Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR39 Gene

protein-coding   GIFtS: 57
GCID: GC02P133196

G Protein-Coupled Receptor 39

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor 391 2
G-Protein Coupled Receptor 392

External Ids:    HGNC: 44961   Entrez Gene: 28632   Ensembl: ENSG000001838407   OMIM: 6028865   UniProtKB: O431943   

Export aliases for GPR39 gene to outside databases

Previous GC identifers: GC02P130862 GC02P131462 GC02P133385 GC02P133008 GC02P132891 GC02P125167


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GPR39 Gene: 
GPR39 (G protein-coupled receptor 39) is a protein-coding gene. Diseases associated with GPR39 include obesity, association with, and hyperparathyroidism, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signaling. GO annotations related to this gene include G-protein coupled receptor activity and metal ion binding. An important paralog of this gene is GHSR.

UniProtKB/Swiss-Prot: GPR39_HUMAN, O43194
Function: Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate
a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and
G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and
cell death (By similarity)

Gene Wiki entry for GPR39 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR39 gene promoter:
         E2F-4   E2F-3a   E2F-5   Sox5   AML1a   E2F-2   E2F   E2F-1   HFH-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR39 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPR39

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21-q22   Ensembl cytogenetic band:  2q21.2   HGNC cytogenetic band: 2q21-q22

GPR39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR39 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P133196:  view genomic region     (about GC identifiers)

Start:
133,174,147 bp from pter      End:
133,404,169 bp from pter
Size:
230,023 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPR39_HUMAN, O43194 (See protein sequence)
Recommended Name: G-protein coupled receptor 39  
Size: 453 amino acids; 51329 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RC12 B6V9G4 Q08AS2 Q53R01

Explore the universe of human proteins at neXtProt for GPR39: NX_O43194

Explore proteomics data for GPR39 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43194

  • GPR39 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPR39 Protein Expression
    REFSEQ proteins: NP_001499.1  
    ENSEMBL proteins: 
     ENSP00000327417  
    Reactome Protein details: O43194
    Human Recombinant Protein Products for GPR39: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GPR39
    GenScript Custom Purified and Recombinant Proteins Services for GPR39
    Novus Biologicals GPR39 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPR39 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9441746
    GO:0016021integral to membrane ----

    GPR39 for ontologies           About GeneDecksing



    GPR39 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for GPR39
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GPR39
    GenScript Custom Superior Antibodies Services for GPR39
    Novus Biologicals GPR39 Antibodies
    Abcam antibodies for GPR39
    Cloud-Clone Corp. Antibodies for GPR39 
    ThermoFisher Antibodies for GPR39
    LSBio Antibodies in human, mouse, rat for GPR39 

    Assay Products for GPR39: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GPR39
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GPR39
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GPR39 
    Cloud-Clone Corp. CLIAs for GPR39


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR39 
    Class A Orphans

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O43194

    ProtoNet protein and cluster: O43194

    UniProtKB/Swiss-Prot: GPR39_HUMAN, O43194
    Similarity: Belongs to the G-protein coupled receptor 1 family


    GPR39 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPR39_HUMAN, O43194
    Function: Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate
    a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and
    G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and
    cell death (By similarity)

         Genatlas biochemistry entry for GPR39:
    G protein coupled receptor 39,with two forms generated by alternative polyadenylation sites,highly homolog to
    growth hormone,secretagogue receptor (GSHR) and neurotensin receptors,expressed in the brain and other tissues

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0046872metal ion binding IEA--
         
    GPR39 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gpr39):
     adipose tissue  behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism 

    GPR39 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gpr39tm1Dgen for GPR39

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GPR39 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPR39

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPR39 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPR39 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPR39
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GPR39:
    hsa-miR-4314 hsa-miR-1276 hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidGPR39 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GPR39
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPR39

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GPR39
    Sirion Biotech Customized adenovirus for overexpression of GPR39

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GPR39 (see all 7)
    OriGene ORF clones in mouse, rat for GPR39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPR39 (NM_001508)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR39
    Sirion Biotech Customized lentivirus for stable overexpression of GPR39 
                         Customized lentivirus expression plasmids for stable overexpression of GPR39 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GPR39
    Search LifeMap BioReagents cell lines for GPR39
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR39


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPR39 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GPR39
        GPCRs, Class A Rhodopsin-like

    4        Reactome Pathways for GPR39
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)



    GPR39 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPR39

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for GPR39 (O431942, 3 ENSP000003274174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8257317 I2D: score=2 
    AVPR1AENSP000002991784STRING: ENSP00000299178
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9441746

    GPR39 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPR39

    1 IUPHAR Ligand for GPR39 (GPR39)    About this table 
    LigandTypeActionAffinityPubmed IDs
    Zn2+
    AgonistAgonist16959833

    Search CenterWatch for drugs/clinical trials and news about GPR39

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPR39 gene: 
    NM_001508.2  

    Unigene Cluster for GPR39:

    G protein-coupled receptor 39
    Hs.744392  [show with all ESTs]
    Unigene Representative Sequence: NM_001508
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329321(uc002ttl.3) ENST00000470071
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPR39
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GPR39:
    hsa-miR-4314 hsa-miR-1276 hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidGPR39 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GPR39
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPR39
    Clone
    Products:
         
    OriGene clones in human, mouse for GPR39 (see all 7)
    OriGene ORF clones in mouse, rat for GPR39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPR39 (NM_001508)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR39
    Sirion Biotech Customized lentivirus for stable overexpression of GPR39 
                         Customized lentivirus expression plasmids for stable overexpression of GPR39 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GPR39
    OriGene qSTAR qPCR primer pairs in human, mouse for GPR39
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GPR39
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR39
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR39

    Additional mRNA sequence: 

    AF034633.1 AK122643.1 AK123759.1 AK314895.1 BC125046.1 BC125047.1 EU076432.1 FJ348258.1 

    3 DOTS entries:

    DT.92438042  DT.100740281  DT.100781860 

    24/28 AceView cDNA sequences (see all 28):

    AA620332 AA582576 AF034633 AA926905 CA749039 AK123759 NM_001508 AI932891 
    AI767459 CA426790 BM981455 AA960903 AI272281 AA994321 AI140655 AA776783 
    BV179651 AW014802 AI138793 BM980701 AK122643 AI299246 BM974798 AW861731 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPR39 expression in normal human tissues (normalized intensities)      GPR39 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GPR39 Expression
    About this image


    GPR39 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Forebrain White Matter
     
     Ovary (Reproductive System)

    See GPR39 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPR39

    SOURCE GeneReport for Unigene cluster: Hs.744392

    UniProtKB/Swiss-Prot: GPR39_HUMAN, O43194
    Tissue specificity: Expressed in many tissues, including the stomach, intestine and hypothalamus

        SABiosciences Expression via Pathway-Focused PCR Array including GPR39: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GPR39
    OriGene qSTAR qPCR primer pairs in human, mouse for GPR39
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GPR39
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR39
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR39
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR39

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GPR39 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr391 , 5 G protein-coupled receptor 391, 5 80.21(n)1
    81.68(a)1
      1 (54.70 cM)5
    711111  NM_027677.21  NP_081953.21 
     1256769955 
    chicken
    (Gallus gallus)
    Aves GPR391 G protein-coupled receptor 39 67.49(n)
    63.29(a)
      424282  NM_001080105.1  NP_001073574.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    63(a)
    56(a)
    1 ↔ many
    1 ↔ many
    GL343350.1(1622-2533)
    GL343350.1(205396-205920)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc641872 hypothetical protein MGC64187 74.11(n)   393389  BC054634.1 


    ENSEMBL Gene Tree for GPR39 (if available)
    TreeFam Gene Tree for GPR39 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPR39 gene
    GHSR2  NTSR12  NMUR12  MLNR2  NMUR22  TRHR2  NTSR22  
    1 SIMAP similar gene for GPR39 using alignment to 4 protein entries:     GPR39_HUMAN (see all proteins):
    NTSR1

    GPR39 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GPR39
    PGOHUM00000238881


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4916 SNPs in GPR39 are shown (see all 4916)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0493934
    ----see VAR_0493932 R C mis40--------
    rs720435411,2
    C--132893723(+) ACCTC-/TGTGTG
            
    TGTGT
    1 -- int10--------
    rs1113048871,2
    C--133172183(+) AGTGCAG/-ACTGT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs106490041,2
    C--133172184(+) GTGCA-/AG/GA 
            
    CTGTG
    1 -- us2k10--------
    rs1121383891,2
    C,F--133172213(+) CCGGGC/TGCAGT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs67275501,2
    C,F--133172253(+) gaagcC/Tgaggt 1 -- us2k16Minor allele frequency- T:0.42NA WA CSA 12
    rs1908353761,2
    --133172360(+) GGCACA/GCACCT 1 -- us2k10--------
    rs113481231,2
    C--133172493(+) CCCCTC/-CCCCC 1 -- us2k1 tfbs3 trp31Minor allele frequency- -:0.50CSA 2
    rs729992241,2
    C,F--133172525(+) GTTTCT/AATGTG 1 -- us2k12Minor allele frequency- A:0.02WA 120
    rs1823159491,2
    --133172569(+) GCATTC/GCCAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPR39 (133174147 - 133404169 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/35 variations for GPR39 (see all 35):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720834CNV Deletion23290073
    esv2675998CNV Deletion23128226
    dgv732e199CNV Deletion23128226
    esv2659330CNV Deletion23128226
    esv2422046CNV Duplication20811451
    nsv2930CNV Insertion18451855
    nsv2929CNV Insertion18451855
    nsv508106CNV Loss20534489
    nsv471734CNV Loss16327809
    nsv213758CNV Loss16902084

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR39
    DNA2.0 Custom Variant and Variant Library Synthesis for GPR39

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602886    OMIM disorders: --

    8 diseases for GPR39:    About MalaCards
    obesity, association with    hyperparathyroidism    obesity    esophageal squamous cell carcinoma
    diabetes mellitus    esophagitis    squamous cell carcinoma    gastric cancer


    GPR39 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GPR39
    Human Genome Epidemiology (HuGE) Navigator: GPR39 (2 documents)

    Export disorders for GPR39 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPR39 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with GPR39)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. (PubMed id 9441746)1, 2, 3, 9 McKee K.K.... van der Ploeg L.H.T. (1997)
    2. Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. (PubMed id 18588883)1, 2, 9 Storjohann L.... Schwartz T.W. (2008)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Obestatin does not activate orphan G protein-coupled receptor GPR39. (PubMed id 17054911)1, 9 Lauwers E....Luyten W. (2006)
    9. Zinc sensing receptor signaling, mediated by GPR39, re duces butyrate-induced cell death in HT29 colonocytes via upregulation of cluste rin. (PubMed id 22545109)1 Cohen L....Hershfinkel M. (2012)
    10. Extracellular pH regulates zinc signaling via an Asp r esidue of the zinc-sensing receptor (ZnR/GPR39). (PubMed id 22879599)1 Cohen L....Hershfinkel M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2863 HGNC: 4496 AceView: GPR39 Ensembl:ENSG00000183840 euGenes: HUgn2863
    ECgene: GPR39 H-InvDB: GPR39

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPR39 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPR39 gene:
    Search GeneIP for patents involving GPR39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for GPR39 (GPR39)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for GPR39 (GPR39)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GPR39  
     OriGene qPCR primer pairs and template standards for GPR39   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GPR39  
     OriGene qSTAR qPCR primer pairs in human, mouse for GPR39   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GPR39   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GPR39   OriGene Custom Protein Services for GPR39  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPR39
     QIAGEN SeqTarget long-range PCR primers for resequencing GPR39
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR39
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPR39
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR39
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR39
     GenScript Custom Purified and Recombinant Proteins Services for GPR39 GenScript cDNA clones with any tag delivered in your preferred vector for GPR39
     GenScript Custom Assay Services for GPR39 GenScript Custom Superior Antibodies Services for GPR39
     GenScript Custom overexpressing Cell Line Services for GPR39 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GPR39 promoter
     Search Chromatin IP Primers for GPR39
     RT2 qPCR Primer Assay in human, mouse / rat GPR39
     GNC Network for GPR39
     SABiosciences PCR Arrays including human, mouse, rat GPR39
     Search Tocris compounds for GPR39
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GPR39 antibodies
     GPR39 proteins
     Antibodies for GPR39
     See all of Abcam's Antibodies, Kits and Proteins for GPR39
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GPR39
     Antibodies for GPR39
     ELISAs for GPR39
     CLIAs for GPR39
     Search LifeMap BioReagents cell lines for GPR39
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR39
     SwitchGear 3'UTR luciferase reporter plasmids for GPR39
     SwitchGear Promoter luciferase reporter plasmids for GPR39
     ThermoFisher Antibodies for GPR39
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR39
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GPR39
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPR39
    Customized:
     lentivirus for stable overexpression of GPR39
     lentivirus expression plasmids for stable overexpression of GPR39
     adenovirus for overexpression of GPR39
     LSBio Antibodies in human, mouse, rat for GPR39
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GPR39 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4