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Aliases for GPR55 Gene

Aliases for GPR55 Gene

  • G Protein-Coupled Receptor 55 2 3
  • LPIR1 3

External Ids for GPR55 Gene

Previous GeneCards Identifiers for GPR55 Gene

  • GC02M229835
  • GC02M230503
  • GC02M231736
  • GC02M231974
  • GC02M231597
  • GC02M231480
  • GC02M223614

Summaries for GPR55 Gene

Entrez Gene Summary for GPR55 Gene

  • This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]

GeneCards Summary for GPR55 Gene

GPR55 (G Protein-Coupled Receptor 55) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is GPR35.

UniProtKB/Swiss-Prot for GPR55 Gene

  • May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.

Tocris Summary for GPR55 Gene

  • GPR55 is a non-CB1/CB2 receptor that exhibits affinity for endogenous, plant and synthetic cannabinoids. Originally designated an orphan receptor, GPR55 is now thought to be a functional receptor mediating the effects of ligands known to be inactive at CB1 and CB2.

Gene Wiki entry for GPR55 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR55 Gene

Genomics for GPR55 Gene

Regulatory Elements for GPR55 Gene

Genomic Location for GPR55 Gene

Chromosome:
2
Start:
230,907,318 bp from pter
End:
230,961,227 bp from pter
Size:
53,910 bases
Orientation:
Minus strand

Genomic View for GPR55 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR55 Gene

Proteins for GPR55 Gene

  • Protein details for GPR55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2T6-GPR55_HUMAN
    Recommended name:
    G-protein coupled receptor 55
    Protein Accession:
    Q9Y2T6
    Secondary Accessions:
    • Q8N580

    Protein attributes for GPR55 Gene

    Size:
    319 amino acids
    Molecular mass:
    36637 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results
    SequenceCaution:
    • Sequence=AAD22410.1; Type=Frameshift; Positions=132, 142; Evidence={ECO:0000305};

neXtProt entry for GPR55 Gene

Proteomics data for GPR55 Gene at MOPED

Post-translational modifications for GPR55 Gene

  • Glycosylation at Asn 5 and Asn 171
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR55 Gene

No data available for DME Specific Peptides for GPR55 Gene

Domains & Families for GPR55 Gene

Gene Families for GPR55 Gene

Protein Domains for GPR55 Gene

Suggested Antigen Peptide Sequences for GPR55 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2T6

UniProtKB/Swiss-Prot:

GPR55_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR55: view

Function for GPR55 Gene

Molecular function for GPR55 Gene

GENATLAS Biochemistry:
G protein coupled receptor 55,highly expressed in the caudate nucleus and putamen with homology to P2RY5,GPR23,GPR35,CCR4
UniProtKB/Swiss-Prot Function:
May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.

Gene Ontology (GO) - Molecular Function for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 9931487
GO:0004949 cannabinoid receptor activity IDA 19723626
genes like me logo Genes that share ontologies with GPR55: view
genes like me logo Genes that share phenotypes with GPR55: view

Animal Models for GPR55 Gene

MGI Knock Outs for GPR55:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR55

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GPR55 Gene

Localization for GPR55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR55 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR55 Gene COMPARTMENTS Subcellular localization image for GPR55 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 18757503
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR55: view

Pathways & Interactions for GPR55 Gene

genes like me logo Genes that share pathways with GPR55: view

Pathways by source for GPR55 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Interacting Proteins for GPR55 Gene

Gene Ontology (GO) - Biological Process for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 9931487
GO:0007202 activation of phospholipase C activity IDA 18757503
GO:0035025 positive regulation of Rho protein signal transduction IDA 18757503
GO:0038171 cannabinoid signaling pathway IDA 19723626
GO:0045453 bone resorption IDA 19805329
genes like me logo Genes that share ontologies with GPR55: view

No data available for SIGNOR curated interactions for GPR55 Gene

Drugs & Compounds for GPR55 Gene

(28) Drugs for GPR55 Gene - From: IUPHAR, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rimonabant Approved, Investigational Pharma Antagonist, antagonist CB1 receptor antagonist 45
O-1602 Pharma Agonist Potent GPR55 receptor agonist 0
[<sup>3</sup>H]CP55940 Pharma Full agonist, Agonist 0
[<sup>3</sup>H]rimonabant Pharma Partial agonist, Agonist 0
2-arachidonoylglycerol Pharma Partial agonist, Agonist 0

(7) Additional Compounds for GPR55 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Channel blocker
oleoylethanolamide
Agonist
Palmitoylethanolamide
  • Loramine P 256
  • Monoethanolamine palmitic acid amide
  • N-(2-Hydroxyethyl)hexadecanamide
  • N-Hexadecyl-ethanolamine
  • Palmidrol
Agonist 544-31-0
Abn-CBD
22972-55-0
CID 16020046
834903-43-4
genes like me logo Genes that share compounds with GPR55: view

Transcripts for GPR55 Gene

Unigene Clusters for GPR55 Gene

G protein-coupled receptor 55:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR55

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR55 Gene

No ASD Table

Relevant External Links for GPR55 Gene

GeneLoc Exon Structure for
GPR55
ECgene alternative splicing isoforms for
GPR55

Expression for GPR55 Gene

mRNA expression in normal human tissues for GPR55 Gene

mRNA differential expression in normal tissues according to GTEx for GPR55 Gene

This gene is overexpressed in Testis (x5.5) and Spleen (x4.2).

SOURCE GeneReport for Unigene cluster for GPR55 Gene Hs.114545

mRNA Expression by UniProt/SwissProt for GPR55 Gene

Q9Y2T6-GPR55_HUMAN
Tissue specificity: Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts.
genes like me logo Genes that share expression patterns with GPR55: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR55 Gene

Orthologs for GPR55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR55 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR55 35
  • 83.07 (n)
  • 79.94 (a)
GPR55 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR55 35
  • 85.16 (n)
  • 84.95 (a)
GPR55 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr55 35
  • 81.22 (n)
  • 77.53 (a)
Gpr55 16
Gpr55 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR55 35
  • 98.64 (n)
  • 99.37 (a)
GPR55 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr55 35
  • 79.96 (n)
  • 75 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR55 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR55 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR55 35
  • 59.72 (n)
  • 47.7 (a)
GPR55 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490418 35
  • 54.22 (n)
  • 47 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC793909 35
  • 54.33 (n)
  • 44.13 (a)
gpr55a 36
  • 28 (a)
OneToOne
Species with no ortholog for GPR55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR55 Gene

ENSEMBL:
Gene Tree for GPR55 (if available)
TreeFam:
Gene Tree for GPR55 (if available)

Paralogs for GPR55 Gene

Paralogs for GPR55 Gene

(6) SIMAP similar genes for GPR55 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPR55: view

Variants for GPR55 Gene

Sequence variations from dbSNP and Humsavar for GPR55 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs732065 -- 230,941,502(+) GTGTG(C/G)CCACC intron-variant
rs747882 -- 230,942,466(+) AGGAC(A/G)TTTTG intron-variant
rs755434 -- 230,941,421(+) CCCCC(A/G/T)CTCCC intron-variant
rs755435 -- 230,941,507(+) CCCAC(A/C)ACTTC intron-variant
rs934825 -- 230,941,586(+) GATGC(C/T)GTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR55 Gene

Variant ID Type Subtype PubMed ID
nsv834565 CNV Gain 17160897
nsv470522 CNV Loss 18288195
nsv875956 CNV Gain 21882294

Variation tolerance for GPR55 Gene

Residual Variation Intolerance Score: 48.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.32; 81.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR55 Gene

HapMap Linkage Disequilibrium report
GPR55
Human Gene Mutation Database (HGMD)
GPR55

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR55 Gene

Disorders for GPR55 Gene

Relevant External Links for GPR55

Genetic Association Database (GAD)
GPR55
Human Genome Epidemiology (HuGE) Navigator
GPR55
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR55
genes like me logo Genes that share disorders with GPR55: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR55 Gene

Publications for GPR55 Gene

  1. The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA- dependent Ca2+ signaling and NFAT activation. (PMID: 18757503) Henstridge C.M. … Irving A.J. (FASEB J. 2009) 23 67
  2. Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. (PMID: 9931487) Sawzdargo M. … O'Dowd B.F. (Brain Res. Mol. Brain Res. 1999) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. GPR55: from orphan to metabolic regulator? (PMID: 24972076) Liu B. … Persaud S.J. (Pharmacol. Ther. 2015) 67
  5. Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors. (PMID: 25233417) Ruban E.L. … Falasca M. (Biochem. Soc. Trans. 2014) 67

Products for GPR55 Gene

Sources for GPR55 Gene

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