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GPR174 Gene

protein-coding   GIFtS: 50
GCID: GC0XP078426

G Protein-Coupled Receptor 174

  Search for GPR174
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 1741 2
GPCR172 5
Probable G-Protein Coupled Receptor 1742

External Ids:    HGNC: 302451   Entrez Gene: 846362   Ensembl: ENSG000001471387   OMIM: 3009035   UniProtKB: Q9BXC13   

Export aliases for GPR174 gene to outside databases

Previous GC identifers: GC0XP078232 GC0XP078313 GC0XP072005


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPR174 Gene:
This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are
characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with
various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances.
This family member is classified as an orphan receptor because the cognate ligand has not been identified.
(provided by RefSeq, Sep 2011)

GeneCards Summary for GPR174 Gene:
GPR174 (G protein-coupled receptor 174) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot: GP174_HUMAN, Q9BXC1
Function: Putative receptor for purines coupled to G-proteins (By similarity)

Gene Wiki entry for GPR174 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR174 gene promoter:
         Brachyury   FOXO3   FOXD3   CUTL1   FOXL1   FOXO3b   HFH-1   HSF2   FOXO3a   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR174 promoter sequence
   Search Chromatin IP Primers for GPR174

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR174


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.1   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq13.3

GPR174 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR174 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP078426:  view genomic region     (about GC identifiers)

Start:
78,426,469 bp from pter      End:
78,427,726 bp from pter
Size:
1,258 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GP174_HUMAN, Q9BXC1 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 174  
Size: 333 amino acids; 38503 Da
Secondary accessions: Q2M3F7

Explore the universe of human proteins at neXtProt for GPR174: NX_Q9BXC1

Explore proteomics data for GPR174 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys317
  • Glycosylation2 at Asn4, Asn164
  • Modification sites at PhosphoSitePlus

  • See GPR174 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115942.1  
    ENSEMBL proteins: 
     ENSP00000276077  

    GPR174 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR174
    Class A Orphans

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9BXC1

    ProtoNet protein and cluster: Q9BXC1

    UniProtKB/Swiss-Prot: GP174_HUMAN, Q9BXC1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GPR174           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GP174_HUMAN, Q9BXC1
    Function: Putative receptor for purines coupled to G-proteins (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    Find genes that share ontologies with GPR174           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR174:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR174
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPR174
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    Predesigned siRNA for gene silencing in human, mouse, rat GPR174

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GP174_HUMAN, Q9BXC1: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GPR174           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPR174 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    1 BioSystems Pathway for GPR174
        GPCRs, Class A Rhodopsin-like


        Pathway & Disease-focused RT2 Profiler PCR Array including GPR174: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPR174

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with GPR174           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR174 (GP174)

    1 IUPHAR Ligand for GPR174 (GPR174)    About this table
    LigandTypeActionAffinityPubmed IDs
    lysophosphatidylserine
    AgonistFull agonist7.122983457



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPR174 gene: 
    NM_032553.1  

    Unigene Cluster for GPR174:

    G protein-coupled receptor 174
    Hs.326713  [show with all ESTs]
    Unigene Representative Sequence: NM_032553
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000276077(uc004edg.1)
    miRNA
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    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for GPR174
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPR174
      QuantiTect SYBR Green Assays in human, mouse, rat GPR174
      QuantiFast Probe-based Assays in human, mouse, rat GPR174

    Additional mRNA sequence: 

    AF345567.1 BC104922.1 BC104924.1 

    1 DOTS entry:

    DT.40241778 

    4 AceView cDNA sequences:

    AA654419 AF345567 NM_032553 BU429041 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR174 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTAATTTT
    GPR174 Expression
    About this image


    GPR174 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
    GPR174 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR174 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.326713
        Pathway & Disease-focused RT2 Profiler PCR Array including GPR174: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR174

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPR174 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr1741 , 5 G protein-coupled receptor 1741, 5 86.99(n)1
    88.29(a)1
      X (47.48 cM)5
    2134391  NM_001033251.41  NP_001028423.11 
     1072558785 
    chicken
    (Gallus gallus)
    Aves GPR1741 G protein-coupled receptor 174 67.53(n)
    70.23(a)
      422146  NM_001008464.1  NP_001008464.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR1746
    G protein-coupled receptor 174
    67(a)
    1 ↔ 1
    GL343528.1(217881-218900)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gpr1741 G protein-coupled receptor 174 66.99(n)
    69.06(a)
      100494350  XM_002940433.2  XP_002940479.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001513311 probable G-protein coupled receptor 174-like 59.19(n)
    56.09(a)
      100151331  XM_005157173.1  XP_005157230.1 


    ENSEMBL Gene Tree for GPR174 (if available)
    TreeFam Gene Tree for GPR174 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPR174 gene
    OXGR12  P2RY42  GPR172  P2RY12  P2RY62  LPAR62  LPAR52  CYSLTR12  
    GPR1832  LPAR42  CYSLTR22  P2RY22  SUCNR12  P2RY102  PTAFR2  
    15 SIMAP similar genes for GPR174 using alignment to 1 protein entry:     GP174_HUMAN:
    P2RY10    LPAR6    F2RL1    LPAR4    CYSLTR1    GPR17
    GPR183    P2RY1    P2RY2    P2RY4    PTAFR    CYSLTR2
    KPG_011    P2RY8    P2RY6

    Find genes that share paralogs with GPR174           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPR174 (see all 75)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59127901,2
    C,F,A,H--78396201(+) CAGATT/GTGGAT 1 -- us2k18Minor allele frequency- G:0.47NS EA NA WA 424
    rs732315981,2
    C--78396323(+) CAATTC/TCCTTT 1 -- us2k10--------
    rs1815606351,2
    --78396358(+) AGAAAA/GTAAGT 1 -- us2k10--------
    rs735096231,2
    C,F--78396392(+) TGAGGG/AAAAAA 1 -- us2k12Minor allele frequency- A:0.33WA CSA 3
    rs59122311,2
    C,F,A,H--78396598(+) CGGGTA/GTTTAA 1 -- us2k115Minor allele frequency- G:0.44NS EA NA WA 670
    rs1461102001,2
    --78396650(+) CTTTTA/GAGTAA 1 -- us2k10--------
    rs1894717221,2
    --78396683(+) AAAACA/GTGCTG 1 -- us2k10--------
    rs1401269981,2
    --78396809(+) TTTCAC/TTTTTG 1 -- us2k10--------
    rs59592551,2
    C,F,H--78396878(+) GGCAAT/CTATCC 1 -- us2k119Minor allele frequency- C:0.81NS EA NA 2094
    rs1448301321,2
    --78396902(+) AAAATG/TTACTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPR174 (78426469 - 78427726 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GPR174: --
    Human Gene Mutation Database (HGMD): GPR174
    Locus Specific Mutation Databases (LSDB): GPR174

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR174
    DNA2.0 Custom Variant and Variant Library Synthesis for GPR174

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300903    OMIM disorders: --


    Find genes that share disorders with GPR174           About GenesLikeMe


    Export disorders for GPR174 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR174 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with GPR174)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    4. An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease. (PubMed id 23667180)1 Chu X....Huang W. (J. Med. Genet. 2013)
    5. Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. (PubMed id 23612905)1 Zhao S.X....Song H.D. (Hum. Mol. Genet. 2013)
    6. Expression of orphan G-protein coupled receptor GPR174 in CHO cells induced morphological changes and proliferation delay via increasing intracellular cAMP. (PubMed id 23178570)1 Sugita K....Fujita N. (Biochem. Biophys. Res. Commun. 2013)
    7. Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target. (PubMed id 20880198)1 Qin Y....Osanto S. (amp 2011)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84636 HGNC: 30245 AceView: GPR174 Ensembl:ENSG00000147138 euGenes: HUgn84636
    ECgene: GPR174 H-InvDB: GPR174

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPR174 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPR174 gene:
    Search GeneIP for patents involving GPR174

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Antibodies for GPR174   OriGene RNAi products in human, mouse, rat for GPR174  
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     Search Addgene for plasmids for GPR174
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