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GPR37L1 Gene

protein-coding   GIFtS: 56
GCID: GC01P202091

G Protein-Coupled Receptor 37 Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 37 Like 11 2     Endothelin Type B Receptor-Like Protein 22
Endothelin B Receptor-Like Protein 22 3     G-Protein Coupled Receptor 37 Like 12
ETBR-LP-22 3     Prosaposin Receptor GPR37L12
G-Protein Coupled Receptor 37-Like 12 3     ETBRLP23
ET(B)R-LP-22     

External Ids:    HGNC: 149231   Entrez Gene: 92832   Ensembl: ENSG000001700757   UniProtKB: O608833   

Export aliases for GPR37L1 gene to outside databases

Previous GC identifers: GC01U990381 GC01P199381 GC01P198823 GC01P200358 GC01P173257


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GPR37L1 Gene:
GPR37L1 (G protein-coupled receptor 37 like 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is EDNRA.

UniProtKB/Swiss-Prot: ETBR2_HUMAN, O60883
Function: Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces
endocytosis, followed by an ERK phosphorylation cascade

Gene Wiki entry for GPR37L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR37L1 gene promoter:
         ER-alpha   HOXA9   HOXA9B   NF-1   Elk-1   Meis-1b   NF-AT4   NF-AT3   Meis-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR37L1 promoter sequence
   Search Chromatin IP Primers for GPR37L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR37L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

GPR37L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR37L1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P202091:  view genomic region     (about GC identifiers)

Start:
202,091,986 bp from pter      End:
202,102,720 bp from pter
Size:
10,735 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ETBR2_HUMAN, O60883 (See protein sequence)
Recommended Name: Prosaposin receptor GPR37L1 precursor  
Size: 481 amino acids; 52771 Da
Secondary accessions: B2R7M9 Q5SXP7 Q86VP7

Explore the universe of human proteins at neXtProt for GPR37L1: NX_O60883

Explore proteomics data for GPR37L1 at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Glycosylation2 at Thr79, Thr85, Ser86, Thr95, Asn105, Thr107
  • Modification sites at PhosphoSitePlus

  • See GPR37L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004758.3  
    ENSEMBL proteins: 
     ENSP00000356251  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR37L1
    Class A Orphans

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003909 GPR37_orph
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O60883

    ProtoNet protein and cluster: O60883

    1 Blocks protein domain: IPB003909 GPR37 orphan receptor signature

    UniProtKB/Swiss-Prot: ETBR2_HUMAN, O60883
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GPR37L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ETBR2_HUMAN, O60883
    Function: Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces
    endocytosis, followed by an ERK phosphorylation cascade

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with GPR37L1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR37L1:
     Increased circadian period len 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gpr37l1):
     behavior/neurological  cellular  nervous system  normal  vision/eye 

    Find genes that share phenotypes with GPR37L1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GPR37L1: Gpr37l1tm1Lex Gpr37l1tm1.2Gtva

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR37L1
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    miRNA
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    miRTarBase miRNAs that target GPR37L1:
    hsa-mir-335-5p (MIRT017851)

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    SwitchGear 3'UTR luciferase reporter plasmidGPR37L1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ETBR2_HUMAN, O60883: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane NAS9539149
    GO:0043235receptor complex IDA--

    Find genes that share ontologies with GPR37L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPR37L1 About    
    See pathways by source

    SuperPathContained pathways About
    1Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    2Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    1 BioSystems Pathway for GPR37L1
        GPCRs, Class A Rhodopsin-like



        Pathway & Disease-focused RT2 Profiler PCR Array including GPR37L1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPR37L1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for GPR37L1 (O608831, 3 ENSP000003562514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRCPP427851, 3, ENSP000003770554EBI-2927498,EBI-2803892 I2D: score=1 STRING: ENSP00000377055
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0008150biological_process ND--

    Find genes that share ontologies with GPR37L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR37L1 (ETBR2)

    1 IUPHAR Ligand for GPR37L1 (GPR37L1)    About this table
    LigandTypeActionAffinityPubmed IDs
    prosaptide
    AgonistAgonist8.323690594



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPR37L1 gene: 
    NM_004767.3  

    Unigene Cluster for GPR37L1:

    G protein-coupled receptor 37 like 1
    Hs.132049  [show with all ESTs]
    Unigene Representative Sequence: BC050334
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367282(uc001gxj.3)
    miRNA
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    hsa-miR-3168 hsa-miR-149 hsa-miR-1291 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidGPR37L1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat GPR37L1
      QuantiFast Probe-based Assays in human, mouse, rat GPR37L1

    Additional mRNA sequence: 

    AK222639.1 AK295576.1 AK313044.1 BC050334.1 Y16280.1 

    5 DOTS entries:

    DT.305161  DT.95260006  DT.99935257  DT.86858229  DT.87007355 

    Selected AceView cDNA sequences (see all 34):

    R19791 BC050334 BX282104 AA350595 NM_004767 BX645405 T27053 T09143 
    Y16280 BI819816 AL038963 BF346123 BI824943 BG699788 BF924566 BG821031 
    BF528589 BG819832 BI604112 BI546091 BF530127 BQ345919 BF530565 BI601027 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR37L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGGTGCGA
    GPR37L1 Expression
    About this image


    GPR37L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
    GPR37L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR37L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132049

    UniProtKB/Swiss-Prot: ETBR2_HUMAN, O60883
    Tissue specificity: Expressed in the central nervous system

        Pathway & Disease-focused RT2 Profiler PCR Array including GPR37L1: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPR37L1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr37l11 , 5 G protein-coupled receptor 37-like 11, 5 86.07(n)1
    90.85(a)1
      1 (58.25 cM)5
    1714691  NM_134438.31  NP_602320.21 
     1351602345 
    chicken
    (Gallus gallus)
    Aves GPR37L11 G protein-coupled receptor 37 like 1 76.09(n)
    70.36(a)
      421176  XM_419256.4  XP_419256.4 
    lizard
    (Anolis carolinensis)
    Reptilia GPR37L16
    G protein-coupled receptor 37 like 1
    59(a)
    1 ↔ 1
    4(132546153-132559821)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.181032 Xenopus laevis transcribed sequence with weak similarity more 74.36(n)    BG885786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gpr37l1b1 G protein-coupled receptor 37 like 1b 59.46(n)
    53.06(a)
      567796  XM_691100.3  XP_696192.2 


    ENSEMBL Gene Tree for GPR37L1 (if available)
    TreeFam Gene Tree for GPR37L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPR37L1 gene
    EDNRA2  GRPR2  GPR372  BRS32  EDNRB2  NMBR2  
    1 SIMAP similar gene for GPR37L1 using alignment to 1 protein entry:     ETBR2_HUMAN:
    GPR37

    Find genes that share paralogs with GPR37L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPR37L1 (see all 278)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345444041,2
    C--202090052(+) TTTTG-/TAGACA 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1929872351,2
    --202090126(+) ATCTCA/GGATCA 1 -- us2k10--------
    rs1440232871,2
    --202090528(+) CTTGAC/TTCTGG 1 -- us2k10--------
    rs1852821311,2
    --202090573(+) CCCCCA/GGTCTC 1 -- us2k10--------
    rs743884461,2
    C,F--202090581(+) CTCTGC/TATCCT 1 -- us2k12Minor allele frequency- T:0.05CSA WA 120
    rs43295631,2
    C,F,A,H--202090641(+) AATAAC/GTTAGT 1 -- us2k129Minor allele frequency- G:0.31NS EA NA WA CSA 2981
    rs1464593641,2
    --202090729(+) GCATAA/CAAAGT 1 -- us2k10--------
    rs1905087061,2
    C--202090749(+) TCCAGC/TTCCTC 1 -- us2k10--------
    rs1163317271,2
    F--202090827(+) AGTCCC/TCTCGA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1406553021,2
    C--202090831(+) CCCTCA/GACAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPR37L1 (202091986 - 202102720 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GPR37L1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR37L1
    DNA2.0 Custom Variant and Variant Library Synthesis for GPR37L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with GPR37L1           About GenesLikeMe

    Genetic Association Database (GAD): GPR37L1
    Human Genome Epidemiology (HuGE) Navigator: GPR37L1 (2 documents)

    Export disorders for GPR37L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR37L1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with GPR37L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new family of orphan G protein-coupled receptors predominantly expressed in the brain. (PubMed id 9539149)1, 2, 3, 9 Valdenaire O....Richards J.G. (FEBS Lett. 1998)
    2. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. (PubMed id 23690594)1, 2 Meyer R.C....Hall R.A. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    3. Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. (PubMed id 20360844)1, 4 Arking D.E....Chugh S.S. (PLoS ONE 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)2 Halim A.... Nilsson J. (J. Proteome Res. 2013)
    6. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9283 HGNC: 14923 AceView: GPR37L1 Ensembl:ENSG00000170075 euGenes: HUgn9283
    ECgene: GPR37L1 H-InvDB: GPR37L1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPR37L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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