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Aliases for GPR162 Gene

Aliases for GPR162 Gene

  • G Protein-Coupled Receptor 162 2 3 5
  • Gene-Rich Cluster Gene A Protein 3 4
  • GRCA 3 4
  • Probable G-Protein Coupled Receptor 162 3
  • Gene Rich Cluster, A 3
  • A-2 3

External Ids for GPR162 Gene

Previous GeneCards Identifiers for GPR162 Gene

  • GC12P006941
  • GC12P006987
  • GC12P006997
  • GC12P007004
  • GC12P007013
  • GC12P007030
  • GC12P007051
  • GC12P007108
  • GC12P007135

Summaries for GPR162 Gene

Entrez Gene Summary for GPR162 Gene

  • This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR162 Gene

GPR162 (G Protein-Coupled Receptor 162) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR153.

UniProtKB/Swiss-Prot for GPR162 Gene

  • Orphan receptor.

Gene Wiki entry for GPR162 Gene

Additional gene information for GPR162 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR162 Gene

Genomics for GPR162 Gene

Regulatory Elements for GPR162 Gene

Enhancers for GPR162 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H006777 1.6 Ensembl ENCODE dbSUPER 12.4 -42.6 -42566 2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 GPR162 P3H3 EMG1 ZNF384 ING4 ENSG00000219410 PIANP ACRBP LPAR5 GAPDH
GH12H006788 1.5 FANTOM5 ENCODE dbSUPER 12.3 -30.5 -30469 4 ELF3 HDGF FOXA2 MLX ARID4B RAD21 THRB RARA YY1 SLC30A9 CD4 LPAR5 GPR162 P3H3 PTPN6 ING4 PTMS MLF2 GNB3 PIANP
GH12H006722 1.2 ENCODE 11.6 -97.5 -97493 2 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF384 CHD4 ENSG00000219410 NOP2 ATN1 ENSG00000247853 NCAPD2 GNB3 SPSB2 CD4
GH12H006784 1.1 Ensembl ENCODE dbSUPER 12.4 -35.6 -35631 3 MAFG ZNF223 ZNF316 MAFF ZFHX2 ZNF341 MAFK EMSY SPI1 CD4 GPR162 P3H3 ZNF384 ENSG00000219410 ING4 ACRBP PIANP LPAR5 GAPDH
GH12H006735 1.1 Ensembl ENCODE 11.5 -85.7 -85698 1 INSM2 ARID4B RAD21 YY1 SCRT2 ZNF143 RUNX3 MIXL1 ZNF654 ZEB2 PTMS MLF2 LAG3 CD4 GPR162 P3H3 ENSG00000219410 ING4 ACRBP CHD4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR162 on UCSC Golden Path with GeneCards custom track

Promoters for GPR162 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048352 155 601 HDGF MXI1 KLF1 KLF17 MAX ZIC2 BCL11B GLIS2 POLR2A ZBTB48

Genomic Location for GPR162 Gene

Chromosome:
12
Start:
6,821,545 bp from pter
End:
6,829,972 bp from pter
Size:
8,428 bases
Orientation:
Plus strand

Genomic View for GPR162 Gene

Genes around GPR162 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR162 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR162 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR162 Gene

Proteins for GPR162 Gene

  • Protein details for GPR162 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16538-GP162_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 162
    Protein Accession:
    Q16538
    Secondary Accessions:
    • Q16664
    • Q59EH5
    • Q66K56

    Protein attributes for GPR162 Gene

    Size:
    588 amino acids
    Molecular mass:
    63930 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR162 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR162 Gene

Post-translational modifications for GPR162 Gene

  • Glycosylation at posLast=8686
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR162 Gene

No data available for DME Specific Peptides for GPR162 Gene

Domains & Families for GPR162 Gene

Gene Families for GPR162 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for GPR162 Gene

Suggested Antigen Peptide Sequences for GPR162 Gene

Graphical View of Domain Structure for InterPro Entry

Q16538

UniProtKB/Swiss-Prot:

GP162_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR162: view

Function for GPR162 Gene

Molecular function for GPR162 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR162 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR162: view
genes like me logo Genes that share phenotypes with GPR162: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR162

CRISPR Products

miRNA for GPR162 Gene

miRTarBase miRNAs that target GPR162

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPR162
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR162 Gene

Localization for GPR162 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR162 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR162 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR162 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR162: view

Pathways & Interactions for GPR162 Gene

SuperPathways for GPR162 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR162: view

Pathways by source for GPR162 Gene

1 BioSystems pathway for GPR162 Gene

Interacting Proteins for GPR162 Gene

Gene Ontology (GO) - Biological Process for GPR162 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR162: view

No data available for SIGNOR curated interactions for GPR162 Gene

Drugs & Compounds for GPR162 Gene

No Compound Related Data Available

Transcripts for GPR162 Gene

Unigene Clusters for GPR162 Gene

G protein-coupled receptor 162:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPR162
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GPR162 Gene

No ASD Table

Relevant External Links for GPR162 Gene

GeneLoc Exon Structure for
GPR162
ECgene alternative splicing isoforms for
GPR162

Expression for GPR162 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR162 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR162 Gene

This gene is overexpressed in Brain - Cerebellum (x6.5), Brain - Cerebellar Hemisphere (x5.5), Brain - Cortex (x5.5), and Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for GPR162 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR162 Gene



Protein tissue co-expression partners for GPR162 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR162 Gene:

GPR162

SOURCE GeneReport for Unigene cluster for GPR162 Gene:

Hs.631654

Evidence on tissue expression from TISSUES for GPR162 Gene

  • Lung(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with GPR162: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR162 Gene

Orthologs for GPR162 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR162 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR162 33 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia LEPREL2 34
  • 96 (a)
OneToOne
GPR162 33
  • 91.1 (n)
cow
(Bos Taurus)
Mammalia GPR162 33 34
  • 91.04 (n)
rat
(Rattus norvegicus)
Mammalia Gpr162 33
  • 89.63 (n)
mouse
(Mus musculus)
Mammalia Gpr162 33 16 34
  • 89.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GPR162 33 34
  • 72.24 (n)
lizard
(Anolis carolinensis)
Reptilia GPR162 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr162 33
  • 61.04 (n)
Species where no ortholog for GPR162 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GPR162 Gene

ENSEMBL:
Gene Tree for GPR162 (if available)
TreeFam:
Gene Tree for GPR162 (if available)

Paralogs for GPR162 Gene

Paralogs for GPR162 Gene

(2) SIMAP similar genes for GPR162 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR162: view

Variants for GPR162 Gene

Sequence variations from dbSNP and Humsavar for GPR162 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000128122 -- 6,821,419(+) CAACA(A/C)CACCA upstream-variant-2KB
rs1000506439 -- 6,825,330(+) CCTCT(A/G)TTCAC intron-variant
rs1000577100 -- 6,826,327(+) TCCCT(C/T)CTCTT reference, missense
rs1001516582 -- 6,821,496(+) CACCA(A/G)TGAAG upstream-variant-2KB
rs1001850396 -- 6,820,075(+) GTGCT(A/G)GAGTC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR162 Gene

Variant ID Type Subtype PubMed ID
esv3580405 CNV gain 25503493
nsv832323 CNV loss 17160897
nsv832324 CNV loss 17160897

Variation tolerance for GPR162 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR162 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR162

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR162 Gene

Disorders for GPR162 Gene

Relevant External Links for GPR162

Genetic Association Database (GAD)
GPR162
Human Genome Epidemiology (HuGE) Navigator
GPR162
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR162

No disorders were found for GPR162 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR162 Gene

Publications for GPR162 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 45 60
  2. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. (PMID: 15777626) Gloriam DE … Fredriksson R (Biochimica et biophysica acta 2005) 2 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PMID: 9074930) Ansari-Lari MA … Gibbs RA (Genome research 1997) 3 4 60
  5. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. (PMID: 8723724) Ansari-Lari MA … Gibbs RA (Genome research 1996) 3 4 60

Products for GPR162 Gene

Sources for GPR162 Gene

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