GPR56 Gene

Aliases
for GPR56 gene

Previous GC identifers: GC16P048070 GC16P057736 GC16P057388 GC16P057450 GC16P057429 GC16P056211 GC16P043521

Summaries
for GPR56 gene

Genomic Views
for GPR56 gene

RefSeq DNA sequence:

NC_000016.9  NC_018927.1  NT_010498.15  

SwitchGear Promoter luciferase reporter plasmids (see all 2): GPR56 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR56

GPR56 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057653:  view genomic region     (about GC identifiers)

Proteins
for GPR56 gene

Explore the universe of human proteins at neXtProt for GPR56: NX_Q9Y653

Post-translational modifications:

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	R&D Systems Recombinant & Natural Proteins for GPR56
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	OriGene Purified Proteins (see all 3): GPR56 OriGene Protein Over-expression Lysate (see all 2): GPR56 OriGene Custom Protein Services for GPR56
	GenScript Custom Purified and Recombinant Proteins Services for GPR56
	Novus Biologicals GPR56 Proteins Novus Biologicals GPR56 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for GPR56

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

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	Novus Biologicals GPR56 Antibodies
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	Uscn Antibodies for GPR56
	ThermoFisher Antibodies for GPR56

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for GPR56
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GPR56

Protein Domains /
Families
for GPR56 gene

ProtoNet protein and cluster: Q9Y653

Function
for GPR56 gene

miRNA Products:		miRTarBase miRNAs that target GPR56: hsa-let-7b (MIRT001629)
		OriGene 3'-UTR Clone (see all 8): GPR56 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPR56
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate GPR56 (see all 9):
		hsa-miR-4264 hsa-miR-1226 hsa-miR-1283 hsa-miR-139-5p hsa-miR-582-5p hsa-miR-889 hsa-miR-3662 hsa-miR-1264
		SwitchGear 3'UTR luciferase reporter plasmid: GPR56 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPR56 (see all 7) OriGene shRNA RFP: GPR56 OriGene siRNA: GPR56
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPR56

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for GPR56

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR56 (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR56 (see all 8) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 8): GPR56 (NM_001145770)
		Sino Biological Human cDNA Clone for GPR56
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR56
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR56

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GPR56
		Search LifeMap BioReagents cell lines for GPR56

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR56

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Gpr56)

Pathways & Interactions
for GPR56 gene

	Super-pathway	contained gene-specific pathways
1	GPCRs, Other	GPCRs, Other 1.00

1 BioSystems Pathway for GPR56

GPCRs, Other

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for GPR56 gene

Transcripts
for GPR56 gene

Expression
for GPR56 gene

GPR56 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCATTGTAG

10 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic Angioblasts			Endothelium
	Gut TubeHindgutHindgut Endoderm Cells			Endoderm
	Gut TubeMidgutMidgut Endoderm Cells			Endoderm
	OvaryAntral FollicleCumulus Cells			Ovary
	OvaryPrimary FollicleGranulosa Cells			Ovary
	OvaryPrimordial FolliclePre-Granulosa Cells			Ovary
	Gut TubeHindgut			Gut Tube
	Gut TubeMidgut			Gut Tube
	LiverLiver Lobule			Liver
	LungTrachea			Lung
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	N2/LSB/S/F8-induced cells (Generation of midbra...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR56 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPR56
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR56
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR56

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR56

Orthologs
for GPR56 gene

Paralogs
for GPR56 gene

Paralogs for GPR56 gene

GPR97²  ELTD1²  CD97²  LPHN1²  LPHN2²  GPR114²  EMR1²  LPHN3²  

EMR2²  GPR112²  GPR133²  GPR144²  EMR3²  GPR126²  GPR64²  

3 SIMAP similar genes for GPR56 using alignment to 49 protein entries:     GPR56_HUMAN (see all proteins):

GPR97    GPR114    KPG_006

GPR56 for paralogs           About GeneDecksing

Genomic Variants
for GPR56 gene

10/1041 NCBI SNPs in GPR56 are shown (see all 1041)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1219084621,2	C	pathogenic	43552800(+)	GCCAGC/TGGAAC	16	R W	mis1		1		NA	4552
rs735487801,2	C,F,	--	43519514(+)	AAGAGG/AGGCAA	2	--	us2k1		5		WA CSA NA	244
rs747656191,2		--	43520736(+)	TTGCCC/TGGATG	2	--	us2k1		2		CSA WA	120
rs762670191,2	F,	--	43520884(+)	ACAAGG/CAGTGA	2	--	us2k1		1		WA	118
rs771176341,2	C,F,	--	43521212(+)	GCCTGG/CACTGA	2	--	us2k1		3		NA CSA	124
rs752288621,2	C,F,	--	43521228(+)	GAGGCA/CGGAAG	2	--	us2k1		1		WA	118
rs24046901,2	C,F,H,	--	43521792(+)	CTGGGC/AGTCTC	2	--	int1		11		NS NA CSA WA	1050
rs794550061,2	F,	--	43521954(+)	GTGACG/ACCGCG	2	--	int1		1		WA	118
rs118637091,2	C,F,H,	--	43522166(+)	GGGGGC/TGTGCC	2	--	int1		5		WA NA CSA	244
rs118639331,2	C,F,H,	--	43522783(+)	GAAGGC/TGGCAT	2	--	int1		5		NS EA NA	412

HapMap Linkage Disequilibrium report for GPR56 (57644564 - 57698944 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GPR56
     1 CNV: 4958
Human Gene Mutation Database (HGMD): GPR56

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR56

DNA2.0 Custom Variant and Variant Library Synthesis for GPR56

Disorders / Diseases
for GPR56 gene

20 diseases for GPR56

2 Novoseek disease relationships for GPR56 gene    About this table

Publications
for GPR56 gene

PubMed articles for GPR56 gene, integrated from 9 sources (see all 47): (articles sorted by number of sources associating them with GPR56)

Utopia: connect your pdf to the dynamic world of online information

1. TM7XN1, a novel human EGF-TM7 like protein, detected with mRNA differential display using human melanoma cell lines with different metastatic potential. (PubMed id 10100861)^{1, 2, 3} Zendman A.J.W....van Muijen G.N.P. (1999)
2. GPR56, a novel secretin-like human G-protein-coupled receptor gene. (PubMed id 10049584)^{1, 2, 3} Liu M.... Herzog H. (1999)
3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. G protein-coupled receptor-dependent development of human frontal cortex. (PubMed id 15044805)^{1, 2} Piao X....Walsh C.A. (2004)
6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
7. GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion. (PubMed id 15674329)^{1, 9} Shashidhar S....Foehr E.D. (2005)
8. Bilateral frontoparietal polymicrogyria, Lennox-Gasta ut syndrome, and GPR56 gene mutations. (PubMed id 19016831)^{1, 9} Parrini E....Guerrini R. (2009)
9. Differential expression of G-protein coupled receptor 56 in human esophageal squamous cell carcinoma. (PubMed id 15916848)^{1, 9} Sud N....Ralhan R. (2006)
10. Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association. (PubMed id 15004227)^{1, 9} Little K.D....Stipp C.S. (2004)

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Products
for GPR56 gene