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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR18 Gene

protein-coding   GIFtS: 54
GCID: GC13M099906

G Protein-Coupled Receptor 18

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor 181 2
NAGly Receptor2 3
N-Arachidonyl Glycine Receptor2
GPCRW3
G-Protein Coupled Receptor 183

External Ids:    HGNC: 44721   Entrez Gene: 28412   Ensembl: ENSG000001252457   OMIM: 6020425   UniProtKB: Q143303   

Export aliases for GPR18 gene to outside databases

Previous GC identifers: GC13M098266 GC13M094294 GC13M098743 GC13M097604 GC13M098704 GC13M080501


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GPR18 Gene: 
GPR18 (G protein-coupled receptor 18) is a protein-coding gene. Diseases associated with GPR18 include peritonitis, and bipolar disorder, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity and G-protein coupled receptor activity. An important paralog of this gene is GPR35.

UniProtKB/Swiss-Prot: GPR18_HUMAN, Q14330
Function: Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which
inhibit adenylyl cyclase. May contribute to regulation of the immune system

Gene Wiki entry for GPR18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR18 gene promoter:
         AhR   Elk-1   AML1a   p53   C/EBPalpha   Arnt   RORalpha1   PPAR-gamma1   SEF-1 (1)   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR18 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPR18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32   Ensembl cytogenetic band:  13q32.3   HGNC cytogenetic band: 13q32

GPR18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR18 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M099906:  view genomic region     (about GC identifiers)

Start:
99,906,967 bp from pter      End:
99,913,998 bp from pter
Size:
7,032 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPR18_HUMAN, Q14330 (See protein sequence)
Recommended Name: N-arachidonyl glycine receptor  
Size: 331 amino acids; 38134 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAG44671.1; Type=Frameshift; Positions=78, 81, 129;
Secondary accessions: Q6GTM3 Q96HI6 Q9H2L2

Explore the universe of human proteins at neXtProt for GPR18: NX_Q14330

Explore proteomics data for GPR18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14330

  • GPR18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPR18 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001091670.1  NP_005283.1  

    ENSEMBL proteins: 
     ENSP00000343428   ENSP00000401611   ENSP00000380613   ENSP00000380610  
    Reactome Protein details: Q14330
    Human Recombinant Protein Products for GPR18: 
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    Cloud-Clone Corp. Proteins for GPR18 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS9205118

    GPR18 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR18 
    GPR18, GPR55 and GPR119
    Class A Orphans

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002286 purinergic_P2Y_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q14330

    ProtoNet protein and cluster: Q14330

    UniProtKB/Swiss-Prot: GPR18_HUMAN, Q14330
    Similarity: Belongs to the G-protein coupled receptor 1 family


    GPR18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPR18_HUMAN, Q14330
    Function: Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which
    inhibit adenylyl cyclase. May contribute to regulation of the immune system

         Genatlas biochemistry entry for GPR18:
    G protein coupled receptor 18,abundantly expressed in testis and spleen

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity NAS9205118
    GO:0045028G-protein coupled purinergic nucleotide receptor activity ----
         
    GPR18 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPR18 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3GPCRs, Other
    GPCRs, Other

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GPR18
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like

    5/6        Reactome Pathways for GPR18 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events
    GPCR ligand binding



    GPR18 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/143 Interacting proteins for GPR18 (ENSP000003434284) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY7ENSP000002542354STRING: ENSP00000254235
    ANXA1ENSP000002574974STRING: ENSP00000257497
    CCL19ENSP000003088154STRING: ENSP00000308815
    CCL5ENSP000002932724STRING: ENSP00000293272
    CCR1ENSP000002961404STRING: ENSP00000296140
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway NAS9205118

    GPR18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPR18

    1 HMDB Compound for GPR18    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glycine2-Aminoacetate (see all 15)56-40-6--

    1 DrugBank Compound for GPR18    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--17139284 17016423

    8 IUPHAR Ligands for GPR18 (GPR18)    About this table 
    LigandTypeActionAffinityPubmed IDs
    N-arachidonoylglycine
    AgonistFull agonist7.35 - 7.721595653
    O-1602
    AgonistAgonist7.1921595653
    abnormal cannabidiol
    AgonistAgonist6.0821595653
    Δ9-tetrahydrocannabinol
    AgonistFull agonist6.0221595653 22014123
    anandamide
    AgonistFull agonist5.4221595653
    arachidonyl cyclopropylamide
    AgonistAgonist4.8721595653
    cannabidiol
    AgonistPartial agonist4.2921595653
    AM251
    AgonistPartial agonist4.0221595653

    Search CenterWatch for drugs/clinical trials and news about GPR18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPR18 gene (2 alternative transcripts): 
    NM_001098200.1  NM_005292.3  

    Unigene Cluster for GPR18:

    G protein-coupled receptor 18
    Hs.741589  [show with all ESTs]
    Unigene Representative Sequence: BC066927
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340807(uc010afv.3) ENST00000416594 ENST00000397473(uc001voe.4)
    ENST00000397470
    miRNA
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    Additional mRNA sequence: 

    AF261135.1 AF339781.1 BC008569.1 BC050646.1 BC066927.1 BT009907.1 JQ308176.1 

    4 DOTS entries:

    DT.40117945  DT.95157497  DT.86857234  DT.75119902 

    24/34 AceView cDNA sequences (see all 34):

    BC050646 BC066927 NM_005292 BX102267 BF794361 AW574811 BC008569 BI828900 
    AA258898 AF339781 CN835171 AA258793 AW968257 BI770379 BT009907 BU182977 
    AA705077 AW406896 AA748438 AI208357 AW574862 BG501756 AF261135 AW403055 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GPR18    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for GPR18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPR18 expression in normal human tissues (normalized intensities)      GPR18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCAGAAAAA
    GPR18 Expression
    About this image


    GPR18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             LYMPH NODE   

    See GPR18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPR18

    SOURCE GeneReport for Unigene cluster: Hs.741589

    UniProtKB/Swiss-Prot: GPR18_HUMAN, Q14330
    Tissue specificity: Most abundant in testis and spleen. Highly expressed in CD4 and CD8-positive T-cells as well
    as CD19-positive B-cells

        SABiosciences Expression via Pathway-Focused PCR Array including GPR18: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GPR18 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr181 , 5 G protein-coupled receptor 181, 5 82.68(n)1
    85.8(a)1
      14 (65.86 cM)5
    1101681  NM_182806.11  NP_877958.11 
     1219114355 
    chicken
    (Gallus gallus)
    Aves LOC1008582631 N-arachidonyl glycine receptor-like 73.78(n)
    74.52(a)
      100858263  XM_003640541.1  XP_003640589.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR186
    Uncharacterized protein
    74(a)
    1 ↔ 1
    3(98774842-98775831)
    zebrafish
    (Danio rerio)
    Actinopterygii gpr181 G protein-coupled receptor 18 65.84(n)
    63.66(a)
      556711  XM_679580.4  XP_684672.4 


    ENSEMBL Gene Tree for GPR18 (if available)
    TreeFam Gene Tree for GPR18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPR18 gene
    GPR352  GPR552  
    18/35 SIMAP similar genes for GPR18 using alignment to 2 protein entries:     GPR18_HUMAN (see all proteins) (see all similar genes):
    F2RL1    AGTR1    F2RL2    OPRK1    GPR1    P2RY6
    C3AR1    CCR5    CX3CR1    CCR7    P2RY14    CCR2
    C5AR1    GALR1    CCRL1    FPR1    OPRM1    RXFP3

    GPR18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GPR18:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523519CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602042    OMIM disorders: --

    4 diseases for GPR18:    About MalaCards
    peritonitis    bipolar disorder    schizophrenia    melanoma


    GPR18 for disorders           About GeneDecksing


    Export disorders for GPR18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPR18 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with GPR18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis. (PubMed id 9205118)1, 2, 3 Gantz I.... Yamada T. (1997)
    2. Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. (PubMed id 16844083)1, 2 Kohno M....Yasukawa M. (2006)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    6. Quantitative expression profiling of G-protein-couple d receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GP CR GPR18 as novel drug target. (PubMed id 20880198)1 Qin Y....Osanto S. (2011)
    7. EBI2, GPR18 and GPR17--three structurally related, bu t biologically distinct 7TM receptors. (PubMed id 21261596)1 NA...Rosenkilde M.M. (2011)
    8. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (2008)
    9. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2841 HGNC: 4472 AceView: GPR18 Ensembl:ENSG00000125245 euGenes: HUgn2841
    ECgene: GPR18 H-InvDB: GPR18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPR18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPR18 gene:
    Search GeneIP for patents involving GPR18

    GeneCards and IP:
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