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GPR182 Gene

protein-coding   GIFtS: 49

GC12P055675
G protein-coupled receptor 182
(Previous name: adrenomedullin receptor )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ADMR)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
7TMR 2
ADMR 2, 3
AM-R 1, 2
AMR 2
G10D 1, 2
MGC34399 2
gamrh 2
hrhAMR 1, 2
Descriptions
G protein-coupled receptor 182 2
adrenomedullin receptor 1, 2
External Ids
HGNC: 137081
Entrez Gene: 113182
UniProtKB: O152183
Ensembl: ENSG000001668567
Search outside databases for aliases for GPR182 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for GPR182:
Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular
function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of
G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may
function as a receptor for adrenomedullin. [provided by RefSeq]

UniProtKB/Swiss-Prot: GP182_HUMAN, O15218
Function: Orphan receptor

Gene Wiki entry for GPR182

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

GPR182 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P055675:     (about GC identifiers)

Start:
55,674,497 bp from pter
End:
55,676,736 bp from pter
Size:
2,240 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000012.10  NT_029419.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GP182_HUMAN, O15218 (See protein sequence)
Recommended Name: G-protein coupled receptor 182  
Size: 404 amino acids; 45323 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: Was originally (PubMed:9367907) thought to be a receptor for adrenomedullin

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_009195.1  

    ENSEMBL proteins: 
    ENSP00000300098 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Adrenomedullin Receptor L1)
    Human Recombinant Proteins from Abnova (GPR182)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane TAS9367907
    About this table

    Antibodies for GPR182: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for GPR182
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Adrenomedullin Receptor L1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (GPR182)
    Novus Biologicals Antibodies for GPR182

    Assays for GPR182: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR001350 G10D_rcpt
     IPR000276 7TM_GPCR_Rhodpsn


       GeneDecks  GPR182 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O15218

    ProtoNet protein and cluster: O15218

    1 Blocks protein family: IPB001350 G10D orphan receptor signature

    UniProtKB/Swiss-Prot: GP182_HUMAN, O15218
    Similarity: Belongs to the G-protein coupled receptor 1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (GPR182)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (GPR182)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007264

                  Applied Biosystems Silencer® siRNAs for GPR182

                  Sigma-Aldrich siRNA and siRNA Panels for GPR182  
                         Sigma-Aldrich shRNA Panels and shRNA for GPR182  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for GPR182
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007264
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007264
                                     untagged cDNA clone in CMV expression vector: NM_007264 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_007264

    UniProtKB/Swiss-Prot: GP182_HUMAN, O15218
    Function: Orphan receptor

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930 G-protein coupled receptor activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for GPR182
     Adenylate cyclase-activating neuropeptides

       GeneDecks  GPR182 for the pathways selected above  
    About GeneDecksing


    5/10 Interacting proteins for GPR182 (ENSP000003000983) via UniProtKB, MINT, and/or STRING (see all 10 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLNENSP000003054643STRING (score=.866)
    P4HBENSP000003278013STRING (score=.866)
    ADMENSP000002781753STRING (score=.821)
    KIAA2022ENSP000003625673STRING (score=.819)
    CISD2ENSP000002739863STRING (score=.734)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186 G-protein coupled receptor protein signaling pathway IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for GPR182
    3 Novoseek chemical compound relationships for GPR182 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibn 4096 bs 80.63 2 12970090 (1), 12183333 (1)
    glyceraldehyde 3-phosphate 21.90 1 11905404 (1)
    tyrosine 0.00 1 16267056 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (GPR182)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (GPR182)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007264

                  Sigma-Aldrich siRNA and siRNA Panels for GPR182  
                         Sigma-Aldrich shRNA Panels and shRNA for GPR182  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_007264  

    REFSEQ mRNAs for GPR182 gene: 

    NM_007264.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_007264  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007264
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007264
                                     untagged cDNA clone in CMV expression vector: NM_007264 

    Additional cDNA sequence: 

    BC034761.1 Y13583.1 

    2 DOTS entries:

    DT.92416997  DT.121199001 

    18 AceView cDNA sequences:

    BI759854 AI433867 NM_007264 BM919720 BC034761 AI379917 BI830122 BX114393 
    AI962628 BM091055 CD246170 AW135380 Y13583 BM091360 AA704594 AI243295 
    T90363 BP340154 

    Unigene Cluster for GPR182:

    G protein-coupled receptor 182
    Hs.483909  [show with all ESTs]
    Unigene Representative Sequence: BC034761


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000300098  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    GPR182 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for GPR182

    1 / 2

    4 probe-sets matching GPR182 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36429_at2 U95-A 1 1.00 1.00 1.00 1.00 -- -- -- -- --

    214506_at2 U133-A 1 0.46 1.00 -- -- -- -- -- -- --

    1552440_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    214506_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    GeneDecks  GPR182 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.483909

    UniProtKB/Swiss-Prot: GP182_HUMAN, O15218
    Tissue specificity: Highly expressed in heart, skeletal muscle, immune system, adrenal gland and
    liver

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for GPR182 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    GPR1821   -- G protein-coupled receptor 182 78.28(n)
    70.21(a)
    481120  XM_538241.1  XP_538241.1 
    cow
    (Bos taurus)
    GPR1821   -- G protein-coupled receptor 182 85.64(n)
    80.16(a)
    509554  XM_586542.3  XP_586542.2 
    rat
    (Rattus norvegicus)
    Gpr1821   -- G protein-coupled receptor 182 81.03(n)
    74.87(a)
    29307  NM_053302.2  NP_445754.2 
    mouse
    (Mus musculus)
    Gpr1821, 5 10 (72.00 cM)5
    G protein-coupled receptor 1821, 5 80.74(n)1
    74.09(a)1
    115361  NM_007412.21  NP_031438.21 
     AF0012295  AK0314805  (see all 12)
    zebrafish
    (Danio rerio)
    gpr1821   -- G protein-coupled receptor 182 53.03(n)
    41.79(a)
    323641  NM_001020478.1  NP_001018314.1 
    About this table        Species with no ortholog for GPR182

    ENSEMBL Gene Tree for GPR182
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for GPR182 gene
    GPR252  CXCR72  GPR152  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/16 NCBI SNPs in GPR182 are shown (see all 16 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 27)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs22793731,2
    F,H55674465(+) CACACC/TGGGTC 1 -- ng514Minor allele frequency- T:0.13EU EA WA 416
    --
    rs724434731,2
    --55673017(+) TGTGG-/GTTGTGT 1 -- ng510--------
    --
    rs679826071,2
    --55673051(+) ATATG-/ATATATATATATATATAT
    ATATATATATATATATACAT
    GGAAT
    1 -- ng510--------
    --
    rs674765351,2
    --55674377(+) CTGAGG/TCTGAG 1 -- ng510--------
    --
    rs733326811,2
    --55673094(+) ATGCAG/TGCTCC 1 -- ng510--------
    --
    rs731311201,2
    --55674253(+) ACATAC/TGTAAA 1 -- ng510--------
    --
    rs723237131,2
    --55673030(+) TGTGT-/TATATATATATA
    TATATATATATATA
    ATATA
    1 -- ng510--------
    --
    rs613032421,2
    --55673520(+) AGAGGG/TTGAAG 1 -- ng510--------
    --
    rs570593971,2
    --55672804(+) GTTTAA/CGAAAA 1 -- ng510--------
    --
    rs722772061,2
    --55673030(+) GTGTG-/TATATAT 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for GPR182 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605307

    8 Novoseek disease relationships for GPR182 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertension renal 48.89 2 9120666 (1), 8951571 (1)
    heart failure congestive 10.69 2 9120666 (1), 8951571 (1)
    sepsis 9.33 1 11997081 (1)
    tumors 3.77 3 9016306 (1), 17363587 (1), 15245870 (1)
    pulmonary disease chronic obstructive 1.26 5 14720432 (2), 12877796 (1)
    heart failure 0.00 1 12630824 (1)
    cardiovascular diseases 0.00 1 15273827 (1)
    renal failure 0.00 2 9120666 (1), 8951571 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/91 PubMed articles for GPR182 gene (see all 91 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 11318 HGNC: 13708 AceView: ADMR Ensembl:ENSG00000166856 euGenes: HUgn11318
    ECgene: GPR182 H-InvDB: GPR182
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for GPR182:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for GPR182-related products

     Millipore Custom Antibody & Bulk Services
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     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for GPR182 Antibodies for GPR182
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for GPR182 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search for Antibodies & Assays

     Recombinant Proteins
    (Adrenomedullin Receptor L1)
     Antibodies (Adrenomedullin Receptor L1)
     Search OriGene for GPR182
     Search Tocris compounds for GPR182




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for GPR182

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