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Aliases for GPR50 Gene

Aliases for GPR50 Gene

  • G Protein-Coupled Receptor 50 2 3 4 5
  • H9 3 4
  • Mel1c 3

External Ids for GPR50 Gene

Previous GeneCards Identifiers for GPR50 Gene

  • GC0XP144664
  • GC0XP147028
  • GC0XP148116
  • GC0XP148985
  • GC0XP150015
  • GC0XP150095
  • GC0XP150345
  • GC0XP139205

Summaries for GPR50 Gene

Entrez Gene Summary for GPR50 Gene

  • This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]

GeneCards Summary for GPR50 Gene

GPR50 (G Protein-Coupled Receptor 50) is a Protein Coding gene. Diseases associated with GPR50 include Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment. Among its related pathways are Glucose / Energy Metabolism and Ca, cAMP and Lipid Signaling. GO annotations related to this gene include G-protein coupled receptor activity and melatonin receptor activity. An important paralog of this gene is MTNR1B.

UniProtKB/Swiss-Prot for GPR50 Gene

  • Does not bind melatonin.

Gene Wiki entry for GPR50 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR50 Gene

Genomics for GPR50 Gene

Regulatory Elements for GPR50 Gene

Enhancers for GPR50 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR50 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR50 Gene

151,176,584 bp from pter
151,182,855 bp from pter
6,272 bases
Plus strand

Genomic View for GPR50 Gene

Genes around GPR50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR50 Gene

Proteins for GPR50 Gene

  • Protein details for GPR50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melatonin-related receptor
    Protein Accession:
    Secondary Accessions:
    • Q0VGG3
    • Q3ZAR0

    Protein attributes for GPR50 Gene

    617 amino acids
    Molecular mass:
    67369 Da
    Quaternary structure:
    • Homodimer, and heterodimer with MTNR1A and MTNR1B.

neXtProt entry for GPR50 Gene

Proteomics data for GPR50 Gene at MOPED

Post-translational modifications for GPR50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR50 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GPR50 (GPR50)
  • Santa Cruz Biotechnology (SCBT) Antibodies for GPR50

No data available for DME Specific Peptides for GPR50 Gene

Domains & Families for GPR50 Gene

Gene Families for GPR50 Gene

Suggested Antigen Peptide Sequences for GPR50 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR50: view

Function for GPR50 Gene

Molecular function for GPR50 Gene

GENATLAS Biochemistry:
melatonin-related receptor,G protein coupled receptor,expressed in hypothalamus and pituitary,potentially involved in neuroendocrine function
UniProtKB/Swiss-Prot Function:
Does not bind melatonin.

Gene Ontology (GO) - Molecular Function for GPR50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16778767
genes like me logo Genes that share ontologies with GPR50: view
genes like me logo Genes that share phenotypes with GPR50: view

Animal Models for GPR50 Gene

MGI Knock Outs for GPR50:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR50

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR50 Gene

Localization for GPR50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR50 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR50 Gene COMPARTMENTS Subcellular localization image for GPR50 gene
Compartment Confidence
plasma membrane 5
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for GPR50 Gene

Pathways & Interactions for GPR50 Gene

genes like me logo Genes that share pathways with GPR50: view

Pathways by source for GPR50 Gene

3 Cell Signaling Technology pathways for GPR50 Gene
2 BioSystems pathways for GPR50 Gene
1 KEGG pathway for GPR50 Gene

Gene Ontology (GO) - Biological Process for GPR50 Gene


No data available for SIGNOR curated interactions for GPR50 Gene

Drugs & Compounds for GPR50 Gene

(1) Drugs for GPR50 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GPR50 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPR50: view

Transcripts for GPR50 Gene

mRNA/cDNA for GPR50 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR50 Gene

G protein-coupled receptor 50:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR50 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b

Relevant External Links for GPR50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR50 Gene

mRNA expression in normal human tissues for GPR50 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR50 Gene

This gene is overexpressed in Pituitary (x47.1).

Protein differential expression in normal tissues from HIPED for GPR50 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR50 Gene

SOURCE GeneReport for Unigene cluster for GPR50 Gene Hs.567390

mRNA Expression by UniProt/SwissProt for GPR50 Gene

Tissue specificity: Hypothalamus and pituitary.
genes like me logo Genes that share expression patterns with GPR50: view

Protein tissue co-expression partners for GPR50 Gene

Primer Products

Orthologs for GPR50 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR50 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR50 35
  • 82.89 (n)
  • 79.61 (a)
GPR50 36
  • 77 (a)
(Canis familiaris)
Mammalia GPR50 35
  • 87.1 (n)
  • 85.08 (a)
GPR50 36
  • 82 (a)
(Mus musculus)
Mammalia Gpr50 35
  • 82.14 (n)
  • 77.32 (a)
Gpr50 16
Gpr50 36
  • 70 (a)
(Pan troglodytes)
Mammalia GPR50 35
  • 98.92 (n)
  • 97.24 (a)
GPR50 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Gpr50 35
  • 81.3 (n)
  • 77.06 (a)
(Monodelphis domestica)
Mammalia GPR50 36
  • 42 (a)
(Gallus gallus)
Aves -- 36
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
(Danio rerio)
Actinopterygii mtnr1al 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30340 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea npr-35 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
CSA.5131 36
  • 17 (a)
Species with no ortholog for GPR50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GPR50 Gene

Gene Tree for GPR50 (if available)
Gene Tree for GPR50 (if available)

Paralogs for GPR50 Gene

Paralogs for GPR50 Gene

(9) SIMAP similar genes for GPR50 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPR50: view

Variants for GPR50 Gene

Sequence variations from dbSNP and Humsavar for GPR50 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs561077 - 151,181,177(+) AGCCC(A/G)CTGCT reference, missense
rs13440581 - 151,181,399(+) TGGTT(A/G)TTGAT reference, missense
rs747785501 -- 151,181,041(+) GGCAG(C/G)CACTC reference, missense
rs747834622 -- 151,180,888(+) TCTGC(A/C)ACTGT reference, synonymous-codon
rs747935324 -- 151,182,476(+) GAATT(C/G)AATAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR50 Gene

Variant ID Type Subtype PubMed ID
nsv7152 CNV Loss 18451855
dgv1406e199 CNV Deletion 23128226

Variation tolerance for GPR50 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR50 Gene

Disorders for GPR50 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR50 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search GPR50 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR50

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR50: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR50 Gene

Publications for GPR50 Gene

  1. Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels. (PMID: 16436372) Bhattacharyya S. … O'Rahilly S. (J. Lipid Res. 2006) 3 4 23 48 67
  2. Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). (PMID: 9933574) Gubitz A.K. … Reppert S.M. (Genomics 1999) 2 3 23
  3. Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population. (PMID: 20371266) Macintyre D.J. … Blackwood D.H. (Neurosci. Lett. 2010) 3 23
  4. Mutation screening of melatonin-related genes in patients with autism spectrum disorders. (PMID: 20377855) Jonsson L. … Melke J. (BMC Med Genomics 2010) 3 23
  5. GPR50 is the mammalian ortholog of Mel1c: evidence of rapid evolution in mammals. (PMID: 18400093) Dufourny L. … Monget P. (BMC Evol. Biol. 2008) 2 3

Products for GPR50 Gene

Sources for GPR50 Gene