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Aliases for GPR19 Gene

Aliases for GPR19 Gene

  • G Protein-Coupled Receptor 19 2 3 5
  • GPR-NGA 3 4
  • Probable G-Protein Coupled Receptor 19 3

External Ids for GPR19 Gene

Previous GeneCards Identifiers for GPR19 Gene

  • GC12M012541
  • GC12M012958
  • GC12M012714
  • GC12M012813

Summaries for GPR19 Gene

GeneCards Summary for GPR19 Gene

GPR19 (G Protein-Coupled Receptor 19) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is CCKBR.

UniProtKB/Swiss-Prot for GPR19 Gene

  • Orphan receptor.

Gene Wiki entry for GPR19 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR19 Gene

Genomics for GPR19 Gene

Regulatory Elements for GPR19 Gene

Enhancers for GPR19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F012580 1.1 Ensembl ENCODE 20.1 +132.5 132548 7.6 HDGF PKNOX1 WRNIP1 ZFP64 ZNF493 FEZF1 YY1 ZNF121 ELK1 CBX5 DDX47 GPR19 DUSP16 LRP6 CDKN1B RPL19P17 GC12M012561
GH12F012660 0.2 Ensembl 16.1 +57.0 56972 0.2 ATF1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ELK1 ZNF143 ZNF207 DEK GPR19 CREBL2 CDKN1B DDX47 MIR614 ENSG00000240424 DUSP16 MANSC1 GC12P012657 ENSG00000257004
GH12F012665 0.5 ENCODE 11.7 +51.9 51935 0.4 MLLT1 GPR19 CREBL2 CDKN1B ENSG00000257004 GC12P012657
GH12F012655 1.2 Ensembl ENCODE 11.6 +61.3 61272 0.8 HDGF ELF3 PKNOX1 WRNIP1 ARID4B BMI1 ZBTB40 RAD21 RFX5 SLC30A9 GPR19 CREBL2 CDKN1B ENSG00000240424 DUSP16 MANSC1 GC12P012657 ENSG00000275963
GH12F012628 0.8 Ensembl 11.1 +89.2 89171 0.2 ZNF362 TSHZ1 ZEB1 ZNF121 ZFHX2 ZNF366 KLF8 SP7 EGR2 ZNF558 ENSG00000240424 DUSP16 GPR19 GC12P012621 ENSG00000275963
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR19 on UCSC Golden Path with GeneCards custom track

Promoters for GPR19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001609555 -28 6601 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 FOS

Genomic Location for GPR19 Gene

Chromosome:
12
Start:
12,660,884 bp from pter
End:
12,717,272 bp from pter
Size:
56,389 bases
Orientation:
Minus strand

Genomic View for GPR19 Gene

Genes around GPR19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR19 Gene

Proteins for GPR19 Gene

  • Protein details for GPR19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15760-GPR19_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 19
    Protein Accession:
    Q15760

    Protein attributes for GPR19 Gene

    Size:
    415 amino acids
    Molecular mass:
    47687 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR19 Gene

Post-translational modifications for GPR19 Gene

  • Glycosylation at Asn 25 and Asn 52
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR19 Gene

Domains & Families for GPR19 Gene

Gene Families for GPR19 Gene

Protein Domains for GPR19 Gene

Graphical View of Domain Structure for InterPro Entry

Q15760

UniProtKB/Swiss-Prot:

GPR19_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR19: view

Function for GPR19 Gene

Molecular function for GPR19 Gene

GENATLAS Biochemistry:
G protein coupled receptor 19,with strong homology with D2 dopamine and adregenic receptors,expressed in caudate nucleus,putamen and thalamus,involved in cancer cells
UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with GPR19: view
genes like me logo Genes that share phenotypes with GPR19: view

Animal Models for GPR19 Gene

MGI Knock Outs for GPR19:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR19

miRNA for GPR19 Gene

miRTarBase miRNAs that target GPR19

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR19 Gene

Localization for GPR19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR19 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR19 Gene COMPARTMENTS Subcellular localization image for GPR19 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 8830667
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR19: view

Pathways & Interactions for GPR19 Gene

SuperPathways for GPR19 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with GPR19: view

Pathways by source for GPR19 Gene

1 BioSystems pathway for GPR19 Gene

Interacting Proteins for GPR19 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000333744%0d%0a9606.ENSP00000349238%0d%0a
Selected Interacting proteins: ENSP00000333744 Q15760-GPR19_HUMAN for GPR19 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GPR19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with GPR19: view

No data available for SIGNOR curated interactions for GPR19 Gene

Transcripts for GPR19 Gene

Unigene Clusters for GPR19 Gene

G protein-coupled receptor 19:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR19 Gene

No ASD Table

Relevant External Links for GPR19 Gene

GeneLoc Exon Structure for
GPR19
ECgene alternative splicing isoforms for
GPR19

Expression for GPR19 Gene

mRNA expression in normal human tissues for GPR19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR19 Gene

This gene is overexpressed in Pituitary (x4.8), Brain - Nucleus accumbens (basal ganglia) (x4.2), and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for GPR19 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR19 Gene



Protein tissue co-expression partners for GPR19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR19 Gene:

GPR19

SOURCE GeneReport for Unigene cluster for GPR19 Gene:

Hs.657862

mRNA Expression by UniProt/SwissProt for GPR19 Gene:

Q15760-GPR19_HUMAN
Tissue specificity: Abundant expression in the brain.
genes like me logo Genes that share expression patterns with GPR19: view

Primer Products

Orthologs for GPR19 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR19 34 35
  • 98.55 (n)
dog
(Canis familiaris)
Mammalia GPR19 34 35
  • 90.2 (n)
cow
(Bos Taurus)
Mammalia GPR19 34 35
  • 87.39 (n)
rat
(Rattus norvegicus)
Mammalia Gpr19 34
  • 83.61 (n)
mouse
(Mus musculus)
Mammalia Gpr19 34 16 35
  • 83.05 (n)
chicken
(Gallus gallus)
Aves GPR19 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR19 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr19 34
  • 66.43 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr19 34 35
  • 62.24 (n)
zgc63912 34
fruit fly
(Drosophila melanogaster)
Insecta TrissinR 35
  • 12 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea npr-10 35
  • 20 (a)
OneToMany
npr-3 35
  • 18 (a)
OneToMany
npr-7 35
  • 18 (a)
OneToMany
npr-2 35
  • 16 (a)
OneToMany
npr-1 35
  • 15 (a)
OneToMany
npr-13 35
  • 15 (a)
OneToMany
npr-4 35
  • 15 (a)
OneToMany
npr-5 35
  • 15 (a)
OneToMany
npr-8 35
  • 12 (a)
OneToMany
Species where no ortholog for GPR19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR19 Gene

ENSEMBL:
Gene Tree for GPR19 (if available)
TreeFam:
Gene Tree for GPR19 (if available)

Paralogs for GPR19 Gene

Paralogs for GPR19 Gene

(5) SIMAP similar genes for GPR19 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR19: view

Variants for GPR19 Gene

Sequence variations from dbSNP and Humsavar for GPR19 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs121917832 Pathogenic 12,718,066(+) CGAGT(A/G)GCAAG upstream-variant-2KB, reference, stop-gained
rs551236750 Pathogenic 12,717,760(+) TCGGG(C/T)TGCGT upstream-variant-2KB, utr-variant-5-prime
rs774454456 Pathogenic 12,717,808(+) AGTGC(-/GAGA)GAGGC upstream-variant-2KB, utr-variant-5-prime
rs777354267 Pathogenic 12,718,045(+) CAAAC(C/T)CCTAG upstream-variant-2KB, reference, missense
rs786201007 Pathogenic 12,717,916(+) AAGCC(-/AGGCGGAGCACCCCAAGCC)CTCGG upstream-variant-2KB, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR19 Gene

Variant ID Type Subtype PubMed ID
dgv89n21 CNV gain 19592680
esv2745567 CNV deletion 23290073
nsv1046355 CNV loss 25217958
nsv509456 CNV insertion 20534489
nsv983287 CNV duplication 23825009

Variation tolerance for GPR19 Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR19 Gene

Disorders for GPR19 Gene

Relevant External Links for GPR19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR19

No disorders were found for GPR19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR19 Gene

Publications for GPR19 Gene

  1. A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. (PMID: 8830667) O'Dowd B.F. … George S.R. (FEBS Lett. 1996) 3 4 64
  2. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PMID: 23273568) Yang W. … Lau Y.L. (Am. J. Hum. Genet. 2013) 3 64
  3. Expression of G protein-coupled receptor 19 in human lung cancer cells is triggered by entry into S-phase and supports G(2)-M cell-cycle progression. (PMID: 22912338) Kastner S. … Sommergruber W. (Mol. Cancer Res. 2012) 3 64
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for GPR19 Gene

Sources for GPR19 Gene

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