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Aliases for GPR37 Gene

Aliases for GPR37 Gene

  • G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like) 2 3
  • Parkin-Associated Endothelin Receptor-Like Receptor 3 4
  • Endothelin B Receptor-Like Protein 1 3 4
  • G-Protein Coupled Receptor 37 3 4
  • ETBR-LP-1 3 4
  • PAELR 3 4
  • Probable G-Protein Coupled Receptor 37 3
  • Prosaposin Receptor GPR37 3
  • HET(B)R-LP 3
  • EDNRBL 3

External Ids for GPR37 Gene

Previous GeneCards Identifiers for GPR37 Gene

  • GC07M122864
  • GC07M123926
  • GC07M123940
  • GC07M123980
  • GC07M124173
  • GC07M124386
  • GC07M118751

Summaries for GPR37 Gene

Entrez Gene Summary for GPR37 Gene

  • This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

GeneCards Summary for GPR37 Gene

GPR37 (G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like)) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Proteolysis_Putative ubiquitin pathway. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is EDNRB.

UniProtKB/Swiss-Prot for GPR37 Gene

  • Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Wiki entry for GPR37 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR37 Gene

Genomics for GPR37 Gene

Regulatory Elements for GPR37 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPR37 Gene

124,745,601 bp from pter
124,766,025 bp from pter
20,425 bases
Minus strand

Genomic View for GPR37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR37 Gene

Proteins for GPR37 Gene

  • Protein details for GPR37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prosaposin receptor GPR37
    Protein Accession:
    Secondary Accessions:
    • A4D0Y6
    • O00348
    • O14768
    • Q8TD39

    Protein attributes for GPR37 Gene

    613 amino acids
    Molecular mass:
    67114 Da
    Quaternary structure:
    • Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG.

neXtProt entry for GPR37 Gene

Proteomics data for GPR37 Gene at MOPED

Post-translational modifications for GPR37 Gene

  • Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.
  • Glycosylation at Asn36, Asn222, and Asn239
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR37 Gene

Domains for GPR37 Gene

Gene Families for GPR37 Gene

  • GPCRAO :GPCR / Class A : Orphans

Protein Domains for GPR37 Gene

Suggested Antigen Peptide Sequences for GPR37 Gene

Graphical View of Domain Structure for InterPro Entry



  • O15354
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR37: view

Function for GPR37 Gene

Molecular function for GPR37 Gene

GENATLAS Biochemistry: putative G protein coupled receptor 37,expressed at highest levels in human brain,spinal cord and at lower levels in testis,placenta,liver,with homology to bombesin receptor
UniProtKB/Swiss-Prot Function: Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Ontology (GO) - Molecular Function for GPR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 9144577
GO:0005515 protein binding IPI 14532270
GO:0008528 G-protein coupled peptide receptor activity IDA 23690594
GO:0030544 Hsp70 protein binding IPI 12150907
GO:0031072 heat shock protein binding IPI 12150907
genes like me logo Genes that share ontologies with GPR37: view
genes like me logo Genes that share phenotypes with GPR37: view

Animal Models for GPR37 Gene

MGI Knock Outs for GPR37:

Animal Model Products

CRISPR Products

miRNA for GPR37 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR37

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GPR37 Gene

Localization for GPR37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR37 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR37 Gene COMPARTMENTS Subcellular localization image for GPR37 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 12150907
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9144577
genes like me logo Genes that share ontologies with GPR37: view

Pathways for GPR37 Gene

genes like me logo Genes that share pathways with GPR37: view

Pathways by source for GPR37 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for GPR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 9144577
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA 23690594
GO:0031987 locomotion involved in locomotory behavior IEA --
GO:0042416 dopamine biosynthetic process IEA --
GO:0043410 positive regulation of MAPK cascade IDA 23690594
genes like me logo Genes that share ontologies with GPR37: view

Compounds for GPR37 Gene

(2) IUPHAR Ligand for GPR37 Gene

Ligand Type Action Affinity Pubmed IDs
neuropeptide head activator Agonist Agonist 8.48
prosaptide Agonist Agonist 8.15
genes like me logo Genes that share compounds with GPR37: view

Transcripts for GPR37 Gene

mRNA/cDNA for GPR37 Gene

(79) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR37 Gene

G protein-coupled receptor 37 (endothelin receptor type B-like):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR37

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR37 Gene

No ASD Table

Relevant External Links for GPR37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR37 Gene

mRNA expression in normal human tissues for GPR37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR37 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (11.3), Brain - Substantia nigra (6.3), Brain - Hippocampus (5.4), Brain - Putamen (basal ganglia) (4.3), and Brain - Amygdala (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPR37 Gene

SOURCE GeneReport for Unigene cluster for GPR37 Gene Hs.731392

mRNA Expression by UniProt/SwissProt for GPR37 Gene

Tissue specificity: Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).
genes like me logo Genes that share expressions with GPR37: view

In Situ Assay Products

Orthologs for GPR37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR37 35
  • 99.56 (n)
  • 100 (a)
GPR37 36
  • 100 (a)
(Bos Taurus)
Mammalia GPR37 35
  • 87.42 (n)
  • 88.73 (a)
GPR37 36
  • 89 (a)
(Canis familiaris)
Mammalia GPR37 35
  • 87.91 (n)
  • 87.25 (a)
GPR37 36
  • 87 (a)
(Mus musculus)
Mammalia Gpr37 35
  • 81.67 (n)
  • 83.5 (a)
Gpr37 16
Gpr37 36
  • 83 (a)
(Monodelphis domestica)
Mammalia GPR37 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia GPR37 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Gpr37 35
  • 81.21 (n)
  • 83.91 (a)
(Gallus gallus)
Aves GPR37 35
  • 80.32 (n)
  • 89.95 (a)
GPR37 36
  • 84 (a)
(Anolis carolinensis)
Reptilia GPR37 36
  • 91 (a)
(Danio rerio)
Actinopterygii Dr.17898 35
GPR37 (2 of 2) 36
  • 55 (a)
gpr37b 36
  • 47 (a)
LOC100537916 35
  • 67.11 (n)
  • 73.6 (a)
Species with no ortholog for GPR37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR37 Gene

Gene Tree for GPR37 (if available)
Gene Tree for GPR37 (if available)

Paralogs for GPR37 Gene

Paralogs for GPR37 Gene

Selected SIMAP similar genes for GPR37 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR37: view

Variants for GPR37 Gene

Sequence variations from dbSNP and Humsavar for GPR37 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2835 -- 124,746,120(+) AATCA(A/T)CTCAC utr-variant-3-prime
rs724356 -- 124,747,320(-) ACCAC(C/T)TTCAC synonymous-codon, reference
rs1003897 -- 124,765,056(-) CCTAA(C/T)TCTCA utr-variant-5-prime
rs1003898 -- 124,765,054(-) TAACT(C/T)TCAGC utr-variant-5-prime
rs1557969 -- 124,765,684(-) CAGCC(C/T)GCTTC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR37 Gene

Variant ID Type Subtype PubMed ID
nsv366106 CNV Loss 16902084

Relevant External Links for GPR37 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR37 Gene

Disorders for GPR37 Gene

(1) University of Copenhagen DISEASES for GPR37 Gene

(3) Novoseek inferred disease relationships for GPR37 Gene

Disease -log(P) Hits PubMed IDs
parkinsonism juvenile autosomal recessive 94.1 1
parkinson disease 60.9 4
neurodegeneration 40.8 3

Relevant External Links for GPR37

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GPR37: view

No data available for UniProtKB/Swiss-Prot for GPR37 Gene

Publications for GPR37 Gene

  1. A novel endothelin receptor type-B-like gene enriched in the brain. (PMID: 9144577) Zeng Z. … Li Y. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  2. CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. (PMID: 12150907) Imai Y. … Takahashi R. (Mol. Cell 2002) 3 4 23
  3. A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. (PMID: 17059562) Omura T. … Nomura Y. (J. Neurochem. 2006) 3 4 23
  4. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PMID: 14532270) Imai Y. … Takahashi R. (J. Biol. Chem. 2003) 3 4 23
  5. Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library. (PMID: 9339362) Marazziti D. … Tocchini-Valentini G.P. (Genomics 1997) 2 3 4

Products for GPR37 Gene

Sources for GPR37 Gene

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