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Aliases for GPR161 Gene

Aliases for GPR161 Gene

  • G Protein-Coupled Receptor 161 2 3 5
  • G-Protein Coupled Receptor RE2 3 4
  • G-Protein Coupled Receptor 161 3
  • RE2 3

External Ids for GPR161 Gene

Previous GeneCards Identifiers for GPR161 Gene

  • GC01M165241
  • GC01M164780
  • GC01M166321
  • GC01M139298

Summaries for GPR161 Gene

Entrez Gene Summary for GPR161 Gene

  • The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]

GeneCards Summary for GPR161 Gene

GPR161 (G Protein-Coupled Receptor 161) is a Protein Coding gene. Diseases associated with GPR161 include Pituitary Stalk Interruption Syndrome and Spindle Cell Hemangioma. Among its related pathways are Signaling by Hedgehog and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled amine receptor activity. An important paralog of this gene is GPR101.

UniProtKB/Swiss-Prot for GPR161 Gene

  • Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Gene Wiki entry for GPR161 Gene

Additional gene information for GPR161 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR161 Gene

Genomics for GPR161 Gene

GeneHancer (GH) Regulatory Elements for GPR161 Gene

Promoters and enhancers for GPR161 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I168135 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.9 937 2.3 RB1 KLF17 MZF1 ZNF76 SIN3A GLI4 ZNF2 ZNF335 GLIS2 ZNF213 GPR161 TIPRL SFT2D2 MPC2 GC01M168079 GC01M168113
GH01I168121 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 550.4 +16.0 15955 1.3 NR2F2 GPR161 TBX19 MPC2 TIPRL GC01M168079 GC01M168113
GH01I168177 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 7.5 -41.7 -41652 2.9 HDGF HNRNPUL1 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TIPRL MPZL1 POU2F1 GPR161 MPC2 RPL34P1 GC01M168113
GH01I168112 Enhancer 1 Ensembl ENCODE 12.4 +24.5 24527 0.9 PKNOX1 SMAD1 NFIB MZF1 ZNF195 ZNF366 ZNF350 FOS ZNF174 ZNF680 POU2F1 GPR161 ENSG00000272205 TBX19 GC01M168079
GH01I168093 Enhancer 0.6 ENCODE 11.5 +44.5 44489 0.2 ELF3 CTCF REST CEBPG ELF1 RAD21 TEAD3 CC2D1A SMARCA4 IKZF1 GPR161 TIPRL GC01M168079
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR161 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR161 gene promoter:

Genomic Locations for GPR161 Gene

Genomic Locations for GPR161 Gene
chr1:168,079,542-168,137,667
(GRCh38/hg38)
Size:
58,126 bases
Orientation:
Minus strand
chr1:168,053,997-168,106,821
(GRCh37/hg19)

Genomic View for GPR161 Gene

Genes around GPR161 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR161 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR161 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR161 Gene

Proteins for GPR161 Gene

  • Protein details for GPR161 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6U8-GP161_HUMAN
    Recommended name:
    G-protein coupled receptor 161
    Protein Accession:
    Q8N6U8
    Secondary Accessions:
    • B3KV34
    • B7Z5D7
    • B7Z5E8
    • B7Z5Z6
    • F5GXD6
    • F5H6J7
    • O75963
    • Q5TGK0
    • Q5TGK1
    • Q5TGK2

    Protein attributes for GPR161 Gene

    Size:
    529 amino acids
    Molecular mass:
    58559 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR161 Gene

neXtProt entry for GPR161 Gene

Post-translational modifications for GPR161 Gene

  • Glycosylation at posLast=44 and isoforms=2, 615

No data available for DME Specific Peptides for GPR161 Gene

Domains & Families for GPR161 Gene

Gene Families for GPR161 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for GPR161 Gene

Suggested Antigen Peptide Sequences for GPR161 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6U8

UniProtKB/Swiss-Prot:

GP161_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR161: view

Function for GPR161 Gene

Molecular function for GPR161 Gene

UniProtKB/Swiss-Prot Function:
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Phenotypes From GWAS Catalog for GPR161 Gene

Gene Ontology (GO) - Molecular Function for GPR161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity ISS --
genes like me logo Genes that share ontologies with GPR161: view
genes like me logo Genes that share phenotypes with GPR161: view

Human Phenotype Ontology for GPR161 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GPR161 Gene

MGI Knock Outs for GPR161:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GPR161 Gene

Localization for GPR161 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR161 Gene

Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR161 gene
Compartment Confidence
plasma membrane 5
endosome 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005929 cilium ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with GPR161: view

Pathways & Interactions for GPR161 Gene

genes like me logo Genes that share pathways with GPR161: view

Pathways by source for GPR161 Gene

1 BioSystems pathway for GPR161 Gene
1 KEGG pathway for GPR161 Gene

Gene Ontology (GO) - Biological Process for GPR161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway ISS --
GO:0007275 multicellular organism development IEA --
GO:0030819 positive regulation of cAMP biosynthetic process IEA,ISS --
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning ISS,IEA --
genes like me logo Genes that share ontologies with GPR161: view

No data available for SIGNOR curated interactions for GPR161 Gene

Drugs & Compounds for GPR161 Gene

No Compound Related Data Available

Transcripts for GPR161 Gene

Unigene Clusters for GPR161 Gene

G protein-coupled receptor 161:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR161 Gene

No ASD Table

Relevant External Links for GPR161 Gene

GeneLoc Exon Structure for
GPR161
ECgene alternative splicing isoforms for
GPR161

Expression for GPR161 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR161 Gene

mRNA differential expression in normal tissues according to GTEx for GPR161 Gene

This gene is overexpressed in Uterus (x5.8).

NURSA nuclear receptor signaling pathways regulating expression of GPR161 Gene:

GPR161

SOURCE GeneReport for Unigene cluster for GPR161 Gene:

Hs.271809

Evidence on tissue expression from TISSUES for GPR161 Gene

  • Nervous system(4.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR161 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
Organs:
Head and neck:
  • brain
  • ear
  • eye
  • head
  • hypothalamus
  • neck
  • pituitary gland
  • thyroid
Thorax:
  • heart
  • lung
Abdomen:
  • adrenal gland
  • intestine
  • large intestine
  • small intestine
Pelvis:
  • penis
  • uterus
General:
  • blood
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • sweat gland
genes like me logo Genes that share expression patterns with GPR161: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GPR161 Gene

Orthologs for GPR161 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR161 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR161 33
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia GPR161 33 34
  • 90.55 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR161 34
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR161 33 34
  • 88.57 (n)
rat
(Rattus norvegicus)
Mammalia Gpr161 33
  • 88.36 (n)
mouse
(Mus musculus)
Mammalia Gpr161 33 16 34
  • 88.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR161 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR161 33 34
  • 76.39 (n)
lizard
(Anolis carolinensis)
Reptilia GPR161 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr161 33
  • 66.67 (n)
Str.10351 33
zebrafish
(Danio rerio)
Actinopterygii gpr161 33 34
  • 67.35 (n)
GPR161 (2 of 2) 34
  • 60 (a)
OneToMany
Species where no ortholog for GPR161 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR161 Gene

ENSEMBL:
Gene Tree for GPR161 (if available)
TreeFam:
Gene Tree for GPR161 (if available)

Paralogs for GPR161 Gene

Paralogs for GPR161 Gene

genes like me logo Genes that share paralogs with GPR161: view

Variants for GPR161 Gene

Sequence variations from dbSNP and Humsavar for GPR161 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs200635937 uncertain-significance, likely-pathogenic, not provided, Pituitary stalk interruption syndrome 168,104,855(-) A/T 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant
rs200664972 benign, not specified 168,136,344(-) GGGGG/GGGGGG 5_prime_UTR_variant, coding_sequence_variant, frameshift, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000085009 -- 168,102,994(-) T/G intron_variant
rs1000105416 -- 168,094,870(-) T/C intron_variant
rs1000133741 -- 168,104,113(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR161 Gene

Variant ID Type Subtype PubMed ID
esv2666700 CNV deletion 23128226
esv2719239 CNV deletion 23290073
esv32660 CNV loss 17666407
esv3587858 CNV loss 21293372
nsv1078878 OTHER inversion 25765185
nsv1079039 CNV deletion 25765185
nsv1120074 OTHER inversion 24896259
nsv441719 CNV loss 18776908
nsv506964 OTHER sequence alteration 20534489
nsv825309 CNV loss 20364138

Variation tolerance for GPR161 Gene

Residual Variation Intolerance Score: 8.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR161 Gene

Human Gene Mutation Database (HGMD)
GPR161
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR161

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR161 Gene

Disorders for GPR161 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR161 Gene - From: HGMD, Orphanet, and DISEASES

Disorder Aliases PubMed IDs
pituitary stalk interruption syndrome
  • ectopic neurohypophysis
spindle cell hemangioma
  • sch
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR161

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR161: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR161 Gene

Publications for GPR161 Gene

  1. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 44 58
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GPR161 Gene

Sources for GPR161 Gene

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