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Aliases for GPR18 Gene

Aliases for GPR18 Gene

  • G Protein-Coupled Receptor 18 2 3
  • G-Protein Coupled Receptor 18 4
  • NAGly Receptor 4
  • GPCRW 4

External Ids for GPR18 Gene

Previous GeneCards Identifiers for GPR18 Gene

  • GC13M098266
  • GC13M094294
  • GC13M098743
  • GC13M097604
  • GC13M098704
  • GC13M099906
  • GC13M080501

Summaries for GPR18 Gene

GeneCards Summary for GPR18 Gene

GPR18 (G Protein-Coupled Receptor 18) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR35.

UniProtKB/Swiss-Prot for GPR18 Gene

  • Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system.

Gene Wiki entry for GPR18 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR18 Gene

Genomics for GPR18 Gene

Regulatory Elements for GPR18 Gene

Genomic Location for GPR18 Gene

99,254,713 bp from pter
99,261,895 bp from pter
7,183 bases
Minus strand

Genomic View for GPR18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR18 Gene

Proteins for GPR18 Gene

  • Protein details for GPR18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-arachidonyl glycine receptor
    Protein Accession:
    Secondary Accessions:
    • Q6GTM3
    • Q96HI6
    • Q9H2L2

    Protein attributes for GPR18 Gene

    331 amino acids
    Molecular mass:
    38134 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG44671.1; Type=Frameshift; Positions=78, 81, 129; Evidence={ECO:0000305};

neXtProt entry for GPR18 Gene

Proteomics data for GPR18 Gene at MOPED

Post-translational modifications for GPR18 Gene

  • Glycosylation at Asn14
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR18 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR18 Gene

Domains for GPR18 Gene

Gene Families for GPR18 Gene

  • GPCRAO :GPCR / Class A : Orphans

Protein Domains for GPR18 Gene

Suggested Antigen Peptide Sequences for GPR18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q14330
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR18: view

Function for GPR18 Gene

Molecular function for GPR18 Gene

GENATLAS Biochemistry: G protein coupled receptor 18,abundantly expressed in testis and spleen
UniProtKB/Swiss-Prot Function: Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system.

Gene Ontology (GO) - Molecular Function for GPR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity NAS 9205118
genes like me logo Genes that share ontologies with GPR18: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GPR18 Gene

Localization for GPR18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR18 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR18 Gene COMPARTMENTS Subcellular localization image for GPR18 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 9205118
genes like me logo Genes that share ontologies with GPR18: view

Pathways for GPR18 Gene

genes like me logo Genes that share pathways with GPR18: view

Pathways by source for GPR18 Gene

Interacting Proteins for GPR18 Gene

Gene Ontology (GO) - Biological Process for GPR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway NAS 9205118
genes like me logo Genes that share ontologies with GPR18: view

Compounds for GPR18 Gene

(1) HMDB Compounds for GPR18 Gene

Compound Synonyms Cas Number PubMed IDs
  • 2-Aminoacetate

(1) Drugbank Compounds for GPR18 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • 2-Aminoacetic acid
56-40-6 target

(8) IUPHAR Ligand for GPR18 Gene

Ligand Type Action Affinity Pubmed IDs
N-arachidonoylglycine Agonist Full agonist 7.7
O-1602 Agonist Agonist 7.19
abnormal cannabidiol Agonist Agonist 6.08
arachidonyl cyclopropylamide Agonist Agonist 4.87
AM251 Agonist Partial agonist 4.02
Delta9-tetrahydrocannabinol Channel blocker None
anandamide Channel blocker None
cannabidiol Channel blocker None
genes like me logo Genes that share compounds with GPR18: view

Transcripts for GPR18 Gene

Unigene Clusters for GPR18 Gene

G protein-coupled receptor 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR18 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for GPR18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR18 Gene

mRNA expression in normal human tissues for GPR18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR18 Gene

This gene is overexpressed in Testis (13.1), Whole Blood (11.2), and Spleen (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPR18 Gene

SOURCE GeneReport for Unigene cluster for GPR18 Gene Hs.741589

mRNA Expression by UniProt/SwissProt for GPR18 Gene

Tissue specificity: Most abundant in testis and spleen. Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells.
genes like me logo Genes that share expressions with GPR18: view

Orthologs for GPR18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR18 35
  • 99.9 (n)
  • 100 (a)
GPR18 36
  • 100 (a)
(Bos Taurus)
Mammalia GPR18 35
  • 87.71 (n)
  • 89.12 (a)
GPR18 36
  • 87 (a)
(Canis familiaris)
Mammalia GPR18 35
  • 89.73 (n)
  • 90.03 (a)
GPR18 36
  • 89 (a)
(Mus musculus)
Mammalia Gpr18 35
  • 82.68 (n)
  • 85.8 (a)
Gpr18 16
Gpr18 36
  • 85 (a)
(Monodelphis domestica)
Mammalia GPR18 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
-- 36
  • 66 (a)
(Rattus norvegicus)
Mammalia Gpr18 35
  • 83.69 (n)
  • 85.63 (a)
(Gallus gallus)
Aves GPR18 35
  • 73.29 (n)
  • 73.82 (a)
GPR18 36
  • 70 (a)
(Anolis carolinensis)
Reptilia GPR18 36
  • 74 (a)
(Danio rerio)
Actinopterygii gpr18 35
  • 65.84 (n)
  • 63.66 (a)
gpr18 36
  • 62 (a)
Species with no ortholog for GPR18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR18 Gene

Gene Tree for GPR18 (if available)
Gene Tree for GPR18 (if available)

Paralogs for GPR18 Gene

Paralogs for GPR18 Gene

genes like me logo Genes that share paralogs with GPR18: view

Variants for GPR18 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR18 Gene

Variant ID Type Subtype PubMed ID
nsv523519 CNV Loss 19592680

Relevant External Links for GPR18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GPR18 Gene

Disorders for GPR18 Gene

No disorders were found for GPR18 Gene.

No data available for UniProtKB/Swiss-Prot for GPR18 Gene

Publications for GPR18 Gene

  1. Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis. (PMID: 9205118) Gantz I. … Yamada T. (Genomics 1997) 2 3 4
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. (PMID: 16844083) Kohno M. … Yasukawa M. (Biochem. Biophys. Res. Commun. 2006) 3 4
  5. Dissociation of heterotrimeric g proteins in cells. (PMID: 18577758) Lambert N.A. (Sci Signal 2008) 3

Products for GPR18 Gene

Sources for GPR18 Gene

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