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Aliases for GPR37L1 Gene

Aliases for GPR37L1 Gene

  • G Protein-Coupled Receptor 37 Like 1 2 3 5
  • Endothelin B Receptor-Like Protein 2 3 4
  • ETBR-LP-2 3 4
  • ETBRLP2 3 4
  • Endothelin Type B Receptor-Like Protein 2 3
  • G-Protein Coupled Receptor 37-Like 1 4
  • Prosaposin Receptor GPR37L1 3
  • ET(B)R-LP-2 3

External Ids for GPR37L1 Gene

Previous GeneCards Identifiers for GPR37L1 Gene

  • GC01U990381
  • GC01P199381
  • GC01P198823
  • GC01P200358
  • GC01P202091
  • GC01P173257

Summaries for GPR37L1 Gene

GeneCards Summary for GPR37L1 Gene

GPR37L1 (G Protein-Coupled Receptor 37 Like 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled peptide receptor activity. An important paralog of this gene is GPR37.

UniProtKB/Swiss-Prot for GPR37L1 Gene

  • Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Wiki entry for GPR37L1 Gene

Additional gene information for GPR37L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR37L1 Gene

Genomics for GPR37L1 Gene

Regulatory Elements for GPR37L1 Gene

Enhancers for GPR37L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H202117 1.6 Ensembl ENCODE dbSUPER 8.9 -0.1 -88 2.1 PKNOX1 ARNT ARID4B SIN3A ZBTB7B ZNF766 ZNF207 ZNF143 DEK REST RNPEP ENSG00000273478 HNRNPA1P59 ELF3-AS1 KDM5B LOC100506672 IPO9 RPS27P8 GPR37L1 PTPRVP
GH01H201954 1.2 ENCODE 11.2 -163.2 -163185 2.5 HNRNPUL1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 RNPEP KDM5B ENSG00000273478 TIMM17A RPS27P8 LMOD1 ARL8A GPR37L1 LOC100506672 IPO9
GH01H202103 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.1 -11.8 -11758 6.6 HDGF FOXA2 PKNOX1 ZBTB7B YY1 FOS DEK SP3 SMARCB1 ZNF592 ELF3-AS1 ELF3 RNPEP ENSG00000273478 HNRNPA1P59 ENSG00000249007 RPS27P8 TIMM17A GPR37L1 PTPRVP
GH01H202112 1.4 Ensembl ENCODE dbSUPER 8 -4.8 -4797 3.8 FOXA2 NFIB NFXL1 BMI1 RAD21 ZBTB7B YY1 SCRT2 ZNF207 FOS GPR37L1 PTPRVP CRIP1P3
GH01H201999 1 ENCODE dbSUPER 11.1 -118.9 -118918 0.2 CTCF PKNOX1 ZNF2 THRB RAD21 CC2D1A POLR2A ZBTB48 SCRT2 SMC3 LMOD1 GPR37L1 TIMM17A ARL8A PTPN7 ENSG00000273478 MIR6740
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR37L1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GPR37L1 Gene

Genomic Locations for GPR37L1 Gene
14,888 bases
Plus strand

Genomic View for GPR37L1 Gene

Genes around GPR37L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR37L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR37L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR37L1 Gene

Proteins for GPR37L1 Gene

  • Protein details for GPR37L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prosaposin receptor GPR37L1
    Protein Accession:
    Secondary Accessions:
    • B2R7M9
    • Q5SXP7
    • Q86VP7

    Protein attributes for GPR37L1 Gene

    481 amino acids
    Molecular mass:
    52771 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR37L1 Gene

Post-translational modifications for GPR37L1 Gene

  • O-glycosylated.
  • Glycosylation at isoforms=79, posLast=8585, isoforms=86, posLast=9595, posLast=105105, and posLast=107107
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR37L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR37L1 Gene

Domains & Families for GPR37L1 Gene

Gene Families for GPR37L1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR37L1 Gene

Suggested Antigen Peptide Sequences for GPR37L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR37L1: view

Function for GPR37L1 Gene

Molecular function for GPR37L1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Ontology (GO) - Molecular Function for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 20517885
GO:0008528 G-protein coupled peptide receptor activity IDA 23690594
GO:0036505 prosaposin receptor activity IDA 23690594
GO:0042277 peptide binding IPI 23690594
genes like me logo Genes that share ontologies with GPR37L1: view
genes like me logo Genes that share phenotypes with GPR37L1: view

Animal Models for GPR37L1 Gene

MGI Knock Outs for GPR37L1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR37L1 Gene

Localization for GPR37L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR37L1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR37L1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9539149
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR37L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR37L1 Gene

Pathways & Interactions for GPR37L1 Gene

genes like me logo Genes that share pathways with GPR37L1: view

Pathways by source for GPR37L1 Gene

Gene Ontology (GO) - Biological Process for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA 23690594
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation IEA --
GO:0043410 positive regulation of MAPK cascade IEA,IDA 23690594
genes like me logo Genes that share ontologies with GPR37L1: view

No data available for SIGNOR curated interactions for GPR37L1 Gene

Drugs & Compounds for GPR37L1 Gene

(1) Drugs for GPR37L1 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
prosaptide Pharma Agonist 0
genes like me logo Genes that share compounds with GPR37L1: view

Transcripts for GPR37L1 Gene

mRNA/cDNA for GPR37L1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR37L1 Gene

G protein-coupled receptor 37 like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR37L1 Gene

No ASD Table

Relevant External Links for GPR37L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR37L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR37L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR37L1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.9), Brain - Putamen (basal ganglia) (x5.4), Brain - Nucleus accumbens (basal ganglia) (x5.3), Brain - Amygdala (x5.1), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GPR37L1 Gene

This gene is overexpressed in Spinal cord (46.8) and Frontal cortex (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR37L1 Gene

Protein tissue co-expression partners for GPR37L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR37L1 Gene:


SOURCE GeneReport for Unigene cluster for GPR37L1 Gene:


mRNA Expression by UniProt/SwissProt for GPR37L1 Gene:

Tissue specificity: Expressed in the central nervous system.

Evidence on tissue expression from TISSUES for GPR37L1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with GPR37L1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR37L1 Gene

Orthologs for GPR37L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR37L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR37L1 33 34
  • 99.1 (n)
(Rattus norvegicus)
Mammalia Gpr37l1 33
  • 86.97 (n)
(Canis familiaris)
Mammalia GPR37L1 33 34
  • 86.93 (n)
(Mus musculus)
Mammalia Gpr37l1 33 16 34
  • 86.07 (n)
(Monodelphis domestica)
Mammalia GPR37L1 34
  • 82 (a)
(Bos Taurus)
Mammalia GPR37L1 33 34
  • 78.93 (n)
(Ornithorhynchus anatinus)
Mammalia GPR37L1 34
  • 77 (a)
(Gallus gallus)
Aves GPR37L1 33 34
  • 76.09 (n)
(Anolis carolinensis)
Reptilia GPR37L1 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr37l1 33
  • 57.51 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18103 33
(Danio rerio)
Actinopterygii gpr37l1b 33 34
  • 59.46 (n)
gpr37l1a 34
  • 48 (a)
Species where no ortholog for GPR37L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR37L1 Gene

Gene Tree for GPR37L1 (if available)
Gene Tree for GPR37L1 (if available)

Paralogs for GPR37L1 Gene

Paralogs for GPR37L1 Gene

(1) SIMAP similar genes for GPR37L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR37L1: view

Variants for GPR37L1 Gene

Sequence variations from dbSNP and Humsavar for GPR37L1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000921 -- 202,122,461(+) CTACA(A/C)ACCTC intron-variant, upstream-variant-2KB
rs1000115168 -- 202,122,135(+) GGGAG(A/G)CTGAG intron-variant, upstream-variant-2KB
rs1000115749 -- 202,125,881(+) CACGC(C/T)CGGCT intron-variant, upstream-variant-2KB
rs1000299850 -- 202,133,299(+) CGCTC(C/T)GTGGC intron-variant, utr-variant-3-prime
rs1000415742 -- 202,133,576(+) CAAAC(A/G)GAACC utr-variant-3-prime

Variation tolerance for GPR37L1 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR37L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR37L1 Gene

Disorders for GPR37L1 Gene

Relevant External Links for GPR37L1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR37L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR37L1 Gene

Publications for GPR37L1 Gene

  1. A new family of orphan G protein-coupled receptors predominantly expressed in the brain. (PMID: 9539149) Valdenaire O … Richards JG (FEBS letters 1998) 2 3 4 22 60
  2. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. (PMID: 23690594) Meyer RC … Hall RA (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 60
  3. Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. (PMID: 20360844) Arking DE … Chugh SS (PloS one 2010) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity. (PMID: 27072655) Coleman JL … Smith NJ (Science signaling 2016) 3 60

Products for GPR37L1 Gene

Sources for GPR37L1 Gene

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