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Aliases for GPR32 Gene

Aliases for GPR32 Gene

  • G Protein-Coupled Receptor 32 2 3 5
  • Resolvin D1 Receptor 2 3
  • RVDR1 3

External Ids for GPR32 Gene

Previous GeneCards Identifiers for GPR32 Gene

  • GC19P051902
  • GC19P051635
  • GC19P055949
  • GC19P055965
  • GC19P051276
  • GC19P047608

Summaries for GPR32 Gene

Entrez Gene Summary for GPR32 Gene

  • This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. The encoded protein binds to resolvin D1 and lipoxin A4 and has been linked to pulmonary inflammation. A related pseudogene has been identified on chromosome 19. [provided by RefSeq, Nov 2012]

GeneCards Summary for GPR32 Gene

GPR32 (G Protein-Coupled Receptor 32) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for GPR32 Gene

  • Orphan receptor.

Gene Wiki entry for GPR32 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR32 Gene

Genomics for GPR32 Gene

Regulatory Elements for GPR32 Gene

Genomic Location for GPR32 Gene

Chromosome:
19
Start:
50,770,464 bp from pter
End:
50,771,732 bp from pter
Size:
1,269 bases
Orientation:
Plus strand

Genomic View for GPR32 Gene

Genes around GPR32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR32 Gene

Proteins for GPR32 Gene

  • Protein details for GPR32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75388-GPR32_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 32
    Protein Accession:
    O75388
    Secondary Accessions:
    • Q502U7
    • Q6NWS5

    Protein attributes for GPR32 Gene

    Size:
    356 amino acids
    Molecular mass:
    40087 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR32 Gene

Proteomics data for GPR32 Gene at MOPED

Post-translational modifications for GPR32 Gene

  • Glycosylation at Asn 30 and Asn 199
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR32 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR32 Gene

Domains & Families for GPR32 Gene

Protein Domains for GPR32 Gene

Suggested Antigen Peptide Sequences for GPR32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75388

UniProtKB/Swiss-Prot:

GPR32_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR32: view

Function for GPR32 Gene

Molecular function for GPR32 Gene

GENATLAS Biochemistry:
G protein coupled receptor 32,chemoattractant related receptor
UniProtKB/Swiss-Prot Function:
Orphan receptor.
genes like me logo Genes that share phenotypes with GPR32: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR32

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR32 Gene

Localization for GPR32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR32 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR32 Gene COMPARTMENTS Subcellular localization image for GPR32 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GPR32: view

Pathways & Interactions for GPR32 Gene

genes like me logo Genes that share pathways with GPR32: view

Pathways by source for GPR32 Gene

Interacting Proteins for GPR32 Gene

Gene Ontology (GO) - Biological Process for GPR32 Gene

None

No data available for SIGNOR curated interactions for GPR32 Gene

Drugs & Compounds for GPR32 Gene

(4) Drugs for GPR32 Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>3</sup>H]resolvin D1 Pharma Agonist 0
LXA<sub>4</sub> Pharma Partial agonist, Agonist 0
resolvin D1 Pharma Full agonist, Agonist 0
RVD1-ME Pharma 0
genes like me logo Genes that share compounds with GPR32: view

Transcripts for GPR32 Gene

mRNA/cDNA for GPR32 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR32 Gene

G protein-coupled receptor 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR32 Gene

No ASD Table

Relevant External Links for GPR32 Gene

GeneLoc Exon Structure for
GPR32
ECgene alternative splicing isoforms for
GPR32

Expression for GPR32 Gene

mRNA expression in normal human tissues for GPR32 Gene

mRNA differential expression in normal tissues according to GTEx for GPR32 Gene

This gene is overexpressed in Testis (x16.8), Brain - Cerebellum (x7.0), and Brain - Cerebellar Hemisphere (x6.5).

SOURCE GeneReport for Unigene cluster for GPR32 Gene Hs.515555

genes like me logo Genes that share expression patterns with GPR32: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR32 Gene

Orthologs for GPR32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR32 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR32 35
  • 70.48 (n)
  • 57.14 (a)
chimpanzee
(Pan troglodytes)
Mammalia GPR32 35
  • 99.34 (n)
  • 99.16 (a)
GPR32 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR32 36
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CR847899.1 36
  • 22 (a)
ManyToMany
Species with no ortholog for GPR32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR32 Gene

ENSEMBL:
Gene Tree for GPR32 (if available)
TreeFam:
Gene Tree for GPR32 (if available)

Paralogs for GPR32 Gene

Paralogs for GPR32 Gene

(8) SIMAP similar genes for GPR32 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GPR32 Gene

genes like me logo Genes that share paralogs with GPR32: view

Variants for GPR32 Gene

Sequence variations from dbSNP and Humsavar for GPR32 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1864011 - 50,771,579(-) GAAAA(A/G)CTTTT reference, missense
rs7252155 -- 50,769,586(+) ggttt(A/G)gaact upstream-variant-2KB
rs7248485 -- 50,769,247(+) tgaga(C/T)ggagt upstream-variant-2KB
rs7248753 -- 50,769,517(+) tgtgc(A/C)tggcc upstream-variant-2KB
rs8106072 -- 50,768,480(+) tcctg(C/T)ggtct upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR32 Gene

Variant ID Type Subtype PubMed ID
esv26629 CNV Gain+Loss 19812545
nsv517376 CNV Loss 19592680
esv2718749 CNV Deletion 23290073

Variation tolerance for GPR32 Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR32 Gene

HapMap Linkage Disequilibrium report
GPR32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR32 Gene

Disorders for GPR32 Gene

Relevant External Links for GPR32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR32

No disorders were found for GPR32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR32 Gene

Publications for GPR32 Gene

  1. Cloning genes encoding receptors related to chemoattractant receptors. (PMID: 9653656) Marchese A. … O'Dowd B.F. (Genomics 1998) 2 3 4 67
  2. Effect of diclofenac on the levels of lipoxin A4 and Resolvin D1 and E1 in the post-ERCP pancreatitis. (PMID: 25030943) Zhao X.W. … Xu J.M. (Dig. Dis. Sci. 2014) 3
  3. Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1. (PMID: 25320283) Hsiao H.M. … Sime P.J. (J. Immunol. 2014) 3
  4. Resolvin D1 inhibits TGF-I^1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32. (PMID: 24120851) Lee H.J. … Lee C.H. (Int. J. Biochem. Cell Biol. 2013) 3
  5. Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs. (PMID: 22542696) Im D.S. (Prog. Lipid Res. 2012) 3

Products for GPR32 Gene

Sources for GPR32 Gene

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