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Aliases for GPR39 Gene

Aliases for GPR39 Gene

  • G Protein-Coupled Receptor 39 2 3 5

External Ids for GPR39 Gene

Previous GeneCards Identifiers for GPR39 Gene

  • GC02P130862
  • GC02P131462
  • GC02P133196
  • GC02P133385
  • GC02P133008
  • GC02P132891
  • GC02P125167

Summaries for GPR39 Gene

Entrez Gene Summary for GPR39 Gene

  • This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]

GeneCards Summary for GPR39 Gene

GPR39 (G Protein-Coupled Receptor 39) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is NTSR1.

UniProtKB/Swiss-Prot for GPR39 Gene

  • Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).

Tocris Summary for GPR39 Gene

  • Orphan 7-TM receptors (orphan GPCRs) are receptors for which there are no defined ligands. Traditionally, receptors are characterized by specific ligands and stimuli; the search for ligands of orphan receptors is therefore akin to reverse-engineering this process.

Gene Wiki entry for GPR39 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR39 Gene

Genomics for GPR39 Gene

Regulatory Elements for GPR39 Gene

Enhancers for GPR39 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GPR39 on UCSC Golden Path with GeneCards custom track

Promoters for GPR39 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GPR39 Gene

Chromosome:
2
Start:
132,416,161 bp from pter
End:
132,646,596 bp from pter
Size:
230,436 bases
Orientation:
Plus strand

Genomic View for GPR39 Gene

Genes around GPR39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR39 Gene

Proteins for GPR39 Gene

  • Protein details for GPR39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43194-GPR39_HUMAN
    Recommended name:
    G-protein coupled receptor 39
    Protein Accession:
    O43194
    Secondary Accessions:
    • B2RC12
    • B6V9G4
    • Q08AS2
    • Q53R01

    Protein attributes for GPR39 Gene

    Size:
    453 amino acids
    Molecular mass:
    51329 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR39 Gene

Post-translational modifications for GPR39 Gene

  • Glycosylation at Asn 192, Asn 206, and Asn 212
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR39 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR39 Gene

Domains & Families for GPR39 Gene

Gene Families for GPR39 Gene

Protein Domains for GPR39 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR39 Gene

Graphical View of Domain Structure for InterPro Entry

O43194

UniProtKB/Swiss-Prot:

GPR39_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR39: view

Function for GPR39 Gene

Molecular function for GPR39 Gene

GENATLAS Biochemistry:
G protein coupled receptor 39,with two forms generated by alternative polyadenylation sites,highly homolog to growth hormone,secretagogue receptor (GSHR) and neurotensin receptors,expressed in the brain and other tissues
UniProtKB/Swiss-Prot Function:
Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).

Gene Ontology (GO) - Molecular Function for GPR39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GPR39: view
genes like me logo Genes that share phenotypes with GPR39: view

Animal Models for GPR39 Gene

MGI Knock Outs for GPR39:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR39

CRISPR Products

miRNA for GPR39 Gene

miRTarBase miRNAs that target GPR39

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR39

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR39 Gene

Localization for GPR39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR39 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR39 Gene COMPARTMENTS Subcellular localization image for GPR39 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9441746
genes like me logo Genes that share ontologies with GPR39: view

Pathways & Interactions for GPR39 Gene

genes like me logo Genes that share pathways with GPR39: view

Pathways by source for GPR39 Gene

Gene Ontology (GO) - Biological Process for GPR39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR39: view

No data available for SIGNOR curated interactions for GPR39 Gene

Drugs & Compounds for GPR39 Gene

(3) Drugs for GPR39 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zn<sup>2+</sup> Pharma Positive, Allosteric regulator 0
COMPOUND 1 [PMID: 24900608] Pharma 0
COMPOUND 15 [PMID: 25313322] Pharma 0
genes like me logo Genes that share compounds with GPR39: view

Transcripts for GPR39 Gene

mRNA/cDNA for GPR39 Gene

Unigene Clusters for GPR39 Gene

G protein-coupled receptor 39:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR39

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR39 Gene

No ASD Table

Relevant External Links for GPR39 Gene

GeneLoc Exon Structure for
GPR39
ECgene alternative splicing isoforms for
GPR39

Expression for GPR39 Gene

mRNA expression in normal human tissues for GPR39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR39 Gene

This gene is overexpressed in Colon - Transverse (x8.4), Stomach (x5.4), Bladder (x4.9), Liver (x4.2), and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for GPR39 Gene

This gene is overexpressed in Kidney (26.4), Platelet (21.8), Heart (9.9), and Esophagus (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPR39 Gene



Protein tissue co-expression partners for GPR39 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR39 Gene:

GPR39

SOURCE GeneReport for Unigene cluster for GPR39 Gene:

Hs.744392

mRNA Expression by UniProt/SwissProt for GPR39 Gene:

O43194-GPR39_HUMAN
Tissue specificity: Expressed in many tissues, including the stomach, intestine and hypothalamus.
genes like me logo Genes that share expression patterns with GPR39: view

Primer Products

Orthologs for GPR39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR39 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR39 34
  • 83.81 (n)
  • 82.12 (a)
GPR39 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR39 34
  • 82.28 (n)
  • 79.16 (a)
GPR39 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr39 34
  • 80.21 (n)
  • 81.68 (a)
Gpr39 16
Gpr39 35
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR39 34
  • 99.41 (n)
  • 99.12 (a)
GPR39 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr39 34
  • 79.18 (n)
  • 80.79 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR39 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR39 34
  • 67.49 (n)
  • 63.29 (a)
GPR39 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii gpr39 34
  • 57.73 (n)
  • 50.78 (a)
zgc64187 34
gpr39 35
  • 43 (a)
OneToOne
Species where no ortholog for GPR39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR39 Gene

ENSEMBL:
Gene Tree for GPR39 (if available)
TreeFam:
Gene Tree for GPR39 (if available)

Paralogs for GPR39 Gene

Paralogs for GPR39 Gene

(1) SIMAP similar genes for GPR39 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GPR39 Gene

genes like me logo Genes that share paralogs with GPR39: view

Variants for GPR39 Gene

Sequence variations from dbSNP and Humsavar for GPR39 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2241764 - 132,417,191(-) TGGTG(A/G)CGCTG reference, missense
VAR_049393 -
rs1075655 -- 132,504,139(+) cctgc(A/G)gtcgt intron-variant
rs1109172 -- 132,462,716(+) cagcc(A/G)cgcac intron-variant
rs4309626 -- 132,430,307(+) AGCCT(G/T)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR39 Gene

Variant ID Type Subtype PubMed ID
dgv2042n106 CNV duplication 24896259
dgv2251e59 CNV tandem duplication 20981092
dgv228n21 CNV gain 19592680
dgv34n64 CNV gain 17921354
dgv4081n100 CNV gain 25217958
dgv4082n100 CNV gain 25217958
dgv4083n100 CNV gain 25217958
dgv7085n54 CNV gain 21841781
dgv7086n54 CNV gain 21841781
dgv732e199 CNV deletion 23128226
esv22729 CNV loss 19812545
esv2422046 CNV duplication 20811451
esv24608 CNV loss 19812545
esv2659330 CNV deletion 23128226
esv2675998 CNV deletion 23128226
esv2720834 CNV deletion 23290073
esv2759092 CNV gain+loss 17122850
esv2759093 CNV gain 17122850
esv2760549 CNV gain 21179565
esv2763165 CNV gain 21179565
esv28074 CNV loss 19812545
esv29562 CNV gain 19812545
esv3374747 CNV duplication 20981092
esv3392961 CNV duplication 20981092
esv3423868 CNV duplication 20981092
esv3584081 CNV loss 25503493
esv3584083 CNV loss 25503493
esv3592508 CNV loss 21293372
esv3592510 CNV loss 21293372
esv3592511 CNV gain 21293372
esv3592512 CNV loss 21293372
esv3592513 CNV loss 21293372
esv4378 OTHER complex 18987735
nsv1011421 CNV gain 25217958
nsv10192 CNV loss 18304495
nsv10193 CNV gain 18304495
nsv10194 CNV loss 18304495
nsv1077379 CNV duplication 25765185
nsv1138848 CNV deletion 24896259
nsv1138849 CNV deletion 24896259
nsv1153848 CNV duplication 26484159
nsv1160867 CNV duplication 26073780
nsv213758 CNV deletion 16902084
nsv2929 CNV insertion 18451855
nsv2930 CNV insertion 18451855
nsv433356 CNV gain 18776910
nsv442835 CNV gain 18776908
nsv459429 CNV loss 19166990
nsv459441 CNV gain 19166990
nsv471734 CNV loss 16327809
nsv473033 CNV novel sequence insertion 20440878
nsv475377 CNV novel sequence insertion 20440878
nsv481057 CNV novel sequence insertion 20440878
nsv508106 OTHER sequence alteration 20534489
nsv526029 CNV gain 19592680
nsv583152 CNV gain 21841781
nsv583153 CNV gain 21841781
nsv583154 CNV loss 21841781
nsv583155 CNV loss 21841781
nsv583158 CNV gain 21841781
nsv834378 CNV loss 17160897
nsv953184 CNV deletion 24416366

Variation tolerance for GPR39 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.92; 91.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR39 Gene

Disorders for GPR39 Gene

Relevant External Links for GPR39

Genetic Association Database (GAD)
GPR39
Human Genome Epidemiology (HuGE) Navigator
GPR39
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR39

No disorders were found for GPR39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR39 Gene

Publications for GPR39 Gene

  1. Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. (PMID: 9441746) McKee K.K. … van der Ploeg L.H.T. (Genomics 1997) 2 3 4 22 65
  2. Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. (PMID: 18588883) Storjohann L. … Schwartz T.W. (FEBS Lett. 2008) 3 4 22 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 65
  5. Obestatin does not activate orphan G protein-coupled receptor GPR39. (PMID: 17054911) Lauwers E. … Luyten W. (Biochem. Biophys. Res. Commun. 2006) 3 22 65

Products for GPR39 Gene

Sources for GPR39 Gene

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