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Aliases for GPR17 Gene

Aliases for GPR17 Gene

  • G Protein-Coupled Receptor 17 2 3 5
  • UDP/CysLT Receptor 3 4
  • P2Y-Like Receptor 3 4
  • R12 3 4
  • Uracil Nucleotide/Cysteinyl Leukotriene Receptor 3
  • G-Protein Coupled Receptor 17 4

External Ids for GPR17 Gene

Previous GeneCards Identifiers for GPR17 Gene

  • GC02P125701
  • GC02P126328
  • GC02P128308
  • GC02P128497
  • GC02P128119
  • GC02P128403
  • GC02P120709

Summaries for GPR17 Gene

GeneCards Summary for GPR17 Gene

GPR17 (G Protein-Coupled Receptor 17) is a Protein Coding gene. Diseases associated with GPR17 include Suppression Amblyopia. Among its related pathways are Nucleotide-like (purinergic) receptors and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot for GPR17 Gene

  • Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Gene Wiki entry for GPR17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR17 Gene

Genomics for GPR17 Gene

Regulatory Elements for GPR17 Gene

Enhancers for GPR17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G127635 1.4 Ensembl ENCODE dbSUPER 23.1 -6.8 -6770 7.8 FOXA2 ARID4B DMAP1 ZNF48 GLIS2 ZNF207 ZNF143 FOS KAT8 MAFF GPR17 MYO7B ENSG00000272789 LIMS2 ENSG00000236682 MAP3K2 ERCC3 LOC101927834
GH02G127385 1.8 FANTOM5 ENCODE dbSUPER 17 -257.4 -257438 5.4 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ENSG00000236682 ERCC3 MAP3K2 GPR17 SFT2D3 WDR33 AMMECR1L GC02P127380
GH02G127562 1.3 Ensembl ENCODE 21.3 -82.2 -82198 1.7 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF143 ZNF207 KLF13 ZNF263 SP3 GPR17 MYO7B LIMS2 LOC105373609
GH02G127621 0.9 dbSUPER 26.2 -20.9 -20879 7.2 FOXA2 MLX ARID4B ZNF48 ZNF121 FOS SP5 MXD4 ZHX2 MIER2 GPR17 MYO7B LIMS2 ENSG00000236682 BIN1 ENSG00000272789 LOC105373609
GH02G127534 1.1 ENCODE dbSUPER 18.6 -109.8 -109824 3.6 PKNOX1 NFIB SIN3A RAD21 ZNF48 ZBTB7B ZSCAN5C ZNF207 RCOR1 EGR2 ERCC3 GPR17 ENSG00000236682 WDR33 MAP3K2 IWS1 MYO7B LOC105373609
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR17 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR17 Gene

Chromosome:
2
Start:
127,645,864 bp from pter
End:
127,652,639 bp from pter
Size:
6,776 bases
Orientation:
Plus strand

Genomic View for GPR17 Gene

Genes around GPR17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR17 Gene

Proteins for GPR17 Gene

  • Protein details for GPR17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13304-GPR17_HUMAN
    Recommended name:
    Uracil nucleotide/cysteinyl leukotriene receptor
    Protein Accession:
    Q13304
    Secondary Accessions:
    • A8K9L0
    • B2R9X0
    • Q8N5S7
    • Q9UDZ6
    • Q9UE21

    Protein attributes for GPR17 Gene

    Size:
    367 amino acids
    Molecular mass:
    40989 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR17 Gene

Post-translational modifications for GPR17 Gene

  • Glycosylation at isoforms=242, isoforms=2204, and isoforms=2282
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR17 Gene

No data available for DME Specific Peptides for GPR17 Gene

Domains & Families for GPR17 Gene

Gene Families for GPR17 Gene

Protein Domains for GPR17 Gene

Suggested Antigen Peptide Sequences for GPR17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13304

UniProtKB/Swiss-Prot:

GPR17_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR17: view

Function for GPR17 Gene

Molecular function for GPR17 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Gene Ontology (GO) - Molecular Function for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004950 chemokine receptor activity TAS 8558062
genes like me logo Genes that share ontologies with GPR17: view
genes like me logo Genes that share phenotypes with GPR17: view

Animal Models for GPR17 Gene

MGI Knock Outs for GPR17:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR17

CRISPR Products

miRNA for GPR17 Gene

miRTarBase miRNAs that target GPR17

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR17 Gene

Localization for GPR17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR17 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR17 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8558062
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR17: view

Pathways & Interactions for GPR17 Gene

genes like me logo Genes that share pathways with GPR17: view

Gene Ontology (GO) - Biological Process for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IBA --
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8558062
GO:0035025 positive regulation of Rho protein signal transduction IBA --
genes like me logo Genes that share ontologies with GPR17: view

No data available for SIGNOR curated interactions for GPR17 Gene

Drugs & Compounds for GPR17 Gene

(12) Drugs for GPR17 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uracil Experimental Pharma 0
ASN02563583 Pharma Agonist 0
ASN04421891 Pharma Agonist 0
ASN04450772 Pharma Agonist 0
ASN04885796 Pharma Agonist 0

(1) Additional Compounds for GPR17 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
UDP
Agonist
genes like me logo Genes that share compounds with GPR17: view

Transcripts for GPR17 Gene

Unigene Clusters for GPR17 Gene

G protein-coupled receptor 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR17 Gene

No ASD Table

Relevant External Links for GPR17 Gene

GeneLoc Exon Structure for
GPR17
ECgene alternative splicing isoforms for
GPR17

Expression for GPR17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR17 Gene

This gene is overexpressed in Colon - Sigmoid (x4.2).

Protein differential expression in normal tissues from HIPED for GPR17 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR17 Gene



Protein tissue co-expression partners for GPR17 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR17 Gene:

GPR17

SOURCE GeneReport for Unigene cluster for GPR17 Gene:

Hs.46453

mRNA Expression by UniProt/SwissProt for GPR17 Gene:

Q13304-GPR17_HUMAN
Tissue specificity: Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.

Evidence on tissue expression from TISSUES for GPR17 Gene

  • Nervous system(4.9)
  • Kidney(4)
genes like me logo Genes that share expression patterns with GPR17: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR17 Gene

Orthologs for GPR17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR17 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia GPR17 34 35
  • 90.46 (n)
cow
(Bos Taurus)
Mammalia GPR17 34 35
  • 87.32 (n)
mouse
(Mus musculus)
Mammalia Gpr17 34 16 35
  • 84.37 (n)
rat
(Rattus norvegicus)
Mammalia Gpr17 34
  • 83.78 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR17 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR17 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR17 34 35
  • 74.01 (n)
lizard
(Anolis carolinensis)
Reptilia GPR17 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr17 34
  • 57.72 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-194h10.4 34
  • 59.25 (n)
GPR17 35
  • 55 (a)
OneToOne
Species where no ortholog for GPR17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR17 Gene

ENSEMBL:
Gene Tree for GPR17 (if available)
TreeFam:
Gene Tree for GPR17 (if available)

Paralogs for GPR17 Gene

Variants for GPR17 Gene

Sequence variations from dbSNP and Humsavar for GPR17 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000023950 -- 127,652,732(+) CAGCC(C/T)CGTGG intron-variant, downstream-variant-500B
rs1000035540 -- 127,647,396(+) CCTAA(C/G)ACAAG intron-variant, upstream-variant-2KB
rs1000118169 -- 127,652,975(+) CTCAG(A/G)AAGGA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000435329 -- 127,644,179(+) GCCCA(A/G)CAGTC intron-variant, upstream-variant-2KB
rs1000636411 -- 127,646,212(+) CAGAC(C/T)CCTGT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR17 Gene

Variant ID Type Subtype PubMed ID
dgv4068n100 CNV gain 25217958
dgv4069n100 CNV gain 25217958
nsv470482 CNV loss 18288195
nsv508864 CNV insertion 20534489
nsv517532 CNV loss 19592680
nsv518085 CNV loss 19592680
nsv583038 CNV loss 21841781
nsv953155 CNV deletion 24416366

Variation tolerance for GPR17 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR17 Gene

Disorders for GPR17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR17 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
suppression amblyopia
  • strabismic amblyopia
- elite association - COSMIC cancer census association via MalaCards
Search GPR17 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR17
genes like me logo Genes that share disorders with GPR17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR17 Gene

Publications for GPR17 Gene

  1. New members of the chemokine receptor gene family. (PMID: 8558062) Raport C.J. … Gray P.W. (J. Leukoc. Biol. 1996) 2 3 4 64
  2. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. (PMID: 16990797) Ciana P. … Abbracchio M.P. (EMBO J. 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21. (PMID: 9523551) Blaesius R.H. … Ogilvie A. (J. Neurochem. 1998) 3 4 64
  5. The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes. (PMID: 28254957) Simon K. … Kostenis E. (Mol. Pharmacol. 2017) 3 64

Products for GPR17 Gene

  • Addgene plasmids for GPR17

Sources for GPR17 Gene

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