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Aliases for GPR31 Gene

Aliases for GPR31 Gene

  • G Protein-Coupled Receptor 31 2 3 5
  • Hydroxyeicosatetraenoic (HETE) Acid Receptor 1 2 3
  • G-Protein Coupled Receptor 31 3 4
  • 12-(S)-HETE Acid Receptor 2 3
  • 12-(S)-HETE Receptor 3 4
  • 12-HETER 3 4
  • 12-(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid (HETE) Receptor 3
  • BA517H2.2 (G Protein-Coupled Receptor 31) 3
  • Probable G-Protein Coupled Receptor 31 3
  • HETER1 3
  • HETER 3

External Ids for GPR31 Gene

Previous GeneCards Identifiers for GPR31 Gene

  • GC06M166923
  • GC06M167443
  • GC06M167479
  • GC06M167540
  • GC06M165042

Summaries for GPR31 Gene

GeneCards Summary for GPR31 Gene

GPR31 (G Protein-Coupled Receptor 31) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is HCAR3.

UniProtKB/Swiss-Prot for GPR31 Gene

  • High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.

Gene Wiki entry for GPR31 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR31 Gene

Genomics for GPR31 Gene

Genomic Location for GPR31 Gene

Chromosome:
6
Start:
167,156,271 bp from pter
End:
167,158,329 bp from pter
Size:
2,059 bases
Orientation:
Minus strand

Genomic View for GPR31 Gene

Genes around GPR31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR31 Gene

Proteins for GPR31 Gene

  • Protein details for GPR31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00270-GPR31_HUMAN
    Recommended name:
    12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
    Protein Accession:
    O00270
    Secondary Accessions:
    • B0M0K2
    • Q4VBL3
    • Q9NQ20

    Protein attributes for GPR31 Gene

    Size:
    319 amino acids
    Molecular mass:
    35075 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR31 Gene

Proteomics data for GPR31 Gene at MOPED

Post-translational modifications for GPR31 Gene

Other Protein References for GPR31 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GPR31

No data available for DME Specific Peptides for GPR31 Gene

Domains & Families for GPR31 Gene

Gene Families for GPR31 Gene

Protein Domains for GPR31 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR31 Gene

Graphical View of Domain Structure for InterPro Entry

O00270

UniProtKB/Swiss-Prot:

GPR31_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR31: view

Function for GPR31 Gene

Molecular function for GPR31 Gene

GENATLAS Biochemistry:
G protein coupled receptor 31,with homology with the orphan receptor HM74
UniProtKB/Swiss-Prot Function:
High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.
genes like me logo Genes that share phenotypes with GPR31: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR31

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR31 Gene

Localization for GPR31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR31 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR31 Gene COMPARTMENTS Subcellular localization image for GPR31 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GPR31: view

Pathways & Interactions for GPR31 Gene

genes like me logo Genes that share pathways with GPR31: view

Pathways by source for GPR31 Gene

Interacting Proteins for GPR31 Gene

Gene Ontology (GO) - Biological Process for GPR31 Gene

None

No data available for SIGNOR curated interactions for GPR31 Gene

Drugs & Compounds for GPR31 Gene

No Compound Related Data Available

Transcripts for GPR31 Gene

mRNA/cDNA for GPR31 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR31 Gene

G protein-coupled receptor 31:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR31 Gene

No ASD Table

Relevant External Links for GPR31 Gene

GeneLoc Exon Structure for
GPR31
ECgene alternative splicing isoforms for
GPR31

Expression for GPR31 Gene

mRNA expression in normal human tissues for GPR31 Gene

mRNA differential expression in normal tissues according to GTEx for GPR31 Gene

This gene is overexpressed in Testis (x12.4), Small Intestine - Terminal Ileum (x8.7), and Spleen (x5.3).

SOURCE GeneReport for Unigene cluster for GPR31 Gene Hs.248124

genes like me logo Genes that share expression patterns with GPR31: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR31 Gene

Orthologs for GPR31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR31 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR31 35
  • 72.53 (n)
  • 64.17 (a)
GPR31 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR31 35
  • 74.87 (n)
  • 67.64 (a)
GPR31 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr31b 35
  • 71.06 (n)
  • 61.13 (a)
Gpr31b 16
Gpr31b 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR31 35
  • 99.37 (n)
  • 99.06 (a)
GPR31 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr31 35
  • 71.26 (n)
  • 59.87 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR31 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPR31 36
  • 26 (a)
OneToOne
Species with no ortholog for GPR31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR31 Gene

ENSEMBL:
Gene Tree for GPR31 (if available)
TreeFam:
Gene Tree for GPR31 (if available)

Paralogs for GPR31 Gene

Paralogs for GPR31 Gene

(7) SIMAP similar genes for GPR31 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR31: view

Variants for GPR31 Gene

Sequence variations from dbSNP and Humsavar for GPR31 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_049392 -

Structural Variations from Database of Genomic Variants (DGV) for GPR31 Gene

Variant ID Type Subtype PubMed ID
esv2752099 CNV Gain 17911159
nsv469673 CNV Loss 16826518
essv22845 CNV CNV 17122850
dgv2033e1 CNV Complex 17122850

Variation tolerance for GPR31 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR31 Gene

HapMap Linkage Disequilibrium report
GPR31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR31 Gene

Disorders for GPR31 Gene

Relevant External Links for GPR31

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR31

No disorders were found for GPR31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR31 Gene

Publications for GPR31 Gene

  1. Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid. (PMID: 21712392) Guo Y. … Honn K.V. (J. Biol. Chem. 2011) 2 3 4 67
  2. Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor. (PMID: 9205127) Zingoni A. … Napolitano M. (Genomics 1997) 2 3
  3. Genome-wide association study of autistic-like traits in a general population study of young adults. (PMID: 24133439) Jones R.M. … Moses E.K. (Front Hum Neurosci 2013) 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GPR31 Gene

Sources for GPR31 Gene

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