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GPR37 Gene

protein-coding   GIFtS: 59

GC07M124173
G protein-coupled receptor 37 (endothelin receptor type B-like)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EDNRBL 1, 2
ETBR-LP-1 3
PAELR 1, 2, 3
hET(B)R-LP 1, 2
Descriptions
Endothelin B receptor-like protein 1 3
G protein-coupled receptor 37 2
G protein-coupled receptor 37 (endothelin receptor type
B-like) 2
Parkin-associated endothelin receptor-like receptor 2, 3
endothelin receptor type B-like 2
External Ids
HGNC: 44941
Entrez Gene: 28612
UniProtKB: O153543
Ensembl: ENSG000001707757
Search outside databases for aliases for GPR37 gene

Previous GC identifers: GC07M122864 GC07M123926 GC07M123940 GC07M123980

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354
Function: Orphan receptor. May have a unique functional role in the central nervous system

Gene Wiki entry for GPR37

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the GPR37 gene  

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.33   HGNC cytogenetic band: 7q31

GPR37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M124173:     (about GC identifiers)

Start:
124,173,350 bp from pter
End:
124,192,917 bp from pter
Size:
19,568 bases
Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 123,775,505-123,795,072     
RefSeq DNA sequence:
NC_000007.12  NT_007933.14  NT_079596.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 37 precursor  
Size: 613 amino acids; 67114 Da
Subunit: Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases
during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating
PARK2-mediated GPR37 ubiquitination. Interacts with PACRG
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane;
Multi-pass membrane protein
Secondary accessions: O00348 O14768 Q8TD39

Post-translational modifications:

  • Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The
    unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation
    and prevents neuronal cell death1


  • REFSEQ proteins: NP_005293.1  

    ENSEMBL proteins: 
    ENSP00000306449 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (GPCR GPR37)
    Human Recombinant Proteins from Abnova (GPR37)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783 endoplasmic reticulum IEA--
    GO:0005789 endoplasmic reticulum membrane IEA--
    GO:0005886 plasma membrane IEA--
    GO:0005887 integral to plasma membrane TAS9144577
    About this table

    Antibodies for GPR37: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of GPR37
    Browse Antibodies at Sigma-Aldrich
    R&D Systems Antibodies for GPR37
    Antibodies from Abcam (GPCR GPR37), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (GPR37)
    Novus Biologicals Antibodies for GPR37

    Assays for GPR37: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR003909 GPR37_rcpt
     IPR000276 7TM_GPCR_Rhodpsn


       GeneDecks  GPR37 for the domains selected above  
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    Graphical View of Domain Structure for InterPro Entry O15354

    ProtoNet protein and cluster: O15354

    1 Blocks protein family: IPB003909 GPR37 orphan receptor signature

    UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354
    Similarity: Belongs to the G-protein coupled receptor 1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (GPR37)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (GPR37)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005302

                  Applied Biosystems Silencer® siRNAs for GPR37

                  Sigma-Aldrich siRNA and siRNA Panels for GPR37  
                         Sigma-Aldrich shRNA Panels and shRNA for GPR37  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for GPR37
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005302
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005302
                                     untagged cDNA clones in CMV expression vector (see all 2): BC040007 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: BC040007

    UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354
    Function: Orphan receptor. May have a unique functional role in the central nervous system

    Genatlas biochemistry entry for GPR37:
    putative G protein coupled receptor 37,expressed at highest levels in human brain,spinal cord and
    at lower levels in testis,placenta,liver,with homology to bombesin receptor

    6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Gpr37):

    adipose tissuebehavior/neurologicalhomeostasis/metabolismnervous systemno phenotypic analysis
    normal

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004930 G-protein coupled receptor activity TAS9144577
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for GPR37 (Maps provided by GeneGo):
     Putative ubiquitin pathway

       GeneDecks  GPR37 for the pathways selected above  
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    2 Millipore Pathways for GPR37
     Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
     Proteolysis Putative ubiquitin pathway

       GeneDecks  GPR37 for the pathways selected above  
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    3 Sigma-Aldrich "Your Favorite Gene" Pathways for  GPR37  (Your Favorite Gene powered by Ingenuity) 
     Parkinson's Signaling
     Cellular Effects of Sildenafil (Viagra)
     Neuropathic Pain Signaling In Dorsal Horn Neurons

       GeneDecks  GPR37 for the pathways selected above  
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    1 Kegg Pathway  (Kegg details for GPR37):
     hsa05012 Parkinson's disease

       GeneDecks  GPR37 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  GPR37 


    5/7 Interacting proteins for GPR37 (ENSP000003064493) via UniProtKB, MINT, and/or STRING (see all 7 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARK2ENSP000003558653STRING (score=.997)
    SLC6A3ENSP000002703493STRING (score=.878)
    HSPA1AENSP000003648023STRING (score=.83)
    STUB1ENSP000002195483STRING (score=.82)
    HSPA8ENSP000002273783STRING (score=.81)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction IEA--
    GO:0007186 G-protein coupled receptor protein signaling pathway TAS9144577
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for GPR37

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (GPR37)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (GPR37)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005302

                  Sigma-Aldrich siRNA and siRNA Panels for GPR37  
                         Sigma-Aldrich shRNA Panels and shRNA for GPR37  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005302  

    REFSEQ mRNAs for GPR37 gene: 

    NM_005302.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005302  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005302
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005302
                                     untagged cDNA clones in CMV expression vector (see all 2): BC040007 

    Additional cDNA sequence: 

    AF017262.1 AF502281.2 BC040007.1 BX649006.1 

    5 DOTS entries:

    DT.97779229  DT.100837475  DT.40295718  DT.217334  DT.92426999 

    24/79 AceView cDNA sequences (see all 79 ):

    AL048884 BC040007 BE465524 BE465532 AF017262 BG623764 BX649006 BQ000998 
    BI824622 AI362294 NM_005302 Z40458 BF365222 F07401 BI754952 AA741351 
    BI551804 BQ441347 BQ432802 BI547606 BU733966 BX369149 BG204812 BI548497 

    highest scoring ESTs for GPR37:

    AF017262 AF502281 BC040007 BF918493 BG717859 BG722287 BI457867 BI545341 BI545736 BI548497 

    Unigene Cluster for GPR37:

    G protein-coupled receptor 37 (endothelin receptor type B-like)
    Hs.406094  [show with all ESTs]
    Unigene Representative Sequence: BX649006


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000303921  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    GPR37 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for GPR37

    1 / 2 / 3

    3 probe-sets matching GPR37 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    34297_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U87460 0.60 1.00 0.82 1

    209631_s_at2, 3 U133-A 1 0.82 1.00 -- -- U87460 0.60 1.00 0.82 1

    209631_s_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    GeneDecks  GPR37 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAGTGCTGCT

    SOURCE GeneReport for Unigene cluster: Hs.406094

    Expression variation in blood from EXPOLDB for GPR37

    UniProtKB/Swiss-Prot: GPR37_HUMAN, O15354
    Tissue specificity: Expressed in brain and spinal cord, and at lower levels in testis, placenta and
    liver, but no detectable expression observed in any other tissue. When overexpressed in cells,
    tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to
    dopaminergic neuronal death in juvenile Parkinson disease (PDJ)

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for GPR37 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    GPR371   -- G protein-coupled receptor 37 (endothelin receptor more 87.85(n)
    87.25(a)
    482275  XM_539394.2  XP_539394.1 
    chimpanzee
    (Pan troglodytes)
    GPR371   -- G protein-coupled receptor 37 (endothelin receptor more 99.62(n)
    100(a)
    738926  XM_001149034.1  XP_001149034.1 
    cow
    (Bos taurus)
    GPR371   -- G protein-coupled receptor 37 (endothelin receptor more 87.47(n)
    88.73(a)
    532626  NM_001075969.1  NP_001069437.1 
    rat
    (Rattus norvegicus)
    Gpr371   -- G protein-coupled receptor 37 81.26(n)
    83.91(a)
    117549  NM_057201.1  NP_476549.1 
    mouse
    (Mus musculus)
    Gpr371, 5 6 (7.20 cM)5
    G protein-coupled receptor 371, 5 81.67(n)1
    83.33(a)1
    147631  NM_010338.11  NP_034468.11 
     AF1320395  AI8486305  (see all 15)
    About this table        Species with no ortholog for GPR37

    ENSEMBL Gene Tree for GPR37
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for GPR37 gene
    GPR37L12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/106 NCBI SNPs in GPR37 are shown (see all 106 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 80)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs15579691,2
    A,C,F124192974(-) CAGCCT/CGCTTC 1 -- ng312Minor allele frequency- C:0.50MN EA 1094
    --
    rs77910451,2
    A,C,F124173078(+) ATTCAT/CATTTT 1 -- ng513Minor allele frequency- C:0.39NA 142
    rs47312061,2
    C,F,H124172901(+) TGCTTT/AACGTA 1 -- ng517Minor allele frequency- A:0.28EU EA WA NA 562
    rs22395321,2
    C,F124192912(-) GGGGTT/GGGAAT 1 -- ut511Minor allele frequency- G:0.36EA 1496
    rs37352701,2
    A,C,F,H124174328(-) AGACTG/CTGGTG 1 L/L syn113Minor allele frequency- C:0.50EA EU WA NA 2534
    rs7243561,2
    A,C,F,H124174610(-) ACCACC/TTTCAC 1 T/T syn1 ese319Minor allele frequency- T:0.29EA NA NS MN EU WA 1216
    rs22842141,2
    A,C,F,H,O124175440(-) ATTCAC/TAGGGA 1 -- int110Minor allele frequency- T:0.47EU EA WA NA 810
    rs22677081,2
    A,C,F,H,O124179748(-) CATATG/ATAAAG 1 -- int112Minor allele frequency- A:0.46EA NA EU WA 2274
    rs47312071,2
    A,C,F,H124183881(+) AAAGAA/GTATTA 1 -- int112Minor allele frequency- N:0.00EA NA EU WA 1054
    rs38075441,2
    A,C,F,H124187941(-) CTTTCC/TGCTCC 1 -- int1 trp37Minor allele frequency- T:0.47NA EU EA WA 556
    About this table

    HapMap Linkage Disequilibrium images for GPR37 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 602583

    3 Novoseek disease relationships for GPR37 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinsonism juvenile autosomal recessive 93.79 1 15572843 (1)
    parkinson disease 58.76 3 17301052 (2), 17251065 (1)
    neurodegeneration 32.56 3 15572841 (1), 12150907 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/24 PubMed articles for GPR37 gene (see all 24 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 2861 HGNC: 4494 AceView: GPR37 Ensembl:ENSG00000170775 euGenes: HUgn2861
    ECgene: GPR37 H-InvDB: GPR37
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for GPR37:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for GPR37 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for GPR37 Browse small molecules at Sigma-Aldrich
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     Antibodies for GPR37

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