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Aliases for GPR4 Gene

Aliases for GPR4 Gene

  • G Protein-Coupled Receptor 4 2 3 5
  • G-Protein Coupled Receptor 19 4
  • GPR19 4

External Ids for GPR4 Gene

Previous GeneCards Identifiers for GPR4 Gene

  • GC19M046736
  • GC19M046483
  • GC19M050769
  • GC19M050784
  • GC19M046093
  • GC19M042522

Summaries for GPR4 Gene

GeneCards Summary for GPR4 Gene

GPR4 (G Protein-Coupled Receptor 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR68.

UniProtKB/Swiss-Prot for GPR4 Gene

  • Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.

Gene Wiki entry for GPR4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR4 Gene

Genomics for GPR4 Gene

Regulatory Elements for GPR4 Gene

Enhancers for GPR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F045601 0.5 FANTOM5 19.3 +1.0 965 0.4 NR2F2 EZH2 GPR4 NOVA2 GC19P045560
GH19F045575 1.2 Ensembl ENCODE 12.5 +24.9 24947 3.8 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 SLC30A9 ZNF766 ZNF143 FOS GPR4 OPA3 IRF2BP1 ENSG00000268810 EML2 MIR330 QPCTL LOC105372418 GC19P045560
GH19F045690 0.6 ENCODE 11 -90.3 -90265 3.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ENSG00000267395 DMWD ENSG00000268810 SNRPD2 CCDC61 QPCTL SIX5 FBXO46 BHMG1 EML2
GH19F045597 0.8 Ensembl ENCODE 0.8 +3.2 3231 2.8 KLF1 KLF17 EBF1 ZIC2 ZNF664 ZFHX2 ZBTB48 PRDM10 ZNF548 ZNF600 CCDC61 ENSG00000268810 APOC1P1 GPR4 GC19P045560
GH19F045591 0.5 ENCODE 0.4 +11.1 11101 0.2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 NFYC MXD4 MIER2 REST GPR4 GC19P045560
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR4 on UCSC Golden Path with GeneCards custom track

Promoters for GPR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001818031 308 1001 SP3 ZNF48 NR2F2 ZNF121 ZNF366 KDM1A ZNF600 ZNF652 EZH2

Genomic Location for GPR4 Gene

Chromosome:
19
Start:
45,589,764 bp from pter
End:
45,602,208 bp from pter
Size:
12,445 bases
Orientation:
Minus strand

Genomic View for GPR4 Gene

Genes around GPR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR4 Gene

Proteins for GPR4 Gene

  • Protein details for GPR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46093-GPR4_HUMAN
    Recommended name:
    G-protein coupled receptor 4
    Protein Accession:
    P46093
    Secondary Accessions:
    • A8K3T3
    • B0M0K1
    • Q6NWM4

    Protein attributes for GPR4 Gene

    Size:
    362 amino acids
    Molecular mass:
    40982 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA63180.1; Type=Frameshift; Positions=347; Evidence={ECO:0000305};

neXtProt entry for GPR4 Gene

Post-translational modifications for GPR4 Gene

  • Glycosylation at Asn 3 and Asn 164
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR4 Gene

Domains & Families for GPR4 Gene

Gene Families for GPR4 Gene

Protein Domains for GPR4 Gene

Suggested Antigen Peptide Sequences for GPR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46093

UniProtKB/Swiss-Prot:

GPR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR4: view

Function for GPR4 Gene

Molecular function for GPR4 Gene

GENATLAS Biochemistry:
G protein coupled receptor 4,with homology to the platelet-activating factor receptor (PTAFR),expressed in kidney,heart and lung
UniProtKB/Swiss-Prot Function:
Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.

Gene Ontology (GO) - Molecular Function for GPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with GPR4: view
genes like me logo Genes that share phenotypes with GPR4: view

Animal Models for GPR4 Gene

MGI Knock Outs for GPR4:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR4

miRNA for GPR4 Gene

miRTarBase miRNAs that target GPR4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR4 Gene

Localization for GPR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR4 Gene COMPARTMENTS Subcellular localization image for GPR4 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for GPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8595909
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR4: view

Pathways & Interactions for GPR4 Gene

genes like me logo Genes that share pathways with GPR4: view

Gene Ontology (GO) - Biological Process for GPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 7498459
GO:0010447 response to acidic pH IEA --
GO:0016525 negative regulation of angiogenesis IEA --
GO:0035025 positive regulation of Rho protein signal transduction IBA --
genes like me logo Genes that share ontologies with GPR4: view

No data available for SIGNOR curated interactions for GPR4 Gene

Drugs & Compounds for GPR4 Gene

(2) Drugs for GPR4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GPR4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPR4: view

Transcripts for GPR4 Gene

mRNA/cDNA for GPR4 Gene

Unigene Clusters for GPR4 Gene

G protein-coupled receptor 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR4 Gene

No ASD Table

Relevant External Links for GPR4 Gene

GeneLoc Exon Structure for
GPR4
ECgene alternative splicing isoforms for
GPR4

Expression for GPR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR4 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.7).

Protein differential expression in normal tissues from HIPED for GPR4 Gene

This gene is overexpressed in Esophagus (27.8), Liver (16.0), Ovary (9.4), Urinary Bladder (6.2), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR4 Gene



NURSA nuclear receptor signaling pathways regulating expression of GPR4 Gene:

GPR4

SOURCE GeneReport for Unigene cluster for GPR4 Gene:

Hs.17170
genes like me logo Genes that share expression patterns with GPR4: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GPR4 Gene

Orthologs for GPR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GPR4 34 35
  • 92.15 (n)
cow
(Bos Taurus)
Mammalia GPR4 34 35
  • 91.07 (n)
rat
(Rattus norvegicus)
Mammalia Gpr4 34
  • 87.8 (n)
mouse
(Mus musculus)
Mammalia Gpr4 34 16 35
  • 87.06 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 26 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC563762 34
  • 69.14 (n)
gpr4 35
  • 66 (a)
OneToOne
Species where no ortholog for GPR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR4 Gene

ENSEMBL:
Gene Tree for GPR4 (if available)
TreeFam:
Gene Tree for GPR4 (if available)

Paralogs for GPR4 Gene

Paralogs for GPR4 Gene

(11) SIMAP similar genes for GPR4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR4: view

Variants for GPR4 Gene

Sequence variations from dbSNP and Humsavar for GPR4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10405576 -- 45,595,627(+) TGACT(A/G)TCATC intron-variant, upstream-variant-2KB
rs10407126 -- 45,596,266(+) AATGT(C/T)CCAAT intron-variant, upstream-variant-2KB
rs10410540 -- 45,593,081(+) TAGTC(A/C)CAGCT intron-variant
rs10411518 -- 45,601,940(+) ACGCA(A/G)AGCCA intron-variant, upstream-variant-2KB
rs10411821 -- 45,592,874(+) ATATT(G/T)TCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR4 Gene

Variant ID Type Subtype PubMed ID
esv1941589 CNV deletion 18987734
esv2718633 CNV deletion 23290073
esv2718634 CNV deletion 23290073
nsv833848 CNV loss 17160897

Variation tolerance for GPR4 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR4 Gene

Disorders for GPR4 Gene

Relevant External Links for GPR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR4

No disorders were found for GPR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR4 Gene

Publications for GPR4 Gene

  1. Proton-sensing G-protein-coupled receptors. (PMID: 12955148) Ludwig M.-G. … Seuwen K. (Nature 2003) 3 4 22 64
  2. Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3. (PMID: 8595909) Mahadevan M.S. … Korneluk R.G. (Genomics 1995) 2 3 4 64
  3. Previously postulated 'ligand-independent' signaling of GPR4 is mediated through proton-sensing mechanisms. (PMID: 17462861) Tobo M. … Okajima F. (Cell. Signal. 2007) 3 4 64
  4. A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration. (PMID: 17364894) Huang F. … Lum H. (Endothelium 2007) 3 22 64
  5. Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4. (PMID: 16461426) Qiao J. … Lum H. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006) 3 22 64

Products for GPR4 Gene

Sources for GPR4 Gene

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