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Aliases for GPR20 Gene

Aliases for GPR20 Gene

  • G Protein-Coupled Receptor 20 2 3 5
  • G-Protein Coupled Receptor 20 3
  • CTD-3064M3.3 3

External Ids for GPR20 Gene

Previous GeneCards Identifiers for GPR20 Gene

  • GC08U990036
  • GC08P142612
  • GC08M142051
  • GC08M142338
  • GC08M142436
  • GC08M142437
  • GC08M142366
  • GC08M137677

Summaries for GPR20 Gene

GeneCards Summary for GPR20 Gene

GPR20 (G Protein-Coupled Receptor 20) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR35.

UniProtKB/Swiss-Prot for GPR20 Gene

  • Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.

Gene Wiki entry for GPR20 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR20 Gene

Genomics for GPR20 Gene

Regulatory Elements for GPR20 Gene

Enhancers for GPR20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F141225 1.8 FANTOM5 Ensembl ENCODE 12.6 +139.8 139780 3.4 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SLC45A4 DENND3 ENSG00000253307 LOC105375787 LINC01300 GPR20 PTP4A3 ENSG00000280035
GH08F141391 1.1 ENCODE 18.7 -25.1 -25077 1.9 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF766 ZNF143 ZNF207 GPR20 ENSG00000261655 LINC01300 ENSG00000244998 PTP4A3
GH08F140509 1.1 ENCODE 12.5 +855.3 855317 4.4 HDGF CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF143 CHRAC1 GPR20 ENSG00000261655 GC08P140525
GH08F141317 1 Ensembl ENCODE 12.9 +49.0 48971 1.0 KLF1 SP3 CBX3 SP2 CEBPB ZEB2 RFX5 ZFHX2 ZNF707 CBX5 LINC01300 GPR20 LOC105375787 ENSG00000253307 SLC45A4 ENSG00000254291
GH08F141372 1.5 FANTOM5 Ensembl ENCODE 7.4 -7.6 -7594 4.3 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 GLIS2 ZNF143 SP5 ENSG00000259891 GPR20 SLC45A4 LOC101928037 LOC105375790
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR20 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR20 Gene

141,353,407 bp from pter
141,367,271 bp from pter
13,865 bases
Minus strand

Genomic View for GPR20 Gene

Genes around GPR20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR20 Gene

Proteins for GPR20 Gene

  • Protein details for GPR20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 20
    Protein Accession:
    Secondary Accessions:
    • Q17R96

    Protein attributes for GPR20 Gene

    358 amino acids
    Molecular mass:
    38650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR20 Gene

Post-translational modifications for GPR20 Gene

  • Glycosylation at Asn 16 and Asn 26
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR20 Gene

Domains & Families for GPR20 Gene

Gene Families for GPR20 Gene

Protein Domains for GPR20 Gene

Suggested Antigen Peptide Sequences for GPR20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR20: view

Function for GPR20 Gene

Molecular function for GPR20 Gene

GENATLAS Biochemistry:
G protein coupled receptor 20,expressed in brain,liver
UniProtKB/Swiss-Prot Function:
Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.

Gene Ontology (GO) - Molecular Function for GPR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 18347022
genes like me logo Genes that share ontologies with GPR20: view

Phenotypes for GPR20 Gene

genes like me logo Genes that share phenotypes with GPR20: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR20

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR20

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR20 Gene

Localization for GPR20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR20 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR20 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 18347022
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR20: view

Pathways & Interactions for GPR20 Gene

genes like me logo Genes that share pathways with GPR20: view

Pathways by source for GPR20 Gene

Interacting Proteins for GPR20 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000366970 Q99678-GPR20_HUMAN for GPR20 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GPR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0035025 positive regulation of Rho protein signal transduction IBA --
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA --
genes like me logo Genes that share ontologies with GPR20: view

No data available for SIGNOR curated interactions for GPR20 Gene

Transcripts for GPR20 Gene

mRNA/cDNA for GPR20 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR20 Gene

G protein-coupled receptor 20:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPR20

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR20 Gene

No ASD Table

Relevant External Links for GPR20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR20 Gene

mRNA differential expression in normal tissues according to GTEx for GPR20 Gene

This gene is overexpressed in Artery - Tibial (x5.1) and Artery - Coronary (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of GPR20 Gene:


SOURCE GeneReport for Unigene cluster for GPR20 Gene:


mRNA Expression by UniProt/SwissProt for GPR20 Gene:

Tissue specificity: Ubiquitous with highest levels in intestinal tissues. In the brain detected in thalamus, putamen, and caudate, but not in frontal cortex, pons and hypothalamus.
genes like me logo Genes that share expression patterns with GPR20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR20 Gene

Orthologs for GPR20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR20 34 35
  • 98.23 (n)
(Canis familiaris)
Mammalia GPR20 34 35
  • 88.01 (n)
(Bos Taurus)
Mammalia GPR20 34 35
  • 87.62 (n)
(Mus musculus)
Mammalia Gpr20 34 16 35
  • 82.63 (n)
(Rattus norvegicus)
Mammalia Gpr20 34
  • 82.24 (n)
(Monodelphis domestica)
Mammalia GPR20 35
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia GPR20 35
  • 59 (a)
(Gallus gallus)
Aves GPR20 34 35
  • 61.37 (n)
(Anolis carolinensis)
Reptilia GPR20 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr20 34
  • 63.72 (n)
(Danio rerio)
Actinopterygii LOC794428 34
  • 61.64 (n)
GPR20 (2 of 2) 35
  • 54 (a)
GPR20 (1 of 2) 35
  • 44 (a)
Species where no ortholog for GPR20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR20 Gene

Gene Tree for GPR20 (if available)
Gene Tree for GPR20 (if available)

Paralogs for GPR20 Gene

Paralogs for GPR20 Gene

(1) SIMAP similar genes for GPR20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR20: view

Variants for GPR20 Gene

Sequence variations from dbSNP and Humsavar for GPR20 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10090104 -- 141,360,762(+) GTGAT(A/G)AGCAG intron-variant
rs10090941 -- 141,360,772(+) GTCAC(C/G)AGCAC intron-variant
rs10101616 -- 141,363,425(+) TCCAA(A/G)GGGTG intron-variant
rs10875472 -- 141,357,235(+) CCTGG(C/T)GGAGC reference, missense
rs111386128 -- 141,365,844(+) AGCCC(C/T)GCACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR20 Gene

Variant ID Type Subtype PubMed ID
nsv949996 CNV deletion 24416366
nsv831484 CNV loss 17160897
nsv612578 CNV loss 21841781
nsv612577 CNV loss 21841781
nsv612576 CNV loss 21841781
nsv612575 CNV gain 21841781
nsv509285 CNV insertion 20534489
nsv470240 CNV loss 18288195
nsv465959 CNV loss 19166990
nsv465958 CNV loss 19166990
nsv465957 CNV loss 19166990
nsv465956 CNV gain 19166990
nsv1126125 CNV deletion 24896259
nsv1023036 CNV loss 25217958
esv2737756 CNV deletion 23290073
dgv7331n100 CNV gain 25217958
dgv7330n100 CNV gain 25217958

Variation tolerance for GPR20 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR20 Gene

Disorders for GPR20 Gene

Relevant External Links for GPR20

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR20 Gene

Publications for GPR20 Gene

  1. Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins. (PMID: 18347022) Hase M. … Nakamura M. (J. Biol. Chem. 2008) 2 3 4 64
  2. Cloning and chromosomal mapping of four putative novel human G- protein-coupled receptor genes. (PMID: 9073069) O'Dowd B.F. … George S.R. (Gene 1997) 3 4 64
  3. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 64
  4. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 64
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64

Products for GPR20 Gene

Sources for GPR20 Gene

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