Aliases for GPR20 Gene
External Ids for GPR20 Gene
- HGNC: 4475
- Entrez Gene: 2843
- Ensembl: ENSG00000204882
- OMIM: 601908
- UniProtKB: Q99678
Previous GeneCards Identifiers for GPR20 Gene
- GC08U990036
- GC08P142612
- GC08M142051
- GC08M142338
- GC08M142436
- GC08M142437
- GC08M142366
- GC08M137677
Summaries for GPR20 Gene
GeneCards Summary for GPR20 Gene
GPR20 (G Protein-Coupled Receptor 20) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR55.
UniProtKB/Swiss-Prot for GPR20 Gene
-
Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR20 Gene
Genomics for GPR20 Gene
Regulatory Elements for GPR20 Gene
Enhancers for GPR20 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around GPR20 on UCSC Golden Path with GeneCards custom track
Promoters for GPR20 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around GPR20 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the GPR20 gene promoter:
Regulatory Element Products
Genomic Location for GPR20 Gene
- Chromosome:
- 8
- Start:
- 141,353,407 bp from pter
- End:
- 141,367,271 bp from pter
- Size:
- 13,865 bases
- Orientation:
- Minus strand
Genomic View for GPR20 Gene
Genes around GPR20 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.3 by Ensembl
- 8q24.3 by Entrez Gene
- 8q24.3 by HGNC
GPR20 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR20 Gene
Proteins for GPR20 Gene
-
Protein details for GPR20 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99678-GPR20_HUMAN
- Recommended name:
- G-protein coupled receptor 20
- Protein Accession:
- Q99678
- Q17R96
Protein attributes for GPR20 Gene
- Size:
- 358 amino acids
- Molecular mass:
- 38650 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for GPR20 Gene
Other Protein References for GPR20 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GPR20
- Abcam antibodies for GPCR GPR20
- Invitrogen Antibodies for GPR20
- antibodies-online Antibodies for GPR20: See all 69
- GeneTex GPR20 antibody for GPR20
-
Santa Cruz Biotechnology (SCBT) Antibodies for GPR20
Protein Products
-
OriGene Purified Proteins for GPR20
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR20
- Origene Custom Protein Services for GPR20
- Novus Biologicals lysates for GPR20
- Search GeneTex for Proteins for GPR20
Assay Products
No data available for DME Specific Peptides for GPR20 Gene
Domains & Families for GPR20 Gene
Gene Families for GPR20 Gene
- HGNC:
- IUPHAR :
Protein Domains for GPR20 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR20 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99678- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR20 Gene
Molecular function for GPR20 Gene
- GENATLAS Biochemistry:
- G protein coupled receptor 20,expressed in brain,liver
- UniProtKB/Swiss-Prot Function:
- Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
Phenotypes for GPR20 Gene
- GenomeRNAi human phenotypes for GPR20:
Animal Model Products
-
Taconic Biosciences Mouse Models for GPR20
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR20 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR20 gene
- Search ViGene Biosciences for GPR20
CRISPR Products
-
OriGene CRISPR knockouts for GPR20
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR20
- GenScript: Design CRISPR guide RNA sequences for GPR20
miRNA for GPR20 Gene
- miRTarBase miRNAs that target GPR20
-
- hsa-mir-128-2-5p (MIRT487783)
- hsa-mir-128-1-5p (MIRT487784)
- hsa-mir-6780b-5p (MIRT487785)
- hsa-mir-4725-3p (MIRT487786)
- hsa-mir-4271 (MIRT487787)
- hsa-mir-6721-5p (MIRT487788)
- hsa-mir-6781-5p (MIRT487789)
- hsa-mir-5196-5p (MIRT487790)
- hsa-mir-4747-5p (MIRT487791)
- hsa-mir-6787-5p (MIRT487792)
- hsa-mir-663a (MIRT487793)
- hsa-mir-1908-5p (MIRT487794)
- hsa-mir-4763-3p (MIRT487795)
- hsa-mir-1207-5p (MIRT487796)
- hsa-mir-3202 (MIRT487797)
- hsa-mir-7-5p (MIRT487798)
- hsa-mir-4749-5p (MIRT487799)
- hsa-mir-4706 (MIRT487800)
- hsa-mir-3179 (MIRT487801)
- hsa-mir-9500 (MIRT487802)
- hsa-mir-4463 (MIRT487803)
- hsa-mir-584-3p (MIRT573385)
- hsa-mir-3200-3p (MIRT573386)
miRNA Products
- Search ViGene Biosciences for GPR20
Clone Products
- OriGene clones in human for GPR20
- OriGene ORF clones in human,mouse,rat for GPR20
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPR20
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for GPR20
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GPR20 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR20 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR20 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR20 Gene
Localization for GPR20 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR20 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 18347022 |
Pathways & Interactions for GPR20 Gene
More details on SuperPathways for GPR20| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | G alpha (s) signalling events | ||
| 3 | Peptide ligand-binding receptors |
Pathways by source for GPR20 Gene
1 BioSystems pathway for GPR20 Gene
4 Reactome pathways for GPR20 Gene
Interacting Proteins for GPR20 Gene
No data available for SIGNOR curated interactions for GPR20 Gene
Transcripts for GPR20 Gene
mRNA/cDNA for GPR20 Gene
- (3) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GPR20 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPR20
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR20
- GenScript: Design CRISPR guide RNA sequences for GPR20
miRNA Products
- Search ViGene Biosciences for GPR20
Clone Products
- OriGene clones in human for GPR20
- OriGene ORF clones in human,mouse,rat for GPR20
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPR20
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for GPR20
Flow Cytometry Products
Expression for GPR20 Gene
mRNA differential expression in normal tissues according to GTEx for GPR20 Gene
This gene is overexpressed in Artery - Tibial (x5.1) and Artery - Coronary (x5.0).
SOURCE GeneReport for Unigene cluster for GPR20 Gene Hs.188859
mRNA Expression by UniProt/SwissProt for GPR20 Gene
Q99678-GPR20_HUMAN
Tissue specificity:
Ubiquitous with highest levels in intestinal tissues. In the brain detected in thalamus, putamen, and caudate, but not in frontal cortex, pons and hypothalamus.
Primer Products
-
OriGene qPCR primer pairs and template standards for GPR20
-
OriGene qPCR primer pairs for GPR20
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR20 Gene
Orthologs for GPR20 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | GPR20 35 |
|
||
| GPR20 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | GPR20 35 |
|
||
| GPR20 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Gpr20 35 |
|
||
| Gpr20 16 |
|
||||
| Gpr20 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | GPR20 35 |
|
||
| GPR20 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Gpr20 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GPR20 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GPR20 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GPR20 35 |
|
||
| GPR20 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | GPR20 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gpr20 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC794428 35 |
|
||
| GPR20 (1 of 2) 36 |
|
OneToMany | |||
| GPR20 (2 of 2) 36 |
|
OneToMany |
- Species with no ortholog for GPR20:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GPR20 Gene
(1) SIMAP similar genes for GPR20 Gene using alignment to 1 proteins:
Variants for GPR20 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10875472 | - | 141,357,235(+) | CCTGG(C/T)GGAGC | reference, missense | |
| rs36092215 | - | 141,357,146(+) | TTGGC(A/C/G)GGCGT | reference, missense | |
| rs34591516 | - | 141,356,987(+) | CTGGC(C/T)GAAGA | reference, missense | |
| rs7830293 | -- | 141,363,409(+) | CACGG(C/T)CCTGG | intron-variant | |
| rs7830979 | -- | 141,367,639(+) | GAGAC(A/G)GTGGC | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2737756 | CNV | Deletion | 23290073 |
| nsv831484 | CNV | Loss | 17160897 |
| dgv7894n71 | CNV | Loss | 21882294 |
| dgv7895n71 | CNV | Loss | 21882294 |
| nsv465956 | CNV | Gain | 19166990 |
| dgv7896n71 | CNV | Loss | 21882294 |
| nsv470240 | CNV | Loss | 18288195 |
| dgv7897n71 | CNV | Loss | 21882294 |
| nsv509285 | CNV | Insertion | 20534489 |
| nsv465957 | CNV | Loss | 19166990 |
| nsv465958 | CNV | Loss | 19166990 |
| nsv891565 | CNV | Loss | 21882294 |
| nsv465959 | CNV | Loss | 19166990 |
Residual Variation Intolerance Score:
91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.25;
70.16% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR20 Gene
Disorders for GPR20 Gene
Relevant External Links for GPR20
No disorders were found for GPR20 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR20 Gene
Publications for GPR20 Gene
- Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins. (PMID: 18347022) Hase M. … Nakamura M. (J. Biol. Chem. 2008) 2 3 4 67
- Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
- Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3
- Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
Products for GPR20 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for GPR20
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GPR20
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR20
- Origene Custom Protein Services for GPR20
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for GPR20
- Browse OriGene Inhibitory RNA Products For GPR20
- OriGene qPCR primer pairs for GPR20
- OriGene qPCR primer pairs and template standards for GPR20
- OriGene CRISPR knockouts for GPR20
- OriGene clones in human for GPR20
- OriGene ORF clones in human,mouse,rat for GPR20
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for GPR20
- GenScript Custom Assay Services for GPR20
- GenScript Custom overexpressing Cell Line Services for GPR20
- GenScript: Design CRISPR guide RNA sequences for GPR20
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GPR20
- Novus Biologicals Antibodies for GPR20
- Novus Biologicals lysates for GPR20
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for GPR20
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- ViGene Biosciences adenoviral particle packaged cDNA for GPR20 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GPR20 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GPR20 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GPR20 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GPR20 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GPR20 gene
- Search ViGene Biosciences for GPR20
- Search ViGene Biosciences for GPR20
- Santa Cruz Biotechnology (SCBT) Antibodies for GPR20
- Search Santa Cruz Biotechnology (SCBT) for GPR20 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GPR20
Sources for GPR20 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon