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Aliases for GPR173 Gene

Aliases for GPR173 Gene

  • G Protein-Coupled Receptor 173 2 3 5
  • Super Conserved Receptor Expressed In Brain 3 3 4
  • SREB3 3 4
  • Probable G-Protein Coupled Receptor 173 3
  • G-Protein Coupled Receptor 173 2
  • G Protein Coupled Receptor 173 2

External Ids for GPR173 Gene

Previous GeneCards Identifiers for GPR173 Gene

  • GC0XP052961
  • GC0XP053095
  • GC0XP050140

Summaries for GPR173 Gene

Entrez Gene Summary for GPR173 Gene

  • This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009]

GeneCards Summary for GPR173 Gene

GPR173 (G Protein-Coupled Receptor 173) is a Protein Coding gene. Diseases associated with GPR173 include Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and gonadotropin-releasing hormone receptor activity. An important paralog of this gene is GPR85.

UniProtKB/Swiss-Prot for GPR173 Gene

  • Orphan receptor.

Gene Wiki entry for GPR173 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR173 Gene

Genomics for GPR173 Gene

Regulatory Elements for GPR173 Gene

Enhancers for GPR173 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF053420 1.1 ENCODE 18 +373.2 373240 2.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ACTG1P10 ENSG00000227329 ENSG00000233250 KDM5C KDM5C-IT1 GPR173 RPSAP62 SSXP5 RPL7AP71 XAGE1A
GH0XF053681 1.1 ENCODE 10.2 +635.3 635281 5.9 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 DEK ACTG1P10 ENSG00000233250 KANTR KDM5C ENSG00000227329 ENSG00000270189 FGD1 HSD17B10 GPR173 KDM5C-IT1
GH0XF054042 1.1 ENCODE 10.2 +995.3 995301 3.8 PKNOX1 CREB3L1 SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 FOS KLF13 KDM5C KANTR RPL7AP71 RPSAP62 APEX2 ACTG1P10 ENSG00000270189 FGD1 ENSG00000227329 GPR173
GH0XF053317 0.9 Ensembl 10.2 +268.6 268611 0.6 KLF17 ZNF2 RAD21 GLIS2 SCRT2 ZNF143 EGR2 ZNF263 ZNF654 REST ENSG00000270189 KANTR GPR173 ENSG00000233250 IQSEC2 GC0XP053261
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR173 on UCSC Golden Path with GeneCards custom track

Promoters for GPR173 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001917295 -91 2001 CTCF KLF1 JUN KLF17 ZIC2 GLIS2 ZBTB48 POLR2A ZNF366 KLF7

Genomic Location for GPR173 Gene

53,049,091 bp from pter
53,080,615 bp from pter
31,525 bases
Plus strand

Genomic View for GPR173 Gene

Genes around GPR173 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR173 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR173 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR173 Gene

Proteins for GPR173 Gene

  • Protein details for GPR173 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 173
    Protein Accession:
    Secondary Accessions:
    • B1B0A5

    Protein attributes for GPR173 Gene

    373 amino acids
    Molecular mass:
    41481 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR173 Gene

Post-translational modifications for GPR173 Gene

  • Glycosylation at Asn 3 and Asn 184
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR173 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR173 Gene

Domains & Families for GPR173 Gene

Gene Families for GPR173 Gene

Protein Domains for GPR173 Gene

Suggested Antigen Peptide Sequences for GPR173 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR173: view

Function for GPR173 Gene

Molecular function for GPR173 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10833454
GO:0004968 gonadotropin-releasing hormone receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with GPR173: view
genes like me logo Genes that share phenotypes with GPR173: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR173 Gene

Localization for GPR173 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR173 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR173 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR173: view

Pathways & Interactions for GPR173 Gene

genes like me logo Genes that share pathways with GPR173: view

Pathways by source for GPR173 Gene

1 BioSystems pathway for GPR173 Gene

Interacting Proteins for GPR173 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9NS66-GP173_HUMAN ENSP00000331600 for GPR173 Gene via IID STRING

Gene Ontology (GO) - Biological Process for GPR173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10833454
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0097211 cellular response to gonadotropin-releasing hormone IEA --
GO:2001223 negative regulation of neuron migration IEA --
genes like me logo Genes that share ontologies with GPR173: view

No data available for SIGNOR curated interactions for GPR173 Gene

Transcripts for GPR173 Gene

mRNA/cDNA for GPR173 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR173 Gene

G protein-coupled receptor 173:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR173 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for GPR173 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR173 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR173 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of GPR173 Gene:


SOURCE GeneReport for Unigene cluster for GPR173 Gene:


mRNA Expression by UniProt/SwissProt for GPR173 Gene:

Tissue specificity: Expressed at high levels in brain and ovary. Lower levels in small intestine. In brain regions, detected in all regions tested. Highest levels in the cerebellum and cerebral cortex.
genes like me logo Genes that share expression patterns with GPR173: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR173 Gene

Orthologs for GPR173 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR173 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR173 34 35
  • 98.75 (n)
(Bos Taurus)
Mammalia GPR173 34 35
  • 95.08 (n)
(Canis familiaris)
Mammalia GPR173 34 35
  • 94.82 (n)
(Mus musculus)
Mammalia Gpr173 34 16 35
  • 94.64 (n)
(Rattus norvegicus)
Mammalia Gpr173 34
  • 94.64 (n)
(Monodelphis domestica)
Mammalia GPR173 35
  • 86 (a)
(Gallus gallus)
Aves GPR27 34
  • 73.94 (n)
(Anolis carolinensis)
Reptilia GPR173 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr173 34
  • 74.12 (n)
(Danio rerio)
Actinopterygii gpr173 34 35
  • 74.41 (n)
Species where no ortholog for GPR173 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR173 Gene

Gene Tree for GPR173 (if available)
Gene Tree for GPR173 (if available)

Paralogs for GPR173 Gene

Paralogs for GPR173 Gene

(2) SIMAP similar genes for GPR173 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR173: view

Variants for GPR173 Gene

Sequence variations from dbSNP and Humsavar for GPR173 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10855213 -- 53,061,354(+) CGGGG(A/G)ATGTT intron-variant
rs11091720 -- 53,077,683(+) ACTCA(C/T)GCCCC reference, synonymous-codon
rs111320267 -- 53,079,605(+) GTGTG(-/GC/GG/TG)CGTGC utr-variant-3-prime
rs111655908 -- 53,069,145(+) ACTAG(A/G)GACAG intron-variant
rs111684869 -- 53,060,876(+) TTATA(C/T)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR173 Gene

Variant ID Type Subtype PubMed ID
nsv508773 CNV insertion 20534489
nsv435891 CNV deletion 17901297
nsv1153074 CNV duplication 26484159
nsv1129081 CNV duplication 24896259
nsv1076709 CNV duplication 25765185
esv3576878 CNV gain 25503493
esv3450158 CNV duplication 20981092
esv2740175 CNV deletion 23290073
esv24544 CNV gain 19812545
esv1009949 CNV insertion 20482838

Variation tolerance for GPR173 Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR173 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR173 Gene

Disorders for GPR173 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR173 Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-syndromic x-linked intellectual disability
  • mrx
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPR173

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR173: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR173 Gene

Publications for GPR173 Gene

  1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PMID: 10833454) Matsumoto M. … Furuichi K. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey P.S. … Stratton M.R. (Nat. Genet. 2009) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for GPR173 Gene

Sources for GPR173 Gene

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