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Aliases for GPR45 Gene

Aliases for GPR45 Gene

  • G Protein-Coupled Receptor 45 2 3 5
  • PSP24-Alpha 3 4
  • PSP24-1 3 4
  • High-Affinity Lysophosphatidic Acid Receptor 3
  • Probable G-Protein Coupled Receptor 45 3
  • PSP24(ALPHA) 3
  • PSP24A 3
  • PSP24 3

External Ids for GPR45 Gene

Previous GeneCards Identifiers for GPR45 Gene

  • GC02P103722
  • GC02P104310
  • GC02P105462
  • GC02P105479
  • GC02P105316
  • GC02P105224
  • GC02P105858
  • GC02P099627

Summaries for GPR45 Gene

Entrez Gene Summary for GPR45 Gene

  • This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR45 Gene

GPR45 (G Protein-Coupled Receptor 45) is a Protein Coding gene. Among its related pathways are G alpha (s) signalling events and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR63.

UniProtKB/Swiss-Prot for GPR45 Gene

  • Orphan receptor. May play a role in brain function.

Gene Wiki entry for GPR45 Gene

Additional gene information for GPR45 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR45 Gene

Genomics for GPR45 Gene

Regulatory Elements for GPR45 Gene

Enhancers for GPR45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H104847 0.9 FANTOM5 dbSUPER 16.9 -394.6 -394619 0.3 PKNOX1 MXI1 POLR2A SUZ12 CREB1 EZH2 GPR45 POU3F3 LINC01158 GC02M104827
GH02H104848 1.6 VISTA FANTOM5 dbSUPER 7.1 -391.9 -391939 2.6 CTCF PKNOX1 MXI1 FEZF1 RAD21 ETS1 CTBP1 POLR2A ZNF366 SMC3 POU3F3 GPR45 LINC01158 GC02M104827
GH02H104844 1 FANTOM5 dbSUPER 9.1 -397.1 -397062 0.4 CTCF MXI1 L3MBTL2 SUZ12 ZBTB8A ZNF501 ZNF398 ZFHX2 GLIS2 POLR2A POU3F3 GPR45 LINC01158 GC02M104827
GH02H105143 0.8 ENCODE 11 -97.9 -97919 0.6 PKNOX1 KLF1 SUZ12 ZNF76 CEBPG NFXL1 ZFHX2 GLIS2 ZNF366 POLR2A GPR45 LINC01918 LOC105373528
GH02H105129 0.7 ENCODE 11.3 -111.8 -111846 0.1 BMI1 EED ATF7 ETV6 RUNX3 IKZF2 CREM NR2F1 CBFB TRIM22 GPR45 LINC01918 LOC105373527
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR45 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GPR45 Gene

Genomic Locations for GPR45 Gene
1,725 bases
Plus strand

Genomic View for GPR45 Gene

Genes around GPR45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR45 Gene

Proteins for GPR45 Gene

  • Protein details for GPR45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 45
    Protein Accession:
    Secondary Accessions:
    • Q6NWS4
    • Q6NXU6

    Protein attributes for GPR45 Gene

    372 amino acids
    Molecular mass:
    41967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR45 Gene

Post-translational modifications for GPR45 Gene

  • Glycosylation at isoforms=4, posLast=1717, and posLast=2020
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR45 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR45 Gene

Domains & Families for GPR45 Gene

Gene Families for GPR45 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR45 Gene

Suggested Antigen Peptide Sequences for GPR45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR45: view

Function for GPR45 Gene

Molecular function for GPR45 Gene

GENATLAS Biochemistry:
G protein coupled receptor 45,X Laevis oocyte lysophosphatidic acid receptor homolog,expressed in the brain (basal forebrain,frontal cortex,and caudate) and in the liver
UniProtKB/Swiss-Prot Function:
Orphan receptor. May play a role in brain function.

Phenotypes From GWAS Catalog for GPR45 Gene

Gene Ontology (GO) - Molecular Function for GPR45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with GPR45: view
genes like me logo Genes that share phenotypes with GPR45: view

Animal Model Products

Clone Products

  • Addgene plasmids for GPR45

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR45 Gene

Localization for GPR45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR45 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR45 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR45: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR45 Gene

Pathways & Interactions for GPR45 Gene

genes like me logo Genes that share pathways with GPR45: view

Pathways by source for GPR45 Gene

Interacting Proteins for GPR45 Gene

Gene Ontology (GO) - Biological Process for GPR45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR45: view

No data available for SIGNOR curated interactions for GPR45 Gene

Drugs & Compounds for GPR45 Gene

No Compound Related Data Available

Transcripts for GPR45 Gene

mRNA/cDNA for GPR45 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR45 Gene

G protein-coupled receptor 45:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR45

Alternative Splicing Database (ASD) splice patterns (SP) for GPR45 Gene

No ASD Table

Relevant External Links for GPR45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR45 Gene

mRNA differential expression in normal tissues according to GTEx for GPR45 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.3), Brain - Cortex (x5.0), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of GPR45 Gene:


SOURCE GeneReport for Unigene cluster for GPR45 Gene:


mRNA Expression by UniProt/SwissProt for GPR45 Gene:

Tissue specificity: Expressed in brain; detected in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen.
genes like me logo Genes that share expression patterns with GPR45: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR45 Gene

Orthologs for GPR45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR45 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR45 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia GPR45 33 34
  • 88.98 (n)
(Rattus norvegicus)
Mammalia Gpr45 33
  • 85.66 (n)
(Mus musculus)
Mammalia Gpr45 33 16 34
  • 85.22 (n)
(Bos Taurus)
Mammalia GPR45 33 34
  • 83.15 (n)
(Monodelphis domestica)
Mammalia GPR45 34
  • 74 (a)
(Anolis carolinensis)
Reptilia GPR45 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr45 33
  • 66.22 (n)
African clawed frog
(Xenopus laevis)
Amphibia lpar-A-prov 33
(Danio rerio)
Actinopterygii si:dkeyp-118h3.5 33
  • 63.69 (n)
GPR45 34
  • 62 (a)
Species where no ortholog for GPR45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR45 Gene

Gene Tree for GPR45 (if available)
Gene Tree for GPR45 (if available)

Paralogs for GPR45 Gene

Paralogs for GPR45 Gene

(1) SIMAP similar genes for GPR45 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR45: view

Variants for GPR45 Gene

Sequence variations from dbSNP and Humsavar for GPR45 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035759 A breast cancer sample
rs1000431061 -- 105,241,815(+) GGGGA(C/G)CCCTC utr-variant-5-prime
rs1000864987 -- 105,243,547(+) AGAAA(A/C)CAAAA downstream-variant-500B
rs1000872948 -- 105,240,616(+) TCCTC(A/C)TGTCT upstream-variant-2KB
rs1000925099 -- 105,240,999(+) AAAAT(G/T)ATAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR45 Gene

Variant ID Type Subtype PubMed ID
nsv582577 CNV loss 21841781
nsv1012462 CNV gain 25217958

Variation tolerance for GPR45 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR45 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR45 Gene

Disorders for GPR45 Gene

Relevant External Links for GPR45

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR45 Gene

Publications for GPR45 Gene

  1. Discovery of three novel orphan G-protein-coupled receptors. (PMID: 10036181) Marchese A … O'dowd BF (Genomics 1999) 2 3 4 60
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. (PMID: 11027574) Kawasawa Y … Shimizu T (Biochemical and biophysical research communications 2000) 3 22 60
  5. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry JR … Ong KK (Nature 2014) 3 60

Products for GPR45 Gene

  • Addgene plasmids for GPR45

Sources for GPR45 Gene

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