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Aliases for GPR22 Gene

Aliases for GPR22 Gene

  • G Protein-Coupled Receptor 22 2 3 5

External Ids for GPR22 Gene

Previous GeneCards Identifiers for GPR22 Gene

  • GC07P105598
  • GC07P106661
  • GC07P106675
  • GC07P106704
  • GC07P106897
  • GC07P107110
  • GC07P101471

Summaries for GPR22 Gene

Entrez Gene Summary for GPR22 Gene

  • This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR22 Gene

GPR22 (G Protein-Coupled Receptor 22) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and peptide binding.

UniProtKB/Swiss-Prot for GPR22 Gene

  • Orphan receptor.

Gene Wiki entry for GPR22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR22 Gene

Genomics for GPR22 Gene

Regulatory Elements for GPR22 Gene

Enhancers for GPR22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR22 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR22 Gene

107,470,018 bp from pter
107,476,212 bp from pter
6,195 bases
Plus strand

Genomic View for GPR22 Gene

Genes around GPR22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR22 Gene

Proteins for GPR22 Gene

  • Protein details for GPR22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 22
    Protein Accession:
    Secondary Accessions:
    • O14554

    Protein attributes for GPR22 Gene

    433 amino acids
    Molecular mass:
    49265 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR22 Gene

Proteomics data for GPR22 Gene at MOPED

Post-translational modifications for GPR22 Gene

  • Glycosylation at Asn 16 and Asn 192
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR22 Gene

Domains & Families for GPR22 Gene

Gene Families for GPR22 Gene

Protein Domains for GPR22 Gene


Suggested Antigen Peptide Sequences for GPR22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR22: view

Function for GPR22 Gene

Molecular function for GPR22 Gene

GENATLAS Biochemistry:
G protein coupled receptor 22,expressed in brain
UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with GPR22: view
genes like me logo Genes that share phenotypes with GPR22: view

Animal Models for GPR22 Gene

MGI Knock Outs for GPR22:

Animal Model Products

miRNA for GPR22 Gene

miRTarBase miRNAs that target GPR22

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR22 Gene

Localization for GPR22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR22 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR22 Gene COMPARTMENTS Subcellular localization image for GPR22 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for GPR22 Gene

Pathways & Interactions for GPR22 Gene

SuperPathways for GPR22 Gene

genes like me logo Genes that share pathways with GPR22: view

Pathways by source for GPR22 Gene

1 BioSystems pathway for GPR22 Gene

Interacting Proteins for GPR22 Gene

Gene Ontology (GO) - Biological Process for GPR22 Gene


No data available for SIGNOR curated interactions for GPR22 Gene

Drugs & Compounds for GPR22 Gene

No Compound Related Data Available

Transcripts for GPR22 Gene

mRNA/cDNA for GPR22 Gene

Unigene Clusters for GPR22 Gene

G protein-coupled receptor 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR22 Gene

No ASD Table

Relevant External Links for GPR22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR22 Gene

mRNA expression in normal human tissues for GPR22 Gene

mRNA differential expression in normal tissues according to GTEx for GPR22 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.5), Brain - Anterior cingulate cortex (BA24) (x7.4), Heart - Left Ventricle (x5.9), Brain - Cortex (x5.5), and Brain - Hippocampus (x4.4).

SOURCE GeneReport for Unigene cluster for GPR22 Gene Hs.657277

mRNA Expression by UniProt/SwissProt for GPR22 Gene

Tissue specificity: In the brain regions frontal cortex, caudate, putamen and thalamus; not in pons, hypothalamus and hippocampus.
genes like me logo Genes that share expression patterns with GPR22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR22 Gene

Orthologs for GPR22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR22 35
  • 96.3 (n)
  • 97.69 (a)
GPR22 36
  • 90 (a)
(Canis familiaris)
Mammalia GPR22 35
  • 96.38 (n)
  • 98.61 (a)
GPR22 36
  • 99 (a)
(Mus musculus)
Mammalia Gpr22 35
  • 90.9 (n)
  • 96.99 (a)
Gpr22 16
Gpr22 36
  • 89 (a)
(Pan troglodytes)
Mammalia GPR22 35
  • 99.92 (n)
  • 100 (a)
GPR22 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr22 35
  • 90.66 (n)
  • 96.53 (a)
(Monodelphis domestica)
Mammalia GPR22 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia GPR22 36
  • 89 (a)
(Gallus gallus)
Aves GPR22 35
  • 84.37 (n)
  • 94.46 (a)
GPR22 36
  • 94 (a)
(Anolis carolinensis)
Reptilia GPR22 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr22 35
  • 79.69 (n)
  • 88.14 (a)
(Danio rerio)
Actinopterygii gpr22 35
  • 69.19 (n)
  • 79.02 (a)
gpr22 36
  • 70 (a)
GPR22 (2 of 2) 36
  • 72 (a)
Species with no ortholog for GPR22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR22 Gene

Gene Tree for GPR22 (if available)
Gene Tree for GPR22 (if available)

Paralogs for GPR22 Gene

No data available for Paralogs for GPR22 Gene

Variants for GPR22 Gene

Variation tolerance for GPR22 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GPR22 Gene

Disorders for GPR22 Gene

Relevant External Links for GPR22

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR22 Gene

Publications for GPR22 Gene

  1. Cloning and chromosomal mapping of four putative novel human G- protein-coupled receptor genes. (PMID: 9073069) O'Dowd B.F. … George S.R. (Gene 1997) 2 3 4 67
  2. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. (PMID: 21068099) Evangelou E. … Spector T.D. (Ann. Rheum. Dis. 2011) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. (PMID: 20112360) Kerkhof H.J. … van Meurs J.B. (Arthritis Rheum. 2010) 3
  5. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. (PMID: 18539757) Adams J.W. … Connolly D. (Am. J. Physiol. Heart Circ. Physiol. 2008) 3

Products for GPR22 Gene

Sources for GPR22 Gene