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Aliases for GPR25 Gene

Aliases for GPR25 Gene

  • G Protein-Coupled Receptor 25 2 3 5

External Ids for GPR25 Gene

Previous GeneCards Identifiers for GPR25 Gene

  • GC01P198572
  • GC01P196300
  • GC01P197308
  • GC01P198130
  • GC01P197573
  • GC01P199108
  • GC01P200842
  • GC01P172009

Summaries for GPR25 Gene

Entrez Gene Summary for GPR25 Gene

  • This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. [provided by RefSeq, Nov 2012]

GeneCards Summary for GPR25 Gene

GPR25 (G Protein-Coupled Receptor 25) is a Protein Coding gene. Among its related pathways are G alpha (s) signalling events and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR15.

UniProtKB/Swiss-Prot for GPR25 Gene

  • Orphan receptor.

Gene Wiki entry for GPR25 Gene

Additional gene information for GPR25 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR25 Gene

Genomics for GPR25 Gene

Regulatory Elements for GPR25 Gene

Enhancers for GPR25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H200907 1.1 ENCODE dbSUPER 11.3 +34.8 34813 0.2 ELF3 PKNOX1 FOXA2 ARID4B SIN3A BATF RAD21 RARA ATF7 IKZF2 RNU6-704P GPR25 ENSG00000234132 MROH3P GC01M200900
GH01H200906 1.1 ENCODE dbSUPER 11.3 +32.9 32883 0.4 PKNOX1 FOXA2 BMI1 BATF RARA ATF7 RUNX3 CREM IKZF2 SMARCA5 MROH3P ENSG00000234132 RNU6-704P GPR25 GC01M200900
GH01H200802 1.1 Ensembl ENCODE 10.8 -69.9 -69868 0.2 ELF3 HDGF RB1 ARNT SIN3A ZNF2 RAD21 RFX5 ZNF366 ZNF143 DDX59 KIF14 GPR25 LOC101929224 GC01M200787 RPL34P6
GH01H200908 0.9 ENCODE dbSUPER 11.2 +35.7 35693 0.2 SMARCE1 ZNF687 EBF1 DPF2 ZNF592 ZNF217 CTBP1 GATA3 TARDBP ZFX MROH3P ENSG00000234132 RNU6-704P GPR25 GC01M200900
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR25 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GPR25 Gene

Genomic Locations for GPR25 Gene
1,224 bases
Plus strand

Genomic View for GPR25 Gene

Genes around GPR25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR25 Gene

Proteins for GPR25 Gene

  • Protein details for GPR25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 25
    Protein Accession:
    Secondary Accessions:
    • A0AVJ5

    Protein attributes for GPR25 Gene

    361 amino acids
    Molecular mass:
    38779 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR25 Gene

Post-translational modifications for GPR25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR25 Gene

Domains & Families for GPR25 Gene

Gene Families for GPR25 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR25 Gene

Suggested Antigen Peptide Sequences for GPR25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR25: view

Function for GPR25 Gene

Molecular function for GPR25 Gene

GENATLAS Biochemistry:
G protein coupled receptor 25
UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR25 Gene

Gene Ontology (GO) - Molecular Function for GPR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GPR25: view

Phenotypes for GPR25 Gene

genes like me logo Genes that share phenotypes with GPR25: view

Clone Products

  • Addgene plasmids for GPR25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR25 Gene

Localization for GPR25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR25 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR25 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9020062
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR25 Gene

Pathways & Interactions for GPR25 Gene

genes like me logo Genes that share pathways with GPR25: view

Pathways by source for GPR25 Gene

Gene Ontology (GO) - Biological Process for GPR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
genes like me logo Genes that share ontologies with GPR25: view

No data available for SIGNOR curated interactions for GPR25 Gene

Drugs & Compounds for GPR25 Gene

No Compound Related Data Available

Transcripts for GPR25 Gene

mRNA/cDNA for GPR25 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR25 Gene

G protein-coupled receptor 25:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR25

Alternative Splicing Database (ASD) splice patterns (SP) for GPR25 Gene

No ASD Table

Relevant External Links for GPR25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR25 Gene

mRNA differential expression in normal tissues according to GTEx for GPR25 Gene

This gene is overexpressed in Whole Blood (x11.1), Testis (x4.5), and Stomach (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR25 Gene

Protein tissue co-expression partners for GPR25 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR25 Gene:


SOURCE GeneReport for Unigene cluster for GPR25 Gene:


Evidence on tissue expression from TISSUES for GPR25 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with GPR25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR25 Gene

Orthologs for GPR25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR25 33 34
  • 99.54 (n)
(Mus musculus)
Mammalia Gpr25 33 16 34
  • 81.47 (n)
(Canis familiaris)
Mammalia GPR25 33 34
  • 78.31 (n)
(Ornithorhynchus anatinus)
Mammalia GPR25 34
  • 62 (a)
(Gallus gallus)
Aves -- 34
  • 34 (a)
(Anolis carolinensis)
Reptilia GPR25 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486541 33
  • 53.77 (n)
(Danio rerio)
Actinopterygii LOC795188 33
  • 52.11 (n)
GPR25 34
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
Species where no ortholog for GPR25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR25 Gene

Gene Tree for GPR25 (if available)
Gene Tree for GPR25 (if available)

Paralogs for GPR25 Gene

Paralogs for GPR25 Gene

(5) SIMAP similar genes for GPR25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR25: view

Variants for GPR25 Gene

Sequence variations from dbSNP and Humsavar for GPR25 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000116139 -- 200,871,958(+) TCCTT(C/T)AGGAG upstream-variant-2KB
rs1000420389 -- 200,872,330(+) CTGAC(G/T)GGGTC upstream-variant-2KB
rs1001731879 -- 200,871,404(+) CCCAC(A/G)TTCCT upstream-variant-2KB
rs1003585136 -- 200,874,479(+) TCCTT(A/C)TCTGT downstream-variant-500B
rs1004056585 -- 200,871,146(+) ACCCT(C/T)CCATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR25 Gene

Variant ID Type Subtype PubMed ID
esv33174 CNV loss 17666407
esv3588563 CNV gain 21293372
nsv1000619 CNV gain 25217958
nsv1012562 CNV gain 25217958
nsv506973 OTHER sequence alteration 20534489
nsv548991 CNV gain 21841781

Variation tolerance for GPR25 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR25 Gene

Disorders for GPR25 Gene

Relevant External Links for GPR25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR25 Gene

Publications for GPR25 Gene

  1. Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1. (PMID: 9020062) Jung BP … O'Dowd BF (Biochemical and biophysical research communications 1997) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. A catalogue of putative HIV-1 protease host cell substrates. (PMID: 22944692) Impens F … Gevaert K (Biological chemistry 2012) 3 60
  5. A whole genome scan for pulse pressure/stroke volume ratio in African Americans: the HyperGEN study. (PMID: 17386346) Sherva R … Arnett DK (American journal of hypertension 2007) 3 60

Products for GPR25 Gene

  • Addgene plasmids for GPR25

Sources for GPR25 Gene

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