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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR35 Gene

protein-coding   GIFtS: 56
GCID: GC02P241588

G Protein-Coupled Receptor 35

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor 351 2
Kynurenic Acid Receptor2 3
KYNA Receptor2 3
G-Protein Coupled Receptor 352

External Ids:    HGNC: 44921   Entrez Gene: 28592   Ensembl: ENSG000001786237   OMIM: 6026465   UniProtKB: Q9HC973   

Export aliases for GPR35 gene to outside databases

Previous GC identifers: GC02M239906 GC02M240750 GC02P241889 GC02P241286 GC02P241215 GC02P233327


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GPR35 Gene: 
GPR35 (G protein-coupled receptor 35) is a protein-coding gene. Diseases associated with GPR35 include cholecystolithiasis, and pseudopseudohypoparathyroidism, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors). GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR18.

UniProtKB/Swiss-Prot: GPR35_HUMAN, Q9HC97
Function: Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity
of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production
through G(qi/o) proteins

Gene Wiki entry for GPR35 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005416.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR35 gene promoter:
         ER-alpha   USF1   p300   STAT5A   MIF-1   Max   USF-1   HOXA5   ATF   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GPR35

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

GPR35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR35 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P241588:  view genomic region     (about GC identifiers)

Start:
241,544,825 bp from pter      End:
241,570,676 bp from pter
Size:
25,852 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPR35_HUMAN, Q9HC97 (See protein sequence)
Recommended Name: G-protein coupled receptor 35  
Size: 309 amino acids; 34072 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Internalized to the cytoplasm after
exposure to kynurenic acid
Secondary accessions: J3KR30 O43495 Q17R58 Q4VBN5 Q4ZFV2 Q6FHI8 Q86UH4
Alternative splicing: 2 isoforms:  Q9HC97-1   Q9HC97-2   (No experimental confirmation available. Ref.4 (AK172786) sequence is in conflict in position: 13:R->H)

Explore the universe of human proteins at neXtProt for GPR35: NX_Q9HC97

Explore proteomics data for GPR35 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HC97

  • GPR35 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPR35 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001182310.1  NP_001182311.1  NP_005292.2  

    ENSEMBL proteins: 
     ENSP00000322731   ENSP00000385140   ENSP00000384263   ENSP00000415890   ENSP00000411788  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPR35 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IDA16754668
    GO:0016021integral to membrane ----

    GPR35 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR35 
    Class A Orphans

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9HC97

    ProtoNet protein and cluster: Q9HC97

    UniProtKB/Swiss-Prot: GPR35_HUMAN, Q9HC97
    Similarity: Belongs to the G-protein coupled receptor 1 family


    GPR35 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPR35_HUMAN, Q9HC97
    Function: Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity
    of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production
    through G(qi/o) proteins

         Genatlas biochemistry entry for GPR35:
    G protein coupled receptor 35,expressed in heart,spleen,liver,lung,ovary kidney

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IDA16754668
         
    GPR35 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR35:
     Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Gpr35 (no phenotypes)

    GPR35 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gpr35tm1Lex for GPR35

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPR35 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    GPCRs, Class A Rhodopsin-like0.41
    Neuroactive ligand-receptor interaction0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GPR35
        GPCRs, Class A Rhodopsin-like



    1         Kegg Pathway  (Kegg details for GPR35):
        Neuroactive ligand-receptor interaction


    GPR35 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR35

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IDA16754668

    GPR35 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPR35

    6 IUPHAR Ligands for GPR35 (GPR35)    About this table 
    LigandTypeActionAffinityPubmed IDs
    2-oleoyl-LPA
    AgonistAgonist7.3 - 7.5220361937
    pamoic acid
    AgonistAgonist7.2920919992
    zaprinast
    AgonistAgonist6.116934253
    furosemide
    AgonistAgonist5.21 - 5.6322236570
    bumetanide
    AgonistAgonist5 - 5.5422236570
    kynurenic acid
    AgonistAgonist3.9 - 4.4123396314 16754668

    Search CenterWatch for drugs/clinical trials and news about GPR35

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPR35 gene (3 alternative transcripts): 
    NM_001195381.1  NM_001195382.1  NM_005301.3  

    Unigene Cluster for GPR35:

    G protein-coupled receptor 35
    Hs.112218  [show with all ESTs]
    Unigene Representative Sequence: NM_001195381
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319838(uc010fzi.2 uc010fzh.2 uc021vze.1) ENST00000403859
    ENST00000407714 ENST00000438013 ENST00000430267(uc002vzs.2)
    miRNA
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    Additional mRNA sequence: 

    AF089087.1 AK172786.1 AK290256.1 AK314002.1 BC095500.1 BC117453.1 BC117455.1 CR541765.1 

    4 DOTS entries:

    DT.40120882  DT.121644089  DT.100680822  DT.91654058 

    24/153 AceView cDNA sequences (see all 153):

    BM786145 AI739542 BG333889 AA515711 NM_023089 BQ947982 AI339652 BQ187478 
    BM742098 AF089095 BU527319 CB127286 BU186381 BQ057475 BM748220 BM927087 
    BM772079 BM477401 C00612 CD722325 BM784104 AA489024 BI767415 BX645162 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPR35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGGAGT
    GPR35 Expression
    About this image


    See GPR35 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPR35

    SOURCE GeneReport for Unigene cluster: Hs.112218

    UniProtKB/Swiss-Prot: GPR35_HUMAN, Q9HC97
    Tissue specificity: Predominantly expressed in immune and gastrointestinal tissues

        SABiosciences Expression via Pathway-Focused PCR Array including GPR35: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GPR35 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr351 , 5 G protein-coupled receptor 351, 5 78.18(n)1
    74.01(a)1
      1 (46.65 cM)5
    640951  NM_001104529.11  NP_001097999.11 
     929731195 
    chicken
    (Gallus gallus)
    Aves GPR356
    GGA.295366
    Uncharacterized protein
    37(a)
    30(a)
    possible ortholog
    1 ↔ 1
    9(4810585-4811532)
    9(4797355-4799022)
    lizard
    (Anolis carolinensis)
    Reptilia --
    GPR356
    Uncharacterized protein
    37(a)
    31(a)
    possible ortholog
    1 ↔ 1
    3(28299368-28300288)
    3(28306514-28308990)
    zebrafish
    (Danio rerio)
    Actinopterygii GPR35 (1 of 3)6
    GPR35 (3 of 3)6
    (see all 3)
    G protein-coupled receptor 35
    (see all 3)
    27(a)
    26(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    22(3236776-3244103)
    22(3223960-3225952)


    ENSEMBL Gene Tree for GPR35 (if available)
    TreeFam Gene Tree for GPR35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPR35 gene
    GPR182  GPR552  
    10 SIMAP similar genes for GPR35 using alignment to 1 protein entry:     GPR35_HUMAN:
    KPG_007    LPAR4    LPAR6    P2RY5    HCAR3    CYSLTR2
    HCAR2    KPG_011    GPR55    HCAR1

    GPR35 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/832 SNPs in GPR35 are shown (see all 832)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557320951,2
    C--241542923(+) ACCTGC/TGCCTT 2 -- us2k12Minor allele frequency- T:0.19NA 122
    rs1831989251,2
    --241542990(+) GCCCCC/TAGCAG 2 -- us2k10--------
    rs758256161,2
    C,F--241543110(+) GTCCTC/TATTGC 2 -- us2k13Minor allele frequency- T:0.12NA WA 240
    rs1873699841,2
    --241543217(+) TTGGGC/TGCAAG 2 -- us2k10--------
    rs1158114231,2
    C,F--241543310(+) TGAAAC/TGCCTG 2 -- us2k11Minor allele frequency- T:0.06WA 118
    rs75614491,2
    C,F,A,H--241543432(+) GGGCTC/ACCGCC 2 -- us2k110Minor allele frequency- A:0.13NA WA CSA EA 372
    rs1153784391,2
    F--241543435(+) CTACCG/ACCCCG 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1912306531,2
    --241543527(+) ACACCC/TGCGGG 2 -- us2k10--------
    rs1148598761,2
    F--241543529(+) ACCTGC/TGGGGA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1831459871,2
    --241543554(+) CTGGCA/GGCTTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPR35 (241544825 - 241570676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for GPR35 (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2721937CNV Deletion23290073
    esv2721938CNV Deletion23290073
    esv2721939CNV Deletion23290073
    nsv820464CNV Duplication20802225
    esv1170354CNV Insertion17803354
    nsv3240CNV Insertion18451855
    esv1425277CNV Insertion17803354
    nsv876116CNV Loss21882294
    esv29214CNV Loss19812545
    nsv876157CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602646    OMIM disorders: --

    9 diseases for GPR35:    About MalaCards
    cholecystolithiasis    pseudopseudohypoparathyroidism    primary sclerosing cholangitis    sclerosing cholangitis
    cholangitis    diabetes mellitus    ulcerative colitis    gastric cancer
    neuronitis


    GPR35 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GPR35
    Human Genome Epidemiology (HuGE) Navigator: GPR35 (1 document)

    Export disorders for GPR35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPR35 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with GPR35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of three novel G-protein-coupled receptor genes. (PubMed id 9479505)1, 2, 3 O'Dowd B.F.... George S.R. (1998)
    2. Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (2011)
    3. Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design. (PubMed id 18271057)1, 4 Sun Y.V....Kardia S.L. (2008)
    4. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. (PubMed id 16754668)1, 2 Wang J....Ling L. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. (PubMed id 11017071)1, 2 Horikawa Y....Bell G.I. (2000)
    7. GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors. (PubMed id 22820167)1 Zhao P. and Abood M.E. (2013)
    8. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    9. Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. (PubMed id 22821403)1 Ellinghaus D....Karlsen T.H. (2012)
    10. Expression of functional GPR35 in human iNKT cells. (PubMed id 20599711)1 Fallarini S....Lombardi G. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2859 HGNC: 4492 AceView: GPR35andCAPN10 Ensembl:ENSG00000178623 euGenes: HUgn2859
    ECgene: GPR35 Kegg: 2859 H-InvDB: GPR35

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPR35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPR35 gene:
    Search GeneIP for patents involving GPR35

    GeneCards and IP:
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