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Aliases for GPR26 Gene

Aliases for GPR26 Gene

  • G Protein-Coupled Receptor 26 2 3 5

External Ids for GPR26 Gene

Previous GeneCards Identifiers for GPR26 Gene

  • GC10U990029
  • GC10P124675
  • GC10P125432
  • GC10P124966
  • GC10P125415
  • GC10P119041

Summaries for GPR26 Gene

GeneCards Summary for GPR26 Gene

GPR26 (G Protein-Coupled Receptor 26) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR78.

UniProtKB/Swiss-Prot for GPR26 Gene

  • Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Gene Wiki entry for GPR26 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR26 Gene

Genomics for GPR26 Gene

Regulatory Elements for GPR26 Gene

Enhancers for GPR26 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR26 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR26 Gene

123,666,355 bp from pter
123,697,399 bp from pter
31,045 bases
Plus strand

Genomic View for GPR26 Gene

Genes around GPR26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR26 Gene

Proteins for GPR26 Gene

  • Protein details for GPR26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 26
    Protein Accession:
    Secondary Accessions:
    • Q2M2E2

    Protein attributes for GPR26 Gene

    337 amino acids
    Molecular mass:
    37604 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR26 Gene

Proteomics data for GPR26 Gene at MOPED

Post-translational modifications for GPR26 Gene

No Post-translational modifications

Other Protein References for GPR26 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GPR26

No data available for DME Specific Peptides for GPR26 Gene

Domains & Families for GPR26 Gene

Gene Families for GPR26 Gene

Protein Domains for GPR26 Gene


Suggested Antigen Peptide Sequences for GPR26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR26: view

Function for GPR26 Gene

Molecular function for GPR26 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
genes like me logo Genes that share phenotypes with GPR26: view

Animal Models for GPR26 Gene

MGI Knock Outs for GPR26:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR26

miRNA for GPR26 Gene

miRTarBase miRNAs that target GPR26

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR26 Gene

Localization for GPR26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR26 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR26 Gene COMPARTMENTS Subcellular localization image for GPR26 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with GPR26: view

Pathways & Interactions for GPR26 Gene

SuperPathways for GPR26 Gene

No Data Available

Interacting Proteins for GPR26 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q8NDV2-GPR26_HUMAN ENSP00000284674 for GPR26 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for GPR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0031647 regulation of protein stability IMP 24270810
genes like me logo Genes that share ontologies with GPR26: view

No data available for Pathways by source and SIGNOR curated interactions for GPR26 Gene

Drugs & Compounds for GPR26 Gene

No Compound Related Data Available

Transcripts for GPR26 Gene

mRNA/cDNA for GPR26 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR26 Gene

G protein-coupled receptor 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR26 Gene

No ASD Table

Relevant External Links for GPR26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR26 Gene

mRNA expression in normal human tissues for GPR26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR26 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x9.2), Brain - Frontal Cortex (BA9) (x8.1), Brain - Cortex (x7.6), Brain - Substantia nigra (x5.5), and Brain - Hippocampus (x4.8).

Protein differential expression in normal tissues from HIPED for GPR26 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR26 Gene

SOURCE GeneReport for Unigene cluster for GPR26 Gene Hs.12751

mRNA Expression by UniProt/SwissProt for GPR26 Gene

Tissue specificity: Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma.
genes like me logo Genes that share expression patterns with GPR26: view

Protein tissue co-expression partners for GPR26 Gene

- Elite partner

Primer Products

Orthologs for GPR26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR26 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GPR26 35
  • 94.76 (n)
  • 97.63 (a)
GPR26 36
  • 98 (a)
(Mus musculus)
Mammalia Gpr26 35
  • 91.2 (n)
  • 95.25 (a)
Gpr26 16
Gpr26 36
  • 95 (a)
(Pan troglodytes)
Mammalia GPR26 35
  • 99.31 (n)
  • 99.7 (a)
GPR26 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr26 35
  • 91 (n)
  • 95.25 (a)
(Bos Taurus)
Mammalia GPR26 36
  • 74 (a)
(Monodelphis domestica)
Mammalia GPR26 36
  • 79 (a)
(Gallus gallus)
Aves GPR26 35
  • 69.63 (n)
  • 70.33 (a)
GPR26 36
  • 70 (a)
(Anolis carolinensis)
Reptilia GPR26 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr26 35
  • 67.26 (n)
  • 64.58 (a)
(Danio rerio)
Actinopterygii LOC564928 35
  • 66.77 (n)
  • 65.64 (a)
GPR26 36
  • 61 (a)
Species with no ortholog for GPR26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR26 Gene

Gene Tree for GPR26 (if available)
Gene Tree for GPR26 (if available)

Paralogs for GPR26 Gene

Paralogs for GPR26 Gene

(1) SIMAP similar genes for GPR26 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR26: view

Variants for GPR26 Gene

Sequence variations from dbSNP and Humsavar for GPR26 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1516305 -- 123,669,143(-) TCCAA(C/T)GAGAC intron-variant
rs1533435 -- 123,685,304(-) CCAGA(C/T)CCGGG intron-variant
rs1850259 -- 123,669,035(-) ATCGA(A/G)GGCAA intron-variant
rs1878166 -- 123,688,189(-) CTCAT(C/T)CTAAA utr-variant-3-prime
rs1878167 -- 123,668,548(-) CACTC(A/G)TGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR26 Gene

Variant ID Type Subtype PubMed ID
nsv832011 CNV Gain+Loss 17160897
nsv896065 CNV Loss 21882294
nsv467469 CNV Loss 19166990
esv2742484 CNV Deletion 23290073
esv991778 CNV Deletion 20482838
esv1711299 CNV Insertion 17803354
esv1548382 CNV Deletion 17803354
nsv527554 CNV Loss 19592680
esv2742495 CNV Deletion 23290073

Variation tolerance for GPR26 Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR26 Gene

Disorders for GPR26 Gene

Relevant External Links for GPR26

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR26 Gene

Publications for GPR26 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. (PMID: 23247143) Yu B. … Boerwinkle E. (Circ Cardiovasc Genet 2013) 3
  3. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3
  4. The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas. (PMID: 19787267) Boulay J.L. … Merlo A. (Int. J. Oncol. 2009) 3
  5. Proteomic analysis of bone tissues of patients with osteonecrosis of the femoral head. (PMID: 20001860) Zhang H. … Lin B. (OMICS 2009) 23

Products for GPR26 Gene

Sources for GPR26 Gene