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Aliases for GPR25 Gene

Aliases for GPR25 Gene

  • G Protein-Coupled Receptor 25 2 3 5

External Ids for GPR25 Gene

Previous GeneCards Identifiers for GPR25 Gene

  • GC01P198572
  • GC01P196300
  • GC01P197308
  • GC01P198130
  • GC01P197573
  • GC01P199108
  • GC01P200842
  • GC01P172009

Summaries for GPR25 Gene

Entrez Gene Summary for GPR25 Gene

  • This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. [provided by RefSeq, Nov 2012]

GeneCards Summary for GPR25 Gene

GPR25 (G Protein-Coupled Receptor 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for GPR25 Gene

  • Orphan receptor.

Gene Wiki entry for GPR25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR25 Gene

Genomics for GPR25 Gene

Regulatory Elements for GPR25 Gene

Enhancers for GPR25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR25 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR25 Gene

200,872,955 bp from pter
200,874,178 bp from pter
1,224 bases
Plus strand

Genomic View for GPR25 Gene

Genes around GPR25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR25 Gene

Proteins for GPR25 Gene

  • Protein details for GPR25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 25
    Protein Accession:
    Secondary Accessions:
    • A0AVJ5

    Protein attributes for GPR25 Gene

    361 amino acids
    Molecular mass:
    38779 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR25 Gene

Proteomics data for GPR25 Gene at MOPED

Post-translational modifications for GPR25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR25 Gene

Domains & Families for GPR25 Gene

Gene Families for GPR25 Gene

Protein Domains for GPR25 Gene


Suggested Antigen Peptide Sequences for GPR25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR25: view

Function for GPR25 Gene

Molecular function for GPR25 Gene

GENATLAS Biochemistry:
G protein coupled receptor 25
UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GPR25: view

Phenotypes for GPR25 Gene

genes like me logo Genes that share phenotypes with GPR25: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR25 Gene

Localization for GPR25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR25 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR25 Gene COMPARTMENTS Subcellular localization image for GPR25 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GPR25: view

Pathways & Interactions for GPR25 Gene

genes like me logo Genes that share pathways with GPR25: view

Pathways by source for GPR25 Gene

Gene Ontology (GO) - Biological Process for GPR25 Gene


No data available for SIGNOR curated interactions for GPR25 Gene

Drugs & Compounds for GPR25 Gene

No Compound Related Data Available

Transcripts for GPR25 Gene

mRNA/cDNA for GPR25 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR25 Gene

G protein-coupled receptor 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR25 Gene

No ASD Table

Relevant External Links for GPR25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR25 Gene

mRNA expression in normal human tissues for GPR25 Gene

mRNA differential expression in normal tissues according to GTEx for GPR25 Gene

This gene is overexpressed in Whole Blood (x11.1), Testis (x4.5), and Stomach (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR25 Gene

SOURCE GeneReport for Unigene cluster for GPR25 Gene Hs.534316

genes like me logo Genes that share expression patterns with GPR25: view

Protein tissue co-expression partners for GPR25 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPR25 Gene

Orthologs for GPR25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR25 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GPR25 35
  • 78.31 (n)
  • 68.44 (a)
GPR25 36
  • 69 (a)
(Mus musculus)
Mammalia Gpr25 35
  • 81.47 (n)
  • 75.42 (a)
Gpr25 16
Gpr25 36
  • 75 (a)
(Pan troglodytes)
Mammalia GPR25 35
  • 99.54 (n)
  • 99.72 (a)
GPR25 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia GPR25 36
  • 62 (a)
(Gallus gallus)
Aves -- 36
  • 34 (a)
(Anolis carolinensis)
Reptilia GPR25 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486541 35
  • 53.77 (n)
  • 44.86 (a)
(Danio rerio)
Actinopterygii LOC795188 35
  • 52.11 (n)
  • 45.67 (a)
GPR25 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for GPR25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR25 Gene

Gene Tree for GPR25 (if available)
Gene Tree for GPR25 (if available)

Paralogs for GPR25 Gene

Paralogs for GPR25 Gene

(5) SIMAP similar genes for GPR25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR25: view

Variants for GPR25 Gene

Sequence variations from dbSNP and Humsavar for GPR25 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs968497 -- 200,872,982(+) GCTCA(A/G)AGCTG utr-variant-5-prime
rs2131833 -- 200,871,273(+) CAGAT(C/T)GATGC upstream-variant-2KB
rs2292097 -- 200,874,640(+) AAAAC(C/T)CTTGC downstream-variant-500B
rs3738250 -- 200,874,177(+) CCAGA(G/T)GTCCC utr-variant-3-prime
rs3738251 -- 200,874,246(+) GCATC(C/G)CATTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GPR25 Gene

Variant ID Type Subtype PubMed ID
nsv873098 CNV Gain 21882294
esv33174 CNV Loss 17666407
nsv873099 CNV Loss 21882294
nsv506973 CNV Insertion 20534489

Variation tolerance for GPR25 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR25 Gene

Disorders for GPR25 Gene

Relevant External Links for GPR25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR25 Gene

Publications for GPR25 Gene

  1. Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1. (PMID: 9020062) Jung B.P. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. A catalogue of putative HIV-1 protease host cell substrates. (PMID: 22944692) Impens F. … Gevaert K. (Biol. Chem. 2012) 3
  4. A whole genome scan for pulse pressure/stroke volume ratio in African Americans: the HyperGEN study. (PMID: 17386346) Sherva R. … Arnett D.K. (Am. J. Hypertens. 2007) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for GPR25 Gene

Sources for GPR25 Gene