Aliases for GPR37 Gene
External Ids for GPR37 Gene
Previous GeneCards Identifiers for GPR37 Gene
This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
GeneCards Summary for GPR37 Gene
GPR37 (G Protein-Coupled Receptor 37) is a Protein Coding gene. Diseases associated with GPR37 include parkinson disease, late-onset. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Chks in Checkpoint Regulation. GO annotations related to this gene include G-protein coupled receptor activity and peptide binding. An important paralog of this gene is EDNRB.
UniProtKB/Swiss-Prot for GPR37 Gene
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.