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Aliases for GPR35 Gene

Aliases for GPR35 Gene

  • G Protein-Coupled Receptor 35 2 3
  • Kynurenic Acid Receptor 4
  • KYNA Receptor 4

External Ids for GPR35 Gene

Previous GeneCards Identifiers for GPR35 Gene

  • GC02M239906
  • GC02M240750
  • GC02P241588
  • GC02P241889
  • GC02P241286
  • GC02P241215
  • GC02P233327

Summaries for GPR35 Gene

GeneCards Summary for GPR35 Gene

GPR35 (G Protein-Coupled Receptor 35) is a Protein Coding gene. Diseases associated with GPR35 include cholangitis, primary sclerosing. Among its related pathways are Peptide ligand-binding receptors and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR55.

UniProtKB/Swiss-Prot for GPR35 Gene

  • Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.

Gene Wiki entry for GPR35 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR35 Gene

Genomics for GPR35 Gene

Regulatory Elements for GPR35 Gene

Genomic Location for GPR35 Gene

240,605,408 bp from pter
240,631,259 bp from pter
25,852 bases
Plus strand

Genomic View for GPR35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR35 Gene

Proteins for GPR35 Gene

  • Protein details for GPR35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 35
    Protein Accession:
    Secondary Accessions:
    • J3KR30
    • O43495
    • Q17R58
    • Q4VBN5
    • Q4ZFV2
    • Q6FHI8
    • Q86UH4

    Protein attributes for GPR35 Gene

    309 amino acids
    Molecular mass:
    34072 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR35 Gene


neXtProt entry for GPR35 Gene

Proteomics data for GPR35 Gene at MOPED

Post-translational modifications for GPR35 Gene

  • Glycosylation at Asn2
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR35 Gene

No data available for DME Specific Peptides for GPR35 Gene

Domains for GPR35 Gene

Gene Families for GPR35 Gene

  • GPCRAO :GPCR / Class A : Orphans

Protein Domains for GPR35 Gene


Suggested Antigen Peptide Sequences for GPR35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9HC97
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR35: view

Function for GPR35 Gene

Molecular function for GPR35 Gene

GENATLAS Biochemistry: G protein coupled receptor 35,expressed in heart,spleen,liver,lung,ovary kidney
UniProtKB/Swiss-Prot Function: Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.

Gene Ontology (GO) - Molecular Function for GPR35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 16754668
genes like me logo Genes that share ontologies with GPR35: view

Phenotypes for GPR35 Gene

GenomeRNAi human phenotypes for GPR35:
genes like me logo Genes that share phenotypes with GPR35: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GPR35 Gene

Localization for GPR35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR35 Gene

Cell membrane; Multi-pass membrane protein. Note=Internalized to the cytoplasm after exposure to kynurenic acid.

Subcellular locations from

Jensen Localization Image for GPR35 Gene COMPARTMENTS Subcellular localization image for GPR35 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 16754668
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR35: view

Pathways for GPR35 Gene

genes like me logo Genes that share pathways with GPR35: view

Pathways by source for GPR35 Gene

1 BioSystems pathway for GPR35 Gene
1 KEGG pathway for GPR35 Gene

Interacting Proteins for GPR35 Gene

Gene Ontology (GO) - Biological Process for GPR35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 16754668
genes like me logo Genes that share ontologies with GPR35: view

Compounds for GPR35 Gene

(5) Tocris Compounds for GPR35 Gene

Compound Action Cas Number
CID 2745687 GPR35 antagonist [264233-05-8]
ML 145 GPR35 antagonist [1164500-72-4]
Pamoic acid disodium salt GPR35 agonist [6640-22-8]
TC-G 1001 GPR35 agonist; more potent than zaprinast (Cat. No. 0947) [494191-73-0]
TCS 3035 GPR35 agonist [871085-49-3]

(6) IUPHAR Ligand for GPR35 Gene

Ligand Type Action Affinity Pubmed IDs
2-oleoyl-LPA Agonist Agonist 8
pamoic acid Agonist Agonist 7.29
zaprinast Inhibitor Inhibition 6.8
kynurenic acid Agonist Agonist 4.41
furosemide Inhibitor Inhibition
bumetanide Inhibitor Inhibition
genes like me logo Genes that share compounds with GPR35: view

Transcripts for GPR35 Gene

Unigene Clusters for GPR35 Gene

G protein-coupled receptor 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR35 Gene

No ASD Table

Relevant External Links for GPR35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR35 Gene

mRNA expression in normal human tissues for GPR35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR35 Gene

This gene is overexpressed in Colon - Transverse (8.6) and Small Intestine - Terminal Ileum (6.4).

SOURCE GeneReport for Unigene cluster for GPR35 Gene Hs.112218

mRNA Expression by UniProt/SwissProt for GPR35 Gene

Tissue specificity: Predominantly expressed in immune and gastrointestinal tissues.
genes like me logo Genes that share expressions with GPR35: view

No data available for Protein expression for GPR35 Gene

Orthologs for GPR35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR35 35
  • 97.05 (n)
  • 97.15 (a)
GPR35 36
  • 98 (a)
(Bos Taurus)
Mammalia GPR35 35
  • 78.88 (n)
  • 71.17 (a)
GPR35 36
  • 63 (a)
(Canis familiaris)
Mammalia GPR35 36
  • 65 (a)
LOC100855802 35
  • 79.47 (n)
  • 72.24 (a)
(Mus musculus)
Mammalia Gpr35 35
  • 78.18 (n)
  • 74.01 (a)
Gpr35 16
Gpr35 36
  • 67 (a)
(Monodelphis domestica)
Mammalia GPR35 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
-- 36
  • 35 (a)
-- 36
  • 35 (a)
(Rattus norvegicus)
Mammalia Gpr35 35
  • 77.26 (n)
  • 72.19 (a)
(Gallus gallus)
Aves -- 36
  • 29 (a)
-- 36
  • 37 (a)
GPR35 35
  • 51.79 (n)
  • 40.38 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
-- 36
  • 30 (a)
(Danio rerio)
Actinopterygii GPR35 (1 of 3) 36
  • 28 (a)
GPR35 (2 of 3) 36
  • 27 (a)
GPR35 (3 of 3) 36
  • 26 (a)
Species with no ortholog for GPR35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR35 Gene

Gene Tree for GPR35 (if available)
Gene Tree for GPR35 (if available)

Paralogs for GPR35 Gene

Paralogs for GPR35 Gene

Selected SIMAP similar genes for GPR35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR35: view

Variants for GPR35 Gene

Sequence variations from dbSNP and Humsavar for GPR35 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1509 -- 240,616,574(-) atgag(A/C)cccct intron-variant
rs2953147 -- 240,614,576(+) GGTCC(C/T)GAGGA intron-variant
rs2953148 -- 240,618,729(+) TTTGT(A/G)GCTTA intron-variant
rs2953149 -- 240,619,922(+) CGGGG(A/G)CCCGA intron-variant
rs2953150 -- 240,622,003(+) gagta(A/G)ctggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR35 Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
nsv876125 CNV Loss 21882294
dgv1295e1 CNV Complex 17122850
nsv876132 CNV Loss 21882294
nsv834586 CNV Loss 17160897
dgv4471n71 CNV Loss 21882294
dgv4472n71 CNV Loss 21882294
nsv876144 CNV Loss 21882294
dgv4473n71 CNV Loss 21882294
nsv876157 CNV Loss 21882294
nsv470529 CNV Loss 18288195
dgv4477n71 CNV Loss 21882294
nsv10227 CNV Gain 18304495
nsv3240 CNV Insertion 18451855
nsv876165 CNV Loss 21882294
dgv4478n71 CNV Loss 21882294
esv2721937 CNV Deletion 23290073
esv2721938 CNV Deletion 23290073
esv2721939 CNV Deletion 23290073
nsv876169 CNV Loss 21882294
esv29214 CNV Loss 19812545
nsv820464 CNV Duplication 20802225
esv1170354 CNV Insertion 17803354
esv1425277 CNV Insertion 17803354
nsv460159 CNV Loss 19166990

Relevant External Links for GPR35 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR35 Gene

Disorders for GPR35 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GPR35 Gene including...

Search for GPR35 Gene in MalaCards »

Relevant External Links for GPR35

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GPR35: view

No data available for UniProtKB/Swiss-Prot for GPR35 Gene

Publications for GPR35 Gene

  1. Discovery of three novel G-protein-coupled receptor genes. (PMID: 9479505) O'Dowd B.F. … George S.R. (Genomics 1998) 2 3 4
  2. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. (PMID: 11017071) Horikawa Y. … Bell G.I. (Nat. Genet. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3 48
  5. Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design. (PMID: 18271057) Sun Y.V. … Kardia S.L. (Genet. Epidemiol. 2008) 3 48

Products for GPR35 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GPR35
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GPR35
    • Block miRNA regulation of GPR35 using miScript Target Protectors
    • antibodies-online peptides for GPR35
    • antibodies-online antibodies for GPR35
    • antibodies-online kits for GPR35

    Sources for GPR35 Gene

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