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Aliases for GPR26 Gene

Aliases for GPR26 Gene

  • G Protein-Coupled Receptor 26 2 3 5

External Ids for GPR26 Gene

Previous GeneCards Identifiers for GPR26 Gene

  • GC10U990029
  • GC10P124675
  • GC10P125432
  • GC10P124966
  • GC10P125415
  • GC10P119041

Summaries for GPR26 Gene

Entrez Gene Summary for GPR26 Gene

  • This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]

GeneCards Summary for GPR26 Gene

GPR26 (G Protein-Coupled Receptor 26) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR78.

UniProtKB/Swiss-Prot for GPR26 Gene

  • Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Gene Wiki entry for GPR26 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR26 Gene

Genomics for GPR26 Gene

Regulatory Elements for GPR26 Gene

Enhancers for GPR26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F124339 1.4 FANTOM5 Ensembl ENCODE 6.2 +674.4 674448 3.4 KLF1 ZNF146 PKNOX1 MAX EBF1 POLR2A NFE2 TRIM24 FOS CREM CHST15 GPR26 FAM53B OAT LOC105378536
GH10F123800 0.6 ENCODE 10.2 +134.3 134338 0.8 TAL1 MAFG DPF2 ARID1B MEF2D NCOR1 IKZF1 PBX2 NFE2 GPR26 LOC105378533 LOC105378534
GH10F123639 0.4 ENCODE 12.2 -26.1 -26057 0.8 JUND GPR26 GC10P123648 ENSG00000234542
GH10F123758 0.4 ENCODE 10.2 +93.3 93272 1.4 ZNF652 GPR26 LOC105378533 LOC105378532
GH10F123797 0.4 ENCODE 10.2 +131.6 131635 0.2 POU5F1 GPR26 LOC105378533 LOC105378534
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR26 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR26 Gene

Chromosome:
10
Start:
123,666,355 bp from pter
End:
123,697,399 bp from pter
Size:
31,045 bases
Orientation:
Plus strand

Genomic View for GPR26 Gene

Genes around GPR26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR26 Gene

Proteins for GPR26 Gene

  • Protein details for GPR26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDV2-GPR26_HUMAN
    Recommended name:
    G-protein coupled receptor 26
    Protein Accession:
    Q8NDV2
    Secondary Accessions:
    • Q2M2E2

    Protein attributes for GPR26 Gene

    Size:
    337 amino acids
    Molecular mass:
    37604 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR26 Gene

Post-translational modifications for GPR26 Gene

No Post-translational modifications

Other Protein References for GPR26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR26 Gene

Domains & Families for GPR26 Gene

Gene Families for GPR26 Gene

Protein Domains for GPR26 Gene

Suggested Antigen Peptide Sequences for GPR26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDV2

UniProtKB/Swiss-Prot:

GPR26_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR26: view

Function for GPR26 Gene

Molecular function for GPR26 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Gene Ontology (GO) - Molecular Function for GPR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 17363172
genes like me logo Genes that share ontologies with GPR26: view
genes like me logo Genes that share phenotypes with GPR26: view

Animal Models for GPR26 Gene

MGI Knock Outs for GPR26:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR26

miRNA for GPR26 Gene

miRTarBase miRNAs that target GPR26

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR26

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR26 Gene

Localization for GPR26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR26 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR26 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR26: view

Pathways & Interactions for GPR26 Gene

SuperPathways for GPR26 Gene

No Data Available

Interacting Proteins for GPR26 Gene

Gene Ontology (GO) - Biological Process for GPR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA 17363172
GO:0031647 regulation of protein stability IMP 24270810
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with GPR26: view

No data available for Pathways by source and SIGNOR curated interactions for GPR26 Gene

Transcripts for GPR26 Gene

mRNA/cDNA for GPR26 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR26 Gene

G protein-coupled receptor 26:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR26

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR26 Gene

No ASD Table

Relevant External Links for GPR26 Gene

GeneLoc Exon Structure for
GPR26
ECgene alternative splicing isoforms for
GPR26

Expression for GPR26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR26 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x9.2), Brain - Frontal Cortex (BA9) (x8.1), Brain - Cortex (x7.6), Brain - Substantia nigra (x5.5), and Brain - Hippocampus (x4.8).

Protein differential expression in normal tissues from HIPED for GPR26 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR26 Gene



Protein tissue co-expression partners for GPR26 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR26 Gene:

GPR26

SOURCE GeneReport for Unigene cluster for GPR26 Gene:

Hs.12751

mRNA Expression by UniProt/SwissProt for GPR26 Gene:

Q8NDV2-GPR26_HUMAN
Tissue specificity: Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma.
genes like me logo Genes that share expression patterns with GPR26: view

Primer Products

Orthologs for GPR26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR26 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia GPR26 34 35
  • 94.76 (n)
mouse
(Mus musculus)
Mammalia Gpr26 34 16 35
  • 91.2 (n)
rat
(Rattus norvegicus)
Mammalia Gpr26 34
  • 91 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR26 35
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR26 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR26 34 35
  • 69.63 (n)
lizard
(Anolis carolinensis)
Reptilia GPR26 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr26 34
  • 67.26 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC564928 34
  • 66.77 (n)
GPR26 35
  • 61 (a)
OneToOne
Species where no ortholog for GPR26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR26 Gene

ENSEMBL:
Gene Tree for GPR26 (if available)
TreeFam:
Gene Tree for GPR26 (if available)

Paralogs for GPR26 Gene

Paralogs for GPR26 Gene

(1) SIMAP similar genes for GPR26 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR26: view

Variants for GPR26 Gene

Sequence variations from dbSNP and Humsavar for GPR26 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs193920957 Uncertain significance 123,666,478(+) CAACG(C/T)GCTGG reference, missense
rs1008720 -- 123,686,857(-) ATTGA(A/G)GCCCA intron-variant
rs10577678 -- 123,694,541(+) AGAAA(-/TAA)GAAGA utr-variant-3-prime
rs10587929 -- 123,686,587(+) TCCTC(-/CTC)TTCGC intron-variant
rs10608896 -- 123,683,049(+) GTGTG(-/TG)AGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR26 Gene

Variant ID Type Subtype PubMed ID
nsv832011 CNV gain+loss 17160897
nsv552276 CNV loss 21841781
nsv527554 CNV loss 19592680
nsv467469 CNV loss 19166990
nsv1113342 CNV deletion 24896259
esv991778 CNV deletion 20482838
esv3546982 CNV deletion 23714750
esv3144012 CNV deletion 24192839
esv1711299 CNV insertion 17803354
esv1548382 CNV deletion 17803354

Variation tolerance for GPR26 Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR26 Gene

Disorders for GPR26 Gene

Relevant External Links for GPR26

Genetic Association Database (GAD)
GPR26
Human Genome Epidemiology (HuGE) Navigator
GPR26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR26

No disorders were found for GPR26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR26 Gene

Publications for GPR26 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. GPR26: a marker for primary glioblastoma? (PMID: 18037267) Carter A.N. … Shervington A.A. (Mol. Cell. Probes 2008) 3 4 64
  3. Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78. (PMID: 17363172) Jones P.G. … Pausch M.H. (Biochim. Biophys. Acta 2007) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases. (PMID: 26303144) Mori F. … Wakabayashi K. (Neuropathology 2016) 3 64

Products for GPR26 Gene

Sources for GPR26 Gene

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