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Aliases for GPR19 Gene

Aliases for GPR19 Gene

  • G Protein-Coupled Receptor 19 2 3
  • GPR-NGA 3 4
  • Probable G-Protein Coupled Receptor 19 3

External Ids for GPR19 Gene

Previous GeneCards Identifiers for GPR19 Gene

  • GC12M012541
  • GC12M012958
  • GC12M012714
  • GC12M012813

Summaries for GPR19 Gene

GeneCards Summary for GPR19 Gene

GPR19 (G Protein-Coupled Receptor 19) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is CCKBR.

UniProtKB/Swiss-Prot for GPR19 Gene

  • Orphan receptor

Gene Wiki entry for GPR19 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR19 Gene

Genomics for GPR19 Gene

Regulatory Elements for GPR19 Gene

Genomic Location for GPR19 Gene

12,660,891 bp from pter
12,696,207 bp from pter
35,317 bases
Minus strand

Genomic View for GPR19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR19 Gene

Proteins for GPR19 Gene

  • Protein details for GPR19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 19
    Protein Accession:
    Secondary Accessions:

    Protein attributes for GPR19 Gene

    415 amino acids
    Molecular mass:
    47687 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR19 Gene

Proteomics data for GPR19 Gene at MOPED

Post-translational modifications for GPR19 Gene

  • Glycosylation at Asn25 and Asn52
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR19 Gene

Domains for GPR19 Gene

Gene Families for GPR19 Gene

  • GPCRAO :GPCR / Class A : Orphans

Protein Domains for GPR19 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q15760
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR19: view

Function for GPR19 Gene

Molecular function for GPR19 Gene

GENATLAS Biochemistry:
G protein coupled receptor 19,with strong homology with D2 dopamine and adregenic receptors,expressed in caudate nucleus,putamen and thalamus,involved in cancer cells
UniProtKB/Swiss-Prot Function:
Orphan receptor

Gene Ontology (GO) - Molecular Function for GPR19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR19: view

Phenotypes for GPR19 Gene

MGI mutant phenotypes for GPR19:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with GPR19: view

Animal Model Products

miRNA for GPR19 Gene

miRTarBase miRNAs that target GPR19

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR19

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GPR19 Gene

Localization for GPR19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR19 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR19 Gene COMPARTMENTS Subcellular localization image for GPR19 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8830667
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR19: view

Pathways for GPR19 Gene

SuperPathways for GPR19 Gene

genes like me logo Genes that share pathways with GPR19: view

Pathways by source for GPR19 Gene

1 BioSystems pathway for GPR19 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR19 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000333744 for GPR19 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for GPR19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR19: view

Transcripts for GPR19 Gene

Unigene Clusters for GPR19 Gene

G protein-coupled receptor 19:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR19

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR19 Gene

No ASD Table

Relevant External Links for GPR19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR19 Gene

mRNA expression in normal human tissues for GPR19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR19 Gene

This gene is overexpressed in Pituitary (4.8), Brain - Nucleus accumbens (basal ganglia) (4.2), and Brain - Cerebellar Hemisphere (4.1).

Protein differential expression in normal tissues for GPR19 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPR19 Gene

SOURCE GeneReport for Unigene cluster for GPR19 Gene Hs.657862

mRNA Expression by UniProt/SwissProt for GPR19 Gene

Tissue specificity: Abundant expression in the brain
genes like me logo Genes that share expressions with GPR19: view

Expression partners for GPR19 Gene

In Situ Assay Products

Orthologs for GPR19 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR19 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR19 35
  • 87.39 (n)
  • 91.08 (a)
GPR19 36
  • 91 (a)
(Canis familiaris)
Mammalia GPR19 35
  • 90.2 (n)
  • 92.05 (a)
GPR19 36
  • 92 (a)
(Mus musculus)
Mammalia Gpr19 35
  • 83.05 (n)
  • 89.4 (a)
Gpr19 16
Gpr19 36
  • 89 (a)
(Pan troglodytes)
Mammalia GPR19 35
  • 98.55 (n)
  • 98.31 (a)
GPR19 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Gpr19 35
  • 83.61 (n)
  • 88.67 (a)
(Gallus gallus)
Aves GPR19 36
  • 74 (a)
(Anolis carolinensis)
Reptilia GPR19 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr19 35
  • 66.43 (n)
  • 70.53 (a)
(Danio rerio)
Actinopterygii gpr19 35
  • 62.24 (n)
  • 65.11 (a)
zgc63912 35
gpr19 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta TrissinR 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea npr-1 36
  • 15 (a)
npr-10 36
  • 20 (a)
npr-13 36
  • 15 (a)
npr-2 36
  • 16 (a)
npr-3 36
  • 18 (a)
npr-4 36
  • 15 (a)
npr-5 36
  • 15 (a)
npr-7 36
  • 18 (a)
npr-8 36
  • 12 (a)
Species with no ortholog for GPR19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR19 Gene

Gene Tree for GPR19 (if available)
Gene Tree for GPR19 (if available)

Paralogs for GPR19 Gene

Paralogs for GPR19 Gene

Selected SIMAP similar genes for GPR19 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR19: view

Variants for GPR19 Gene

Sequence variations from dbSNP and Humsavar for GPR19 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs719839 -- 12,666,927(-) TTAGA(A/T)GAGAT intron-variant
rs719840 -- 12,666,702(-) ACATC(G/T)AATAA intron-variant
rs722598 -- 12,679,349(-) CCTCC(A/G)AAAGT intron-variant
rs759746 -- 12,673,539(-) ttcag(A/C)caggg intron-variant
rs1544727 -- 12,685,641(-) ATCCA(A/C/G)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR19 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
nsv898811 CNV Gain 21882294
nsv509456 CNV Insertion 20534489
dgv89n21 CNV Gain 19592680

Relevant External Links for GPR19 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR19 Gene

Disorders for GPR19 Gene

No disorders were found for GPR19 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GPR19 Gene

Publications for GPR19 Gene

  1. A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. (PMID: 8830667) O'Dowd B.F. … George S.R. (FEBS Lett. 1996) 3 4
  2. Physical mapping of the G-protein coupled receptor 19 (GPR19) in the chromosome 12p12.3 region frequently rearranged in cancer cells. (PMID: 10480372) Montpetit A. … Sinnett D. (Hum. Genet. 1999) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3

Products for GPR19 Gene

Sources for GPR19 Gene

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