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Aliases for GPR176 Gene

Aliases for GPR176 Gene

  • G Protein-Coupled Receptor 176 2 3 5
  • HB-954 3 4
  • Probable G-Protein Coupled Receptor 176 3

External Ids for GPR176 Gene

Previous GeneCards Identifiers for GPR176 Gene

  • GC15M037881
  • GC15M040091
  • GC15M016936

Summaries for GPR176 Gene

Entrez Gene Summary for GPR176 Gene

  • Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]

GeneCards Summary for GPR176 Gene

GPR176 (G Protein-Coupled Receptor 176) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is ENSG00000283382.

UniProtKB/Swiss-Prot for GPR176 Gene

  • Orphan receptor.

Gene Wiki entry for GPR176 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR176 Gene

Genomics for GPR176 Gene

Regulatory Elements for GPR176 Gene

Enhancers for GPR176 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F039884 1.4 FANTOM5 Ensembl ENCODE 19.5 +33.4 33375 6.9 ELF3 ARID4B RAD21 GATA2 SCRT2 THAP11 ZNF654 SP5 CBFB CEBPB GPR176 EIF2AK4 LOC100505534 ENSG00000200305 FSIP1 GC15P039911 ENSG00000283382
GH15F039786 1.3 Ensembl ENCODE 10.2 +133.4 133372 3.0 ATF1 CREB3L1 ZFP64 ARID4B ZNF766 GATA2 FOS JUNB NCOA1 MIER2 EIF2AK4 ENSG00000200305 GPR176 LOC100505534 FSIP1 ENSG00000259580
GH15F039906 1.2 FANTOM5 Ensembl ENCODE 9.6 +12.7 12676 2.6 SOX13 HLF JUN BHLHE40 CEBPB MAX USF2 ZNF121 RAD51 JUND EIF2AK4 FSIP1 GPR176 GC15P039911 ENSG00000283382
GH15F039877 1.1 Ensembl ENCODE 10.4 +42.5 42468 2.6 BACH1 IRF9 GTF3C2 ZNF316 NCOR1 POLR3A RCOR1 FOS NFE2 TRIM24 DNAJC17 ENSG00000259211 BAHD1 FSIP1 EIF2AK4 BMF ENSG00000200305 GPR176 LOC100505534 GC15P039911
GH15F040002 0.9 ENCODE 10.6 -81.5 -81523 0.2 ELF3 TBP ATF1 MLX ARID4B DMAP1 ZSCAN9 RAD21 RARA YY1 SRP14 SRP14-AS1 ENSG00000200305 GPR176 LOC100505534 EIF2AK4 BMF GC15P039976
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR176 on UCSC Golden Path with GeneCards custom track

Promoters for GPR176 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000406513 992 3401 ATF1 CREB3L1 SIN3A ZNF48 ZNF2 YY1 GLIS2 CBX5 ELK1 FOS

Genomic Location for GPR176 Gene

39,799,022 bp from pter
39,920,892 bp from pter
121,871 bases
Minus strand

Genomic View for GPR176 Gene

Genes around GPR176 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR176 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR176 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR176 Gene

Proteins for GPR176 Gene

  • Protein details for GPR176 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 176
    Protein Accession:
    Secondary Accessions:
    • Q6NXF6

    Protein attributes for GPR176 Gene

    515 amino acids
    Molecular mass:
    56998 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR176 Gene

Post-translational modifications for GPR176 Gene

  • Glycosylation at Asn 4, Asn 11, Asn 17, and Asn 27
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR176 Gene

Domains & Families for GPR176 Gene

Gene Families for GPR176 Gene

Protein Domains for GPR176 Gene

Suggested Antigen Peptide Sequences for GPR176 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR176: view

Function for GPR176 Gene

Molecular function for GPR176 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR176 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with GPR176: view
genes like me logo Genes that share phenotypes with GPR176: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR176

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR176 Gene

Localization for GPR176 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR176 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR176 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GPR176 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7893747
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR176: view

Pathways & Interactions for GPR176 Gene

genes like me logo Genes that share pathways with GPR176: view

Pathways by source for GPR176 Gene

1 BioSystems pathway for GPR176 Gene

Interacting Proteins for GPR176 Gene

Gene Ontology (GO) - Biological Process for GPR176 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0007268 chemical synaptic transmission TAS 7893747
genes like me logo Genes that share ontologies with GPR176: view

No data available for SIGNOR curated interactions for GPR176 Gene

Transcripts for GPR176 Gene

Unigene Clusters for GPR176 Gene

G protein-coupled receptor 176:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR176 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d
SP1: - - - - - -
SP2: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - -

Relevant External Links for GPR176 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR176 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR176 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR176 Gene

This gene is overexpressed in Artery - Aorta (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of GPR176 Gene:


SOURCE GeneReport for Unigene cluster for GPR176 Gene:

genes like me logo Genes that share expression patterns with GPR176: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GPR176 Gene

Orthologs for GPR176 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR176 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR176 34 35
  • 99.29 (n)
(Canis familiaris)
Mammalia GPR176 34 35
  • 91.72 (n)
(Bos Taurus)
Mammalia GPR176 34 35
  • 90.87 (n)
(Rattus norvegicus)
Mammalia Gpr176 34
  • 87.59 (n)
(Mus musculus)
Mammalia Gpr176 34 16 35
  • 87.16 (n)
(Ornithorhynchus anatinus)
Mammalia GPR176 35
  • 81 (a)
(Monodelphis domestica)
Mammalia GPR176 35
  • 76 (a)
(Gallus gallus)
Aves GPR176 34 35
  • 73.4 (n)
(Anolis carolinensis)
Reptilia GPR176 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr176 34
  • 70.1 (n)
(Danio rerio)
Actinopterygii gpr176 34 35
  • 65.03 (n)
Species where no ortholog for GPR176 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR176 Gene

Gene Tree for GPR176 (if available)
Gene Tree for GPR176 (if available)

Paralogs for GPR176 Gene

Paralogs for GPR176 Gene

(2) SIMAP similar genes for GPR176 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR176: view

Variants for GPR176 Gene

Sequence variations from dbSNP and Humsavar for GPR176 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152851 -- 39,831,889(+) cttat(C/T)actct intron-variant
rs10162972 -- 39,903,397(+) CATTC(C/G)TGGGT intron-variant
rs10220849 -- 39,912,288(+) ACAAT(C/T)TTCCA intron-variant
rs1048205 -- 39,799,371(-) GCCTT(C/T)TGGGC utr-variant-3-prime
rs1048206 -- 39,799,232(-) TGTCC(A/C)CTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR176 Gene

Variant ID Type Subtype PubMed ID
nsv471961 CNV novel sequence insertion 20440878
nsv832978 CNV gain 17160897
nsv832979 CNV gain+loss 17160897
nsv832983 CNV gain 17160897
esv3581639 CNV loss 25503493
esv3569465 CNV gain 25503493
esv3333387 CNV insertion 20981092
esv1572077 CNV insertion 17803354

Variation tolerance for GPR176 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR176 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR176 Gene

Disorders for GPR176 Gene

Relevant External Links for GPR176

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR176 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR176 Gene

Publications for GPR176 Gene

  1. cDNA cloning of a putative G protein-coupled receptor from brain. (PMID: 7893747) Hata S. … Osumi T. (Biochim. Biophys. Acta 1995) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 46 64

Products for GPR176 Gene

Sources for GPR176 Gene

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