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Aliases for GPR45 Gene

Aliases for GPR45 Gene

  • G Protein-Coupled Receptor 45 2 3 5
  • PSP24-Alpha 3 4
  • PSP24-1 3 4
  • High-Affinity Lysophosphatidic Acid Receptor 3
  • PSP24(ALPHA) 3
  • PSP24A 3
  • PSP24 3

External Ids for GPR45 Gene

Previous GeneCards Identifiers for GPR45 Gene

  • GC02P103722
  • GC02P104310
  • GC02P105462
  • GC02P105479
  • GC02P105316
  • GC02P105224
  • GC02P105858
  • GC02P099627

Summaries for GPR45 Gene

Entrez Gene Summary for GPR45 Gene

  • This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR45 Gene

GPR45 (G Protein-Coupled Receptor 45) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR63.

UniProtKB/Swiss-Prot for GPR45 Gene

  • Orphan receptor. May play a role in brain function.

Gene Wiki entry for GPR45 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR45 Gene

Genomics for GPR45 Gene

Regulatory Elements for GPR45 Gene

Enhancers for GPR45 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR45 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR45 Gene

Chromosome:
2
Start:
105,241,743 bp from pter
End:
105,243,467 bp from pter
Size:
1,725 bases
Orientation:
Plus strand

Genomic View for GPR45 Gene

Genes around GPR45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR45 Gene

Proteins for GPR45 Gene

  • Protein details for GPR45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y3-GPR45_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 45
    Protein Accession:
    Q9Y5Y3
    Secondary Accessions:
    • Q6NWS4
    • Q6NXU6

    Protein attributes for GPR45 Gene

    Size:
    372 amino acids
    Molecular mass:
    41967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR45 Gene

Proteomics data for GPR45 Gene at MOPED

Post-translational modifications for GPR45 Gene

  • Glycosylation at Asn 4, Asn 17, and Asn 20
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR45 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR45 Gene

Domains & Families for GPR45 Gene

Gene Families for GPR45 Gene

Protein Domains for GPR45 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y3

UniProtKB/Swiss-Prot:

GPR45_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR45: view

Function for GPR45 Gene

Molecular function for GPR45 Gene

GENATLAS Biochemistry:
G protein coupled receptor 45,X Laevis oocyte lysophosphatidic acid receptor homolog,expressed in the brain (basal forebrain,frontal cortex,and caudate) and in the liver
UniProtKB/Swiss-Prot Function:
Orphan receptor. May play a role in brain function.
genes like me logo Genes that share phenotypes with GPR45: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR45 Gene

Localization for GPR45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR45 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR45 Gene COMPARTMENTS Subcellular localization image for GPR45 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
genes like me logo Genes that share ontologies with GPR45: view

Pathways & Interactions for GPR45 Gene

genes like me logo Genes that share pathways with GPR45: view

Pathways by source for GPR45 Gene

Gene Ontology (GO) - Biological Process for GPR45 Gene

None

No data available for SIGNOR curated interactions for GPR45 Gene

Drugs & Compounds for GPR45 Gene

No Compound Related Data Available

Transcripts for GPR45 Gene

mRNA/cDNA for GPR45 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR45 Gene

G protein-coupled receptor 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR45 Gene

No ASD Table

Relevant External Links for GPR45 Gene

GeneLoc Exon Structure for
GPR45
ECgene alternative splicing isoforms for
GPR45

Expression for GPR45 Gene

mRNA expression in normal human tissues for GPR45 Gene

mRNA differential expression in normal tissues according to GTEx for GPR45 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.3), Brain - Cortex (x5.0), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.3).

SOURCE GeneReport for Unigene cluster for GPR45 Gene Hs.590903

mRNA Expression by UniProt/SwissProt for GPR45 Gene

Q9Y5Y3-GPR45_HUMAN
Tissue specificity: Expressed in brain; detected in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen.
genes like me logo Genes that share expression patterns with GPR45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR45 Gene

Orthologs for GPR45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR45 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR45 35
  • 83.15 (n)
  • 80.65 (a)
GPR45 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR45 35
  • 88.98 (n)
  • 88.98 (a)
GPR45 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr45 35
  • 85.22 (n)
  • 88.98 (a)
Gpr45 16
Gpr45 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR45 35
  • 99.46 (n)
  • 99.73 (a)
GPR45 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr45 35
  • 85.66 (n)
  • 88.71 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR45 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR45 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr45 35
  • 66.22 (n)
  • 70.7 (a)
African clawed frog
(Xenopus laevis)
Amphibia lpar-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-118h3.5 35
  • 63.69 (n)
  • 63.51 (a)
GPR45 36
  • 62 (a)
OneToOne
Species with no ortholog for GPR45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR45 Gene

ENSEMBL:
Gene Tree for GPR45 (if available)
TreeFam:
Gene Tree for GPR45 (if available)

Paralogs for GPR45 Gene

Paralogs for GPR45 Gene

(1) SIMAP similar genes for GPR45 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR45: view

Variants for GPR45 Gene

Sequence variations from dbSNP and Humsavar for GPR45 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035759 A breast cancer sample
rs35946826 - 105,242,792(-) ACTGA(A/G)CCACA reference, missense
rs11892753 -- 105,240,268(+) CAGAC(C/T)TGAGC upstream-variant-2KB
rs2576727 -- 105,241,939(+) TCCAC(C/T)CAGTT reference, synonymous-codon
rs34372808 -- 105,239,943(+) AAAAA(-/A)GTTTG upstream-variant-2KB

Variation tolerance for GPR45 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GPR45 Gene

Disorders for GPR45 Gene

Relevant External Links for GPR45

Genetic Association Database (GAD)
GPR45
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR45

No disorders were found for GPR45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR45 Gene

Publications for GPR45 Gene

  1. Discovery of three novel orphan G-protein-coupled receptors. (PMID: 10036181) Marchese A. … O'Dowd B.F. (Genomics 1999) 2 3 4 67
  2. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. (PMID: 11027574) Kawasawa Y. … Shimizu T. (Biochem. Biophys. Res. Commun. 2000) 3 23
  3. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3
  4. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3

Products for GPR45 Gene

Sources for GPR45 Gene

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