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Aliases for GPR161 Gene

Aliases for GPR161 Gene

  • G Protein-Coupled Receptor 161 2 3 5
  • G-Protein Coupled Receptor RE2 3 4
  • G-Protein Coupled Receptor 161 3
  • RE2 3

External Ids for GPR161 Gene

Previous GeneCards Identifiers for GPR161 Gene

  • GC01M165241
  • GC01M164780
  • GC01M166321
  • GC01M139298

Summaries for GPR161 Gene

Entrez Gene Summary for GPR161 Gene

  • Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]).[supplied by OMIM, Aug 2008]

GeneCards Summary for GPR161 Gene

GPR161 (G Protein-Coupled Receptor 161) is a Protein Coding gene. Diseases associated with GPR161 include Pituitary Stalk Interruption Syndrome and Spindle Cell Hemangioma. Among its related pathways are Signaling by Hedgehog and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled amine receptor activity. An important paralog of this gene is GPR101.

UniProtKB/Swiss-Prot for GPR161 Gene

  • Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Gene Wiki entry for GPR161 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR161 Gene

Genomics for GPR161 Gene

Regulatory Elements for GPR161 Gene

Enhancers for GPR161 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F168112 0.9 Ensembl ENCODE 12.4 +24.5 24528 0.9 HDGF PKNOX1 CBX3 ZNF2 RAD21 ZNF366 ZNF143 FOS CREM ZHX1 GPR161 TBX19 GC01M168079
GH01F168115 0.4 ENCODE 12.4 +21.2 21231 1.3 CTCF HINFP TRIM22 MAFG REST ZBTB7A RAD21 ZNF316 JUND ZNF143 GPR161 TBX19 GC01M168079
GH01F168111 0.5 Ensembl 12.4 +26.4 26367 0.2 GATA3 IKZF1 HMBOX1 SP7 TCF7L2 GPR161 TBX19 GC01M168079
GH01F168093 0.6 ENCODE 11.5 +44.5 44490 0.2 ELF3 CTCF CBX3 CEBPG REST RAD21 TEAD3 IKZF1 SMC3 GPR161 TIPRL GC01M168079
GH01F168091 0.2 ENCODE 11.4 +45.4 45415 0.5 ZNF316 ZIC2 GPR161 TIPRL GC01M168079
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR161 on UCSC Golden Path with GeneCards custom track

Promoters for GPR161 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000547140 867 2001 ZFP64 INSM2 ZNF76 KLF17 SIN3A GLI4 ZNF2 RARA GLIS2 ZNF366

Genomic Location for GPR161 Gene

Chromosome:
1
Start:
168,079,542 bp from pter
End:
168,137,667 bp from pter
Size:
58,126 bases
Orientation:
Minus strand

Genomic View for GPR161 Gene

Genes around GPR161 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR161 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR161 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR161 Gene

Proteins for GPR161 Gene

  • Protein details for GPR161 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6U8-GP161_HUMAN
    Recommended name:
    G-protein coupled receptor 161
    Protein Accession:
    Q8N6U8
    Secondary Accessions:
    • B3KV34
    • B7Z5D7
    • B7Z5E8
    • B7Z5Z6
    • F5GXD6
    • F5H6J7
    • O75963
    • Q5TGK0
    • Q5TGK1
    • Q5TGK2

    Protein attributes for GPR161 Gene

    Size:
    529 amino acids
    Molecular mass:
    58559 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR161 Gene

neXtProt entry for GPR161 Gene

Post-translational modifications for GPR161 Gene

  • Glycosylation at Asn 4 and Asn 15
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR161 Gene

Domains & Families for GPR161 Gene

Gene Families for GPR161 Gene

Protein Domains for GPR161 Gene

Suggested Antigen Peptide Sequences for GPR161 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6U8

UniProtKB/Swiss-Prot:

GP161_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR161: view

Function for GPR161 Gene

Molecular function for GPR161 Gene

UniProtKB/Swiss-Prot Function:
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Gene Ontology (GO) - Molecular Function for GPR161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity ISS --
genes like me logo Genes that share ontologies with GPR161: view
genes like me logo Genes that share phenotypes with GPR161: view

Human Phenotype Ontology for GPR161 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GPR161 Gene

MGI Knock Outs for GPR161:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR161

miRNA for GPR161 Gene

miRTarBase miRNAs that target GPR161

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GPR161 Gene

Localization for GPR161 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR161 Gene

Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR161 Gene COMPARTMENTS Subcellular localization image for GPR161 gene
Compartment Confidence
plasma membrane 5
endosome 4
nucleus 2

Gene Ontology (GO) - Cellular Components for GPR161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005929 cilium ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with GPR161: view

Pathways & Interactions for GPR161 Gene

genes like me logo Genes that share pathways with GPR161: view

Pathways by source for GPR161 Gene

1 BioSystems pathway for GPR161 Gene
1 KEGG pathway for GPR161 Gene

Interacting Proteins for GPR161 Gene

Gene Ontology (GO) - Biological Process for GPR161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway ISS --
GO:0007275 multicellular organism development IEA --
GO:0030819 positive regulation of cAMP biosynthetic process ISS --
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning ISS --
genes like me logo Genes that share ontologies with GPR161: view

No data available for SIGNOR curated interactions for GPR161 Gene

Transcripts for GPR161 Gene

Unigene Clusters for GPR161 Gene

G protein-coupled receptor 161:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR161 Gene

No ASD Table

Relevant External Links for GPR161 Gene

GeneLoc Exon Structure for
GPR161
ECgene alternative splicing isoforms for
GPR161

Expression for GPR161 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR161 Gene

mRNA differential expression in normal tissues according to GTEx for GPR161 Gene

This gene is overexpressed in Uterus (x5.8).

NURSA nuclear receptor signaling pathways regulating expression of GPR161 Gene:

GPR161

SOURCE GeneReport for Unigene cluster for GPR161 Gene:

Hs.271809
genes like me logo Genes that share expression patterns with GPR161: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GPR161 Gene

Orthologs for GPR161 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR161 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR161 34
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia GPR161 34 35
  • 90.55 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR161 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR161 34 35
  • 88.57 (n)
rat
(Rattus norvegicus)
Mammalia Gpr161 34
  • 88.36 (n)
mouse
(Mus musculus)
Mammalia Gpr161 34 16 35
  • 88.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR161 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR161 34 35
  • 76.39 (n)
lizard
(Anolis carolinensis)
Reptilia GPR161 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr161 34
  • 66.67 (n)
Str.10351 34
zebrafish
(Danio rerio)
Actinopterygii gpr161 34 35
  • 67.35 (n)
GPR161 (2 of 2) 35
  • 60 (a)
OneToMany
Species where no ortholog for GPR161 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR161 Gene

ENSEMBL:
Gene Tree for GPR161 (if available)
TreeFam:
Gene Tree for GPR161 (if available)

Paralogs for GPR161 Gene

Paralogs for GPR161 Gene

genes like me logo Genes that share paralogs with GPR161: view

Variants for GPR161 Gene

Sequence variations from dbSNP and Humsavar for GPR161 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs200635937 Likely pathogenic 168,104,855(+) TGGTC(A/T)GTGCA intron-variant, reference, missense, utr-variant-5-prime
rs200664972 Benign 168,136,343(+) CCCCA(-/G)GGGGG intron-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs10047139 -- 168,097,853(+) ggaaa(C/T)taaag intron-variant
rs10489207 -- 168,083,315(+) TAATA(G/T)CCCAG utr-variant-3-prime
rs10489208 -- 168,125,471(+) AAATA(C/T)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR161 Gene

Variant ID Type Subtype PubMed ID
esv2666700 CNV deletion 23128226
esv2719239 CNV deletion 23290073
esv32660 CNV loss 17666407
esv3587858 CNV loss 21293372
nsv1078878 OTHER inversion 25765185
nsv1079039 CNV deletion 25765185
nsv1120074 OTHER inversion 24896259
nsv441719 CNV loss 18776908
nsv506964 OTHER sequence alteration 20534489
nsv825309 CNV loss 20364138

Variation tolerance for GPR161 Gene

Residual Variation Intolerance Score: 8.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR161 Gene

Human Gene Mutation Database (HGMD)
GPR161
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR161

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR161 Gene

Disorders for GPR161 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR161 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
pituitary stalk interruption syndrome
  • ectopic neurohypophysis
spindle cell hemangioma
  • sch
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPR161

Genetic Association Database (GAD)
GPR161
Human Genome Epidemiology (HuGE) Navigator
GPR161
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR161
genes like me logo Genes that share disorders with GPR161: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR161 Gene

Publications for GPR161 Gene

  1. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 46 64
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for GPR161 Gene

Sources for GPR161 Gene

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