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Aliases for GPR42 Gene

Aliases for GPR42 Gene

  • G Protein-Coupled Receptor 42 (Gene/Pseudogene) 2 3 5
  • G Protein-Coupled Receptor 42 Pseudogene 2 3
  • GPR42P 3 4
  • G-Protein Coupled Receptor 42 3
  • G-Protein Coupled Receptor 3
  • FFAR1L 3
  • FFAR3L 3
  • GPR41L 3

External Ids for GPR42 Gene

Previous HGNC Symbols for GPR42 Gene

  • GPR42P

Previous GeneCards Identifiers for GPR42 Gene

  • GC19P036501
  • GC19P036311
  • GC19P040540
  • GC19P040553
  • GC19P040554
  • GC19P035862
  • GC19P035966
  • GC19P035505
  • GC19P035515
  • GC19P035524
  • GC19P035543
  • GC19P036136

Summaries for GPR42 Gene

GeneCards Summary for GPR42 Gene

GPR42 (G Protein-Coupled Receptor 42 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is FFAR3.

UniProtKB/Swiss-Prot for GPR42 Gene

  • Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.

Gene Wiki entry for GPR42 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR42 Gene

Genomics for GPR42 Gene

Regulatory Elements for GPR42 Gene

Enhancers for GPR42 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G035374 0.9 ENCODE 0.7 +4.1 4057 0.9 TCF12 FOS KDM4B ZNF263 JUNB REST ZNF518A SMARCA4 MYNN HMBOX1 LINC01801 LOC102723540 FFAR3 GPR42 EEF1A1P7
GH19G035371 0.8 Ensembl dbSUPER 0.7 +0.2 172 0.2 ZBTB10 BCL11A NRF1 SP2 ATF2 GPR42 EEF1A1P7
GH19G035357 1.1 Ensembl ENCODE dbSUPER 0.4 -12.6 -12630 1.0 GLIS2 ATF3 HLF CEBPB CEBPG RAD21 ATF2 FFAR3 GPR42
GH19G035375 0.6 ENCODE 0.7 +5.0 4985 0.1 SUZ12 ZNF512 NBN PRDM10 MLLT1 SALL2 EBF1 LINC00665 TBCB GPR42 EEF1A1P7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR42 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR42 Gene

35,370,929 bp from pter
35,372,962 bp from pter
2,034 bases
Plus strand

Genomic View for GPR42 Gene

Genes around GPR42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR42 Gene

Proteins for GPR42 Gene

  • Protein details for GPR42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 42
    Protein Accession:

    Protein attributes for GPR42 Gene

    346 amino acids
    Molecular mass:
    38695 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR42 Gene

Post-translational modifications for GPR42 Gene

Other Protein References for GPR42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR42 Gene

Domains & Families for GPR42 Gene

Protein Domains for GPR42 Gene

Suggested Antigen Peptide Sequences for GPR42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR42: view

Function for GPR42 Gene

Molecular function for GPR42 Gene

GENATLAS Biochemistry:
G protein coupled receptor 42,tightly linked to CD22
UniProtKB/Swiss-Prot Function:
Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.

Gene Ontology (GO) - Molecular Function for GPR42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity NAS 19630535
genes like me logo Genes that share ontologies with GPR42: view

Phenotypes for GPR42 Gene

GenomeRNAi human phenotypes for GPR42:
genes like me logo Genes that share phenotypes with GPR42: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR42 Gene

Localization for GPR42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR42 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR42 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 9344866
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR42: view

Pathways & Interactions for GPR42 Gene

genes like me logo Genes that share pathways with GPR42: view

Pathways by source for GPR42 Gene

1 BioSystems pathway for GPR42 Gene

Interacting Proteins for GPR42 Gene

Selected Interacting proteins: O15529-GPR42_HUMAN for GPR42 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for GPR42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 19630535
genes like me logo Genes that share ontologies with GPR42: view

No data available for SIGNOR curated interactions for GPR42 Gene

Drugs & Compounds for GPR42 Gene

No Compound Related Data Available

Transcripts for GPR42 Gene

mRNA/cDNA for GPR42 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GPR42 Gene

No ASD Table

Relevant External Links for GPR42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR42 Gene

mRNA differential expression in normal tissues according to GTEx for GPR42 Gene

This gene is overexpressed in Whole Blood (x28.5) and Adipose - Visceral (Omentum) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of GPR42 Gene:

genes like me logo Genes that share expression patterns with GPR42: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR42 Gene

Orthologs for GPR42 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR42 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 97 (a)
(Bos Taurus)
Mammalia GPR41 35
  • 78 (a)
(Mus musculus)
Mammalia Ffar3 35
  • 75 (a)
(Canis familiaris)
Mammalia -- 35
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 41 (a)
(Danio rerio)
Actinopterygii si:ch73-90p23.1 35
  • 47 (a)
CU855821.1 35
  • 43 (a)
CU855821.2 35
  • 41 (a)
si:dkey-211g8.6 35
  • 39 (a)
si:dkey-211g8.7 35
  • 34 (a)
Species where no ortholog for GPR42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR42 Gene

Gene Tree for GPR42 (if available)
Gene Tree for GPR42 (if available)

Paralogs for GPR42 Gene

Paralogs for GPR42 Gene

(4) SIMAP similar genes for GPR42 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR42: view

Variants for GPR42 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GPR42 Gene

Was originally thought to be a pseudogene due to the presence of a Trp at position 174 which prevents activation by short chain fatty acids, such as propionate (PubMed:12496283). However, the inactivating Trp-174 that differentiate GPR42 from the homologous functional G-protein-coupled receptor FFAR3 is most probably polymorphic for both genes in the human population. The frequency of the active allele of GPR42, with Arg at position 174, is estimated to 61%. Moreover, the 5 other amino acid differences at positions 44, 45, 227, 256 and 346 between GPR42 and FFAR3, are also polymorphic in the human population (PubMed:19630535).

Sequence variations from dbSNP and Humsavar for GPR42 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs148192447 -- 35,371,520(+) GCTCC(A/C/T)GCTCA reference, missense
rs180719296 -- 35,371,054(+) CCAAC(A/C/T)GCACT upstream-variant-2KB
rs403989 --
rs424241 --
rs424715 --

Variation tolerance for GPR42 Gene

Gene Damage Index Score: 5.08; 68.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Structural Variations from Database of Genomic Variants (DGV) for GPR42 Gene

Disorders for GPR42 Gene

Relevant External Links for GPR42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR42 Gene

Publications for GPR42 Gene

  1. Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42. (PMID: 19630535) Liaw C.W. … Connolly D.T. (DNA Cell Biol. 2009) 2 3 4 64
  2. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. (PMID: 9344866) Sawzdargo M. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  4. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. (PMID: 12496283) Brown A.J. … Dowell S.J. (J. Biol. Chem. 2003) 3 4 64
  5. Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed. (PMID: 26260360) Puhl H.L. … Ikeda S.R. (Sci Rep 2015) 3 64

Products for GPR42 Gene

Sources for GPR42 Gene

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