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Aliases for GPR34 Gene

Aliases for GPR34 Gene

  • G Protein-Coupled Receptor 34 2 3 5
  • LYPSR1 3

External Ids for GPR34 Gene

Previous GeneCards Identifiers for GPR34 Gene

  • GC0XP039574
  • GC0XP039796
  • GC0XP040392
  • GC0XP040579
  • GC0XP041304
  • GC0XP041433
  • GC0XP041548
  • GC0XP039279

Summaries for GPR34 Gene

Entrez Gene Summary for GPR34 Gene

  • G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]

GeneCards Summary for GPR34 Gene

GPR34 (G Protein-Coupled Receptor 34) is a Protein Coding gene. Diseases associated with GPR34 include Congenital Stationary Night Blindness and Lymphoma, Malt, Somatic. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY14.

UniProtKB/Swiss-Prot for GPR34 Gene

  • Orphan receptor.

Gene Wiki entry for GPR34 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR34 Gene

Genomics for GPR34 Gene

Regulatory Elements for GPR34 Gene

Enhancers for GPR34 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR34 on UCSC Golden Path with GeneCards custom track

Promoters for GPR34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR34 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR34 Gene

41,688,959 bp from pter
41,697,277 bp from pter
8,319 bases
Plus strand

Genomic View for GPR34 Gene

Genes around GPR34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR34 Gene

Proteins for GPR34 Gene

  • Protein details for GPR34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 34
    Protein Accession:
    Secondary Accessions:
    • O95853

    Protein attributes for GPR34 Gene

    381 amino acids
    Molecular mass:
    43860 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR34 Gene

Proteomics data for GPR34 Gene at MOPED

Post-translational modifications for GPR34 Gene

  • Glycosylation at Asn 28, Asn 36, Asn 42, Asn 200, and Asn 295
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR34 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GPR34

No data available for DME Specific Peptides for GPR34 Gene

Domains & Families for GPR34 Gene

Gene Families for GPR34 Gene

Protein Domains for GPR34 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR34: view

Function for GPR34 Gene

Molecular function for GPR34 Gene

GENATLAS Biochemistry:
G protein coupled receptor 34,similar to the P2Y receptor subfamily,expressed in the brain (caudate,frontal cortex,putamen,thalamus) and in peripheral tissues with adipose tissue,placenta,fetal liver,spleen)
UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA --
genes like me logo Genes that share ontologies with GPR34: view
genes like me logo Genes that share phenotypes with GPR34: view

Animal Models for GPR34 Gene

MGI Knock Outs for GPR34:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR34

miRNA for GPR34 Gene

miRTarBase miRNAs that target GPR34

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR34 Gene

Localization for GPR34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR34 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR34 Gene COMPARTMENTS Subcellular localization image for GPR34 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for GPR34 Gene

Pathways & Interactions for GPR34 Gene

SuperPathways for GPR34 Gene

genes like me logo Genes that share pathways with GPR34: view

Pathways by source for GPR34 Gene

1 BioSystems pathway for GPR34 Gene

Interacting Proteins for GPR34 Gene

Gene Ontology (GO) - Biological Process for GPR34 Gene


No data available for SIGNOR curated interactions for GPR34 Gene

Drugs & Compounds for GPR34 Gene

(1) Drugs for GPR34 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lysophosphatidylserine Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with GPR34: view

Transcripts for GPR34 Gene

Unigene Clusters for GPR34 Gene

G protein-coupled receptor 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR34 Gene

No ASD Table

Relevant External Links for GPR34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR34 Gene

mRNA expression in normal human tissues for GPR34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for GPR34 Gene Hs.495989

mRNA Expression by UniProt/SwissProt for GPR34 Gene

Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with GPR34: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR34 Gene

Orthologs for GPR34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR34 35
  • 88.56 (n)
  • 88.83 (a)
GPR34 36
  • 89 (a)
(Canis familiaris)
Mammalia GPR34 35
  • 87.05 (n)
  • 87.54 (a)
GPR34 36
  • 88 (a)
(Mus musculus)
Mammalia Gpr34 35
  • 87.49 (n)
  • 91.69 (a)
Gpr34 16
Gpr34 36
  • 91 (a)
(Pan troglodytes)
Mammalia GPR34 35
  • 99.83 (n)
  • 100 (a)
GPR34 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr34 35
  • 86.34 (n)
  • 90.57 (a)
(Monodelphis domestica)
Mammalia GPR34 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia GPR34 36
  • 69 (a)
(Gallus gallus)
Aves GPR34 35
  • 67.15 (n)
  • 62.97 (a)
GPR34 36
  • 57 (a)
(Anolis carolinensis)
Reptilia GPR34 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170488 35
  • 61.66 (n)
  • 57.06 (a)
(Danio rerio)
Actinopterygii gpr34b 36
  • 39 (a)
Species with no ortholog for GPR34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR34 Gene

Gene Tree for GPR34 (if available)
Gene Tree for GPR34 (if available)

Paralogs for GPR34 Gene

Paralogs for GPR34 Gene

genes like me logo Genes that share paralogs with GPR34: view

Variants for GPR34 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR34 Gene

Variant ID Type Subtype PubMed ID
esv33720 CNV Loss 17666407
nsv523134 CNV Gain 19592680

Variation tolerance for GPR34 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for GPR34 Gene

Disorders for GPR34 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR34 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
congenital stationary night blindness
  • congenital essential nyctalopia
lymphoma, malt, somatic
  • malt lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search GPR34 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR34 Gene

Publications for GPR34 Gene

  1. Discovery of three novel orphan G-protein-coupled receptors. (PMID: 10036181) Marchese A. … O'Dowd B.F. (Genomics 1999) 2 3 4 67
  2. A novel subgroup of class I G-protein-coupled receptors. (PMID: 10395919) Schoneberg T. … Gudermann T. (Biochim. Biophys. Acta 1999) 2 3
  3. G-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro. (PMID: 25673461) Jin Z.T. … Yu W.D. (Chin. Med. J. 2015) 3
  4. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. (PMID: 24602016) Kihara Y. … Chun J. (Br. J. Pharmacol. 2014) 3
  5. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. (PMID: 23383108) Denner J. … AkyA1z L. (PLoS ONE 2013) 3

Products for GPR34 Gene

Sources for GPR34 Gene