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Aliases for GPR3 Gene

Aliases for GPR3 Gene

  • G Protein-Coupled Receptor 3 2 3 5
  • ACCA Orphan Receptor 3 4
  • ACCA 3 4
  • Adenylate Cyclase Constitutive Activator 3
  • G-Protein Coupled Receptor 3 3

External Ids for GPR3 Gene

Previous GeneCards Identifiers for GPR3 Gene

  • GC01M027870
  • GC01P026751
  • GC01P026882
  • GC01P027323
  • GC01P027591
  • GC01P027719
  • GC01P025977

Summaries for GPR3 Gene

Entrez Gene Summary for GPR3 Gene

  • This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]

GeneCards Summary for GPR3 Gene

GPR3 (G Protein-Coupled Receptor 3) is a Protein Coding gene. Diseases associated with GPR3 include Alzheimer Disease. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR6.

UniProtKB/Swiss-Prot for GPR3 Gene

  • Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).

Gene Wiki entry for GPR3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR3 Gene

Genomics for GPR3 Gene

Regulatory Elements for GPR3 Gene

Enhancers for GPR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G027339 1.4 ENCODE dbSUPER 11.4 -50.7 -50670 4.5 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B ENSG00000243659 ENSG00000231207 GPR3 TMEM222 SYTL1 DNAJC8 WDTC1 RNU6-48P
GH01G027348 1.2 ENCODE dbSUPER 13 -42.2 -42218 3.0 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A ZNF121 GLIS2 KLF13 ZNF263 SP3 TMEM222 ENSG00000231207 GPR3 RNU6-48P ACTG1P20 ENSG00000243659 WDTC1 GC01P027353 SYTL1
GH01G027332 1.2 ENCODE dbSUPER 11.6 -59.6 -59644 0.9 HDGF SIN3A E2F7 DMAP1 ZNF143 FOS ZNF263 JUNB ZHX2 REST ENSG00000243659 GPR3 ENSG00000231207 TMEM222 WDTC1 RNU6-48P SYTL1
GH01G027446 1 dbSUPER 11 +55.1 55100 1.6 ARNT CREB3L1 AGO1 ARID4B SIN3A ZNF48 YY1 ZNF121 GLIS2 ELK1 CD164L2 WASF2 LOC105376892 GPR3 ENSG00000231207 TMEM222 RNU6-48P ACTG1P20 ENSG00000243659 RNU6-1245P
GH01G027455 0.9 Ensembl ENCODE dbSUPER 11 +62.9 62946 0.8 ZNF664 CD164L2 LOC105376892 WASF2 GPR3 ENSG00000231207 ENSG00000243659 RNU6-48P TMEM222 ACTG1P20 LOC105376890
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR3 on UCSC Golden Path with GeneCards custom track

Promoters for GPR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003710 56 601 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143

Genomic Location for GPR3 Gene

Chromosome:
1
Start:
27,392,644 bp from pter
End:
27,395,814 bp from pter
Size:
3,171 bases
Orientation:
Plus strand

Genomic View for GPR3 Gene

Genes around GPR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR3 Gene

Proteins for GPR3 Gene

  • Protein details for GPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46089-GPR3_HUMAN
    Recommended name:
    G-protein coupled receptor 3
    Protein Accession:
    P46089
    Secondary Accessions:
    • A8K570

    Protein attributes for GPR3 Gene

    Size:
    330 amino acids
    Molecular mass:
    35010 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR3 Gene

Post-translational modifications for GPR3 Gene

  • Glycosylation at posLast=2020
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR3 Gene

Domains & Families for GPR3 Gene

Gene Families for GPR3 Gene

Protein Domains for GPR3 Gene

Suggested Antigen Peptide Sequences for GPR3 Gene

Graphical View of Domain Structure for InterPro Entry

P46089

UniProtKB/Swiss-Prot:

GPR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR3: view

Function for GPR3 Gene

Molecular function for GPR3 Gene

GENATLAS Biochemistry:
G protein coupled receptor 3,expressed in central nervous system,lung,kidney
UniProtKB/Swiss-Prot Function:
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).
UniProtKB/Swiss-Prot Induction:
Overexpression stimulates amyloid-beta production.

Gene Ontology (GO) - Molecular Function for GPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS,IEA --
GO:0005515 protein binding IPI 24069330
genes like me logo Genes that share ontologies with GPR3: view
genes like me logo Genes that share phenotypes with GPR3: view

Animal Models for GPR3 Gene

MGI Knock Outs for GPR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR3

CRISPR Products

miRNA for GPR3 Gene

miRTarBase miRNAs that target GPR3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR3
  • Applied Biological Materials Clones for GPR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR3 Gene

Localization for GPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR3 gene
Compartment Confidence
plasma membrane 5
endosome 1

Gene Ontology (GO) - Cellular Components for GPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 7639700
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR3: view

Pathways & Interactions for GPR3 Gene

genes like me logo Genes that share pathways with GPR3: view

Pathways by source for GPR3 Gene

1 BioSystems pathway for GPR3 Gene

Gene Ontology (GO) - Biological Process for GPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway TAS 7639700
GO:0040020 regulation of meiotic nuclear division IEA --
genes like me logo Genes that share ontologies with GPR3: view

No data available for SIGNOR curated interactions for GPR3 Gene

Drugs & Compounds for GPR3 Gene

(2) Drugs for GPR3 Gene - From: ApexBio, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphenyleneiodonium chloride Pharma GPR3 agonist 0
sphingosine 1-phosphate Pharma Full agonist, Agonist 0

(1) ApexBio Compounds for GPR3 Gene

Compound Action Cas Number
Diphenyleneiodonium chloride GPR3 agonist 4673-26-1
genes like me logo Genes that share compounds with GPR3: view

Drug Products

Transcripts for GPR3 Gene

mRNA/cDNA for GPR3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR3 Gene

G protein-coupled receptor 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR3
  • Applied Biological Materials Clones for GPR3

Alternative Splicing Database (ASD) splice patterns (SP) for GPR3 Gene

No ASD Table

Relevant External Links for GPR3 Gene

GeneLoc Exon Structure for
GPR3
ECgene alternative splicing isoforms for
GPR3

Expression for GPR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR3 Gene:

GPR3

SOURCE GeneReport for Unigene cluster for GPR3 Gene:

Hs.66542

mRNA Expression by UniProt/SwissProt for GPR3 Gene:

P46089-GPR3_HUMAN
Tissue specificity: Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.

Evidence on tissue expression from TISSUES for GPR3 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with GPR3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR3 Gene

Orthologs for GPR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR3 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia GPR3 34 35
  • 92.2 (n)
cow
(Bos Taurus)
Mammalia GPR3 34 35
  • 91.62 (n)
mouse
(Mus musculus)
Mammalia Gpr3 34 16 35
  • 90 (n)
rat
(Rattus norvegicus)
Mammalia Gpr3 34
  • 87.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR3 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 38 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia GPR3 35
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-24g18.3 35
  • 52 (a)
ManyToMany
Species where no ortholog for GPR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR3 Gene

ENSEMBL:
Gene Tree for GPR3 (if available)
TreeFam:
Gene Tree for GPR3 (if available)

Paralogs for GPR3 Gene

Paralogs for GPR3 Gene

(9) SIMAP similar genes for GPR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR3: view

Variants for GPR3 Gene

Sequence variations from dbSNP and Humsavar for GPR3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000001609 -- 27,395,077(+) AGTCC(C/T)AGATG utr-variant-3-prime
rs1000185542 -- 27,391,837(+) CTGTG(C/T)CCCTC upstream-variant-2KB
rs1000404398 -- 27,392,187(+) ATCGT(C/G)ACCTC upstream-variant-2KB
rs1001409073 -- 27,393,284(+) GCTGG(C/T)GGGAG intron-variant
rs1002276500 -- 27,395,559(+) GTCCG(A/T)CTGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR3 Gene

Variant ID Type Subtype PubMed ID
nsv516766 CNV loss 19592680
nsv526051 CNV gain 19592680
nsv950342 CNV deletion 24416366

Variation tolerance for GPR3 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR3 Gene

Disorders for GPR3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search GPR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR3

Genetic Association Database (GAD)
GPR3
Human Genome Epidemiology (HuGE) Navigator
GPR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR3
genes like me logo Genes that share disorders with GPR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR3 Gene

Publications for GPR3 Gene

  1. Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. (PMID: 7639700) Eggerickx D. … Libert F. (Biochem. J. 1995) 3 4 22 64
  2. Cloning of human genes encoding novel G protein-coupled receptors. (PMID: 7851889) Marchese A. … O'Dowd B.F. (Genomics 1994) 2 3 4 64
  3. The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. (PMID: 19213921) Thathiah A. … Merchiers P. (Science 2009) 3 4 64
  4. Oocyte-specific G-protein-coupled receptor 3 (GPR3): no perturbations found in 82 women with premature ovarian failure (first report). (PMID: 17953967) Kovanci E. … Carson S.A. (Fertil. Steril. 2008) 3 46 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for GPR3 Gene

  • Addgene plasmids for GPR3

Sources for GPR3 Gene

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