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Aliases for GPR35 Gene

Aliases for GPR35 Gene

  • G Protein-Coupled Receptor 35 2 3 5
  • Kynurenic Acid Receptor 4
  • KYNA Receptor 4

External Ids for GPR35 Gene

Previous GeneCards Identifiers for GPR35 Gene

  • GC02M239906
  • GC02M240750
  • GC02P241588
  • GC02P241889
  • GC02P241286
  • GC02P241215
  • GC02P233327

Summaries for GPR35 Gene

GeneCards Summary for GPR35 Gene

GPR35 (G Protein-Coupled Receptor 35) is a Protein Coding gene. Diseases associated with GPR35 include Cholangitis, Primary Sclerosing. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR20.

UniProtKB/Swiss-Prot for GPR35 Gene

  • Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.

Gene Wiki entry for GPR35 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR35 Gene

Genomics for GPR35 Gene

Regulatory Elements for GPR35 Gene

Enhancers for GPR35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR35 on UCSC Golden Path with GeneCards custom track

Promoters for GPR35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR35 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR35 Gene

240,605,408 bp from pter
240,631,259 bp from pter
25,852 bases
Plus strand

Genomic View for GPR35 Gene

Genes around GPR35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR35 Gene

Proteins for GPR35 Gene

  • Protein details for GPR35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 35
    Protein Accession:
    Secondary Accessions:
    • J3KR30
    • O43495
    • Q17R58
    • Q4VBN5
    • Q4ZFV2
    • Q6FHI8
    • Q86UH4

    Protein attributes for GPR35 Gene

    309 amino acids
    Molecular mass:
    34072 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR35 Gene


neXtProt entry for GPR35 Gene

Proteomics data for GPR35 Gene at MOPED

Post-translational modifications for GPR35 Gene

  • Glycosylation at Asn 2
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR35 Gene

Antibody Products

No data available for DME Specific Peptides for GPR35 Gene

Domains & Families for GPR35 Gene

Gene Families for GPR35 Gene

Protein Domains for GPR35 Gene


Suggested Antigen Peptide Sequences for GPR35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR35: view

Function for GPR35 Gene

Molecular function for GPR35 Gene

GENATLAS Biochemistry:
G protein coupled receptor 35,expressed in heart,spleen,liver,lung,ovary kidney
UniProtKB/Swiss-Prot Function:
Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
genes like me logo Genes that share phenotypes with GPR35: view

Human Phenotype Ontology for GPR35 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR35 Gene

Localization for GPR35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR35 Gene

Cell membrane; Multi-pass membrane protein. Note=Internalized to the cytoplasm after exposure to kynurenic acid.

Subcellular locations from

Jensen Localization Image for GPR35 Gene COMPARTMENTS Subcellular localization image for GPR35 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for GPR35 Gene

Pathways & Interactions for GPR35 Gene

genes like me logo Genes that share pathways with GPR35: view

Pathways by source for GPR35 Gene

1 BioSystems pathway for GPR35 Gene
1 KEGG pathway for GPR35 Gene

Interacting Proteins for GPR35 Gene

Gene Ontology (GO) - Biological Process for GPR35 Gene


No data available for SIGNOR curated interactions for GPR35 Gene

Drugs & Compounds for GPR35 Gene

(8) Drugs for GPR35 Gene - From: DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bumetanide Approved Pharma Agonist, blocker NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 15
Furosemide Approved Pharma Agonist, blocker GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA 177
Kynurenic acid Pharma Agonist Broad spectrum EAA antagonist 3
Zaprinast Pharma Agonist GPR35 agonist 0
2-oleoyl-LPA Pharma Agonist 0

(1) Additional Compounds for GPR35 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Kynurenic acid sodium salt

(5) Tocris Compounds for GPR35 Gene

Compound Action Cas Number
Kynurenic acid Broad spectrum EAA antagonist 492-27-3
Kynurenic acid sodium salt Sodium salt of kynurenic acid (Cat. No. 0223) 2439-02-3
NPPB Inhibits calcium-sensitive chloride currents 107254-86-4
Rosmarinic acid Anti-inflammatory, cytostatic and antiviral; GPR35 agonist 20283-92-5
Zaprinast GPR35 agonist 37762-06-4
genes like me logo Genes that share compounds with GPR35: view

Transcripts for GPR35 Gene

Unigene Clusters for GPR35 Gene

G protein-coupled receptor 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR35 Gene

No ASD Table

Relevant External Links for GPR35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR35 Gene

mRNA expression in normal human tissues for GPR35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR35 Gene

This gene is overexpressed in Colon - Transverse (x8.6) and Small Intestine - Terminal Ileum (x6.4).

SOURCE GeneReport for Unigene cluster for GPR35 Gene Hs.112218

mRNA Expression by UniProt/SwissProt for GPR35 Gene

Tissue specificity: Predominantly expressed in immune and gastrointestinal tissues.
genes like me logo Genes that share expression patterns with GPR35: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR35 Gene

Orthologs for GPR35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR35 35
  • 78.88 (n)
  • 71.17 (a)
GPR35 36
  • 63 (a)
(Canis familiaris)
Mammalia LOC100855802 35
  • 79.47 (n)
  • 72.24 (a)
GPR35 36
  • 65 (a)
(Mus musculus)
Mammalia Gpr35 35
  • 78.18 (n)
  • 74.01 (a)
Gpr35 16
Gpr35 36
  • 67 (a)
(Pan troglodytes)
Mammalia GPR35 35
  • 97.05 (n)
  • 97.15 (a)
GPR35 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Gpr35 35
  • 77.26 (n)
  • 72.19 (a)
(Monodelphis domestica)
Mammalia GPR35 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
-- 36
  • 35 (a)
-- 36
  • 35 (a)
(Gallus gallus)
Aves GPR35 35
  • 51.79 (n)
  • 40.38 (a)
-- 36
  • 29 (a)
-- 36
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
-- 36
  • 30 (a)
(Danio rerio)
Actinopterygii GPR35 (1 of 3) 36
  • 28 (a)
GPR35 (2 of 3) 36
  • 27 (a)
GPR35 (3 of 3) 36
  • 26 (a)
Species with no ortholog for GPR35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR35 Gene

Gene Tree for GPR35 (if available)
Gene Tree for GPR35 (if available)

Paralogs for GPR35 Gene

Paralogs for GPR35 Gene

(9) SIMAP similar genes for GPR35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR35: view

Variants for GPR35 Gene

Sequence variations from dbSNP and Humsavar for GPR35 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs35146537 - 240,630,025(+) TCTAC(A/G)CCTAC reference, missense
rs139197368 - 240,630,037(+) TGGGC(A/G)TCCTG reference, missense
rs3749171 - 240,630,275(+) GGTCA(C/T)GGCCA reference, missense
rs34778053 - 240,630,325(+) GTGCC(A/C/T)GCGGG reference, missense
rs12468485 - 240,630,710(+) GGAGA(C/T)GATCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GPR35 Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
nsv876125 CNV Loss 21882294
dgv1295e1 CNV Complex 17122850
nsv876132 CNV Loss 21882294
nsv834586 CNV Loss 17160897
dgv4471n71 CNV Loss 21882294
dgv4472n71 CNV Loss 21882294
nsv876144 CNV Loss 21882294
dgv4473n71 CNV Loss 21882294
nsv876157 CNV Loss 21882294
nsv470529 CNV Loss 18288195
dgv4477n71 CNV Loss 21882294
nsv10227 CNV Gain 18304495
nsv3240 CNV Insertion 18451855
nsv876165 CNV Loss 21882294
dgv4478n71 CNV Loss 21882294
esv2721937 CNV Deletion 23290073
esv2721938 CNV Deletion 23290073
esv2721939 CNV Deletion 23290073
nsv876169 CNV Loss 21882294
esv29214 CNV Loss 19812545
nsv820464 CNV Duplication 20802225
esv1170354 CNV Insertion 17803354
esv1425277 CNV Insertion 17803354
nsv460159 CNV Loss 19166990

Variation tolerance for GPR35 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR35 Gene

Disorders for GPR35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR35 Gene - From: Orphanet

Disorder Aliases PubMed IDs
cholangitis, primary sclerosing
  • sclerosing cholangitis
- elite association - COSMIC cancer census association via MalaCards
Search GPR35 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR35

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR35 Gene

Publications for GPR35 Gene

  1. Discovery of three novel G-protein-coupled receptor genes. (PMID: 9479505) O'Dowd B.F. … George S.R. (Genomics 1998) 2 3 4 67
  2. Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17. (PMID: 25411203) Maravillas-Montero J.L. … Zlotnik A. (J. Immunol. 2015) 3
  3. Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans. (PMID: 25489960) Yang S.K. … Song K. (Inflamm. Bowel Dis. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Crucial positively charged residues for ligand activation of the GPR35 receptor. (PMID: 24347166) Zhao P. … Abood M.E. (J. Biol. Chem. 2014) 3

Products for GPR35 Gene

Sources for GPR35 Gene