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Aliases for GPR20 Gene

Aliases for GPR20 Gene

  • G Protein-Coupled Receptor 20 2 3
  • CTD-3064M3.3 3

External Ids for GPR20 Gene

Previous GeneCards Identifiers for GPR20 Gene

  • GC08U990036
  • GC08P142612
  • GC08M142051
  • GC08M142338
  • GC08M142436
  • GC08M142437
  • GC08M142366
  • GC08M137677

Summaries for GPR20 Gene

GeneCards Summary for GPR20 Gene

GPR20 (G Protein-Coupled Receptor 20) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR20 Gene

  • Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.

Gene Wiki entry for GPR20 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR20 Gene

Genomics for GPR20 Gene

Regulatory Elements for GPR20 Gene

Genomic Location for GPR20 Gene

Chromosome:
8
Start:
141,353,407 bp from pter
End:
141,367,271 bp from pter
Size:
13,865 bases
Orientation:
Minus strand

Genomic View for GPR20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR20 Gene

Proteins for GPR20 Gene

  • Protein details for GPR20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99678-GPR20_HUMAN
    Recommended name:
    G-protein coupled receptor 20
    Protein Accession:
    Q99678
    Secondary Accessions:
    • Q17R96

    Protein attributes for GPR20 Gene

    Size:
    358 amino acids
    Molecular mass:
    38650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR20 Gene

Proteomics data for GPR20 Gene at MOPED

Post-translational modifications for GPR20 Gene

  • Glycosylation at Asn 16 and Asn 26
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR20 Gene

Domains & Families for GPR20 Gene

Gene Families for GPR20 Gene

Protein Domains for GPR20 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99678

UniProtKB/Swiss-Prot:

GPR20_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR20: view

Function for GPR20 Gene

Molecular function for GPR20 Gene

GENATLAS Biochemistry:
G protein coupled receptor 20,expressed in brain,liver
UniProtKB/Swiss-Prot Function:
Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.

Gene Ontology (GO) - Molecular Function for GPR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 18347022
genes like me logo Genes that share ontologies with GPR20: view

Phenotypes for GPR20 Gene

genes like me logo Genes that share phenotypes with GPR20: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR20

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR20 Gene

Localization for GPR20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR20 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR20 Gene COMPARTMENTS Subcellular localization image for GPR20 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 18347022
GO:0016021 integral component of membrane --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR20: view

Pathways & Interactions for GPR20 Gene

SuperPathways for GPR20 Gene

genes like me logo Genes that share pathways with GPR20: view

Pathways by source for GPR20 Gene

1 BioSystems pathway for GPR20 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR20 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366970%0d%0a9606.ENSP00000386717%0d%0a9606.ENSP00000420419%0d%0a
Selected Interacting proteins: ENSP00000366970 for GPR20 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 9073069
genes like me logo Genes that share ontologies with GPR20: view

No data available for SIGNOR curated interactions for GPR20 Gene

Drugs & Compounds for GPR20 Gene

No Compound Related Data Available

Transcripts for GPR20 Gene

mRNA/cDNA for GPR20 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR20 Gene

G protein-coupled receptor 20:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR20

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR20 Gene

No ASD Table

Relevant External Links for GPR20 Gene

GeneLoc Exon Structure for
GPR20
ECgene alternative splicing isoforms for
GPR20

Expression for GPR20 Gene

mRNA expression in normal human tissues for GPR20 Gene

mRNA differential expression in normal tissues according to GTEx for GPR20 Gene

This gene is overexpressed in Artery - Tibial (x5.1) and Artery - Coronary (x5.0).

SOURCE GeneReport for Unigene cluster for GPR20 Gene Hs.188859

mRNA Expression by UniProt/SwissProt for GPR20 Gene

Q99678-GPR20_HUMAN
Tissue specificity: Ubiquitous with highest levels in intestinal tissues. In the brain detected in thalamus, putamen, and caudate, but not in frontal cortex, pons and hypothalamus.
genes like me logo Genes that share expression patterns with GPR20: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR20 Gene

Orthologs for GPR20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR20 35
  • 87.62 (n)
  • 84.64 (a)
GPR20 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR20 35
  • 88.01 (n)
  • 86.89 (a)
GPR20 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr20 35
  • 82.63 (n)
  • 83.94 (a)
Gpr20 16
Gpr20 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR20 35
  • 98.23 (n)
  • 98.04 (a)
GPR20 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr20 35
  • 82.24 (n)
  • 82.63 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR20 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR20 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR20 35
  • 61.37 (n)
  • 55.66 (a)
GPR20 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR20 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr20 35
  • 63.72 (n)
  • 57.14 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC794428 35
  • 61.64 (n)
  • 57.55 (a)
GPR20 (1 of 2) 36
  • 44 (a)
OneToMany
GPR20 (2 of 2) 36
  • 54 (a)
OneToMany
Species with no ortholog for GPR20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR20 Gene

ENSEMBL:
Gene Tree for GPR20 (if available)
TreeFam:
Gene Tree for GPR20 (if available)

Paralogs for GPR20 Gene

(1) SIMAP similar genes for GPR20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR20: view

No data available for Paralogs for GPR20 Gene

Variants for GPR20 Gene

Sequence variations from dbSNP and Humsavar for GPR20 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3934583 -- 141,360,241(+) CTGAC(C/T)CTGAT intron-variant
rs4961269 -- 141,367,849(-) GCCCC(A/C/G)CACAC upstream-variant-2KB
rs4961374 -- 141,354,063(+) TCAGA(C/T)GTGGG utr-variant-3-prime
rs4961375 -- 141,354,122(+) AGAAA(A/G)GGATT utr-variant-3-prime
rs4961386 -- 141,367,652(-) CACAC(A/G)AGTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR20 Gene

Variant ID Type Subtype PubMed ID
esv2737756 CNV Deletion 23290073
nsv831484 CNV Loss 17160897
dgv7894n71 CNV Loss 21882294
dgv7895n71 CNV Loss 21882294
nsv465956 CNV Gain 19166990
dgv7896n71 CNV Loss 21882294
nsv470240 CNV Loss 18288195
dgv7897n71 CNV Loss 21882294
nsv509285 CNV Insertion 20534489
nsv465957 CNV Loss 19166990
nsv465958 CNV Loss 19166990
nsv891565 CNV Loss 21882294
nsv465959 CNV Loss 19166990

Variation tolerance for GPR20 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR20 Gene

HapMap Linkage Disequilibrium report
GPR20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR20 Gene

Disorders for GPR20 Gene

Relevant External Links for GPR20

Genetic Association Database (GAD)
GPR20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR20
genes like me logo Genes that share disorders with GPR20: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR20 Gene

Publications for GPR20 Gene

  1. Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins. (PMID: 18347022) Hase M. … Nakamura M. (J. Biol. Chem. 2008) 2 67
  2. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 67
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  4. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 67
  5. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (PMID: 17463248) Scott L.J. … Boehnke M. (Science 2007) 67

Products for GPR20 Gene

Sources for GPR20 Gene

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