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Aliases for GPR176 Gene

Aliases for GPR176 Gene

  • G Protein-Coupled Receptor 176 2 3 5
  • HB-954 3 4

External Ids for GPR176 Gene

Previous GeneCards Identifiers for GPR176 Gene

  • GC15M037881
  • GC15M040091
  • GC15M016936

Summaries for GPR176 Gene

Entrez Gene Summary for GPR176 Gene

  • Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]

GeneCards Summary for GPR176 Gene

GPR176 (G Protein-Coupled Receptor 176) is a Protein Coding gene. Diseases associated with GPR176 include Waterhouse-Friderichsen Syndrome. Among its related pathways are Signaling by GPCR and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR161.

UniProtKB/Swiss-Prot for GPR176 Gene

  • Orphan receptor.

Gene Wiki entry for GPR176 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR176 Gene

Genomics for GPR176 Gene

Regulatory Elements for GPR176 Gene

Enhancers for GPR176 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR176 on UCSC Golden Path with GeneCards custom track

Promoters for GPR176 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR176 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR176 Gene

39,799,022 bp from pter
39,920,892 bp from pter
121,871 bases
Minus strand

Genomic View for GPR176 Gene

Genes around GPR176 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR176 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR176 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR176 Gene

Proteins for GPR176 Gene

  • Protein details for GPR176 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 176
    Protein Accession:
    Secondary Accessions:
    • Q6NXF6

    Protein attributes for GPR176 Gene

    515 amino acids
    Molecular mass:
    56998 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR176 Gene

Proteomics data for GPR176 Gene at MOPED

Post-translational modifications for GPR176 Gene

  • Glycosylation at Asn 4, Asn 11, Asn 17, and Asn 27
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR176 Gene

No data available for DME Specific Peptides for GPR176 Gene

Domains & Families for GPR176 Gene

Gene Families for GPR176 Gene

Protein Domains for GPR176 Gene


Suggested Antigen Peptide Sequences for GPR176 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR176: view

Function for GPR176 Gene

Molecular function for GPR176 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
genes like me logo Genes that share phenotypes with GPR176: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR176

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR176 Gene

Localization for GPR176 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR176 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR176 Gene COMPARTMENTS Subcellular localization image for GPR176 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR176 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GPR176: view

Pathways & Interactions for GPR176 Gene

genes like me logo Genes that share pathways with GPR176: view

Pathways by source for GPR176 Gene

1 BioSystems pathway for GPR176 Gene

Interacting Proteins for GPR176 Gene

Gene Ontology (GO) - Biological Process for GPR176 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR176: view

No data available for SIGNOR curated interactions for GPR176 Gene

Drugs & Compounds for GPR176 Gene

No Compound Related Data Available

Transcripts for GPR176 Gene

Unigene Clusters for GPR176 Gene

G protein-coupled receptor 176:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR176 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d
SP1: - - - - - -
SP2: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - -

Relevant External Links for GPR176 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR176 Gene

mRNA expression in normal human tissues for GPR176 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR176 Gene

This gene is overexpressed in Artery - Aorta (x4.0).

SOURCE GeneReport for Unigene cluster for GPR176 Gene Hs.37196

genes like me logo Genes that share expression patterns with GPR176: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR176 Gene

Orthologs for GPR176 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR176 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR176 35
  • 90.87 (n)
  • 92.62 (a)
GPR176 36
  • 93 (a)
(Canis familiaris)
Mammalia GPR176 35
  • 91.72 (n)
  • 92.82 (a)
GPR176 36
  • 93 (a)
(Mus musculus)
Mammalia Gpr176 35
  • 87.16 (n)
  • 90.47 (a)
Gpr176 16
Gpr176 36
  • 89 (a)
(Pan troglodytes)
Mammalia GPR176 35
  • 99.29 (n)
  • 99.61 (a)
GPR176 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr176 35
  • 87.59 (n)
  • 90.45 (a)
(Monodelphis domestica)
Mammalia GPR176 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia GPR176 36
  • 81 (a)
(Gallus gallus)
Aves GPR176 35
  • 73.4 (n)
  • 77.84 (a)
GPR176 36
  • 78 (a)
(Anolis carolinensis)
Reptilia GPR176 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr176 35
  • 70.1 (n)
  • 74.65 (a)
(Danio rerio)
Actinopterygii gpr176 35
  • 65.03 (n)
  • 68.65 (a)
gpr176 36
  • 59 (a)
Species with no ortholog for GPR176:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR176 Gene

Gene Tree for GPR176 (if available)
Gene Tree for GPR176 (if available)

Paralogs for GPR176 Gene

Paralogs for GPR176 Gene

(2) SIMAP similar genes for GPR176 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR176: view

Variants for GPR176 Gene

Sequence variations from dbSNP and Humsavar for GPR176 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs166701 -- 39,863,095(-) cagag(C/T)gagac intron-variant, upstream-variant-2KB
rs166702 -- 39,861,733(-) TCTCT(C/T)TGATG intron-variant
rs166703 -- 39,861,085(-) TTGTT(A/G)ACTCT intron-variant
rs166704 -- 39,843,135(-) CATAC(C/T)ATGTC intron-variant
rs169328 -- 39,858,100(-) GATTT(C/G)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR176 Gene

Variant ID Type Subtype PubMed ID
nsv832978 CNV Gain 17160897
nsv832979 CNV Gain+Loss 17160897
nsv832983 CNV Gain 17160897
esv1572077 CNV Insertion 17803354

Variation tolerance for GPR176 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR176 Gene

Disorders for GPR176 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR176 Gene - From: DISEASES

Disorder Aliases PubMed IDs
waterhouse-friderichsen syndrome
  • wolfram syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPR176

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR176: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR176 Gene

Publications for GPR176 Gene

  1. cDNA cloning of a putative G protein-coupled receptor from brain. (PMID: 7893747) Hata S. … Osumi T. (Biochim. Biophys. Acta 1995) 2 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for GPR176 Gene

Sources for GPR176 Gene