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Aliases for GPR3 Gene

Aliases for GPR3 Gene

  • G Protein-Coupled Receptor 3 2 3 5
  • ACCA Orphan Receptor 3 4
  • ACCA 3 4
  • Adenylate Cyclase Constitutive Activator 3

External Ids for GPR3 Gene

Previous GeneCards Identifiers for GPR3 Gene

  • GC01M027870
  • GC01P026751
  • GC01P026882
  • GC01P027323
  • GC01P027591
  • GC01P027719
  • GC01P025977

Summaries for GPR3 Gene

Entrez Gene Summary for GPR3 Gene

  • This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]

GeneCards Summary for GPR3 Gene

GPR3 (G Protein-Coupled Receptor 3) is a Protein Coding gene. Diseases associated with GPR3 include Alzheimer Disease. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for GPR3 Gene

  • Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).

Gene Wiki entry for GPR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR3 Gene

Genomics for GPR3 Gene

Regulatory Elements for GPR3 Gene

Enhancers for GPR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR3 on UCSC Golden Path with GeneCards custom track

Promoters for GPR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR3 Gene

27,392,644 bp from pter
27,395,814 bp from pter
3,171 bases
Plus strand

Genomic View for GPR3 Gene

Genes around GPR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR3 Gene

Proteins for GPR3 Gene

  • Protein details for GPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 3
    Protein Accession:
    Secondary Accessions:
    • A8K570

    Protein attributes for GPR3 Gene

    330 amino acids
    Molecular mass:
    35010 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR3 Gene

Proteomics data for GPR3 Gene at MOPED

Post-translational modifications for GPR3 Gene

  • Glycosylation at Asn 20
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR3 Gene

Domains & Families for GPR3 Gene

Gene Families for GPR3 Gene

Protein Domains for GPR3 Gene

Suggested Antigen Peptide Sequences for GPR3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR3: view

Function for GPR3 Gene

Molecular function for GPR3 Gene

GENATLAS Biochemistry:
G protein coupled receptor 3,expressed in central nervous system,lung,kidney
UniProtKB/Swiss-Prot Function:
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).
UniProtKB/Swiss-Prot Induction:
Overexpression stimulates amyloid-beta production.

Gene Ontology (GO) - Molecular Function for GPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24069330
genes like me logo Genes that share ontologies with GPR3: view
genes like me logo Genes that share phenotypes with GPR3: view

Animal Models for GPR3 Gene

MGI Knock Outs for GPR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR3

miRNA for GPR3 Gene

miRTarBase miRNAs that target GPR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR3 Gene

Localization for GPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR3 Gene COMPARTMENTS Subcellular localization image for GPR3 gene
Compartment Confidence
plasma membrane 5
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for GPR3 Gene

Pathways & Interactions for GPR3 Gene

SuperPathways for GPR3 Gene

genes like me logo Genes that share pathways with GPR3: view

Pathways by source for GPR3 Gene

1 BioSystems pathway for GPR3 Gene

Gene Ontology (GO) - Biological Process for GPR3 Gene


No data available for SIGNOR curated interactions for GPR3 Gene

Drugs & Compounds for GPR3 Gene

(2) Drugs for GPR3 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0
Diphenyleneiodonium chloride Pharma GPR3 agonist; also inhibits NOS and NADPH oxidases 0
genes like me logo Genes that share compounds with GPR3: view

Transcripts for GPR3 Gene

mRNA/cDNA for GPR3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR3 Gene

G protein-coupled receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR3 Gene

No ASD Table

Relevant External Links for GPR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR3 Gene

mRNA expression in normal human tissues for GPR3 Gene

SOURCE GeneReport for Unigene cluster for GPR3 Gene Hs.66542

mRNA Expression by UniProt/SwissProt for GPR3 Gene

Tissue specificity: Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.
genes like me logo Genes that share expression patterns with GPR3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR3 Gene

Orthologs for GPR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR3 35
  • 91.62 (n)
  • 95.45 (a)
GPR3 36
  • 95 (a)
(Canis familiaris)
Mammalia GPR3 35
  • 92.2 (n)
  • 96.96 (a)
GPR3 36
  • 97 (a)
(Mus musculus)
Mammalia Gpr3 35
  • 90 (n)
  • 93.64 (a)
Gpr3 16
Gpr3 36
  • 94 (a)
(Pan troglodytes)
Mammalia GPR3 35
  • 99.7 (n)
  • 99.7 (a)
GPR3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr3 35
  • 87.23 (n)
  • 89.69 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia GPR3 36
  • 68 (a)
(Anolis carolinensis)
Reptilia GPR3 36
  • 71 (a)
(Danio rerio)
Actinopterygii si:dkey-24g18.3 36
  • 52 (a)
Species with no ortholog for GPR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR3 Gene

Gene Tree for GPR3 (if available)
Gene Tree for GPR3 (if available)

Paralogs for GPR3 Gene

Paralogs for GPR3 Gene

(9) SIMAP similar genes for GPR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR3: view

Variants for GPR3 Gene

Sequence variations from dbSNP and Humsavar for GPR3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs734852 - 27,394,463(+) CTGCC(A/G)CCATG reference, missense
rs2230880 -- 27,394,569(+) TTTGC(C/T)GCCTG reference, synonymous-codon
rs2504785 -- 27,392,450(+) CGGGC(A/C/G)GACTC upstream-variant-2KB
rs2504786 -- 27,393,674(+) GGGAC(C/T)CTATC intron-variant
rs2474284 -- 27,391,167(+) TCCTC(C/T)TCCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR3 Gene

Variant ID Type Subtype PubMed ID
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294
nsv516766 CNV Loss 19592680

Variation tolerance for GPR3 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR3 Gene

Disorders for GPR3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search GPR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR3 Gene

Publications for GPR3 Gene

  1. Cloning of human genes encoding novel G protein-coupled receptors. (PMID: 7851889) Marchese A. … O'Dowd B.F. (Genomics 1994) 2 3 4 67
  2. Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. (PMID: 12649592) Uhlenbrock K. … Kostenis E. (Cell. Physiol. Biochem. 2003) 3 23
  3. Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. (PMID: 7639700) Eggerickx D. … Libert F. (Biochem. J. 1995) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. [G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development]. (PMID: 23732663) Zhang B.L. … Xu Y.X. (Yi Chuan 2013) 3

Products for GPR3 Gene

Sources for GPR3 Gene