Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR174 Gene

Aliases for GPR174 Gene

  • G Protein-Coupled Receptor 174 2 3 5
  • Probable G-Protein Coupled Receptor 174 3
  • FKSG79 3
  • GPCR17 3
  • LYPSR3 3

External Ids for GPR174 Gene

Previous GeneCards Identifiers for GPR174 Gene

  • GC0XP078232
  • GC0XP078313
  • GC0XP078426
  • GC0XP072005

Summaries for GPR174 Gene

Entrez Gene Summary for GPR174 Gene

  • This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]

GeneCards Summary for GPR174 Gene

GPR174 (G Protein-Coupled Receptor 174) is a Protein Coding gene. Diseases associated with GPR174 include Autoimmune Polyendocrine Syndrome, Type Ii and Adrenal Cortical Hypofunction. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is P2RY10.

UniProtKB/Swiss-Prot for GPR174 Gene

  • Putative receptor for purines coupled to G-proteins.

Gene Wiki entry for GPR174 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR174 Gene

Genomics for GPR174 Gene

Regulatory Elements for GPR174 Gene

Enhancers for GPR174 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF079257 1.4 FANTOM5 Ensembl ENCODE 18.8 +88.4 88412 4.7 CTCF PKNOX1 MXI1 TBL1XR1 WRNIP1 ASH2L MAX YBX1 BMI1 EBF1 GPR174 ITM2A ZCCHC5 P2RY10 GC0XM079197 GC0XM079265
GH0XF079106 1.4 FANTOM5 Ensembl ENCODE 6.9 -62.6 -62558 3.8 TBP ZNF146 ZNF280D MTA2 JUNB TBX21 EP300 GABPA RELA TARDBP ITM2A GPR174 P2RY10 LPAR4 GC0XM079072
GH0XF079142 1.4 FANTOM5 Ensembl ENCODE 5.6 -20.3 -20256 15.5 TBP MXI1 TBL1XR1 MAX YBX1 ZBTB40 RELA POLR2A EGR1 ZNF366 ITM2A P2RY10 GPR174 ZCCHC5 LPAR4 GC0XM079072
GH0XF079336 0.6 Ensembl ENCODE 12.5 +166.4 166437 0.9 IRF1 ITM2A GPR174 KIF4CP PIR45005
GH0XF079181 1.1 FANTOM5 ENCODE 2.4 +11.3 11328 2.3 TBP TBL1XR1 BMI1 EBF1 RELA CBX5 EED ZNF207 ETV6 CREM ITM2A GPR174 P2RY10 CTHRC1P1 PIR52489
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR174 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR174 Gene

79,170,972 bp from pter
79,172,229 bp from pter
1,258 bases
Plus strand

Genomic View for GPR174 Gene

Genes around GPR174 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR174 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR174 Gene

Proteins for GPR174 Gene

  • Protein details for GPR174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 174
    Protein Accession:
    Secondary Accessions:
    • Q2M3F7

    Protein attributes for GPR174 Gene

    333 amino acids
    Molecular mass:
    38503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR174 Gene

Post-translational modifications for GPR174 Gene

  • Ubiquitination at Lys 317
  • Glycosylation at Asn 4 and Asn 164
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR174 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR174 Gene

Domains & Families for GPR174 Gene

Gene Families for GPR174 Gene

Protein Domains for GPR174 Gene

Suggested Antigen Peptide Sequences for GPR174 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR174: view

Function for GPR174 Gene

Molecular function for GPR174 Gene

UniProtKB/Swiss-Prot Function:
Putative receptor for purines coupled to G-proteins.

Gene Ontology (GO) - Molecular Function for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0045125 bioactive lipid receptor activity IEA --
genes like me logo Genes that share ontologies with GPR174: view
genes like me logo Genes that share phenotypes with GPR174: view

Animal Models for GPR174 Gene

MGI Knock Outs for GPR174:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR174

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR174 Gene

Localization for GPR174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR174 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR174 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR174: view

Pathways & Interactions for GPR174 Gene

genes like me logo Genes that share pathways with GPR174: view

Pathways by source for GPR174 Gene

1 BioSystems pathway for GPR174 Gene

Interacting Proteins for GPR174 Gene

Selected Interacting proteins: Q9BXC1-GP174_HUMAN for GPR174 Gene via IID

Gene Ontology (GO) - Biological Process for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0043029 T cell homeostasis IEA --
genes like me logo Genes that share ontologies with GPR174: view

No data available for SIGNOR curated interactions for GPR174 Gene

Drugs & Compounds for GPR174 Gene

(1) Drugs for GPR174 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lysophosphatidylserine Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with GPR174: view

Transcripts for GPR174 Gene

mRNA/cDNA for GPR174 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR174 Gene

G protein-coupled receptor 174:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR174 Gene

No ASD Table

Relevant External Links for GPR174 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR174 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR174 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR174 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.5), Whole Blood (x5.8), and Spleen (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of GPR174 Gene:


SOURCE GeneReport for Unigene cluster for GPR174 Gene:

genes like me logo Genes that share expression patterns with GPR174: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GPR174 Gene

Orthologs for GPR174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR174 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR174 34 35
  • 99.6 (n)
(Canis familiaris)
Mammalia GPR174 35
  • 94 (a)
LOC100683878 34
  • 91.18 (n)
(Bos Taurus)
Mammalia GPR174 34 35
  • 89.09 (n)
(Mus musculus)
Mammalia Gpr174 34 16 35
  • 86.99 (n)
(Rattus norvegicus)
Mammalia Gpr174 34
  • 86.79 (n)
(Monodelphis domestica)
Mammalia GPR174 35
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia GPR174 35
  • 63 (a)
(Gallus gallus)
Aves GPR174 34 35
  • 67.53 (n)
(Anolis carolinensis)
Reptilia GPR174 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr174 34
  • 66.99 (n)
(Danio rerio)
Actinopterygii LOC100151331 34
  • 59.19 (n)
CR931764.1 35
  • 54 (a)
Species where no ortholog for GPR174 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR174 Gene

Gene Tree for GPR174 (if available)
Gene Tree for GPR174 (if available)

Paralogs for GPR174 Gene

(15) SIMAP similar genes for GPR174 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR174: view

Variants for GPR174 Gene

Sequence variations from dbSNP and Humsavar for GPR174 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111852372 -- 79,170,454(+) CAGCT(C/G)TGCCT intron-variant, upstream-variant-2KB
rs112344425 -- 79,171,525(+) TCTTC(C/T)TACCA intron-variant, reference, missense
rs137871290 -- 79,171,377(+) ACCCC(C/T)TTCGC intron-variant, reference, missense
rs138028074 -- 79,171,630(+) GAAGA(C/T)GGTTT intron-variant, reference, missense
rs140126998 -- 79,169,620(+) TTTCA(C/T)TTTTG intron-variant, upstream-variant-2KB

Variation tolerance for GPR174 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR174 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR174 Gene

Disorders for GPR174 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR174 Gene - From: DISEASES

Disorder Aliases PubMed IDs
autoimmune polyendocrine syndrome, type ii
  • autoimmune polyendocrine syndrome type 2
adrenal cortical hypofunction
  • adrenal cortical insufficiency
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPR174

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR174: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR174 Gene

Publications for GPR174 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4 64
  4. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. (PMID: 24602016) Kihara Y. … Chun J. (Br. J. Pharmacol. 2014) 3 64
  5. Alteration of Gene Expression Profiling Including GPR174 and GNG2 is Associated with Vasovagal Syncope. (PMID: 25367286) Huang Y.J. … Bao L. (Pediatr Cardiol 2014) 3 64

Products for GPR174 Gene

Sources for GPR174 Gene

Loading form....