Aliases for GPR26 Gene
External Ids for GPR26 Gene
- HGNC: 4481
- Entrez Gene: 2849
- Ensembl: ENSG00000154478
- OMIM: 604847
- UniProtKB: Q8NDV2
Previous GeneCards Identifiers for GPR26 Gene
- GC10U990029
- GC10P124675
- GC10P125432
- GC10P124966
- GC10P125415
- GC10P119041
Summaries for GPR26 Gene
-
This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]
GeneCards Summary for GPR26 Gene
GPR26 (G Protein-Coupled Receptor 26) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR78.
UniProtKB/Swiss-Prot for GPR26 Gene
-
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR26 Gene
Genomics for GPR26 Gene
GeneHancer (GH) Regulatory Elements for GPR26 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10I123666 | Promoter | 0.8 | EPDnew | 550.8 | +0.0 | 4 | 0.1 | SUZ12 MAX ZNF143 SIN3A REST EZH2 | PIR42627 GPR26 | |
GH10I124339 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE | 6.2 | +674.4 | 674447 | 3.4 | PKNOX1 ATF1 TCF12 FOS RUNX3 CREM CEBPB ELF1 NR2F2 SREBF1 | CHST15 GPR26 FAM53B OAT LOC105378536 | |
GH10I123800 | Enhancer | 0.6 | ENCODE | 10.2 | +134.3 | 134338 | 0.8 | TAL1 MAFG CBFA2T3 DPF2 TCF12 MEF2D FOSL1 NCOR1 IKZF1 ZBTB33 | GPR26 LOC105378533 LOC105378534 CPXM2 | |
GH10I123740 | Enhancer | 0.7 | ENCODE | 5 | +76.4 | 76422 | 4 | CTCF NCOA3 PKNOX1 NFIB NEUROD1 RAD21 ZKSCAN1 ZNF507 CTBP1 GATA3 | GPR26 LOC105378532 LOC105378533 GC10P123706 CPXM2 | |
GH10I123758 | Enhancer | 0.3 | ENCODE | 10.2 | +93.3 | 93271 | 1.4 | CREB1 | GPR26 LOC105378533 LOC105378532 GC10P123706 CPXM2 |
Regulatory Element Products
Genomic Locations for GPR26 Gene
- chr10:123,666,355-123,697,399
- (GRCh38/hg38)
- Size:
- 31,045 bases
- Orientation:
- Plus strand
- chr10:125,425,871-125,456,915
- (GRCh37/hg19)
Genomic View for GPR26 Gene
- Cytogenetic band:
-
- 10q26.13 by Ensembl
- 10q26.13 by Entrez Gene
- 10q26.13 by HGNC


RefSeq DNA sequence for GPR26 Gene
Proteins for GPR26 Gene
-
Protein details for GPR26 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NDV2-GPR26_HUMAN
- Recommended name:
- G-protein coupled receptor 26
- Protein Accession:
- Q8NDV2
- Q2M2E2
Protein attributes for GPR26 Gene
- Size:
- 337 amino acids
- Molecular mass:
- 37604 Da
- Quaternary structure:
- No Data Available
Protein Expression for GPR26 Gene
Post-translational modifications for GPR26 Gene
Other Protein References for GPR26 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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Assay Products
No data available for DME Specific Peptides for GPR26 Gene
Domains & Families for GPR26 Gene
Gene Families for GPR26 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for GPR26 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR26 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NDV2- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR26 Gene
Molecular function for GPR26 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
Phenotypes From GWAS Catalog for GPR26 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G-protein coupled receptor activity | IDA | 17363172 |
Phenotypes for GPR26 Gene
- MGI mutant phenotypes for GPR26:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for GPR26:
Animal Model Products
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miRNA for GPR26 Gene
- miRTarBase miRNAs that target GPR26
-
- hsa-mir-526b-5p (MIRT497827)
- hsa-mir-630 (MIRT497828)
- hsa-mir-548l (MIRT497829)
- hsa-mir-548n (MIRT497830)
- hsa-mir-488-3p (MIRT497831)
- hsa-mir-655-3p (MIRT497832)
- hsa-mir-374c-5p (MIRT497833)
- hsa-mir-6821-3p (MIRT497834)
- hsa-mir-6790-3p (MIRT497835)
- hsa-mir-548b-3p (MIRT497836)
- hsa-mir-3133 (MIRT497837)
- hsa-mir-4279 (MIRT531295)
- hsa-mir-197-3p (MIRT531296)
- hsa-mir-6879-3p (MIRT531297)
- hsa-mir-711 (MIRT531298)
- hsa-mir-6846-3p (MIRT531299)
- hsa-mir-6773-3p (MIRT531300)
- hsa-mir-2116-3p (MIRT531301)
- hsa-mir-4673 (MIRT531302)
- hsa-mir-4645-5p (MIRT531303)
- hsa-mir-484 (MIRT531304)
- hsa-mir-3155b (MIRT531305)
- hsa-mir-3155a (MIRT531306)
- hsa-mir-4733-3p (MIRT531307)
- hsa-mir-1226-3p (MIRT531308)
- hsa-mir-940 (MIRT531309)
- hsa-mir-6893-5p (MIRT531310)
- hsa-mir-6808-5p (MIRT531311)
- hsa-mir-1911-3p (MIRT531312)
- hsa-mir-6809-3p (MIRT657660)
- hsa-mir-6833-3p (MIRT657661)
- hsa-mir-4768-5p (MIRT657662)
- hsa-mir-6873-3p (MIRT657663)
- hsa-mir-664b-3p (MIRT657664)
- hsa-mir-579-3p (MIRT657665)
- hsa-mir-5696 (MIRT657666)
- hsa-mir-4290 (MIRT657667)
- hsa-mir-660-3p (MIRT657668)
- hsa-mir-153-5p (MIRT657669)
- hsa-mir-1250-3p (MIRT657670)
- hsa-mir-664a-3p (MIRT657671)
- hsa-mir-4776-3p (MIRT657672)
- hsa-mir-4659b-5p (MIRT657673)
- hsa-mir-4659a-5p (MIRT657674)
- hsa-mir-5590-5p (MIRT657675)
- hsa-mir-1236-3p (MIRT657676)
- hsa-mir-6817-3p (MIRT657677)
- hsa-mir-3679-3p (MIRT725477)
- hsa-mir-4446-5p (MIRT725478)
- hsa-mir-2110 (MIRT725479)
- hsa-mir-4662a-5p (MIRT725480)
- hsa-mir-6826-3p (MIRT725481)
- hsa-mir-6780b-5p (MIRT725482)
- hsa-mir-4725-3p (MIRT725483)
- hsa-mir-8089 (MIRT725484)
- hsa-mir-4271 (MIRT725485)
- hsa-mir-4700-5p (MIRT725486)
- hsa-mir-6852-5p (MIRT725487)
- hsa-mir-4667-5p (MIRT725488)
- hsa-mir-6791-5p (MIRT725489)
- hsa-mir-4292 (MIRT725490)
- hsa-mir-6801-3p (MIRT725491)
- hsa-mir-6810-3p (MIRT725492)
- hsa-mir-331-3p (MIRT725493)
miRNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR26
- Applied Biological Materials Clones for GPR26
-
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR26 Gene
Localization for GPR26 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR26 Gene
- Cell membrane; Multi-pass membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR26 Gene
Pathways & Interactions for GPR26 Gene
Interacting Proteins for GPR26 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | IDA | 17363172 |
GO:0031647 | regulation of protein stability | IMP | 24270810 |
GO:1903955 | positive regulation of protein targeting to mitochondrion | IMP | 24270810 |
No data available for Pathways by source and SIGNOR curated interactions for GPR26 Gene
Transcripts for GPR26 Gene
mRNA/cDNA for GPR26 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (13) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GPR26 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPR26
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR26
- Applied Biological Materials Clones for GPR26
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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Expression for GPR26 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for GPR26 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR26 Gene
NURSA nuclear receptor signaling pathways regulating expression of GPR26 Gene:
GPR26SOURCE GeneReport for Unigene cluster for GPR26 Gene:
Hs.12751mRNA Expression by UniProt/SwissProt for GPR26 Gene:
Q8NDV2-GPR26_HUMANEvidence on tissue expression from TISSUES for GPR26 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for GPR26
-
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No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR26 Gene
Orthologs for GPR26 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GPR26 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | GPR26 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Gpr26 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Gpr26 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | GPR26 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | GPR26 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | GPR26 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | GPR26 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | gpr26 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | LOC564928 33 |
|
||
GPR26 34 |
|
OneToOne |
- Species where no ortholog for GPR26 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GPR26 Gene
(1) SIMAP similar genes for GPR26 Gene using alignment to 1 proteins:
Variants for GPR26 Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs193920957 | uncertain-significance, Malignant tumor of prostate | 123,666,478(+) | C/T | coding_sequence_variant, missense_variant | |
rs1000021807 | -- | 123,692,125(+) | G/T | 3_prime_UTR_variant | |
rs1000143558 | -- | 123,688,639(+) | C/T | 3_prime_UTR_variant | |
rs1000236179 | -- | 123,669,764(+) | C/T | intron_variant | |
rs1000276531 | -- | 123,680,986(+) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1548382 | CNV | deletion | 17803354 |
esv1711299 | CNV | insertion | 17803354 |
esv3144012 | CNV | deletion | 24192839 |
esv3546982 | CNV | deletion | 23714750 |
esv991778 | CNV | deletion | 20482838 |
nsv1113342 | CNV | deletion | 24896259 |
nsv467469 | CNV | loss | 19166990 |
nsv527554 | CNV | loss | 19592680 |
nsv552276 | CNV | loss | 21841781 |
nsv832011 | CNV | gain+loss | 17160897 |
Additional Variant Information for GPR26 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR26
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR26 Gene
Disorders for GPR26 Gene
Additional Disease Information for GPR26
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GPR26 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR26 Gene
Publications for GPR26 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- GPR26: a marker for primary glioblastoma? (PMID: 18037267) Carter AN … Shervington AA (Molecular and cellular probes 2008) 3 4 58
- Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78. (PMID: 17363172) Jones PG … Pausch MH (Biochimica et biophysica acta 2007) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases. (PMID: 26303144) Mori F … Wakabayashi K (Neuropathology : official journal of the Japanese Society of Neuropathology 2016) 3 58
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR26
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- genomics-online: primer clones - Search results for 80 available GPR26 gene related products
- Overview of 80 available GPR26 gene related products
- genomics-online: shRNA clones - Search results for 80 available GPR26 gene related products
- Overview of 80 available GPR26 gene related products
Sources for GPR26 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew