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Aliases for GPR17 Gene

Aliases for GPR17 Gene

  • G Protein-Coupled Receptor 17 2 3
  • G-Protein Coupled Receptor 17 3 4
  • UDP/CysLT Receptor 3 4
  • P2Y-Like Receptor 3 4
  • R12 3 4
  • Uracil Nucleotide/Cysteinyl Leukotriene Receptor 3

External Ids for GPR17 Gene

Previous GeneCards Identifiers for GPR17 Gene

  • GC02P125701
  • GC02P126328
  • GC02P128308
  • GC02P128497
  • GC02P128119
  • GC02P128403
  • GC02P120709

Summaries for GPR17 Gene

GeneCards Summary for GPR17 Gene

GPR17 (G Protein-Coupled Receptor 17) is a Protein Coding gene. Diseases associated with GPR17 include suppression amblyopia and amblyopia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include chemokine receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for GPR17 Gene

  • Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Gene Wiki entry for GPR17 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR17 Gene

Genomics for GPR17 Gene

Regulatory Elements for GPR17 Gene

Genomic Location for GPR17 Gene

Start:
127,645,864 bp from pter
End:
127,652,639 bp from pter
Size:
6,776 bases
Orientation:
Plus strand

Genomic View for GPR17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR17 Gene

Proteins for GPR17 Gene

  • Protein details for GPR17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13304-GPR17_HUMAN
    Recommended name:
    Uracil nucleotide/cysteinyl leukotriene receptor
    Protein Accession:
    Q13304
    Secondary Accessions:
    • A8K9L0
    • B2R9X0
    • Q8N5S7
    • Q9UDZ6
    • Q9UE21

    Protein attributes for GPR17 Gene

    Size:
    367 amino acids
    Molecular mass:
    40989 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR17 Gene

Proteomics data for GPR17 Gene at MOPED

Post-translational modifications for GPR17 Gene

  • Glycosylation at Asn42, Asn204, and Asn282
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR17 Gene

No data available for DME Specific Peptides for GPR17 Gene

Domains for GPR17 Gene

Gene Families for GPR17 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for GPR17 Gene

Suggested Antigen Peptide Sequences for GPR17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13304

UniProtKB/Swiss-Prot:

GPR17_HUMAN :
  • Q13304
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR17: view

Function for GPR17 Gene

Molecular function for GPR17 Gene

UniProtKB/Swiss-Prot Function: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Gene Ontology (GO) - Molecular Function for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity TAS 8558062
genes like me logo Genes that share ontologies with GPR17: view

Phenotypes for GPR17 Gene

genes like me logo Genes that share phenotypes with GPR17: view

miRNA for GPR17 Gene

miRTarBase miRNAs that target GPR17

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GPR17 Gene

Localization for GPR17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR17 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR17 Gene COMPARTMENTS Subcellular localization image for GPR17 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8558062
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR17: view

Pathways for GPR17 Gene

genes like me logo Genes that share pathways with GPR17: view

Gene Ontology (GO) - Biological Process for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0070098 chemokine-mediated signaling pathway TAS 8558062
genes like me logo Genes that share ontologies with GPR17: view

Compounds for GPR17 Gene

(1) HMDB Compounds for GPR17 Gene

Compound Synonyms Cas Number PubMed IDs
Uracil
  • 2,4-Dihydroxypyrimidine
66-22-8

(11) IUPHAR Ligand for GPR17 Gene

Ligand Type Action Affinity Pubmed IDs
ASN04885796 Agonist Agonist 9.96
ASN02563583 Agonist Agonist 9.96
ASN06917370 Agonist Agonist 9.57
LTC4 Agonist Agonist 9.48
ASN04450772 Agonist Agonist 8.93
ASN04421891 Agonist Agonist 8.44
LTD4 Agonist Agonist 8.36
UDP Agonist Full agonist 7.13
UDP-glucose Agonist Full agonist 7.1
UDP-galactose Agonist Full agonist 7
ATP Activator None
genes like me logo Genes that share compounds with GPR17: view

Transcripts for GPR17 Gene

Unigene Clusters for GPR17 Gene

G protein-coupled receptor 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR17 Gene

No ASD Table

Relevant External Links for GPR17 Gene

GeneLoc Exon Structure for
GPR17
ECgene alternative splicing isoforms for
GPR17

Expression for GPR17 Gene

mRNA expression in normal human tissues for GPR17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR17 Gene

This gene is overexpressed in Colon - Sigmoid (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPR17 Gene

SOURCE GeneReport for Unigene cluster for GPR17 Gene Hs.46453

mRNA Expression by UniProt/SwissProt for GPR17 Gene

Q13304-GPR17_HUMAN
Tissue specificity: Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.
genes like me logo Genes that share expressions with GPR17: view

Orthologs for GPR17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR17 35
  • 99.46 (n)
  • 99.46 (a)
GPR17 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR17 35
  • 87.32 (n)
  • 88.79 (a)
GPR17 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR17 35
  • 90.46 (n)
  • 91.45 (a)
GPR17 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr17 35
  • 84.37 (n)
  • 90.27 (a)
Gpr17 16
Gpr17 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR17 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR17 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr17 35
  • 83.78 (n)
  • 89.68 (a)
chicken
(Gallus gallus)
Aves GPR17 35
  • 74.01 (n)
  • 79.82 (a)
GPR17 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR17 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr17 35
  • 57.72 (n)
  • 53.66 (a)
zebrafish
(Danio rerio)
Actinopterygii GPR17 36
  • 55 (a)
OneToOne
si:ch73-194h10.4 35
  • 59.25 (n)
  • 57.01 (a)
Species with no ortholog for GPR17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR17 Gene

ENSEMBL:
Gene Tree for GPR17 (if available)
TreeFam:
Gene Tree for GPR17 (if available)

Paralogs for GPR17 Gene

genes like me logo Genes that share paralogs with GPR17: view

Variants for GPR17 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR17 Gene

Variant ID Type Subtype PubMed ID
nsv875015 CNV Loss 21882294
dgv4298n71 CNV Loss 21882294
dgv4299n71 CNV Loss 21882294
nsv518085 CNV Loss 19592680
nsv508864 CNV Insertion 20534489
nsv470482 CNV Loss 18288195
dgv4300n71 CNV Loss 21882294
nsv875026 CNV Loss 21882294
nsv517532 CNV Loss 19592680
nsv875027 CNV Loss 21882294
nsv875028 CNV Gain 21882294
dgv4301n71 CNV Loss 21882294
nsv875030 CNV Loss 21882294
nsv875031 CNV Loss 21882294

Relevant External Links for GPR17 Gene

HapMap Linkage Disequilibrium report
GPR17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GPR17 Gene

Disorders for GPR17 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for GPR17 Gene including...

Search for GPR17 Gene in MalaCards »

(1) University of Copenhagen DISEASES for GPR17 Gene

genes like me logo Genes that share disorders with GPR17: view

No data available for UniProtKB/Swiss-Prot for GPR17 Gene

Publications for GPR17 Gene

  1. New members of the chemokine receptor gene family. (PMID: 8558062) Raport C.J. … Gray P.W. (J. Leukoc. Biol. 1996) 2 3 4
  2. A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21. (PMID: 9523551) Blaesius R.H. … Ogilvie A. (J. Neurochem. 1998) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. (PMID: 16990797) Ciana P. … Abbracchio M.P. (EMBO J. 2006) 3 4
  5. GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. (PMID: 18533035) Parravicini C. … Fantucci P. (BMC Bioinformatics 2008) 3

Products for GPR17 Gene

Sources for GPR17 Gene

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