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Aliases for GPR31 Gene

Aliases for GPR31 Gene

  • G Protein-Coupled Receptor 31 2 3 5
  • Hydroxyeicosatetraenoic (HETE) Acid Receptor 1 2 3
  • 12-(S)-HETE Acid Receptor 2 3
  • 12-(S)-HETE Receptor 3 4
  • 12-HETER 3 4
  • 12-(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid (HETE) Receptor 3
  • 12-(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid Receptor 3
  • BA517H2.2 (G Protein-Coupled Receptor 31) 3
  • Probable G-Protein Coupled Receptor 31 3
  • G-Protein Coupled Receptor 31 4
  • HETER1 3
  • HETER 3

External Ids for GPR31 Gene

Previous GeneCards Identifiers for GPR31 Gene

  • GC06M166923
  • GC06M167443
  • GC06M167479
  • GC06M167540
  • GC06M165042

Summaries for GPR31 Gene

GeneCards Summary for GPR31 Gene

GPR31 (G Protein-Coupled Receptor 31) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is HCAR3.

UniProtKB/Swiss-Prot for GPR31 Gene

  • High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.

Gene Wiki entry for GPR31 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR31 Gene

Genomics for GPR31 Gene

Regulatory Elements for GPR31 Gene

Enhancers for GPR31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G167150 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24.6 +5.8 5790 3.4 PKNOX1 SIN3A ELK1 CBX5 FOS KLF13 SP5 JUNB REST TBX21 GPR31 RNASET2 CCR6 FGFR1OP LOC105378120 ENSG00000249141 UNC93A RPS6KA2 RPS6KA2-AS1 AFDN
GH06G167089 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +65.4 65359 7.3 HDGF PKNOX1 FOXA2 MLX WRNIP1 DMAP1 ZNF48 ZNF143 ZNF207 MXD4 RNASET2 LOC105378120 FGFR1OP CCR6 GPR31 PIR47545 PIR53334
GH06G167223 1.4 Ensembl ENCODE dbSUPER 11.8 -68.3 -68298 6.9 FOXA2 ATF1 ARID4B DMAP1 GATA2 FOS PAF1 SP5 MXD4 MIER2 UNC93A GPR31 ENSG00000280707 LOC100420305
GH06G167129 1.2 ENCODE dbSUPER 11.3 +27.8 27778 2.7 PKNOX1 FOXA2 MLX ARID4B ZNF48 TCF12 SLC30A9 FOS SP5 MIER2 FGFR1OP LOC105378120 GPR31 RPS6KA2-AS1 RPS6KA2 RNASET2 LOC105378122 LOC105378124 TCP10L2
GH06G166862 0.8 ENCODE 10.2 +295.6 295626 0.9 CTCF ZNF777 ZNF146 RBBP5 RAD21 GLIS2 POLR2A PATZ1 ZNF600 ZBTB20 RPS6KA2-AS1 RPS6KA2 FGFR1OP LOC105378120 GPR31 GC06P166871 LOC645468
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR31 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR31 Gene

Chromosome:
6
Start:
167,156,271 bp from pter
End:
167,158,329 bp from pter
Size:
2,059 bases
Orientation:
Minus strand

Genomic View for GPR31 Gene

Genes around GPR31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR31 Gene

Proteins for GPR31 Gene

  • Protein details for GPR31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00270-GPR31_HUMAN
    Recommended name:
    12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
    Protein Accession:
    O00270
    Secondary Accessions:
    • B0M0K2
    • Q4VBL3
    • Q9NQ20

    Protein attributes for GPR31 Gene

    Size:
    319 amino acids
    Molecular mass:
    35075 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR31 Gene

Post-translational modifications for GPR31 Gene

Other Protein References for GPR31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR31 Gene

Domains & Families for GPR31 Gene

Gene Families for GPR31 Gene

Protein Domains for GPR31 Gene

Suggested Antigen Peptide Sequences for GPR31 Gene

Graphical View of Domain Structure for InterPro Entry

O00270

UniProtKB/Swiss-Prot:

GPR31_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR31: view

Function for GPR31 Gene

Molecular function for GPR31 Gene

GENATLAS Biochemistry:
G protein coupled receptor 31,with homology with the orphan receptor HM74
UniProtKB/Swiss-Prot Function:
High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.

Gene Ontology (GO) - Molecular Function for GPR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR31: view
genes like me logo Genes that share phenotypes with GPR31: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR31

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR31 Gene

Localization for GPR31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR31 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR31 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 9205127
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR31: view

Pathways & Interactions for GPR31 Gene

genes like me logo Genes that share pathways with GPR31: view

Pathways by source for GPR31 Gene

Interacting Proteins for GPR31 Gene

Gene Ontology (GO) - Biological Process for GPR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR31: view

No data available for SIGNOR curated interactions for GPR31 Gene

Transcripts for GPR31 Gene

mRNA/cDNA for GPR31 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR31 Gene

G protein-coupled receptor 31:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR31

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR31 Gene

No ASD Table

Relevant External Links for GPR31 Gene

GeneLoc Exon Structure for
GPR31
ECgene alternative splicing isoforms for
GPR31

Expression for GPR31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR31 Gene

mRNA differential expression in normal tissues according to GTEx for GPR31 Gene

This gene is overexpressed in Testis (x12.4), Small Intestine - Terminal Ileum (x8.7), and Spleen (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of GPR31 Gene:

GPR31

SOURCE GeneReport for Unigene cluster for GPR31 Gene:

Hs.248124
genes like me logo Genes that share expression patterns with GPR31: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR31 Gene

Orthologs for GPR31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR31 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia GPR31 34 35
  • 74.87 (n)
cow
(Bos Taurus)
Mammalia GPR31 34 35
  • 72.53 (n)
rat
(Rattus norvegicus)
Mammalia Gpr31 34
  • 71.26 (n)
mouse
(Mus musculus)
Mammalia Gpr31b 34 16 35
  • 71.06 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR31 35
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPR31 35
  • 26 (a)
OneToOne
Species where no ortholog for GPR31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR31 Gene

ENSEMBL:
Gene Tree for GPR31 (if available)
TreeFam:
Gene Tree for GPR31 (if available)

Paralogs for GPR31 Gene

Paralogs for GPR31 Gene

(7) SIMAP similar genes for GPR31 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR31: view

Variants for GPR31 Gene

Sequence variations from dbSNP and Humsavar for GPR31 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000279678 -- 167,156,762(+) TCCTT(G/T)TATTG downstream-variant-500B
rs1005056292 -- 167,159,013(+) CATAG(A/G)TCTTA upstream-variant-2KB
rs1006916464 -- 167,158,327(+) TGGGA(A/T)CCTTC upstream-variant-2KB
rs1009150760 -- 167,157,644(+) CAGCC(A/C)ACAGC reference, missense
rs1010643133 -- 167,159,489(+) ACTGC(A/C)TGTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR31 Gene

Variant ID Type Subtype PubMed ID
dgv1240e214 CNV gain 21293372
dgv6194n100 CNV gain 25217958
esv2752099 CNV gain 17911159
esv2759492 CNV gain 17122850
esv3611649 CNV gain 21293372
nsv469673 CNV loss 16826518

Variation tolerance for GPR31 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR31 Gene

Disorders for GPR31 Gene

Relevant External Links for GPR31

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR31

No disorders were found for GPR31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR31 Gene

Publications for GPR31 Gene

  1. Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid. (PMID: 21712392) Guo Y. … Honn K.V. (J. Biol. Chem. 2011) 2 3 4 64
  2. Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor. (PMID: 9205127) Zingoni A. … Napolitano M. (Genomics 1997) 2 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. Genome-wide association study of autistic-like traits in a general population study of young adults. (PMID: 24133439) Jones R.M. … Moses E.K. (Front Hum Neurosci 2013) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for GPR31 Gene

Sources for GPR31 Gene

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