External Ids for GPR50 Gene
Previous GeneCards Identifiers for GPR50 Gene
This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
GeneCards Summary for GPR50 Gene
GPR50 (G Protein-Coupled Receptor 50) is a Protein Coding gene. Diseases associated with GPR50 include major depressive disorder and accelerated response to antidepressant drug treatment. Among its related pathways are Peptide ligand-binding receptors and Eicosanoid ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and melatonin receptor activity. An important paralog of this gene is MTNR1B.
UniProtKB/Swiss-Prot for GPR50 Gene
Does not bind melatonin.