Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR174 Gene

Aliases for GPR174 Gene

  • G Protein-Coupled Receptor 174 2 3
  • FKSG79 3
  • GPCR17 3
  • LYPSR3 3

External Ids for GPR174 Gene

Previous GeneCards Identifiers for GPR174 Gene

  • GC0XP078232
  • GC0XP078313
  • GC0XP078426
  • GC0XP072005

Summaries for GPR174 Gene

Entrez Gene Summary for GPR174 Gene

  • This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]

GeneCards Summary for GPR174 Gene

GPR174 (G Protein-Coupled Receptor 174) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for GPR174 Gene

  • Putative receptor for purines coupled to G-proteins.

Gene Wiki entry for GPR174 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR174 Gene

Genomics for GPR174 Gene

Regulatory Elements for GPR174 Gene

Genomic Location for GPR174 Gene

Chromosome:
X
Start:
79,170,972 bp from pter
End:
79,172,229 bp from pter
Size:
1,258 bases
Orientation:
Plus strand

Genomic View for GPR174 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR174 Gene

Proteins for GPR174 Gene

  • Protein details for GPR174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXC1-GP174_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 174
    Protein Accession:
    Q9BXC1
    Secondary Accessions:
    • Q2M3F7

    Protein attributes for GPR174 Gene

    Size:
    333 amino acids
    Molecular mass:
    38503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR174 Gene

Proteomics data for GPR174 Gene at MOPED

Post-translational modifications for GPR174 Gene

  • Ubiquitination at Lys 317
  • Glycosylation at Asn 4 and Asn 164
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR174 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GPR174

No data available for DME Specific Peptides for GPR174 Gene

Domains & Families for GPR174 Gene

Gene Families for GPR174 Gene

Protein Domains for GPR174 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR174 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXC1

UniProtKB/Swiss-Prot:

GP174_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR174: view

Function for GPR174 Gene

Molecular function for GPR174 Gene

UniProtKB/Swiss-Prot Function:
Putative receptor for purines coupled to G-proteins.

Gene Ontology (GO) - Molecular Function for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with GPR174: view
genes like me logo Genes that share phenotypes with GPR174: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR174

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR174 Gene

Localization for GPR174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR174 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR174 Gene COMPARTMENTS Subcellular localization image for GPR174 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR174: view

Pathways & Interactions for GPR174 Gene

SuperPathways for GPR174 Gene

genes like me logo Genes that share pathways with GPR174: view

Pathways by source for GPR174 Gene

1 BioSystems pathway for GPR174 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Interacting Proteins for GPR174 Gene

Gene Ontology (GO) - Biological Process for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with GPR174: view

No data available for SIGNOR curated interactions for GPR174 Gene

Drugs & Compounds for GPR174 Gene

(1) Drugs for GPR174 Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lysophosphatidylserine Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with GPR174: view

Transcripts for GPR174 Gene

mRNA/cDNA for GPR174 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR174 Gene

G protein-coupled receptor 174:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR174

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR174 Gene

No ASD Table

Relevant External Links for GPR174 Gene

GeneLoc Exon Structure for
GPR174
ECgene alternative splicing isoforms for
GPR174

Expression for GPR174 Gene

mRNA expression in normal human tissues for GPR174 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR174 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.5), Whole Blood (x5.8), and Spleen (x5.2).

SOURCE GeneReport for Unigene cluster for GPR174 Gene Hs.326713

genes like me logo Genes that share expression patterns with GPR174: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR174 Gene

Orthologs for GPR174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR174 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR174 35
  • 89.09 (n)
  • 89.79 (a)
GPR174 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100683878 35
  • 91.18 (n)
  • 93.85 (a)
GPR174 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr174 35
  • 86.99 (n)
  • 88.29 (a)
Gpr174 16
Gpr174 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR174 35
  • 99.6 (n)
  • 99.4 (a)
GPR174 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr174 35
  • 86.79 (n)
  • 87.99 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR174 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR174 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR174 35
  • 67.53 (n)
  • 70.23 (a)
GPR174 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR174 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr174 35
  • 66.99 (n)
  • 69.06 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100151331 35
  • 59.19 (n)
  • 56.09 (a)
CR931764.1 36
  • 54 (a)
OneToOne
Species with no ortholog for GPR174:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR174 Gene

ENSEMBL:
Gene Tree for GPR174 (if available)
TreeFam:
Gene Tree for GPR174 (if available)

Paralogs for GPR174 Gene

(15) SIMAP similar genes for GPR174 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR174: view

Variants for GPR174 Gene

Sequence variations from dbSNP and Humsavar for GPR174 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3810711 -- 79,170,991(-) GAGAA(A/G)CTATC utr-variant-5-prime
rs3810712 -- 79,170,974(-) TAATG(A/G)TGGTT utr-variant-5-prime
rs3827440 - 79,171,491(-) GCCAG(A/G/T)GGTAT missense, reference
rs3827441 -- 79,170,796(-) CTCTA(A/G/T)AGTAA upstream-variant-2KB
rs5912231 -- 79,169,409(+) CGGGT(A/G)TTTAA upstream-variant-2KB

Variation tolerance for GPR174 Gene

Residual Variation Intolerance Score: 65.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR174 Gene

HapMap Linkage Disequilibrium report
GPR174
Human Gene Mutation Database (HGMD)
GPR174

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR174 Gene

Disorders for GPR174 Gene

Relevant External Links for GPR174

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR174
genes like me logo Genes that share disorders with GPR174: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR174 Gene

Publications for GPR174 Gene

  1. Role of the X-Linked Gene GPR174 in Autoimmune Addison's Disease. (PMID: 25295623) Napier C. … Pearce S.H. (J. Clin. Endocrinol. Metab. 2014) 67
  2. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. (PMID: 24602016) Kihara Y. … Chun J. (Br. J. Pharmacol. 2014) 67
  3. rs3827440, a nonsynonymous single nucleotide polymorphism within GPR174 gene in X chromosome, is associated with Graves' disease in Polish Caucasian population. (PMID: 24289805) SzymaA8ski K. … PA8oski R. (Tissue Antigens 2014) 67
  4. An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease. (PMID: 23667180) Chu X. … Huang W. (J. Med. Genet. 2013) 67
  5. Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. (PMID: 23612905) Zhao S.X. … Song H.D. (Hum. Mol. Genet. 2013) 67

Products for GPR174 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GPR174
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GPR174
    • Block miRNA regulation of GPR174 using miScript Target Protectors

    Sources for GPR174 Gene

    Back to Top

    Content