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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR37 Gene

protein-coding   GIFtS: 61
GCID: GC07M124386

G protein-coupled receptor 37 (endothelin receptor type...
 Explore 8 diseases affiliated with
GPR37 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GPR37    

Aliases
for GPR37 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like)1 2     Endothelin B Receptor-Like Protein 12 3
PAELR1 2 3     ETBR-LP-12 3
EDNRBL1 2     Parkin-Associated Endothelin Receptor-Like Receptor2 3
HET(B)R-LP1     Probable G-Protein Coupled Receptor 372

External Ids:    HGNC: 44941   Entrez Gene: 28612   Ensembl: ENSG000001707757   OMIM: 6025835   UniProtKB: O153543   

Export aliases for GPR37 gene to outside databases

Previous GC identifers: GC07M122864 GC07M123926 GC07M123940 GC07M123980 GC07M124173 GC07M118751


Summaries
for GPR37 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GPR37:
This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane
domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in
translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and
is involved in juvenile Parkinson disease. (provided by RefSeq, Oct 2012)

UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354
Function: Orphan receptor. May have a unique functional role in the central nervous system

Gene Wiki entry for GPR37


Genomic Views
for GPR37 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR37 gene promoter:
         NF-kappaB   Meis-1b   POU2F1   POU2F1a   Meis-1a   NF-kappaB1   Meis-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GPR37 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPR37

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.33   HGNC cytogenetic band: 7q31

GPR37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR37 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M124386:  view genomic region     (about GC identifiers)

Start:
 124,386,051 bp from pter      End:
 124,405,681 bp from pter
Size:
 19,631 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 123,775,505-123,795,072     

Proteins
for GPR37 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 37 precursor  
Size: 613 amino acids; 67114 Da
Subunit: Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress.
STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts
with PACRG
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane
protein
Secondary accessions: O00348 O14768 Q8TD39

Explore the universe of human proteins at neXtProt for GPR37: NX_O15354

Post-translational modifications:

  • Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is
    • specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15354

    • GPR37 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005293.1  
    ENSEMBL proteins: 
     ENSP00000306449  

    Human Recombinant Protein Products: 
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    Uscn Proteins for GPR37

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005887integral to plasma membrane TAS9144577


    GPR37 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for GPR37 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GPR37 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003909 GPR37_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O15354

    ProtoNet protein and cluster: O15354

    1 Blocks protein family: IPB003909 GPR37 orphan receptor signature

    UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for GPR37 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354
    Function: Orphan receptor. May have a unique functional role in the central nervous system

         Genatlas biochemistry entry for GPR37:
    putative G protein coupled receptor 37,expressed at highest levels in human brain,spinal cord and at lower levels in
    testis,placenta,liver,with homology to bombesin receptor

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate GPR37:
    hsa-miR-186 hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: GPR37 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPR37 (see all 7)
    OriGene shRNA RFP: GPR37
    OriGene siRNA: GPR37
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    Gene Editing
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    Clone
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    Cell Line
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    LifeMap BioReagents: cell lines associated with GPR37: PureStem 4D20.8, NCr-fac Progenitor,
    PureStem MEL2, NCr-fac Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR37

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--


    GPR37 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for GPR37: Gpr37tm2Gtva Gpr37tm1.1Ryot
         7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Gpr37):
     adipose tissue  behavior/neurological  cellular  homeostasis/metabolism  nervous system 
     no phenotypic analysis  normal 

    GPR37 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GPR37 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    		Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway1.00
    		Parkin-Ubiquitin Proteasomal System pathway0.93
    		Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    2Proteolysis Putative ubiquitin pathway
    		Proteolysis Putative ubiquitin pathway1.00
    		Proteolysis_Putative ubiquitin pathway0.97
    3Parkinsons Disease Pathway
    		Parkinsons Disease Pathway1.00
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Parkinson's disease0.61
    5Class A/1 (Rhodopsin-like receptors)
    		GPCRs, Class A Rhodopsin-like0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for GPR37
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GPR37
        Parkinson's Disease Pathway

    2 GeneGo (Thomson Reuters) Pathways for GPR37
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    3 BioSystems Pathways for GPR37 
        Parkinsons Disease Pathway
    GPCRs, Class A Rhodopsin-like
    Parkin-Ubiquitin Proteasomal System pathway


    1         Kegg Pathway  (Kegg details for GPR37):
        Parkinson's disease


    GPR37 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPR37

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for GPR37 (O153543 ENSP000003064494) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    PARK2O602603, ENSP000003558654I2D: score=2 STRING: ENSP00000355865
    STUB1Q9UNE73, ENSP000002195484I2D: score=2 STRING: ENSP00000219548
    DNAJA1P316893, ENSP000003691274I2D: score=1 STRING: ENSP00000369127
    HSPA1BP081073I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9144577


    GPR37 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GPR37 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPR37
    Search CenterWatch for drugs/clinical trials and news about GPR37 

    Transcripts
    for GPR37 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GPR37 gene: 
    NM_005302.3  

    Unigene Cluster for GPR37:

    G protein-coupled receptor 37 (endothelin receptor type B-like)
    Hs.731392  [show with all ESTs]
    Unigene Representative Sequence: NM_005302
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303921(uc003vli.3)

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate GPR37:
    hsa-miR-186 hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: GPR37 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPR37 (see all 7)
    OriGene shRNA RFP: GPR37
    OriGene siRNA: GPR37
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPR37
    Clone
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    GenScript: all cDNA clones in your preferred vector: GPR37 (NM_005302)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR37
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR37 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR37

    Additional cDNA sequence: 

    AF017262.1 AF502281.2 BC040007.1 

    5 DOTS entries:

    DT.100837475  DT.40295718  DT.217334  DT.97779229  DT.92426999 

    24/79 AceView cDNA sequences (see all 79):

    BG623764 BE465524 Z40458 BC040007 BE465532 AI362294 NM_005302 BQ000998 
    BX649006 BI824622 AF017262 AL048884 BX369149 AA741351 BU736607 BU733966 
    BG211140 BX336362 BQ441347 BI551804 AI052393 BX391681 BI766310 AF502281 

    GeneLoc Exon Structure


    Expression
    for GPR37 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPR37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGTGCTGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GPR37 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GPR37 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPR37

    SOURCE GeneReport for Unigene cluster: Hs.731392

    UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354
    Tissue specificity: Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no
    detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and
    unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease
    (PDJ)

        SABiosciences Expression via Pathway-Focused PCR Arrays including GPR37: 
              Parkinson's Disease in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR37

    Orthologs
    for GPR37 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GPR37 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GPR371 G protein-coupled receptor 37 (endothelin receptor type B-like) less 80.32(n)
    89.95(a)    		   417748  NM_001081699.1  NP_001075168.1 
    lizard
    (Anolis carolinensis)    		 Reptilia B8QC68_ANOCA6
    		 G protein-coupled receptor 37 Fragment
    		 91(a)
    		 1 ↔ 1
    		 5(66925165-66925674)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.178982 Transcribed sequence with moderate similarity to protein spO15354 (H.sapiens) GP37_HUMAN Probable G protein-coupled receptor GPR37 precursor (Endothelin B receptor-like protein-1) (ETBR-LP-1) less 77.56(n)    AL718838.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CCHa2r6
    CCHa1r6
    		 CCHamide-1 receptor
    		 17(a)
    16(a)
    		 many ↔ many
    many ↔ many
    		 2R(1938477-1956185)
    2R(13535037-13541801)


    ENSEMBL Gene Tree for GPR37 (if available)
    TreeFam Gene Tree for GPR37 (if available) 

    Paralogs
    for GPR37 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPR37 gene
    EDNRA2  GRPR2  BRS32  EDNRB2  NMBR2  GPR37L12  
    1 SIMAP similar gene for GPR37 using alignment to 2 protein entries:     GPR37_HUMAN (see all proteins):
    GPR37L1

    GPR37 for paralogs           About GeneDecksing



    Genomic Variants
    for GPR37 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/358 NCBI SNPs in GPR37 are shown (see all 358)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1409789521,2
    		--124385191(+) TTATAA/GTTTGG 1 -- ds50010--------
    rs1908803051,2
    		--124385230(+) AGTAGA/CACAGA 1 -- ds50010--------
    rs1449250681,2
    		--124385243(+) TCAACA/GAGCAG 1 -- ds50010--------
    rs96558441,2
    		C,F,H,--124385252(+) AGAAAA/CTACGT 1 -- ds500126Minor allele frequency- C:0.31NS EA NA WA CSA 2401
    rs1479218581,2
    		--124385376(+) TCTCTC/GCCACC 1 -- ds50010--------
    rs47312051,2
    		C,F,A,H,--124385442(+) ACTCCC/AGAAGA 1 -- ds500120Minor allele frequency- A:0.30NS EA NA WA CSA 2017
    rs1834528871,2
    		--124385452(+) AGGCAA/GAAGAG 1 -- ds50010--------
    rs1417908541,2
    		--124385527(+) TTAAAG/TGTAGA 1 -- ds50010--------
    rs1469521641,2
    		--124385560(+) ATATTG/TTATTA 1 -- ds50010--------
    rs1449738081,2
    		--124385576(+) CTCCTA/CTACTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GPR37 (124386051 - 124405681 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GPR37: --

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    Disorders / Diseases
    for GPR37 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GPR37 for disorders           About GeneDecksing

    OMIM gene information: 602583    OMIM disorders: --

    8 diseases for GPR37:    About MalaCards
    hyperaldosteronism    parkinson's disease    neurodegeneration    hepatitis b
    aldosteronism    adenoma    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for GPR37:
    Parkinson's disease

    3 Novoseek disease relationships for GPR37 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinsonism juvenile autosomal recessive 94.1 1 15572843 (1)
    parkinson disease 60.9 5 17301052 (2), 19218498 (1), 17251065 (1)
    neurodegeneration 40.8 4 19348945 (1), 15572841 (1), 12150907 (1)

    Human Genome Epidemiology (HuGE) Navigator: GPR37 (2 documents)

    Export disorders for GPR37 gene to outside databases

    Publications
    for GPR37 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPR37 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with GPR37)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library. (PubMed id 9339362)1, 2, 3 Marazziti D....Tocchini-Valentini G.P. (1997)
    2. A novel endothelin receptor type-B-like gene enriched in the brain. (PubMed id 9144577)1, 2, 9 Zeng Z.... Li Y. (1997)
    3. CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. (PubMed id 12150907)1, 2, 9 Imai Y....Takahashi R. (2002)
    4. A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. (PubMed id 17059562)1, 2, 9 Omura T.... Nomura Y. (2006)
    5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2, 9 Imai Y.... Takahashi R. (2003)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    8. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. (PubMed id 11439185)1, 2 Imai Y.... Takahashi R. (2001)
    9. A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system. (PubMed id 9526070)1, 2 Donohue P.J....Battey J.F. (1998)
    10. GPR37 surface expression enhancement via N-terminal t runcation or protein-protein interactions. (PubMed id 19799451)1, 9 Dunham J.H....Hall R.A. (2009)

    External Searches for GPR37 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GPR37 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2861 HGNC: 4494 AceView: GPR37 Ensembl:ENSG00000170775 euGenes: HUgn2861
    ECgene: GPR37 Kegg: 2861 H-InvDB: GPR37

    Other Databases showing GPR37 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GPR37 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPR37 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GPR37 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GPR37 gene:
    Search GeneIP for patents involving GPR37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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