for GPR56
     ELISAs for GPR56
     CLIAs for GPR56



     Browse ESI BIO Cell Lines and PureStem Progenitors for GPR56
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR56
     SwitchGear 3'UTR luciferase reporter plasmids for GPR56
     SwitchGear Promoter luciferase reporter plasmids for GPR56
     ThermoFisher Antibodies for GPR56
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR56
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR56
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GPR56
     LSBio Antibodies in human, mouse, rat for GPR56
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for GPR56
      Search eBioscience for proteins for GPR56
      Search eBioscience for elisas for GPR56
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GPR56 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4