External Ids for GPR55 Gene
Previous GeneCards Identifiers for GPR55 Gene
This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]
GeneCards Summary for GPR55 Gene
GPR55 (G Protein-Coupled Receptor 55) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is GPR35.
UniProtKB/Swiss-Prot for GPR55 Gene
May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.
GPR55 is a non-CB1/CB2 receptor that exhibits affinity for endogenous, plant and synthetic cannabinoids. Originally designated an orphan receptor, GPR55 is now thought to be a functional receptor mediating the effects of ligands known to be inactive at CB1 and CB2.