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Aliases & Descriptions for GPR37
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EDNRBL 1, 2 | | ETBR-LP-1 3 | | PAELR 1, 2, 3 | | hET(B)R-LP 1, 2 |
| | | Descriptions |
|---|
| Endothelin B receptor-like protein 1 3 | | G protein-coupled receptor 37 2 | G protein-coupled receptor 37 (endothelin receptor type B-like) 2 | | Parkin-associated endothelin receptor-like receptor 2, 3 | | endothelin receptor type B-like 2 |
|
| | Search outside databases for aliases for GPR37 genePrevious GC identifers: GC07M122864 GC07M123926 GC07M123940 GC07M123980 |
Summaries for GPR37(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354Function: Orphan receptor. May have a unique functional role in the central nervous systemGene Wiki entry for GPR37 |
Genomic Location for GPR37
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GPR37 gene 
Entrez Gene cytogenetic band: 7q31 Ensembl cytogenetic band: 7q31.33 HGNC cytogenetic band: 7q31GPR37 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M124173:
(about GC identifiers)
Start:
|
124,173,350 bp from pter |
End:
|
124,192,917 bp from pter |
Size:
|
19,568 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 123,775,505-123,795,072 |
RefSeq DNA sequence:- NC_000007.12 NT_007933.14 NT_079596.2
| Proteins for GPR37
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354 (See
protein sequence)Recommended Name: Probable G-protein coupled receptor 37 precursor Size: 613 amino acids; 67114 Da
Subunit: Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: O00348 O14768 Q8TD39Post-translational modifications:
Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death1
REFSEQ proteins: NP_005293.1
ENSEMBL proteins: ENSP00000306449
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for GPR37: Assays for GPR37: | Protein
Domains/ Families for GPR37(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O15354
ProtoNet protein and cluster: O15354 1 Blocks protein family: IPB003909 GPR37 orphan receptor signature
UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for GPR37
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005302
Applied Biosystems Silencer® siRNAs for GPR37
Sigma-Aldrich siRNA and siRNA Panels for GPR37  Sigma-Aldrich shRNA Panels and shRNA for GPR37  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005302                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005302                                  untagged cDNA clones in CMV expression vector (see all 2): BC040007 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: BC040007
UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354Function: Orphan receptor. May have a unique functional role in the central nervous systemGenatlas biochemistry entry for GPR37:putative G protein coupled receptor 37,expressed at highest levels in human brain,spinal cord and at lower levels in testis,placenta,liver,with homology to bombesin receptor6 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Gpr37):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for GPR37
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Sigma-Aldrich "Your Favorite Gene" Pathways for GPR37 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for GPR37 
5/7 Interacting proteins for GPR37 (ENSP000003064493) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- | | GO:0007186 | G-protein coupled receptor protein signaling pathway |
TAS | 9144577 | About this table
|
Drugs & Compounds for GPR37(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for GPR37
|
Transcripts for GPR37(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005302
Sigma-Aldrich siRNA and siRNA Panels for GPR37  Sigma-Aldrich shRNA Panels and shRNA for GPR37  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005302 REFSEQ mRNAs for GPR37 gene: NM_005302.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005302               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005302                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005302                                  untagged cDNA clones in CMV expression vector (see all 2): BC040007  Additional cDNA sequence: AF017262.1 AF502281.2 BC040007.1 BX649006.1 5 DOTS entries: DT.97779229 DT.100837475 DT.40295718 DT.217334 DT.92426999 24/79 AceView cDNA sequences (see all 79
):AL048884 BC040007 BE465524 BE465532 AF017262 BG623764 BX649006 BQ000998 BI824622 AI362294 NM_005302 Z40458 BF365222 F07401 BI754952 AA741351 BI551804 BQ441347 BQ432802 BI547606 BU733966 BX369149 BG204812 BI548497
highest scoring ESTs for GPR37:AF017262 AF502281 BC040007 BF918493 BG717859 BG722287 BI457867 BI545341 BI545736 BI548497 Unigene Cluster for GPR37: G protein-coupled receptor 37 (endothelin receptor type B-like) Hs.406094 [show with all ESTs]Unigene Representative Sequence: BX649006
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000303921
|
Expression for GPR37
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GPR37 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GPR37
1 / 2 / 3 3 probe-sets matching GPR37 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAGTGCTGCT
SOURCE GeneReport for Unigene cluster: Hs.406094
Expression variation in blood from EXPOLDB for GPR37 UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354Tissue specificity: Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ) |
Orthologs for GPR37
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GPR37 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for GPR37
ENSEMBL Gene Tree for GPR37 | Paralogs for GPR37(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GPR37 gene
- GPR37L12
|
SNPs/Variants for GPR37(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GPR37 (up to first 250kb)
|
Disorders & Mutations for GPR37
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602583
3 Novoseek disease relationships for GPR37 gene
About this table
|
Medical News for GPR37(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GPR37 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/24 PubMed articles for GPR37 gene (see all 24
):- Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library. (PubMed id 9339362)2, 3, 4 Marazziti D....Tocchini-Valentini G.P. (1997)
- A novel endothelin receptor type-B-like gene enriched in the brain. (PubMed id 9144577)1, 3, 4 Zeng Z.... Li Y. (1997)
- CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. (PubMed id 12150907)1, 3, 4 Imai Y....Takahashi R. (2002)
- A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. (PubMed id 17059562)1, 3, 4 Omura T.... Nomura Y. (2006)
- A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 3, 4 Imai Y.... Takahashi R. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. (PubMed id 11439185)3, 4 Imai Y.... Takahashi R. (2001)
- A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system. (PubMed id 9526070)3, 4 Donohue P.J....Battey J.F. (1998)
- Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila. (PubMed id 12670421)1, 3 Yang Y....Lu B. (2003)
|
Search for GPR37
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GPR37
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GPR37
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPR37(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GPR37(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GPR37:

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Incremental update: 13 Oct 2009
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