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Aliases for GPR171 Gene

Aliases for GPR171 Gene

  • G Protein-Coupled Receptor 171 2 3 5
  • Platelet Activating Receptor Homolog 2 3
  • G-Protein Coupled Receptor H963 3 4
  • H963 3 4
  • F730001G15Rik 3

External Ids for GPR171 Gene

Previous GeneCards Identifiers for GPR171 Gene

  • GC03M152398
  • GC03M150915
  • GC03M148288

Summaries for GPR171 Gene

GeneCards Summary for GPR171 Gene

GPR171 (G Protein-Coupled Receptor 171) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY14.

UniProtKB/Swiss-Prot for GPR171 Gene

  • Orphan receptor.

Gene Wiki entry for GPR171 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR171 Gene

Genomics for GPR171 Gene

Regulatory Elements for GPR171 Gene

Enhancers for GPR171 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR171 on UCSC Golden Path with GeneCards custom track

Promoters for GPR171 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR171 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR171 Gene

Chromosome:
3
Start:
151,197,754 bp from pter
End:
151,203,222 bp from pter
Size:
5,469 bases
Orientation:
Minus strand

Genomic View for GPR171 Gene

Genes around GPR171 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR171 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR171 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR171 Gene

Proteins for GPR171 Gene

  • Protein details for GPR171 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14626-GP171_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 171
    Protein Accession:
    O14626
    Secondary Accessions:
    • D3DNJ4
    • Q8IV06

    Protein attributes for GPR171 Gene

    Size:
    319 amino acids
    Molecular mass:
    36754 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR171 Gene

Proteomics data for GPR171 Gene at MOPED

Post-translational modifications for GPR171 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR171 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR171 Gene

Domains & Families for GPR171 Gene

Gene Families for GPR171 Gene

Protein Domains for GPR171 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR171 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14626

UniProtKB/Swiss-Prot:

GP171_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR171: view

Function for GPR171 Gene

Molecular function for GPR171 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA --
genes like me logo Genes that share ontologies with GPR171: view
genes like me logo Genes that share phenotypes with GPR171: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR171

miRNA for GPR171 Gene

miRTarBase miRNAs that target GPR171

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR171 Gene

Localization for GPR171 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR171 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR171 Gene COMPARTMENTS Subcellular localization image for GPR171 gene
Compartment Confidence
plasma membrane 5
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for GPR171 Gene

Pathways & Interactions for GPR171 Gene

SuperPathways for GPR171 Gene

genes like me logo Genes that share pathways with GPR171: view

Pathways by source for GPR171 Gene

1 BioSystems pathway for GPR171 Gene

Interacting Proteins for GPR171 Gene

Gene Ontology (GO) - Biological Process for GPR171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with GPR171: view

No data available for SIGNOR curated interactions for GPR171 Gene

Drugs & Compounds for GPR171 Gene

No Compound Related Data Available

Transcripts for GPR171 Gene

mRNA/cDNA for GPR171 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR171 Gene

G protein-coupled receptor 171:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR171 Gene

No ASD Table

Relevant External Links for GPR171 Gene

GeneLoc Exon Structure for
GPR171
ECgene alternative splicing isoforms for
GPR171

Expression for GPR171 Gene

mRNA expression in normal human tissues for GPR171 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR171 Gene

This gene is overexpressed in Whole Blood (x10.6), Spleen (x6.8), and Small Intestine - Terminal Ileum (x6.4).

Protein differential expression in normal tissues from HIPED for GPR171 Gene

This gene is overexpressed in CD4 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR171 Gene



SOURCE GeneReport for Unigene cluster for GPR171 Gene Hs.549152

genes like me logo Genes that share expression patterns with GPR171: view

Protein tissue co-expression partners for GPR171 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GPR171 Gene

Orthologs for GPR171 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR171 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR171 35
  • 88.92 (n)
  • 93.1 (a)
GPR171 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR171 35
  • 87.88 (n)
  • 91.54 (a)
GPR171 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr171 35
  • 85.85 (n)
  • 89.94 (a)
Gpr171 16
Gpr171 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR171 35
  • 100 (n)
  • 100 (a)
GPR171 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr171 35
  • 85.12 (n)
  • 89.62 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR171 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR171 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR171 35
  • 68.91 (n)
  • 69.23 (a)
GPR171 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR171 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497564 35
  • 65.58 (n)
  • 66.67 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC572354 35
  • 56.97 (n)
  • 51.51 (a)
GPR171 36
  • 47 (a)
OneToOne
Species with no ortholog for GPR171:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR171 Gene

ENSEMBL:
Gene Tree for GPR171 (if available)
TreeFam:
Gene Tree for GPR171 (if available)

Paralogs for GPR171 Gene

Paralogs for GPR171 Gene

(10) SIMAP similar genes for GPR171 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR171: view

Variants for GPR171 Gene

Sequence variations from dbSNP and Humsavar for GPR171 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_049408 -

Structural Variations from Database of Genomic Variants (DGV) for GPR171 Gene

Variant ID Type Subtype PubMed ID
dgv1520e1 CNV Complex 17122850

Variation tolerance for GPR171 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR171 Gene

HapMap Linkage Disequilibrium report
GPR171

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR171 Gene

Disorders for GPR171 Gene

Relevant External Links for GPR171

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR171

No disorders were found for GPR171 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR171 Gene

Publications for GPR171 Gene

  1. A genetic selection for isolating cDNAs encoding secreted proteins. (PMID: 9370294) Jacobs K.A. … McCoy J.M. (Gene 1997) 2 3 4 67
  2. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PMID: 17192395) Macaulay I.C. … Ouwehand W.H. (Blood 2007) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. (PMID: 11524702) Joensuu T. … Sankila E.-M. (Am. J. Hum. Genet. 2001) 3
  5. Pharmacological evidence for the putative existence of two different subtypes of PAF receptors on platelets and leukocytes; studies with yangambin. (PMID: 9302650) Herbert J.M. … TibiriAsa E. (J Lipid Mediat Cell Signal 1997) 23

Products for GPR171 Gene

Sources for GPR171 Gene

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