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Aliases for GPR27 Gene

Aliases for GPR27 Gene

  • G Protein-Coupled Receptor 27 2 3 5
  • Super Conserved Receptor Expressed In Brain 1 3 4
  • SREB1 3 4
  • Probable G-Protein Coupled Receptor 27 3

External Ids for GPR27 Gene

Previous GeneCards Identifiers for GPR27 Gene

  • GC03M070539
  • GC03P071416
  • GC03P071607
  • GC03P071723
  • GC03P071885
  • GC03P071803

Summaries for GPR27 Gene

Entrez Gene Summary for GPR27 Gene

  • GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]

GeneCards Summary for GPR27 Gene

GPR27 (G Protein-Coupled Receptor 27) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR173.

UniProtKB/Swiss-Prot for GPR27 Gene

  • Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

Gene Wiki entry for GPR27 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR27 Gene

Genomics for GPR27 Gene

Regulatory Elements for GPR27 Gene

Enhancers for GPR27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G071779 1.4 FANTOM5 Ensembl ENCODE 49.2 +25.9 25851 1.8 CTCF ETV1 TEAD4 MAX FOXM1 ZNF316 EGR1 SCRT2 NFE2 PRDM10 PROK2 GPR27 EIF4E3 FOXP1
GH03G071720 1.2 FANTOM5 ENCODE 33.9 -30.3 -30307 5.6 PKNOX1 INSM2 SIN3A KLF17 GLIS2 ZNF366 EGR2 CEBPB CBX8 SMARCA4 GPR27 EIF4E3 PROK2 FOXP1 GC03P071727 GC03P071679
GH03G071728 1.1 Ensembl ENCODE 30.1 -24.4 -24393 1.5 ZSCAN4 BMI1 ZBTB40 RAD21 SCRT2 ZNF143 ZNF654 REST SMARCA4 MYNN GPR27 EIF4E3 GC03P071727
GH03G072076 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +326.1 326149 6.9 HDGF PKNOX1 FOXA2 ATF1 FEZF1 YBX1 YY1 TCF12 ZNF766 ELK1 RYBP PROK2 GPR27 EIF4E3 LINC00877 FOXP1 ENSG00000276471 ENSG00000273461
GH03G071784 0.7 FANTOM5 31.5 +30.3 30338 0.2 RNF2 ZBTB48 SUZ12 CBX2 KDM1A EZH2 PROK2 GPR27 EIF4E3 FOXP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR27 on UCSC Golden Path with GeneCards custom track

Promoters for GPR27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000154381 -50 1201 CTCF MXI1 RNF2 SUZ12 RBBP5 REST POLR2A KDM1A ZFX ZBTB26

Genomic Location for GPR27 Gene

Chromosome:
3
Start:
71,754,050 bp from pter
End:
71,756,496 bp from pter
Size:
2,447 bases
Orientation:
Plus strand

Genomic View for GPR27 Gene

Genes around GPR27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR27 Gene

Proteins for GPR27 Gene

  • Protein details for GPR27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS67-GPR27_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 27
    Protein Accession:
    Q9NS67

    Protein attributes for GPR27 Gene

    Size:
    375 amino acids
    Molecular mass:
    39818 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR27 Gene

Post-translational modifications for GPR27 Gene

  • Glycosylation at posLast=33
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR27 Gene

Domains & Families for GPR27 Gene

Gene Families for GPR27 Gene

Protein Domains for GPR27 Gene

Suggested Antigen Peptide Sequences for GPR27 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NS67

UniProtKB/Swiss-Prot:

GPR27_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR27: view

Function for GPR27 Gene

Molecular function for GPR27 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

Gene Ontology (GO) - Molecular Function for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA,TAS --
genes like me logo Genes that share ontologies with GPR27: view
genes like me logo Genes that share phenotypes with GPR27: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR27

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR27

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR27 Gene

Localization for GPR27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR27 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR27 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR27: view

Pathways & Interactions for GPR27 Gene

genes like me logo Genes that share pathways with GPR27: view

Pathways by source for GPR27 Gene

Interacting Proteins for GPR27 Gene

Gene Ontology (GO) - Biological Process for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10833454
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR27: view

No data available for SIGNOR curated interactions for GPR27 Gene

Drugs & Compounds for GPR27 Gene

No Compound Related Data Available

Transcripts for GPR27 Gene

mRNA/cDNA for GPR27 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR27 Gene

G protein-coupled receptor 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR27

Alternative Splicing Database (ASD) splice patterns (SP) for GPR27 Gene

No ASD Table

Relevant External Links for GPR27 Gene

GeneLoc Exon Structure for
GPR27
ECgene alternative splicing isoforms for
GPR27

Expression for GPR27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR27 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR27 Gene:

GPR27

SOURCE GeneReport for Unigene cluster for GPR27 Gene:

Hs.591653

mRNA Expression by UniProt/SwissProt for GPR27 Gene:

Q9NS67-GPR27_HUMAN
Tissue specificity: Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum.

Evidence on tissue expression from TISSUES for GPR27 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with GPR27: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR27 Gene

Orthologs for GPR27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR27 34
  • 96.53 (n)
mouse
(Mus musculus)
Mammalia Gpr27 34 16 35
  • 94.12 (n)
rat
(Rattus norvegicus)
Mammalia Gpr27 34
  • 93.45 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR27 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR27 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR27 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gpr27 35
  • 55 (a)
OneToOne
Species where no ortholog for GPR27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR27 Gene

ENSEMBL:
Gene Tree for GPR27 (if available)
TreeFam:
Gene Tree for GPR27 (if available)

Paralogs for GPR27 Gene

Paralogs for GPR27 Gene

(2) SIMAP similar genes for GPR27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR27: view

Variants for GPR27 Gene

Sequence variations from dbSNP and Humsavar for GPR27 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000236470 -- 71,755,752(+) TCTCA(A/G)TGTTG upstream-variant-2KB, utr-variant-3-prime
rs1002625859 -- 71,753,745(+) AGTAG(C/G)AGGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1002955887 -- 71,752,720(+) AAGTA(C/T)ATAAT intron-variant, upstream-variant-2KB
rs1003049084 -- 71,752,557(+) AAGAA(A/G)AAACA intron-variant, upstream-variant-2KB
rs1003278129 -- 71,755,683(+) GGAAG(A/T)TGTCC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR27 Gene

Variant ID Type Subtype PubMed ID
dgv8373n54 CNV gain 21841781
dgv8374n54 CNV gain 21841781
esv28633 CNV loss 19812545
nsv1144994 CNV deletion 24896259
nsv524847 CNV loss 19592680
nsv590600 CNV loss 21841781
nsv590606 CNV loss 21841781
nsv590610 CNV gain+loss 21841781
nsv590611 CNV loss 21841781

Variation tolerance for GPR27 Gene

Gene Damage Index Score: 0.46; 9.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR27 Gene

Disorders for GPR27 Gene

Relevant External Links for GPR27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR27

No disorders were found for GPR27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR27 Gene

Publications for GPR27 Gene

  1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PMID: 10833454) Matsumoto M. … Furuichi K. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 64
  2. Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress. (PMID: 25113059) Kotov I.N. … Marti T.M. (Mol Oncol 2014) 3 64
  3. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. (PMID: 15893849) Matsumoto M. … Kleinman J.E. (Brain Res. Mol. Brain Res. 2005) 22 64

Products for GPR27 Gene

  • Addgene plasmids for GPR27

Sources for GPR27 Gene

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