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Aliases & Descriptions for GPR182
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 7TMR 2 | | ADMR 2, 3 | | AM-R 1, 2 | | AMR 2 | | G10D 1, 2 | | MGC34399 2 | | gamrh 2 | | hrhAMR 1, 2 |
| | | Descriptions |
|---|
| G protein-coupled receptor 182 2 | | adrenomedullin receptor 1, 2 |
|
| | Search outside databases for aliases for GPR182 gene |
Summaries for GPR182(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GPR182: Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq] UniProtKB/Swiss-Prot: GP182_HUMAN, O15218Function: Orphan receptorGene Wiki entry for GPR182 |
Genomic Location for GPR182
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3GPR182 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P055675:
(about GC identifiers)
Start:
|
55,674,497 bp from pter |
End:
|
55,676,736 bp from pter |
Size:
|
2,240 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for GPR182
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GP182_HUMAN, O15218 (See
protein sequence)Recommended Name: G-protein coupled receptor 182 Size: 404 amino acids; 45323 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: Was originally (PubMed:9367907) thought to be a receptor for adrenomedullinPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_009195.1
ENSEMBL proteins: ENSP00000300098
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for GPR182: Assays for GPR182: | Protein
Domains/ Families for GPR182(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O15218
ProtoNet protein and cluster: O15218 1 Blocks protein family: IPB001350 G10D orphan receptor signature
UniProtKB/Swiss-Prot: GP182_HUMAN, O15218Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for GPR182
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007264
Applied Biosystems Silencer® siRNAs for GPR182
Sigma-Aldrich siRNA and siRNA Panels for GPR182  Sigma-Aldrich shRNA Panels and shRNA for GPR182  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007264                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007264                                  untagged cDNA clone in CMV expression vector: NM_007264 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007264
UniProtKB/Swiss-Prot: GP182_HUMAN, O15218Function: Orphan receptor1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | About this table | Pathways & Interactions for GPR182
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/10 Interacting proteins for GPR182 (ENSP000003000983) via UniProtKB, MINT, and/or STRING (see all 10
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor protein signaling pathway |
IEA | -- | About this table
|
Drugs & Compounds for GPR182(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for GPR182 3 Novoseek chemical compound relationships for GPR182 gene
About this table
|
Transcripts for GPR182(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007264
Sigma-Aldrich siRNA and siRNA Panels for GPR182  Sigma-Aldrich shRNA Panels and shRNA for GPR182  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_007264 REFSEQ mRNAs for GPR182 gene: NM_007264.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007264               OriGene GFP tagged cDNA clone in CMV expression vector: NM_007264                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007264                                  untagged cDNA clone in CMV expression vector: NM_007264  Additional cDNA sequence: BC034761.1 Y13583.1 2 DOTS entries: DT.92416997 DT.121199001 18 AceView cDNA sequences:BI759854 AI433867 NM_007264 BM919720 BC034761 AI379917 BI830122 BX114393 AI962628 BM091055 CD246170 AW135380 Y13583 BM091360 AA704594 AI243295 T90363 BP340154 Unigene Cluster for GPR182: G protein-coupled receptor 182 Hs.483909 [show with all ESTs]Unigene Representative Sequence: BC034761
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000300098
|
Expression for GPR182
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GPR182 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GPR182
1 / 2 4 probe-sets matching GPR182 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.483909 UniProtKB/Swiss-Prot: GP182_HUMAN, O15218Tissue specificity: Highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver |
Orthologs for GPR182
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GPR182 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for GPR182
ENSEMBL Gene Tree for GPR182 | Paralogs for GPR182(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GPR182 gene
- GPR252 CXCR72 GPR152
|
SNPs/Variants for GPR182(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GPR182 (up to first 250kb)
|
Disorders & Mutations for GPR182
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605307
8 Novoseek disease relationships for GPR182 gene
About this table
|
Medical News for GPR182(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GPR182 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/91 PubMed articles for GPR182 gene (see all 91
):- Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response. (PubMed id 9535752)1, 2, 3, 4 Kennedy S.P....Hill R.J. (1998)
- Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system. (PubMed id 9367907)1, 2, 3, 4 Haenze J.... Rascher W. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Localization and distribution of adrenomedullin receptor in the human placenta: changes with gestational age. (PubMed id 17939601)1, 3 Marinoni E....Di Iorio R. (2007)
- [Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease] (PubMed id 14720432)1, 3 Xu P....Song W.D. (2003)
- Adrenomedullin receptor expression in human lung and in pulmonary tumors. (PubMed id 9016306)1, 3 Martinez A....Cuttitta F. (1997)
- The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review). (PubMed id 11956648)1, 3 Fowler D.E. and Wang P. (2002)
- Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia. (PubMed id 11883938)1, 3 Haenze J.... Fischer A. (2002)
- Receptors for adrenomedullin in human vascular endothelial cells. (PubMed id 7621913)1, 3 Kato J....Eto T. (1995)
- Expression of adrenomedullin and its receptor by chondrocyte phenotype cells. (PubMed id 12646214)3 Chosa E....Tajima N. (2003)
|
Search for GPR182
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GPR182
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GPR182
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPR182(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GPR182(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GPR182:

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Incremental update: 13 Oct 2009
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