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Aliases for GPR174 Gene

Aliases for GPR174 Gene

  • G Protein-Coupled Receptor 174 2 3
  • GPCR17 3 6
  • Probable G-Protein Coupled Receptor 174 3
  • FKSG79 3
  • LYPSR3 3

External Ids for GPR174 Gene

Previous GeneCards Identifiers for GPR174 Gene

  • GC0XP078232
  • GC0XP078313
  • GC0XP078426
  • GC0XP072005

Summaries for GPR174 Gene

Entrez Gene Summary for GPR174 Gene

  • This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]

GeneCards Summary for GPR174 Gene

GPR174 (G Protein-Coupled Receptor 174) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for GPR174 Gene

  • Putative receptor for purines coupled to G-proteins.

Gene Wiki entry for GPR174 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR174 Gene

Genomics for GPR174 Gene

Regulatory Elements for GPR174 Gene

Genomic Location for GPR174 Gene

79,170,972 bp from pter
79,172,229 bp from pter
1,258 bases
Plus strand

Genomic View for GPR174 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR174 Gene

Proteins for GPR174 Gene

  • Protein details for GPR174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 174
    Protein Accession:
    Secondary Accessions:
    • Q2M3F7

    Protein attributes for GPR174 Gene

    333 amino acids
    Molecular mass:
    38503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR174 Gene

Proteomics data for GPR174 Gene at MOPED

Post-translational modifications for GPR174 Gene

  • Ubiquitination at Lys317
  • Glycosylation at Asn4 and Asn164
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR174 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR174 Gene

Domains for GPR174 Gene

Gene Families for GPR174 Gene

  • GPCRAO :GPCR / Class A : Orphans

Protein Domains for GPR174 Gene


Suggested Antigen Peptide Sequences for GPR174 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BXC1
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR174: view

Function for GPR174 Gene

Molecular function for GPR174 Gene

UniProtKB/Swiss-Prot Function: Putative receptor for purines coupled to G-proteins.

Gene Ontology (GO) - Molecular Function for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR174: view

Phenotypes for GPR174 Gene

GenomeRNAi human phenotypes for GPR174:
genes like me logo Genes that share phenotypes with GPR174: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR174

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GPR174 Gene

Localization for GPR174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR174 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR174 Gene COMPARTMENTS Subcellular localization image for GPR174 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR174: view

Pathways for GPR174 Gene

SuperPathways for GPR174 Gene

genes like me logo Genes that share pathways with GPR174: view

Pathways by source for GPR174 Gene

1 BioSystems pathway for GPR174 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Interacting Proteins for GPR174 Gene

Gene Ontology (GO) - Biological Process for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR174: view

Compounds for GPR174 Gene

(1) IUPHAR Ligand for GPR174 Gene

Ligand Type Action Affinity Pubmed IDs
lysophosphatidylserine Agonist Full agonist 6.89
genes like me logo Genes that share compounds with GPR174: view

Transcripts for GPR174 Gene

mRNA/cDNA for GPR174 Gene

(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR174 Gene

G protein-coupled receptor 174:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR174

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR174 Gene

No ASD Table

Relevant External Links for GPR174 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR174 Gene

mRNA expression in normal human tissues for GPR174 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR174 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (6.5), Whole Blood (5.8), and Spleen (5.2).

SOURCE GeneReport for Unigene cluster for GPR174 Gene Hs.326713

genes like me logo Genes that share expressions with GPR174: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for GPR174 Gene

Orthologs for GPR174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR174 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR174 35
  • 99.6 (n)
  • 99.4 (a)
GPR174 36
  • 99 (a)
(Bos Taurus)
Mammalia GPR174 35
  • 89.09 (n)
  • 89.79 (a)
GPR174 36
  • 90 (a)
(Canis familiaris)
Mammalia GPR174 36
  • 94 (a)
LOC100683878 35
  • 91.18 (n)
  • 93.85 (a)
(Mus musculus)
Mammalia Gpr174 35
  • 86.99 (n)
  • 88.29 (a)
Gpr174 16
Gpr174 36
  • 88 (a)
(Monodelphis domestica)
Mammalia GPR174 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia GPR174 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Gpr174 35
  • 86.79 (n)
  • 87.99 (a)
(Gallus gallus)
Aves GPR174 35
  • 67.53 (n)
  • 70.23 (a)
GPR174 36
  • 64 (a)
(Anolis carolinensis)
Reptilia GPR174 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr174 35
  • 66.99 (n)
  • 69.06 (a)
(Danio rerio)
Actinopterygii CR931764.1 36
  • 54 (a)
LOC100151331 35
  • 59.19 (n)
  • 56.09 (a)
Species with no ortholog for GPR174:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR174 Gene

Gene Tree for GPR174 (if available)
Gene Tree for GPR174 (if available)

Paralogs for GPR174 Gene

Selected SIMAP similar genes for GPR174 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR174: view

Variants for GPR174 Gene

Sequence variations from dbSNP and Humsavar for GPR174 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3810711 -- 79,170,991(-) GAGAA(A/G)CTATC utr-variant-5-prime
rs3810712 -- 79,170,974(-) TAATG(A/G)TGGTT utr-variant-5-prime
rs3827440 - 79,171,491(-) GCCAG(A/G)GGTAT missense, reference
rs3827441 -- 79,170,796(-) CTCTA(A/G/T)AGTAA upstream-variant-2KB
rs5912231 -- 79,169,409(+) CGGGT(A/G)TTTAA upstream-variant-2KB

Relevant External Links for GPR174 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR174 Gene

Disorders for GPR174 Gene

No disorders were found for GPR174 Gene.

No data available for UniProtKB/Swiss-Prot for GPR174 Gene

Publications for GPR174 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target. (PMID: 20880198) Qin Y. … Osanto S. (Pigment Cell Melanoma Res 2011) 3

Products for GPR174 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GPR174
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GPR174
    • Block miRNA regulation of GPR174 using miScript Target Protectors
    • antibodies-online peptides for GPR174
    • antibodies-online antibodies for GPR174
    • antibodies-online kits for GPR174

    Sources for GPR174 Gene

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