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GPR4 Gene(Protein Coding)

G Protein-Coupled Receptor 4

GCID:
GC19M045589
GIFtS:
56
Genes Participants
UDN Logo

Aliases for GPR4 Gene

Aliases for GPR4 Gene

  • G Protein-Coupled Receptor 4 2 3 5
  • G-Protein Coupled Receptor 19 4
  • GPR19 4

External Ids for GPR4 Gene

Previous GeneCards Identifiers for GPR4 Gene

  • GC19M046736
  • GC19M046483
  • GC19M050769
  • GC19M050784
  • GC19M046093
  • GC19M042522

Summaries for GPR4 Gene

GeneCards Summary for GPR4 Gene

GPR4 (G Protein-Coupled Receptor 4) is a Protein Coding gene. Diseases associated with GPR4 include Central Hypoventilation Syndrome, Congenital. Among its related pathways are RET signaling and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR68.

UniProtKB/Swiss-Prot for GPR4 Gene

  • Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.

Gene Wiki entry for GPR4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR4 Gene

Genomics for GPR4 Gene

Products:

  1. Regulatory Element

Regulatory Elements for GPR4 Gene

Enhancers for GPR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G045575 1.5 Ensembl ENCODE dbSUPER 12.5 +24.9 24947 3.8 PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 SLC30A9 ZNF766 OPA3 GPR4 MIR330 EML2 GC19P045560
GH19G045602 0.8 FANTOM5 dbSUPER 19.3 +1.0 965 0.4 SUZ12 NR2F2 EZH2 GPR4 NOVA2 GC19P045560
GH19G045690 1.1 ENCODE 11 -90.3 -90265 3.2 HDGF PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FBXO46 BHMG1 EML2 GPR4 OPA3 MIR330 DMWD SYMPK FOXA3 SNRPD2
GH19G045597 1.3 Ensembl ENCODE dbSUPER 0.7 +3.2 3231 2.8 KLF1 KLF17 EBF1 ZIC2 ZNF664 ZFHX2 GATA2 ZBTB48 ZNF600 PRDM10 CCDC61 ENSG00000268810 APOC1P1 GPR4 GC19P045560
GH19G045601 0.9 Ensembl dbSUPER 0.7 +0.0 47 0.7 SP3 ZNF777 RBBP5 ZNF48 NR2F2 ZNF121 ZNF366 KDM1A ZNF600 ZNF652 EML2 GPR4 GC19P045560
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GPR4 gene promoter:

Genomic Location for GPR4 Gene

Chromosome:
19
Start:
45,589,764 bp from pter
End:
45,602,208 bp from pter
Size:
12,445 bases
Orientation:
Minus strand

Genomic View for GPR4 Gene

Genes around GPR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GPR4 Gene

Proteins for GPR4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GPR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46093-GPR4_HUMAN
    Recommended name:
    G-protein coupled receptor 4
    Protein Accession:
    P46093
    Secondary Accessions:
    • A8K3T3
    • B0M0K1
    • Q6NWM4

    Protein attributes for GPR4 Gene

    Size:
    362 amino acids
    Molecular mass:
    40982 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA63180.1; Type=Frameshift; Positions=347; Evidence={ECO:0000305};

neXtProt entry for GPR4 Gene

Protein Expression for GPR4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GPR4 Gene

  • Glycosylation at isoforms=3 and isoforms=164
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR4 Gene

Domains & Families for GPR4 Gene

Gene Families for GPR4 Gene

HGNC:
IUPHAR :

Protein Domains for GPR4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46093

UniProtKB/Swiss-Prot:

GPR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR4: view

Function for GPR4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GPR4 Gene

GENATLAS Biochemistry:
G protein coupled receptor 4,with homology to the platelet-activating factor receptor (PTAFR),expressed in kidney,heart and lung
UniProtKB/Swiss-Prot Function:
Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.

Gene Ontology (GO) - Molecular Function for GPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA,TAS --
genes like me logo Genes that share ontologies with GPR4: view
genes like me logo Genes that share phenotypes with GPR4: view

Animal Models for GPR4 Gene

MGI Knock Outs for GPR4:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR4

CRISPR Products

miRNA for GPR4 Gene

miRTarBase miRNAs that target GPR4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR4 Gene

Localization for GPR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR4 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for GPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8595909
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR4: view

Pathways & Interactions for GPR4 Gene

genes like me logo Genes that share pathways with GPR4: view

Gene Ontology (GO) - Biological Process for GPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 7498459
GO:0010447 response to acidic pH IEA --
GO:0016525 negative regulation of angiogenesis IEA --
GO:0035025 positive regulation of Rho protein signal transduction IBA --
genes like me logo Genes that share ontologies with GPR4: view

No data available for SIGNOR curated interactions for GPR4 Gene

Drugs & Compounds for GPR4 Gene

Products:

  1. Drug

(2) Drugs for GPR4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GPR4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPR4: view

Transcripts for GPR4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GPR4 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR4 Gene

G protein-coupled receptor 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR4

Alternative Splicing Database (ASD) splice patterns (SP) for GPR4 Gene

No ASD Table

Relevant External Links for GPR4 Gene

GeneLoc Exon Structure for
GPR4
ECgene alternative splicing isoforms for
GPR4

Expression for GPR4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR4 Gene

mRNA expression in normal human tissues for GPR4 Gene
mRNA expression by BioGPS for GPR4 GenemRNA expression by GTEx for GPR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR4 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.7).

Protein differential expression in normal tissues from HIPED for GPR4 Gene

This gene is overexpressed in Esophagus (27.8), Liver (16.0), Ovary (9.4), Urinary Bladder (6.2), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR4 Gene



NURSA nuclear receptor signaling pathways regulating expression of GPR4 Gene:

GPR4

SOURCE GeneReport for Unigene cluster for GPR4 Gene:

Hs.17170

Evidence on tissue expression from TISSUES for GPR4 Gene

  • Nervous system(4.4)
  • Lung(4.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with GPR4: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR4 Gene

Orthologs for GPR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia GPR4 34 35
  • 92.15 (n)
cow
(Bos Taurus)
 Mammalia GPR4 34 35
  • 91.07 (n)
rat
(Rattus norvegicus)
 Mammalia Gpr4 34
  • 87.8 (n)
mouse
(Mus musculus)
 Mammalia Gpr4 34 16 35
  • 87.06 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 31 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 26 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii LOC563762 34
  • 69.14 (n)
gpr4 35
  • 66 (a)
 OneToOne
Species where no ortholog for GPR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR4 Gene

ENSEMBL:
Gene Tree for GPR4 (if available)
TreeFam:
Gene Tree for GPR4 (if available)

Paralogs for GPR4 Gene

Paralogs for GPR4 Gene

(11) SIMAP similar genes for GPR4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR4: view

Variants for GPR4 Gene

Sequence variations from dbSNP and Humsavar for GPR4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000116765 -- 45,602,359(+) TCATC(G/T)GCTAC upstream-variant-2KB
rs1000314680 -- 45,591,220(+) CCTGG(A/C)GCTCG reference, missense
rs1000475905 -- 45,598,113(+) TCTCT(C/T)CCTTC intron-variant
rs1000487173 -- 45,602,778(+) TTTGC(-/T)TTTTT upstream-variant-2KB
rs1000590080 -- 45,597,853(+) AAAGG(A/T)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR4 Gene

Variant ID Type Subtype PubMed ID
esv1941589 CNV deletion 18987734
esv2718633 CNV deletion 23290073
esv2718634 CNV deletion 23290073
nsv833848 CNV loss 17160897

Variation tolerance for GPR4 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR4 Gene

Disorders for GPR4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
central hypoventilation syndrome, congenital
  • central hypoventilation syndrome, congenital, with or without hirschsprung disease
- elite association - COSMIC cancer census association via MalaCards
Search GPR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR4
genes like me logo Genes that share disorders with GPR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR4 Gene

Publications for GPR4 Gene

  1. Proton-sensing G-protein-coupled receptors. (PMID: 12955148) Ludwig M.-G. … Seuwen K. (Nature 2003) 3 4 22 64
  2. Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3. (PMID: 8595909) Mahadevan M.S. … Korneluk R.G. (Genomics 1995) 2 3 4 64
  3. A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration. (PMID: 17364894) Huang F. … Lum H. (Endothelium 2007) 3 22 64
  4. Previously postulated 'ligand-independent' signaling of GPR4 is mediated through proton-sensing mechanisms. (PMID: 17462861) Tobo M. … Okajima F. (Cell. Signal. 2007) 3 4 64
  5. Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4. (PMID: 16461426) Qiao J. … Lum H. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006) 3 22 64

Products for GPR4 Gene

  • Addgene plasmids for GPR4

Sources for GPR4 Gene

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