External Ids for GPR161 Gene
Previous GeneCards Identifiers for GPR161 Gene
Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]).[supplied by OMIM, Aug 2008]
GeneCards Summary for GPR161 Gene
GPR161 (G Protein-Coupled Receptor 161) is a Protein Coding gene. Diseases associated with GPR161 include pituitary stalk interruption syndrome and spindle cell hemangioma. Among its related pathways are Signaling by GPCR and Signaling by Hedgehog. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled amine receptor activity. An important paralog of this gene is GPR176.
UniProtKB/Swiss-Prot for GPR161 Gene
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).