Aliases for GPR20 Gene
Aliases for GPR20 Gene
External Ids for GPR20 Gene
- HGNC: 4475
- Entrez Gene: 2843
- Ensembl: ENSG00000204882
- OMIM: 601908
- UniProtKB: Q99678
Previous GeneCards Identifiers for GPR20 Gene
- GC08U990036
- GC08P142612
- GC08M142051
- GC08M142338
- GC08M142436
- GC08M142437
- GC08M142366
- GC08M137677
Summaries for GPR20 Gene
GeneCards Summary for GPR20 Gene
GPR20 (G Protein-Coupled Receptor 20) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is OXER1.
UniProtKB/Swiss-Prot for GPR20 Gene
-
Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
Additional gene information for GPR20 Gene
- Monarch Initiative
- Search for GPR20 at DataMed
- Search for GPR20 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR20 Gene
Genomics for GPR20 Gene
GeneHancer (GH) Regulatory Elements for GPR20 Gene
Promoters and enhancers for GPR20 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GPR20 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GPR20 Gene
Genomic Locations for GPR20 Gene
- chr8:141,353,407-141,367,271
- (GRCh38/hg38)
- Size:
- 13,865 bases
- Orientation:
- Minus strand
- chr8:142,366,585-142,377,367
- (GRCh37/hg19)
Genomic View for GPR20 Gene
Genes around GPR20 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.3 by Ensembl
- 8q24.3 by Entrez Gene
- 8q24.3 by HGNC
GPR20 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR20 Gene
Proteins for GPR20 Gene
-
Protein details for GPR20 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99678-GPR20_HUMAN
- Recommended name:
- G-protein coupled receptor 20
- Protein Accession:
- Q99678
- Q17R96
Protein attributes for GPR20 Gene
- Size:
- 358 amino acids
- Molecular mass:
- 38650 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for GPR20 Gene
- Glycosylation at posLast=1616 and posLast=2626
Other Protein References for GPR20 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GPR20
- Invitrogen Antibodies for GPR20
- GeneTex GPR20 antibody for GPR20
Protein Products
-
OriGene Purified Proteins for GPR20
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR20
- Origene Custom Protein Services for GPR20
- Novus Biologicals lysates for GPR20
- Search GeneTex for Proteins for GPR20
Assay Products
No data available for DME Specific Peptides for GPR20 Gene
Domains & Families for GPR20 Gene
Gene Families for GPR20 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for GPR20 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR20 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99678- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR20 Gene
Molecular function for GPR20 Gene
- GENATLAS Biochemistry:
- G protein coupled receptor 20,expressed in brain,liver
- UniProtKB/Swiss-Prot Function:
- Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
Phenotypes From GWAS Catalog for GPR20 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IDA | 18347022 |
Phenotypes for GPR20 Gene
- GenomeRNAi human phenotypes for GPR20:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR20 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR20 gene
- Search ViGene Biosciences for GPR20
CRISPR Products
-
OriGene CRISPR knockouts for GPR20
- genomics-online: gRNA clones - Search results for 94 available GPR20 gene related products
- Overview of 94 available GPR20 gene related products
- Applied Biological Materials CRISPR for GPR20
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR20
- GenScript: Design CRISPR guide RNA sequences for GPR20
miRNA for GPR20 Gene
- miRTarBase miRNAs that target GPR20
-
- hsa-mir-128-2-5p (MIRT487783)
- hsa-mir-128-1-5p (MIRT487784)
- hsa-mir-6780b-5p (MIRT487785)
- hsa-mir-4725-3p (MIRT487786)
- hsa-mir-4271 (MIRT487787)
- hsa-mir-6721-5p (MIRT487788)
- hsa-mir-6781-5p (MIRT487789)
- hsa-mir-5196-5p (MIRT487790)
- hsa-mir-4747-5p (MIRT487791)
- hsa-mir-6787-5p (MIRT487792)
- hsa-mir-663a (MIRT487793)
- hsa-mir-1908-5p (MIRT487794)
- hsa-mir-4763-3p (MIRT487795)
- hsa-mir-1207-5p (MIRT487796)
- hsa-mir-3202 (MIRT487797)
- hsa-mir-7-5p (MIRT487798)
- hsa-mir-4749-5p (MIRT487799)
- hsa-mir-4706 (MIRT487800)
- hsa-mir-3179 (MIRT487801)
- hsa-mir-9500 (MIRT487802)
- hsa-mir-4463 (MIRT487803)
- hsa-mir-584-3p (MIRT573385)
- hsa-mir-3200-3p (MIRT573386)
miRNA Products
- Search ViGene Biosciences for GPR20
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for GPR20
- Browse OriGene Inhibitory RNA Products For GPR20
- genomics-online: shRNA clones - Search results for 94 available GPR20 gene related products
- Overview of 94 available GPR20 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR20 gene
Clone Products
- Sino Biological Human cDNA Clone for GPR20
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GPR20
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR20
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR20
- Applied Biological Materials Clones for GPR20
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GPR20
Cell Line Products
-
Horizon Cell Lines for GPR20
-
ViGene Biosciences adenoviral particle packaged cDNA for GPR20 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR20 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR20 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR20 Gene
Localization for GPR20 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR20 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 18347022 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043235 | receptor complex | IDA | 23382219 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR20 Gene
Pathways & Interactions for GPR20 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | G alpha (s) signalling events | ||
| 3 | Peptide ligand-binding receptors | ||
Pathways by source for GPR20 Gene
1 BioSystems pathway for GPR20 Gene
4 Reactome pathways for GPR20 Gene
Interacting Proteins for GPR20 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0035025 | positive regulation of Rho protein signal transduction | IBA | -- |
| GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | IBA | -- |
No data available for SIGNOR curated interactions for GPR20 Gene
Transcripts for GPR20 Gene
mRNA/cDNA for GPR20 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GPR20 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPR20
- genomics-online: gRNA clones - Search results for 94 available GPR20 gene related products
- Overview of 94 available GPR20 gene related products
- Applied Biological Materials CRISPR for GPR20
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR20
- GenScript: Design CRISPR guide RNA sequences for GPR20
miRNA Products
- Search ViGene Biosciences for GPR20
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for GPR20
- Browse OriGene Inhibitory RNA Products For GPR20
- genomics-online: shRNA clones - Search results for 94 available GPR20 gene related products
- Overview of 94 available GPR20 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR20 gene
Clone Products
- Sino Biological Human cDNA Clone for GPR20
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GPR20
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR20
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR20
- Applied Biological Materials Clones for GPR20
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GPR20
Expression for GPR20 Gene
mRNA differential expression in normal tissues according to GTEx for GPR20 Gene
This gene is overexpressed in Artery - Tibial (x5.1) and Artery - Coronary (x5.0).
NURSA nuclear receptor signaling pathways regulating expression of GPR20 Gene:
GPR20SOURCE GeneReport for Unigene cluster for GPR20 Gene:
Hs.188859mRNA Expression by UniProt/SwissProt for GPR20 Gene:
Q99678-GPR20_HUMAN
Tissue specificity:
Ubiquitous with highest levels in intestinal tissues. In the brain detected in thalamus, putamen, and caudate, but not in frontal cortex, pons and hypothalamus.
Evidence on tissue expression from TISSUES for GPR20 Gene
- Lung(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for GPR20
-
OriGene qPCR primer pairs for GPR20
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR20 Gene
Orthologs for GPR20 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GPR20 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | GPR20 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | GPR20 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Gpr20 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gpr20 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GPR20 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GPR20 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GPR20 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GPR20 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gpr20 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC794428 33 |
|
||
| GPR20 (2 of 2) 34 |
|
OneToMany | |||
| GPR20 (1 of 2) 34 |
|
OneToMany |
- Species where no ortholog for GPR20 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GPR20 Gene
Variants for GPR20 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000272094 | -- | 141,363,580(-) | T/G | intron_variant | |
| rs1000472621 | -- | 141,364,050(-) | G/A | intron_variant | |
| rs1000591995 | -- | 141,362,990(-) | T/C | intron_variant | |
| rs1000880390 | -- | 141,368,479(-) | C/G/T | upstream_transcript_variant | |
| rs1001492976 | -- | 141,360,989(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv7330n100 | CNV | gain | 25217958 |
| dgv7331n100 | CNV | gain | 25217958 |
| esv2737756 | CNV | deletion | 23290073 |
| nsv1023036 | CNV | loss | 25217958 |
| nsv1126125 | CNV | deletion | 24896259 |
| nsv465956 | CNV | gain | 19166990 |
| nsv465957 | CNV | loss | 19166990 |
| nsv465958 | CNV | loss | 19166990 |
| nsv465959 | CNV | loss | 19166990 |
| nsv470240 | CNV | loss | 18288195 |
| nsv509285 | CNV | insertion | 20534489 |
| nsv612575 | CNV | gain | 21841781 |
| nsv612576 | CNV | loss | 21841781 |
| nsv612577 | CNV | loss | 21841781 |
| nsv612578 | CNV | loss | 21841781 |
| nsv831484 | CNV | loss | 17160897 |
| nsv949996 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.25;
70.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPR20 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR20
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR20 Gene
Disorders for GPR20 Gene
Additional Disease Information for GPR20
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GPR20 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR20 Gene
Publications for GPR20 Gene
- Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins. (PMID: 18347022) Hase M … Nakamura M (The Journal of biological chemistry 2008) 2 3 4 58
- Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. (PMID: 9073069) O'Dowd BF … George SR (Gene 1997) 3 4 58
- Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R … Collins BM (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 58
- Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 58
- Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58
Products for GPR20 Gene
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- Invitrogen Antibodies for GPR20
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for GPR20
- VectorBuilder custom plasmid, inducible vectors for GPR20
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR20
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR20
- antibodies-online: Search results for 79 available GPR20 Antibodies ranked by validation data
- Compare Top GPR20 Antibodies
- antibodies-online: Search results for available GPR20 related products ranked by validation data
- antibodies-online: Search results for available GPR20 related products ranked by validation data
- GeneTex GPR20 antibody for GPR20
- Search GeneTex for Proteins for GPR20
- ViGene Biosciences adenoviral particle packaged cDNA for GPR20 gene
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- Search ViGene Biosciences for GPR20
- Horizon Cell Lines for GPR20
- genomics-online: cdna clones - Search results for 94 available GPR20 gene related products
- Overview of 94 available GPR20 gene related products
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- Overview of 94 available GPR20 gene related products
- genomics-online: gRNA clones - Search results for 94 available GPR20 gene related products
- Overview of 94 available GPR20 gene related products
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- Overview of 94 available GPR20 gene related products
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- Overview of 94 available GPR20 gene related products
Sources for GPR20 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
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