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Aliases for GPR18 Gene

Aliases for GPR18 Gene

  • G Protein-Coupled Receptor 18 2 3 5
  • G-Protein Coupled Receptor 18 4
  • NAGly Receptor 4
  • GPCRW 4

External Ids for GPR18 Gene

Previous GeneCards Identifiers for GPR18 Gene

  • GC13M098266
  • GC13M094294
  • GC13M098743
  • GC13M097604
  • GC13M098704
  • GC13M099906
  • GC13M080501

Summaries for GPR18 Gene

GeneCards Summary for GPR18 Gene

GPR18 (G Protein-Coupled Receptor 18) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR55.

UniProtKB/Swiss-Prot for GPR18 Gene

  • Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system.

Gene Wiki entry for GPR18 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR18 Gene

Genomics for GPR18 Gene

Regulatory Elements for GPR18 Gene

Enhancers for GPR18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F099431 1.3 FANTOM5 Ensembl ENCODE 16.2 -172.1 -172108 6.5 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 GPR18 TM9SF2 LINC00449 MIR623 GPR183 CCR12P GC13P099473
GH13F099353 1.1 FANTOM5 Ensembl ENCODE 16 -95.6 -95645 9.0 HDGF TBP CBX3 PKNOX1 ATF1 SIN3A BMI1 FOS CREM JUNB UBAC2 GPR18 GPR183 DOCK9 CLYBL GC13P099358 HMGB3P4
GH13F099419 1.5 FANTOM5 Ensembl ENCODE 15.4 -160.7 -160722 7.5 HDGF ELF3 TBP PKNOX1 TBL1XR1 SIN3A YY1 EGR1 SCRT2 ZNF143 GPR18 MIR623 GPR183 TM9SF2 CCR12P GC13P099473
GH13F099378 1.2 FANTOM5 Ensembl ENCODE 15.4 -119.3 -119295 6.3 HDGF PKNOX1 WRNIP1 ZNF121 ETV6 CREM ZNF202 JUNB TBX21 ZNF781 UBAC2 GPR18 GPR183 MIR623 STK24-AS1 DOCK9 CLYBL GC13P099385 HMGB3P4
GH13F099332 0.6 Ensembl 15.2 -70.0 -69953 0.8 ZNF2 THRB ZNF121 GLIS2 CREM ZNF263 CBFB ZEB2 TBX21 GLIS1 GPR18 MIR623 GPR183 UBAC2 GC13M099261 GC13M099346
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR18 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR18 Gene

Chromosome:
13
Start:
99,254,713 bp from pter
End:
99,262,448 bp from pter
Size:
7,736 bases
Orientation:
Minus strand

Genomic View for GPR18 Gene

Genes around GPR18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR18 Gene

Proteins for GPR18 Gene

  • Protein details for GPR18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14330-GPR18_HUMAN
    Recommended name:
    N-arachidonyl glycine receptor
    Protein Accession:
    Q14330
    Secondary Accessions:
    • Q6GTM3
    • Q96HI6
    • Q9H2L2

    Protein attributes for GPR18 Gene

    Size:
    331 amino acids
    Molecular mass:
    38134 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG44671.1; Type=Frameshift; Positions=78, 81, 129; Evidence={ECO:0000305};

neXtProt entry for GPR18 Gene

Post-translational modifications for GPR18 Gene

  • Glycosylation at Asn 14
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR18 Gene

No data available for DME Specific Peptides for GPR18 Gene

Domains & Families for GPR18 Gene

Protein Domains for GPR18 Gene

Suggested Antigen Peptide Sequences for GPR18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14330

UniProtKB/Swiss-Prot:

GPR18_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR18: view

Function for GPR18 Gene

Molecular function for GPR18 Gene

GENATLAS Biochemistry:
G protein coupled receptor 18,abundantly expressed in testis and spleen
UniProtKB/Swiss-Prot Function:
Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system.

Gene Ontology (GO) - Molecular Function for GPR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity NAS,IBA 9205118
genes like me logo Genes that share ontologies with GPR18: view
genes like me logo Genes that share phenotypes with GPR18: view

Animal Models for GPR18 Gene

MGI Knock Outs for GPR18:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR18

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR18 Gene

Localization for GPR18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR18 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR18 Gene COMPARTMENTS Subcellular localization image for GPR18 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9205118
genes like me logo Genes that share ontologies with GPR18: view

Pathways & Interactions for GPR18 Gene

genes like me logo Genes that share pathways with GPR18: view

Pathways by source for GPR18 Gene

Gene Ontology (GO) - Biological Process for GPR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002300 CD8-positive, alpha-beta intraepithelial T cell differentiation IEA --
GO:0002305 CD8-positive, gamma-delta intraepithelial T cell differentiation IEA --
GO:0002689 negative regulation of leukocyte chemotaxis IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 9205118
genes like me logo Genes that share ontologies with GPR18: view

No data available for SIGNOR curated interactions for GPR18 Gene

Drugs & Compounds for GPR18 Gene

(9) Drugs for GPR18 Gene - From: DrugBank, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved, Vet_approved Nutra Full agonist, Agonist, Target 226
cannabidiol Approved, Investigational Pharma Partial agonist, Agonist 0
abnormal cannabidiol Pharma Agonist 0
AM251 Pharma Partial agonist, Agonist Potent CB1 antagonist, Potent CB1 antagonist; also GPR55 agonist 0
Anandamide Pharma Antagonist, Pore Blocker Endogenous CB receptor agonist 0

(2) Additional Compounds for GPR18 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
arachidonyl cyclopropylamide
Agonist
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist
genes like me logo Genes that share compounds with GPR18: view

Transcripts for GPR18 Gene

Unigene Clusters for GPR18 Gene

G protein-coupled receptor 18:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR18 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for GPR18 Gene

GeneLoc Exon Structure for
GPR18
ECgene alternative splicing isoforms for
GPR18

Expression for GPR18 Gene

mRNA expression in normal human tissues for GPR18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR18 Gene

This gene is overexpressed in Testis (x13.1), Whole Blood (x11.2), and Spleen (x9.5).

Protein differential expression in normal tissues from HIPED for GPR18 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR18 Gene



Protein tissue co-expression partners for GPR18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR18 Gene:

GPR18

SOURCE GeneReport for Unigene cluster for GPR18 Gene:

Hs.741589

mRNA Expression by UniProt/SwissProt for GPR18 Gene:

Q14330-GPR18_HUMAN
Tissue specificity: Most abundant in testis and spleen. Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells.
genes like me logo Genes that share expression patterns with GPR18: view

Primer Products

Orthologs for GPR18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR18 34 35
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia GPR18 34 35
  • 89.73 (n)
cow
(Bos Taurus)
Mammalia GPR18 34 35
  • 87.71 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR18 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr18 34
  • 83.69 (n)
mouse
(Mus musculus)
Mammalia Gpr18 34 16 35
  • 82.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPR18 34 35
  • 73.29 (n)
lizard
(Anolis carolinensis)
Reptilia GPR18 35
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gpr18 34 35
  • 65.84 (n)
Species where no ortholog for GPR18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR18 Gene

ENSEMBL:
Gene Tree for GPR18 (if available)
TreeFam:
Gene Tree for GPR18 (if available)

Paralogs for GPR18 Gene

Paralogs for GPR18 Gene

genes like me logo Genes that share paralogs with GPR18: view

Variants for GPR18 Gene

Sequence variations from dbSNP and Humsavar for GPR18 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1051577 -- 99,255,044(-) TGAAC(A/C)TCAGC intron-variant, reference, missense
rs10640542 -- 99,258,584(+) GCATC(-/ATCT)ATCTA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111340127 -- 99,256,205(+) TCACA(A/G)CAACT intron-variant
rs111654062 -- 99,264,183(+) GAGAC(A/G)GTAAG intron-variant, upstream-variant-2KB
rs111714850 -- 99,259,163(+) GCTGC(C/T)TGCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR18 Gene

Variant ID Type Subtype PubMed ID
nsv1050094 CNV gain 25217958
nsv523519 CNV loss 19592680

Variation tolerance for GPR18 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR18 Gene

Disorders for GPR18 Gene

Relevant External Links for GPR18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR18

No disorders were found for GPR18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR18 Gene

Publications for GPR18 Gene

  1. Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis. (PMID: 9205118) Gantz I. … Yamada T. (Genomics 1997) 2 3 4 64
  2. Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. (PMID: 16844083) Kohno M. … Yasukawa M. (Biochem. Biophys. Res. Commun. 2006) 3 4 64
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for GPR18 Gene

Sources for GPR18 Gene

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