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Aliases for GPR27 Gene

Aliases for GPR27 Gene

  • G Protein-Coupled Receptor 27 2 3
  • Super Conserved Receptor Expressed In Brain 1 3 4
  • SREB1 3 4

External Ids for GPR27 Gene

Previous GeneCards Identifiers for GPR27 Gene

  • GC03M070539
  • GC03P071416
  • GC03P071607
  • GC03P071723
  • GC03P071885
  • GC03P071803

Summaries for GPR27 Gene

Entrez Gene Summary for GPR27 Gene

  • GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]

GeneCards Summary for GPR27 Gene

GPR27 (G Protein-Coupled Receptor 27) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR85.

UniProtKB/Swiss-Prot for GPR27 Gene

  • Orphan receptor. Possible candidate for amine-like G-protein coupled receptor

Gene Wiki entry for GPR27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR27 Gene

Genomics for GPR27 Gene

Regulatory Elements for GPR27 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPR27 Gene

Chromosome:
3
Start:
71,754,050 bp from pter
End:
71,756,496 bp from pter
Size:
2,447 bases
Orientation:
Plus strand

Genomic View for GPR27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for GPR27 Gene

Proteins for GPR27 Gene

  • Protein details for GPR27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS67-GPR27_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 27
    Protein Accession:
    Q9NS67

    Protein attributes for GPR27 Gene

    Size:
    375 amino acids
    Molecular mass:
    39818 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR27 Gene

Proteomics data for GPR27 Gene at MOPED

Post-translational modifications for GPR27 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR27 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR27 Gene

Domains & Families for GPR27 Gene

Gene Families for GPR27 Gene

Protein Domains for GPR27 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR27 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NS67

UniProtKB/Swiss-Prot:

GPR27_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR27: view

Function for GPR27 Gene

Molecular function for GPR27 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Possible candidate for amine-like G-protein coupled receptor

Gene Ontology (GO) - Molecular Function for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR27: view

Phenotypes for GPR27 Gene

GenomeRNAi human phenotypes for GPR27:
genes like me logo Genes that share phenotypes with GPR27: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR27

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR27 Gene

Localization for GPR27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR27 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR27 Gene COMPARTMENTS Subcellular localization image for GPR27 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR27: view

Pathways & Interactions for GPR27 Gene

SuperPathways for GPR27 Gene

genes like me logo Genes that share pathways with GPR27: view

Pathways by source for GPR27 Gene

1 BioSystems pathway for GPR27 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR27 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000303149%0d%0a9606.ENSP00000349238%0d%0a9606.ENSP00000313731%0d%0a9606.ENSP00000248996%0d%0a
Selected Interacting proteins: ENSP00000303149 for GPR27 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10833454
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR27: view

No data available for SIGNOR curated interactions for GPR27 Gene

Drugs & Compounds for GPR27 Gene

No Compound Related Data Available

Transcripts for GPR27 Gene

mRNA/cDNA for GPR27 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR27 Gene

G protein-coupled receptor 27:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR27

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR27 Gene

No ASD Table

Relevant External Links for GPR27 Gene

GeneLoc Exon Structure for
GPR27
ECgene alternative splicing isoforms for
GPR27

Expression for GPR27 Gene

mRNA expression in normal human tissues for GPR27 Gene

SOURCE GeneReport for Unigene cluster for GPR27 Gene Hs.591653

mRNA Expression by UniProt/SwissProt for GPR27 Gene

Q9NS67-GPR27_HUMAN
Tissue specificity: Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum
genes like me logo Genes that share expression patterns with GPR27: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR27 Gene

Orthologs for GPR27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR27 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gpr27 35
  • 94.12 (n)
  • 98.27 (a)
Gpr27 16
Gpr27 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR27 35
  • 96.53 (n)
  • 95.04 (a)
rat
(Rattus norvegicus)
Mammalia Gpr27 35
  • 93.45 (n)
  • 98.27 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR27 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR27 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR27 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gpr27 36
  • 55 (a)
OneToOne
Species with no ortholog for GPR27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR27 Gene

ENSEMBL:
Gene Tree for GPR27 (if available)
TreeFam:
Gene Tree for GPR27 (if available)

Paralogs for GPR27 Gene

Paralogs for GPR27 Gene

(2) SIMAP similar genes for GPR27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR27: view

Variants for GPR27 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR27 Gene

Variant ID Type Subtype PubMed ID
nsv524847 CNV Loss 19592680
esv28633 CNV Loss 19812545

Variation tolerance for GPR27 Gene

Gene Damage Index Score: 0.46; 9.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR27 Gene

HapMap Linkage Disequilibrium report
GPR27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GPR27 Gene

Disorders for GPR27 Gene

Relevant External Links for GPR27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR27
genes like me logo Genes that share disorders with GPR27: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR27 Gene

Publications for GPR27 Gene

  1. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. (PMID: 15893849) Matsumoto M. … Kleinman J.E. (Brain Res. Mol. Brain Res. 2005) 23 67
  2. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PMID: 10833454) Matsumoto M. … Furuichi K. (Biochem. Biophys. Res. Commun. 2000) 2 67

Products for GPR27 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GPR27
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GPR27
    • Block miRNA regulation of GPR27 using miScript Target Protectors

    Sources for GPR27 Gene

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