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Aliases for GPR183 Gene

Aliases for GPR183 Gene

  • G Protein-Coupled Receptor 183 2 3 5
  • EBV-Induced G-Protein Coupled Receptor 2 2 3 4
  • Epstein-Barr Virus Induced Gene 2 (Lymphocyte-Specific G Protein-Coupled Receptor) 2 3
  • Epstein-Barr Virus-Induced G-Protein Coupled Receptor 2 3 4
  • EBI2 3 4
  • G-Protein Coupled Receptor 183 3
  • HEBI2 4

External Ids for GPR183 Gene

Previous HGNC Symbols for GPR183 Gene

  • EBI2

Previous GeneCards Identifiers for GPR183 Gene

  • GC13M098745
  • GC13M099946
  • GC13M080541

Summaries for GPR183 Gene

Entrez Gene Summary for GPR183 Gene

  • This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR183 Gene

GPR183 (G Protein-Coupled Receptor 183) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and oxysterol binding. An important paralog of this gene is CYSLTR2.

UniProtKB/Swiss-Prot for GPR183 Gene

  • G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity).

Gene Wiki entry for GPR183 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR183 Gene

Genomics for GPR183 Gene

Regulatory Elements for GPR183 Gene

Enhancers for GPR183 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GPR183 on UCSC Golden Path with GeneCards custom track

Promoters for GPR183 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR183 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR183 Gene

Chromosome:
13
Start:
99,294,530 bp from pter
End:
99,307,495 bp from pter
Size:
12,966 bases
Orientation:
Minus strand

Genomic View for GPR183 Gene

Genes around GPR183 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR183 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR183 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR183 Gene

Proteins for GPR183 Gene

  • Protein details for GPR183 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32249-GP183_HUMAN
    Recommended name:
    G-protein coupled receptor 183
    Protein Accession:
    P32249
    Secondary Accessions:
    • B2R8N5
    • Q53F99
    • Q5JUH7

    Protein attributes for GPR183 Gene

    Size:
    361 amino acids
    Molecular mass:
    41224 Da
    Quaternary structure:
    • Homodimer and heterodimer (PubMed:22913878). Heterodimerizes with CXCR5; leading to modulate the interaction between of CXCL13 and CXCR5 (PubMed:22913878).
    Miscellaneous:
    • GSK682753A (8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one), an inverse agonist, selectively inhibits the constitutive activity of GPR183 with high potency and efficacy (PubMed:21673108, PubMed:23772388). Specifically inhibited by NIBR189 ((2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one).

neXtProt entry for GPR183 Gene

Post-translational modifications for GPR183 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR183 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR183 Gene

Domains & Families for GPR183 Gene

Gene Families for GPR183 Gene

Protein Domains for GPR183 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR183 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32249

UniProtKB/Swiss-Prot:

GP183_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR183: view

Function for GPR183 Gene

Molecular function for GPR183 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced following Epstein-Barr virus (EBV) infection (PubMed:8383238).

Gene Ontology (GO) - Molecular Function for GPR183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,IDA 18628402
GO:0008142 oxysterol binding IEA,IMP 24678947
genes like me logo Genes that share ontologies with GPR183: view
genes like me logo Genes that share phenotypes with GPR183: view

Animal Models for GPR183 Gene

MGI Knock Outs for GPR183:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR183

CRISPR Products

miRNA for GPR183 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR183 Gene

Localization for GPR183 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR183 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR183 Gene COMPARTMENTS Subcellular localization image for GPR183 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for GPR183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 18628402
GO:0005887 integral component of plasma membrane TAS 8383238
genes like me logo Genes that share ontologies with GPR183: view

Pathways & Interactions for GPR183 Gene

SuperPathways for GPR183 Gene

Superpath Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR183: view

Pathways by source for GPR183 Gene

1 BioSystems pathway for GPR183 Gene

Interacting Proteins for GPR183 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000365596%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000333633%0d%0a
Selected Interacting proteins: P32249-GP183_HUMAN ENSP00000365596 for GPR183 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for GPR183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response ISS --
GO:0002312 B cell activation involved in immune response IBA --
GO:0002313 mature B cell differentiation involved in immune response IEA,ISS --
GO:0002407 dendritic cell chemotaxis ISS --
GO:0006955 immune response TAS 8383238
genes like me logo Genes that share ontologies with GPR183: view

No data available for SIGNOR curated interactions for GPR183 Gene

Drugs & Compounds for GPR183 Gene

(9) Drugs for GPR183 Gene - From: ApexBio, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
25-Hydroxycholesterol Pharma Agonist 0
27-hydroxycholesterol Pharma Agonist 0
NIBR189 Pharma Potent and selective EBI2 (GPR183) receptor antagonist 0
7Α,25-DIHYDROXYCHOLESTEROL Pharma 0
7Α,27-DIHYDROXYCHOLESTEROL Pharma 0

(6) Additional Compounds for GPR183 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7alpha,25-dihydroxycholesterol
Full agonist, Agonist
7alpha,27-dihydroxycholesterol
Agonist
7alpha-hydroxycholesterol
Agonist
7beta, 25-dihydroxycholesterol
Agonist
7beta, 27-dihydroxycholesterol
Agonist

(1) ApexBio Compounds for GPR183 Gene

Compound Action Cas Number
NIBR189 1599432-08-2
genes like me logo Genes that share compounds with GPR183: view

Transcripts for GPR183 Gene

mRNA/cDNA for GPR183 Gene

Unigene Clusters for GPR183 Gene

G protein-coupled receptor 183:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR183 Gene

No ASD Table

Relevant External Links for GPR183 Gene

GeneLoc Exon Structure for
GPR183
ECgene alternative splicing isoforms for
GPR183

Expression for GPR183 Gene

mRNA expression in normal human tissues for GPR183 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR183 Gene

This gene is overexpressed in Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for GPR183 Gene

This gene is overexpressed in Breast (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR183 Gene



Protein tissue co-expression partners for GPR183 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR183 Gene:

GPR183

SOURCE GeneReport for Unigene cluster for GPR183 Gene:

Hs.784

mRNA Expression by UniProt/SwissProt for GPR183 Gene:

P32249-GP183_HUMAN
Tissue specificity: Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes (PubMed:16540462, PubMed:8383238). Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain (PubMed:16540462, PubMed:8383238). Expressed in astrocytes (PubMed:25297897).
genes like me logo Genes that share expression patterns with GPR183: view

Primer Products

Orthologs for GPR183 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR183 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GPR183 34
  • 90.44 (n)
  • 90.53 (a)
GPR183 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr183 34
  • 81.89 (n)
  • 87.96 (a)
Gpr183 16
Gpr183 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR183 34
  • 99.82 (n)
  • 99.72 (a)
GPR183 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr183 34
  • 81.14 (n)
  • 87.96 (a)
cow
(Bos Taurus)
Mammalia GPR183 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR183 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR183 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR183 34
  • 71.41 (n)
  • 70.35 (a)
GPR183 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR183 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731463 34
  • 64.51 (n)
  • 65.88 (a)
zebrafish
(Danio rerio)
Actinopterygii gpr183 34
  • 57.39 (n)
  • 56.29 (a)
gpr183 35
  • 52 (a)
OneToMany
GPR183 (2 of 3) 35
  • 47 (a)
OneToMany
GPR183 (3 of 3) 35
  • 47 (a)
OneToMany
Species where no ortholog for GPR183 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR183 Gene

ENSEMBL:
Gene Tree for GPR183 (if available)
TreeFam:
Gene Tree for GPR183 (if available)

Paralogs for GPR183 Gene

Pseudogenes.org Pseudogenes for GPR183 Gene

genes like me logo Genes that share paralogs with GPR183: view

Variants for GPR183 Gene

Sequence variations from dbSNP and Humsavar for GPR183 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_054147 An acute myeloid leukemia sample

Structural Variations from Database of Genomic Variants (DGV) for GPR183 Gene

Variant ID Type Subtype PubMed ID
nsv1050094 CNV gain 25217958
nsv477538 CNV novel sequence insertion 20440878

Variation tolerance for GPR183 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR183 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR183

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR183 Gene

Disorders for GPR183 Gene

Relevant External Links for GPR183

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR183

No disorders were found for GPR183 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR183 Gene

Publications for GPR183 Gene

  1. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. (PMID: 8383238) Birkenbach M.P. … Kieff E. (J. Virol. 1993) 2 3 4 65
  2. EBI2 regulates intracellular signaling and migration in human astrocyte. (PMID: 25297897) Rutkowska A. … Dev K.K. (Glia 2015) 3 4 65
  3. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. (PMID: 24678947) Gessier F. … Sailer A.W. (J. Med. Chem. 2014) 3 4 65
  4. Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183). (PMID: 22875855) Benned-Jensen T. … Rosenkilde M.M. (J. Biol. Chem. 2012) 3 4 65
  5. EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5. (PMID: 22913878) Barroso R. … Mellado M. (FASEB J. 2012) 3 4 65

Products for GPR183 Gene

Sources for GPR183 Gene

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