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Aliases for GPR18 Gene

Aliases for GPR18 Gene

  • G Protein-Coupled Receptor 18 2 3 5
  • G-Protein Coupled Receptor 18 4
  • NAGly Receptor 4
  • GPCRW 4

External Ids for GPR18 Gene

Previous GeneCards Identifiers for GPR18 Gene

  • GC13M098266
  • GC13M094294
  • GC13M098743
  • GC13M097604
  • GC13M098704
  • GC13M099906
  • GC13M080501

Summaries for GPR18 Gene

GeneCards Summary for GPR18 Gene

GPR18 (G Protein-Coupled Receptor 18) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR20.

UniProtKB/Swiss-Prot for GPR18 Gene

  • Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system.

Gene Wiki entry for GPR18 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR18 Gene

Genomics for GPR18 Gene

Regulatory Elements for GPR18 Gene

Genomic Location for GPR18 Gene

99,254,713 bp from pter
99,262,448 bp from pter
7,736 bases
Minus strand

Genomic View for GPR18 Gene

Genes around GPR18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR18 Gene

Proteins for GPR18 Gene

  • Protein details for GPR18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-arachidonyl glycine receptor
    Protein Accession:
    Secondary Accessions:
    • Q6GTM3
    • Q96HI6
    • Q9H2L2

    Protein attributes for GPR18 Gene

    331 amino acids
    Molecular mass:
    38134 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG44671.1; Type=Frameshift; Positions=78, 81, 129; Evidence={ECO:0000305};

neXtProt entry for GPR18 Gene

Proteomics data for GPR18 Gene at MOPED

Post-translational modifications for GPR18 Gene

  • Glycosylation at Asn 14
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR18 Gene

Antibody Products

No data available for DME Specific Peptides for GPR18 Gene

Domains & Families for GPR18 Gene

Protein Domains for GPR18 Gene

Suggested Antigen Peptide Sequences for GPR18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR18: view

Function for GPR18 Gene

Molecular function for GPR18 Gene

GENATLAS Biochemistry:
G protein coupled receptor 18,abundantly expressed in testis and spleen
UniProtKB/Swiss-Prot Function:
Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system.

Phenotypes for GPR18 Gene

genes like me logo Genes that share phenotypes with GPR18: view

Animal Models for GPR18 Gene

MGI Knock Outs for GPR18:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR18

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR18 Gene

Localization for GPR18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR18 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR18 Gene COMPARTMENTS Subcellular localization image for GPR18 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GPR18: view

Pathways & Interactions for GPR18 Gene

genes like me logo Genes that share pathways with GPR18: view

Pathways by source for GPR18 Gene

Interacting Proteins for GPR18 Gene

Gene Ontology (GO) - Biological Process for GPR18 Gene


No data available for SIGNOR curated interactions for GPR18 Gene

Drugs & Compounds for GPR18 Gene

(9) Drugs for GPR18 Gene - From: IUPHAR, DGIdb, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved Nutra Full agonist, Agonist, Target Endogenous potentiator, co-transmitter 94
abnormal cannabidiol Pharma Agonist 0
AM251 Pharma Partial agonist, Agonist Potent CB1 antagonist, Potent CB1 antagonist; also GPR55 agonist 0
Anandamide Pharma Antagonist, Pore Blocker 0
cannabidiol Pharma Partial agonist, Agonist 0

(2) Additional Compounds for GPR18 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
arachidonyl cyclopropylamide
Partial agonist, Agonist
genes like me logo Genes that share compounds with GPR18: view

Transcripts for GPR18 Gene

Unigene Clusters for GPR18 Gene

G protein-coupled receptor 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR18 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for GPR18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR18 Gene

mRNA expression in normal human tissues for GPR18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR18 Gene

This gene is overexpressed in Testis (x13.1), Whole Blood (x11.2), and Spleen (x9.5).

Protein differential expression in normal tissues from HIPED for GPR18 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR18 Gene

SOURCE GeneReport for Unigene cluster for GPR18 Gene Hs.741589

mRNA Expression by UniProt/SwissProt for GPR18 Gene

Tissue specificity: Most abundant in testis and spleen. Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells.
genes like me logo Genes that share expression patterns with GPR18: view

Protein tissue co-expression partners for GPR18 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for GPR18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR18 35
  • 87.71 (n)
  • 89.12 (a)
GPR18 36
  • 87 (a)
(Canis familiaris)
Mammalia GPR18 35
  • 89.73 (n)
  • 90.03 (a)
GPR18 36
  • 89 (a)
(Mus musculus)
Mammalia Gpr18 35
  • 82.68 (n)
  • 85.8 (a)
Gpr18 16
Gpr18 36
  • 85 (a)
(Pan troglodytes)
Mammalia GPR18 35
  • 99.9 (n)
  • 100 (a)
GPR18 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr18 35
  • 83.69 (n)
  • 85.63 (a)
(Monodelphis domestica)
Mammalia GPR18 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
-- 36
  • 66 (a)
(Gallus gallus)
Aves GPR18 35
  • 73.29 (n)
  • 73.82 (a)
GPR18 36
  • 70 (a)
(Anolis carolinensis)
Reptilia GPR18 36
  • 74 (a)
(Danio rerio)
Actinopterygii gpr18 35
  • 65.84 (n)
  • 63.66 (a)
gpr18 36
  • 62 (a)
Species with no ortholog for GPR18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR18 Gene

Gene Tree for GPR18 (if available)
Gene Tree for GPR18 (if available)

Paralogs for GPR18 Gene

Paralogs for GPR18 Gene

genes like me logo Genes that share paralogs with GPR18: view

Variants for GPR18 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR18 Gene

Variant ID Type Subtype PubMed ID
nsv523519 CNV Loss 19592680

Variation tolerance for GPR18 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GPR18 Gene

Disorders for GPR18 Gene

Relevant External Links for GPR18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR18 Gene

Publications for GPR18 Gene

  1. Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis. (PMID: 9205118) Gantz I. … Yamada T. (Genomics 1997) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Activation of GPR18 by cannabinoid compounds: a tale of biased agonism. (PMID: 24762058) Console-Bram L. … Abood M.E. (Br. J. Pharmacol. 2014) 3

Products for GPR18 Gene

Sources for GPR18 Gene

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