Aliases for GPR4 Gene
External Ids for GPR4 Gene
- HGNC: 4497
- Entrez Gene: 2828
- Ensembl: ENSG00000177464
- OMIM: 600551
- UniProtKB: P46093
Previous GeneCards Identifiers for GPR4 Gene
- GC19M046736
- GC19M046483
- GC19M050769
- GC19M050784
- GC19M046093
- GC19M042522
Summaries for GPR4 Gene
GeneCards Summary for GPR4 Gene
GPR4 (G Protein-Coupled Receptor 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR132.
UniProtKB/Swiss-Prot for GPR4 Gene
-
Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR4 Gene
Genomics for GPR4 Gene
Regulatory Elements for GPR4 Gene
Enhancers for GPR4 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around GPR4 on UCSC Golden Path with GeneCards custom track
Promoters for GPR4 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around GPR4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for GPR4 Gene
- Chromosome:
- 19
- Start:
- 45,589,764 bp from pter
- End:
- 45,602,208 bp from pter
- Size:
- 12,445 bases
- Orientation:
- Minus strand
Genomic View for GPR4 Gene
Genes around GPR4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.32 by Ensembl
- 19q13.3 by Entrez Gene
- 19q13.3 by HGNC
GPR4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR4 Gene
Proteins for GPR4 Gene
-
Protein details for GPR4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46093-GPR4_HUMAN
- Recommended name:
- G-protein coupled receptor 4
- Protein Accession:
- P46093
- A8K3T3
- B0M0K1
- Q6NWM4
Protein attributes for GPR4 Gene
- Size:
- 362 amino acids
- Molecular mass:
- 40982 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAA63180.1; Type=Frameshift; Positions=347; Evidence={ECO:0000305};
Protein Expression for GPR4 Gene
Post-translational modifications for GPR4 Gene
Other Protein References for GPR4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GPR4
- Invitrogen Antibodies for GPR4
- antibodies-online Antibodies for GPR4: See all 25
- GeneTex GPR4 antibody for GPR4
-
Santa Cruz Biotechnology (SCBT) Antibodies for GPR4
Protein Products
-
OriGene Purified Proteins for GPR4
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR4
- Origene Custom Protein Services for GPR4
- antibodies-online Proteins for GPR4: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for GPR4
Assay Products
No data available for DME Specific Peptides for GPR4 Gene
Domains & Families for GPR4 Gene
Gene Families for GPR4 Gene
- HGNC:
- IUPHAR :
Protein Domains for GPR4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P46093- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR4 Gene
Molecular function for GPR4 Gene
- GENATLAS Biochemistry:
- G protein coupled receptor 4,with homology to the platelet-activating factor receptor (PTAFR),expressed in kidney,heart and lung
- UniProtKB/Swiss-Prot Function:
- Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.
Phenotypes for GPR4 Gene
- MGI mutant phenotypes for GPR4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GPR4:
Animal Models for GPR4 Gene
- MGI Knock Outs for GPR4:
-
- Gpr4 tm1Witt
Animal Model Products
-
Taconic Biosciences Mouse Models for GPR4
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR4 gene
- Search ViGene Biosciences for GPR4
CRISPR Products
-
OriGene CRISPR knockouts for GPR4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR4
- GenScript: Design CRISPR guide RNA sequences for GPR4
miRNA for GPR4 Gene
- miRTarBase miRNAs that target GPR4
miRNA Products
- Search ViGene Biosciences for GPR4
Clone Products
- OriGene clones in human for GPR4
- OriGene ORF clones in human,mouse,rat for GPR4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for GPR4
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GPR4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR4 Gene
Localization for GPR4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR4 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for GPR4 Gene
More details on SuperPathways for GPR4| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Interleukin-3, 5 and GM-CSF signaling |
Pathways by source for GPR4 Gene
1 BioSystems pathway for GPR4 Gene
Interacting Proteins for GPR4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
| GO:0060055 | angiogenesis involved in wound healing | IEA | -- |
No data available for SIGNOR curated interactions for GPR4 Gene
Transcripts for GPR4 Gene
mRNA/cDNA for GPR4 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (43) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GPR4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPR4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR4
- GenScript: Design CRISPR guide RNA sequences for GPR4
miRNA Products
- Search ViGene Biosciences for GPR4
Clone Products
- OriGene clones in human for GPR4
- OriGene ORF clones in human,mouse,rat for GPR4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for GPR4
Flow Cytometry Products
Expression for GPR4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Endothelium (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for GPR4 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x4.7).
This gene is overexpressed in Esophagus (27.8), Liver (16.0), Ovary (9.4), Urinary Bladder (6.2), and Prostate (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR4 Gene
SOURCE GeneReport for Unigene cluster for GPR4 Gene Hs.17170
Primer Products
-
OriGene qPCR primer pairs and template standards for GPR4
-
OriGene qPCR primer pairs for GPR4
No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR4 Gene
Orthologs for GPR4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | GPR4 35 |
|
||
| GPR4 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | GPR4 35 |
|
||
| GPR4 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Gpr4 35 |
|
||
| Gpr4 16 |
|
||||
| Gpr4 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Gpr4 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | LOC563762 35 |
|
||
| gpr4 36 |
|
OneToOne |
- Species with no ortholog for GPR4:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GPR4 Gene
Paralogs for GPR4 Gene
(11) SIMAP similar genes for GPR4 Gene using alignment to 1 proteins:
Variants for GPR4 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs36012326 | - | 45,590,983(+) | CATCG(C/T)TGCGG | reference, missense | |
| rs766845 | -- | 45,601,318(-) | CTTTC(C/G)TGCTT | intron-variant | |
| rs13344848 | -- | 45,590,910(+) | AGCGA(A/G)GCATT | reference, synonymous-codon | |
| rs71173185 | -- | 45,594,063(+) | AAAAA(-/AATATA)TATAT | intron-variant | |
| rs1045217 | -- | 45,589,953(-) | ATGCC(A/G)GAAGG | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv833848 | CNV | Loss | 17160897 |
| esv2718633 | CNV | Deletion | 23290073 |
| esv1941589 | CNV | Deletion | 18987734 |
| esv2718634 | CNV | Deletion | 23290073 |
Residual Variation Intolerance Score:
12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.13;
2.87% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR4 Gene
Disorders for GPR4 Gene
Relevant External Links for GPR4
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- GPR4
No disorders were found for GPR4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR4 Gene
Publications for GPR4 Gene
- Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3. (PMID: 8595909) Mahadevan M.S. … Korneluk R.G. (Genomics 1995) 2 3 4 67
- A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration. (PMID: 17364894) Huang F. … Lum H. (Endothelium 2007) 3 23
- Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4. (PMID: 16461426) Qiao J. … Lum H. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006) 3 23
- GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. (PMID: 15857892) Kim K.S. … Xu Y. (FASEB J. 2005) 3 23
- G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers. (PMID: 15221007) Sin W.C. … Yang J. (Oncogene 2004) 3 23
Products for GPR4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for GPR4
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GPR4
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR4
- Origene Custom Protein Services for GPR4
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for GPR4
- Browse OriGene Inhibitory RNA Products For GPR4
- OriGene qPCR primer pairs for GPR4
- OriGene qPCR primer pairs and template standards for GPR4
- OriGene CRISPR knockouts for GPR4
- OriGene clones in human for GPR4
- OriGene ORF clones in human,mouse,rat for GPR4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for GPR4
- GenScript Custom Assay Services for GPR4
- GenScript Custom overexpressing Cell Line Services for GPR4
- GenScript: Design CRISPR guide RNA sequences for GPR4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GPR4
- Novus Biologicals Antibodies for GPR4
- Novus Biologicals proteins and lysates for GPR4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for GPR4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for GPR4: See all 25
- Search antibodies-online for kits
- antibodies-online Proteins for GPR4: See all 5
- Search antibodies-online for peptides
- GeneTex GPR4 antibody for GPR4
- Search GeneTex for Proteins for GPR4
- ViGene Biosciences adenoviral particle packaged cDNA for GPR4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GPR4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GPR4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GPR4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GPR4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GPR4 gene
- Search ViGene Biosciences for GPR4
- Search ViGene Biosciences for GPR4
- Santa Cruz Biotechnology (SCBT) Antibodies for GPR4
- Search Santa Cruz Biotechnology (SCBT) for GPR4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GPR4
Sources for GPR4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
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- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon