Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GPR55 Gene

protein-coding   GIFtS: 57
GCID: GC02M231736

G Protein-Coupled Receptor 55

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
G Protein-Coupled Receptor 551 2
G-Protein Coupled Receptor 552

External Ids:    HGNC: 45111   Entrez Gene: 92902   Ensembl: ENSG000001358987   OMIM: 6041075   UniProtKB: Q9Y2T63   

Export aliases for GPR55 gene to outside databases

Previous GC identifers: GC02M229835 GC02M230503 GC02M231974 GC02M231597 GC02M231480 GC02M223614


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GPR55 Gene:
This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely
cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a
variety of signal transduction pathways. (provided by RefSeq, Aug 2013)

GeneCards Summary for GPR55 Gene:
GPR55 (G protein-coupled receptor 55) is a protein-coding gene. GO annotations related to this gene include cannabinoid receptor activity and G-protein coupled receptor activity. An important paralog of this gene is GPR35.

UniProtKB/Swiss-Prot: GPR55_HUMAN, Q9Y2T6
Function: May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity).
Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the
heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by
regulating osteoclast number and function

summary for GPR55 Gene:
GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic
cannabinoids. Originally designated an orphan receptor, GPR55 is now thought to be a functional receptor
mediating the effects of ligands known to be inactive at CB1 and CB2, e.g. palmitoylethanolamide. GPR55
couples to Galpha13 and can mediate activation of the small G proteins rhoA, cdc42 and rac1. GPR55 mRNA is
expressed in the brain, most abundantly in the caudate nucleus and putamen, with lesser levels in the
hippocampus, thalamus, pons, cerebellum and frontal cortex. Peripherally, GPR55 mRNA is present in the
spleen, adrenals and parts of the gastrointestinal tract. Putative physiological roles of GPR55 include pain
signaling, control of vascular tone and inflammation. The human GPR55 receptor gene is localized to
chromosome 2q36.3.

Gene Wiki entry for GPR55 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR55 gene promoter:
         c-Fos   AP-1   AML1a   JunB   Fra-1   FosB   MEF-2A   JunD   c-Myb   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR55 promoter sequence
   Search Chromatin IP Primers for GPR55

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR55


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

GPR55 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR55 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M231736:  view genomic region     (about GC identifiers)

Start:
231,772,033 bp from pter      End:
231,825,781 bp from pter
Size:
53,749 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GPR55_HUMAN, Q9Y2T6 (See protein sequence)
Recommended Name: G-protein coupled receptor 55  
Size: 319 amino acids; 36637 Da
Miscellaneous: The classification of this protein as a cannabinoid receptor remains a contentious issue due to
conflicting pharmacological results
Sequence caution: Sequence=AAD22410.1; Type=Frameshift; Positions=132, 142;
Secondary accessions: Q8N580

Explore the universe of human proteins at neXtProt for GPR55: NX_Q9Y2T6

Explore proteomics data for GPR55 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn171
  • Modification sites at PhosphoSitePlus

  • See GPR55 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005674.2  
    ENSEMBL proteins: 
     ENSP00000410267   ENSP00000375893   ENSP00000412768   ENSP00000375894  
    Reactome Protein details: Q9Y2T6

    GPR55 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GPR55
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GPR55
    GenScript Custom Purified and Recombinant Proteins Services for GPR55
    Novus Biologicals GPR55 Protein
    Novus Biologicals GPR55 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPR55

     
    Search eBioscience for Proteins for GPR55 

     
    antibodies-online proteins for GPR55 

     
    Search antibodies-online for peptides for GPR55

    GPR55 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GPR55
    OriGene Custom Antibody Services for GPR55
    Novus Biologicals GPR55 Antibodies
    Search for Antibodies for GPR55 at Abcam
    Cloud-Clone Corp. Antibodies for GPR55
    ThermoFisher Antibodies for GPR55
    antibodies-online antibodies for GPR55 (29 products) 

    GPR55 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GPR55
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GPR55
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GPR55
    Cloud-Clone Corp. CLIAs for GPR55
    Search eBioscience for ELISAs for GPR55 
    antibodies-online kits for GPR55 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR55
    GPR18, GPR55 and GPR119
    Class A Orphans

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR028334 GPR55
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9Y2T6

    ProtoNet protein and cluster: Q9Y2T6

    UniProtKB/Swiss-Prot: GPR55_HUMAN, Q9Y2T6
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GPR55           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPR55_HUMAN, Q9Y2T6
    Function: May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity).
    Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the
    heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by
    regulating osteoclast number and function

         Genatlas biochemistry entry for GPR55:
    G protein coupled receptor 55,highly expressed in the caudate nucleus and putamen with homology to
    P2RY5,GPR23,GPR35,CCR4

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS9931487
    GO:0004949cannabinoid receptor activity IDA19723626
         
    Find genes that share ontologies with GPR55           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gpr55):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     normal  skeleton 

    Find genes that share phenotypes with GPR55           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GPR55: Gpr55tm1Lex Gpr55tm1.1Mijr Gpr55tm1Tigm

       genOway: Develop your customized and physiologically relevant rodent model for GPR55

    miRNA
    Products:
        
    miRTarBase miRNAs that target GPR55:
    hsa-mir-18a-3p (MIRT040844), hsa-mir-16-5p (MIRT051125), hsa-mir-92b-3p (MIRT040546)

    Block miRNA regulation of human, mouse, rat GPR55 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate GPR55:
    hsa-miR-525-5p hsa-miR-520a-5p hsa-miR-3182 hsa-miR-4301
    SwitchGear 3'UTR luciferase reporter plasmidGPR55 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GPR55
    Predesigned siRNA for gene silencing in human, mouse, rat GPR55

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GPR55

    Clone
    Products:
         
    OriGene clones in human, mouse for GPR55 (see all 7)
    OriGene ORF clones in mouse, rat for GPR55
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPR55 (NM_005683)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR55
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR55

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GPR55
    Browse ESI BIO Cell Lines and PureStem Progenitors for GPR55 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR55


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GPR55_HUMAN, Q9Y2T6: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA18757503
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with GPR55           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GPR55 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    3GPCRs, Other
    GPCRs, Other


    Find genes that share SuperPaths with GPR55           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GPR55
        GPCRs, Other

    2 Reactome Pathways for GPR55
        G alpha (i) signalling events
    Class A/1 (Rhodopsin-like receptors)


        Pathway & Disease-focused RT2 Profiler PCR Array including GPR55: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPR55

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPR55 (ENSP000003758934) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADRA2AENSP000002801554STRING: ENSP00000280155
    DRD2ENSP000003548594STRING: ENSP00000354859
    GPR18ENSP000003434284STRING: ENSP00000343428
    HCAR2ENSP000003750664STRING: ENSP00000375066
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9931487
    GO:0007202activation of phospholipase C activity IDA18757503
    GO:0035025positive regulation of Rho protein signal transduction IDA18757503
    GO:0038171cannabinoid signaling pathway IDA19723626
    GO:0045453bone resorption IDA19805329

    Find genes that share ontologies with GPR55           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GPR55 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    O-1602Potent GPR55 receptor agonist[317321-41-8]
    Abn-CBDSelective GPR55 agonist; neurobehaviorally inactive[22972-55-0]
    OleylethanolamideGPR55 agonist. Also PPARalpha agonist[111-58-0]

    Selected IUPHAR Ligands for GPR55 (GPR55) (see all 28)    About this table
    LigandTypeActionAffinityPubmed IDs
    O-1602
    AgonistAgonist7.89 - 8.8517876302 10381763 21079038
    2-arachidonoylglycerol
    AgonistAgonist8.5217876302
    AM281
    AntagonistAntagonist7.87 - 8.5217876302 20136841
    JWH015
    AgonistAgonist8.417876302
    palmitoylethanolamide
    AgonistAgonist8.417876302
    CP55940
    AgonistAgonist8.317876302 16318877
    CP55,244
    AgonistInverse agonist8.321233197
    GSK494581A
    AgonistAgonist8.1921233197
    GSK575594A
    AgonistAgonist8.1721233197
    Delta9-tetrahydrocannabinol
    AgonistAgonist8.117876302



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GPR55 gene: 
    NM_005683.3  

    Unigene Cluster for GPR55:

    G protein-coupled receptor 55
    Hs.114545  [show with all ESTs]
    Unigene Representative Sequence: NM_005683
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444078(uc002vrf.3 uc010fxs.1) ENST00000392039 ENST00000438398
    ENST00000392040(uc002vrg.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GPR55 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate GPR55:
    hsa-miR-525-5p hsa-miR-520a-5p hsa-miR-3182 hsa-miR-4301
    SwitchGear 3'UTR luciferase reporter plasmidGPR55 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GPR55
    Predesigned siRNA for gene silencing in human, mouse, rat GPR55
    Clone
    Products:
         
    OriGene clones in human, mouse for GPR55 (see all 7)
    OriGene ORF clones in mouse, rat for GPR55
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPR55 (NM_005683)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR55
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR55
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GPR55
    OriGene qSTAR qPCR primer pairs in human, mouse for GPR55
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPR55
      QuantiTect SYBR Green Assays in human, mouse, rat GPR55
      QuantiFast Probe-based Assays in human, mouse, rat GPR55

    Additional mRNA sequence: 

    AK292223.1 BC032694.1 CR541776.1 FJ348259.1 

    5 DOTS entries:

    DT.40225833  DT.100009397  DT.308450  DT.121016254  DT.97806725 

    21 AceView cDNA sequences:

    BC032694 AW136557 NM_005683 AW136559 AA033905 CR541776 AA352856 BI836584 
    AA778763 AA034005 AV690424 BF056844 N58443 AV686713 AL703806 AI205505 
    BQ710959 AI918782 AI825790 AI699536 AI631719 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GPR55 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGCCTTG
    GPR55 Expression
    About this image

    GPR55 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR55 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.114545

    UniProtKB/Swiss-Prot: GPR55_HUMAN, Q9Y2T6
    Tissue specificity: Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus,
    pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts

        Pathway & Disease-focused RT2 Profiler PCR Array including GPR55: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GPR55
    OriGene qSTAR qPCR primer pairs in human, mouse for GPR55
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPR55
    QuantiTect SYBR Green Assays in human, mouse, rat GPR55
    QuantiFast Probe-based Assays in human, mouse, rat GPR55
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR55

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for GPR55 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr551 , 5 G protein-coupled receptor 551, 5 81.22(n)1
    77.53(a)1
      1 (43.94 cM)5
    2273261  NM_001033290.21  NP_001028462.21 
     859395375 
    chicken
    (Gallus gallus)
    Aves GPR551 G protein-coupled receptor 55 59.72(n)
    47.7(a)
      770641  XM_001233976.3  XP_001233977.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004904181 G-protein coupled receptor 55-like 54.22(n)
    47(a)
      100490418  XM_002933369.2  XP_002933415.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7939091 G-protein coupled receptor 55-like 54.33(n)
    44.13(a)
      793909  XM_005163567.1  XP_005163624.1 


    ENSEMBL Gene Tree for GPR55 (if available)
    TreeFam Gene Tree for GPR55 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GPR55 gene
    GPR352  GPR182  
    6 SIMAP similar genes for GPR55 using alignment to 3 protein entries:     GPR55_HUMAN (see all proteins):
    LPAR4    KPG_007    KPG_010    LPAR5    GPR35    LPAR6

    Find genes that share paralogs with GPR55           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GPR55 (see all 460)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563181831,2
    C--223633778(+) TTTTT-/T/TT  
            
    GATAC
    1 -- us2k11NA 2
    rs1825370451,2
    --231771571(+) TAGAGA/GCTGGC 1 -- ds50010--------
    rs1482983681,2
    --231771813(+) AGCACC/TCGTGT 1 -- ds50010--------
    rs597910031,2
    C,F--231771832(+) GGGAGT/CGGAAA 1 -- ds500111Minor allele frequency- C:0.46WA NA CSA EA 373
    rs597525431,2
    C,F--231771886(+) AGCTGT/GGCTCC 1 -- ds50011Minor allele frequency- G:0.07WA 118
    rs586279931,2
    C,F--231771924(+) CCCACA/GCTTGG 1 -- ds50012Minor allele frequency- G:0.20WA 120
    rs787082941,2
    C,F--231771991(+) TGGGGC/TCTGCT 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1123436681,2
    C,F--231771994(+) GGCCTG/CCTCTT 1 -- ds50012Minor allele frequency- C:0.10CSA WA 120
    rs19921881,2
    C,F,A,H--231772436(-) GAGGAC/ACTGAT 1 -- ut31116Minor allele frequency- A:0.40NS EA NA PA EU CA WA CSA 8737
    rs1868159701,2
    --231772479(+) GAGAGC/TCATGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GPR55 (231772033 - 231825781 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GPR55:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470522CNV Loss18288195
    nsv875956CNV Gain21882294
    nsv834565CNV Gain17160897

    Human Gene Mutation Database (HGMD): GPR55
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR55
    DNA2.0 Custom Variant and Variant Library Synthesis for GPR55

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604107    OMIM disorders: --


    Find genes that share disorders with GPR55           About GenesLikeMe

    Genetic Association Database (GAD): GPR55
    Human Genome Epidemiology (HuGE) Navigator: GPR55 (4 documents)

    Export disorders for GPR55 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GPR55 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with GPR55)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. (PubMed id 9931487)1, 2, 3 Sawzdargo M.... O'Dowd B.F. (Brain Res. Mol. Brain Res. 1999)
    2. The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA- dependent Ca2+ signaling and NFAT activation. (PubMed id 18757503)1, 2, 9 Henstridge C.M....Irving A.J. (FASEB J. 2009)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. (PubMed id 19805329)1, 2 Whyte L.S.... Rogers M.J. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    5. Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. (PubMed id 19723626)1, 2 Kapur A....Abood M.E. (J. Biol. Chem. 2009)
    6. Identification of GPR55 as a lysophosphatidylinositol receptor. (PubMed id 17765871)1, 2 Oka S.... Sugiura T. (Biochem. Biophys. Res. Commun. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors. (PubMed id 22820167)1 Zhao P. and Abood M.E. (Life Sci. 2013)
    9. A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. (PubMed id 23639801)1 Kargl J....Heinemann A. (J. Pharmacol. Exp. Ther. 2013)
    10. A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice. (PubMed id 23603203)1 Li K....Storr M. (Neuropharmacology 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9290 HGNC: 4511 AceView: GPR55 Ensembl:ENSG00000135898 euGenes: HUgn9290
    ECgene: GPR55 H-InvDB: GPR55

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GPR55 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GPR55 gene:
    Search GeneIP for patents involving GPR55

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for GPR55 (GPR55)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GPR55   OriGene RNAi products in human, mouse, rat for GPR55  
     OriGene qPCR primer pairs and template standards for GPR55   OriGene Protein Over-expression Lysate for GPR55  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GPR55  
     OriGene qSTAR qPCR primer pairs in human, mouse for GPR55   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GPR55   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GPR55   OriGene Custom Protein Services for GPR55  

     
     
     Block miRNA regulation of human, mouse, rat GPR55 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GPR55
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR55 Predesigned siRNA for gene silencing in human, mouse, rat GPR55
     QuantiFast Probe-based Assays in human, mouse, rat GPR55 QuantiTect SYBR Green Assays in human, mouse, rat GPR55
     PCR Arrays including human, mouse, rat GPR55 Search Chromatin IP Primers for GPR55
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPR55  Search GeneGlobe Interaction Network for GPR55
     Regulatory tfbs in GPR55 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GPR55 GenScript cDNA clones with any tag delivered in your preferred vector for GPR55
     GenScript Custom Assay Services for GPR55 GenScript Custom overexpressing Cell Line Services for GPR55
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for GPR55
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GPR55 antibodies
     GPR55 proteins
     GPR55 lysates
     Search for Antibodies for GPR55 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for GPR55
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GPR55
     Antibodies for GPR55
     ELISAs for GPR55
     CLIAs for GPR55



     Browse ESI BIO Cell Lines and PureStem Progenitors for GPR55
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR55
     SwitchGear 3'UTR luciferase reporter plasmids for GPR55
     SwitchGear Promoter luciferase reporter plasmids for GPR55
     ThermoFisher Antibodies for GPR55
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR55
     Browse compounds at ApexBio
     Search Addgene for plasmids for GPR55
      Search eBioscience for proteins for GPR55
      Search eBioscience for elisas for GPR55
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for GPR55
     antibodies-online antibodies for GPR55 (29 products)
     antibodies-online kits for GPR55 (4 products)
      Search antibodies-online for peptides for GPR55
     antibodies-online proteins for GPR55
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GPR55 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4