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Aliases for GPR161 Gene

Aliases for GPR161 Gene

  • G Protein-Coupled Receptor 161 2 3 5
  • G-Protein Coupled Receptor RE2 3 4
  • RE2 3

External Ids for GPR161 Gene

Previous GeneCards Identifiers for GPR161 Gene

  • GC01M165241
  • GC01M164780
  • GC01M166321
  • GC01M139298

Summaries for GPR161 Gene

Entrez Gene Summary for GPR161 Gene

  • Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]).[supplied by OMIM, Aug 2008]

GeneCards Summary for GPR161 Gene

GPR161 (G Protein-Coupled Receptor 161) is a Protein Coding gene. Diseases associated with GPR161 include pituitary stalk interruption syndrome and hcl-v. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled amine receptor activity. An important paralog of this gene is GPR176.

UniProtKB/Swiss-Prot for GPR161 Gene

  • Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Gene Wiki entry for GPR161 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR161 Gene

Genomics for GPR161 Gene

Regulatory Elements for GPR161 Gene

Promoters for GPR161 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR161 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR161 Gene

Chromosome:
1
Start:
168,079,542 bp from pter
End:
168,137,667 bp from pter
Size:
58,126 bases
Orientation:
Minus strand

Genomic View for GPR161 Gene

Genes around GPR161 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR161 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR161 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR161 Gene

Proteins for GPR161 Gene

  • Protein details for GPR161 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6U8-GP161_HUMAN
    Recommended name:
    G-protein coupled receptor 161
    Protein Accession:
    Q8N6U8
    Secondary Accessions:
    • B3KV34
    • B7Z5D7
    • B7Z5E8
    • B7Z5Z6
    • F5GXD6
    • F5H6J7
    • O75963
    • Q5TGK0
    • Q5TGK1
    • Q5TGK2

    Protein attributes for GPR161 Gene

    Size:
    529 amino acids
    Molecular mass:
    58559 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR161 Gene

neXtProt entry for GPR161 Gene

Proteomics data for GPR161 Gene at MOPED

Post-translational modifications for GPR161 Gene

  • Glycosylation at Asn 4 and Asn 15
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GPR161 Gene

Domains & Families for GPR161 Gene

Gene Families for GPR161 Gene

Protein Domains for GPR161 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR161 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6U8

UniProtKB/Swiss-Prot:

GP161_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR161: view

Function for GPR161 Gene

Molecular function for GPR161 Gene

UniProtKB/Swiss-Prot Function:
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
genes like me logo Genes that share phenotypes with GPR161: view

Human Phenotype Ontology for GPR161 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GPR161 Gene

MGI Knock Outs for GPR161:

Animal Model Products

miRNA for GPR161 Gene

miRTarBase miRNAs that target GPR161

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for GPR161 Gene

Localization for GPR161 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR161 Gene

Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR161 Gene COMPARTMENTS Subcellular localization image for GPR161 gene
Compartment Confidence
plasma membrane 5
endosome 4
nucleus 2

Gene Ontology (GO) - Cellular Components for GPR161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030666 endocytic vesicle membrane TAS --
GO:0060170 ciliary membrane TAS --
genes like me logo Genes that share ontologies with GPR161: view

Pathways & Interactions for GPR161 Gene

genes like me logo Genes that share pathways with GPR161: view

Pathways by source for GPR161 Gene

1 BioSystems pathway for GPR161 Gene

Interacting Proteins for GPR161 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000271357%0d%0a9606.ENSP00000309591%0d%0a9606.ENSP00000349238%0d%0a9606.ENSP00000386444%0d%0a
Selected Interacting proteins: ENSP00000271357 for GPR161 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,ISS --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with GPR161: view

No data available for SIGNOR curated interactions for GPR161 Gene

Drugs & Compounds for GPR161 Gene

No Compound Related Data Available

Transcripts for GPR161 Gene

Unigene Clusters for GPR161 Gene

G protein-coupled receptor 161:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR161 Gene

No ASD Table

Relevant External Links for GPR161 Gene

GeneLoc Exon Structure for
GPR161
ECgene alternative splicing isoforms for
GPR161

Expression for GPR161 Gene

mRNA expression in normal human tissues for GPR161 Gene

mRNA differential expression in normal tissues according to GTEx for GPR161 Gene

This gene is overexpressed in Uterus (x5.8).

SOURCE GeneReport for Unigene cluster for GPR161 Gene Hs.271809

genes like me logo Genes that share expression patterns with GPR161: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR161 Gene

Orthologs for GPR161 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR161 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR161 35
  • 99.24 (n)
  • 99.18 (a)
cow
(Bos Taurus)
Mammalia GPR161 36
  • 90 (a)
OneToOne
GPR161 35
  • 88.57 (n)
  • 90.15 (a)
dog
(Canis familiaris)
Mammalia GPR161 35
  • 90.55 (n)
  • 93 (a)
GPR161 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr161 16
Gpr161 35
  • 88.28 (n)
  • 92.63 (a)
Gpr161 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR161 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR161 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr161 35
  • 88.36 (n)
  • 93.17 (a)
chicken
(Gallus gallus)
Aves GPR161 35
  • 76.39 (n)
  • 83.3 (a)
GPR161 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR161 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr161 35
  • 66.67 (n)
  • 73.42 (a)
Str.10351 35
zebrafish
(Danio rerio)
Actinopterygii gpr161 36
  • 65 (a)
OneToMany
GPR161 (2 of 2) 36
  • 60 (a)
OneToMany
gpr161 35
  • 67.35 (n)
  • 69.9 (a)
Species with no ortholog for GPR161:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR161 Gene

ENSEMBL:
Gene Tree for GPR161 (if available)
TreeFam:
Gene Tree for GPR161 (if available)

Paralogs for GPR161 Gene

Paralogs for GPR161 Gene

genes like me logo Genes that share paralogs with GPR161: view

Variants for GPR161 Gene

Sequence variations from dbSNP and Humsavar for GPR161 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs275138 -- 168,084,164(+) GTGAC(C/T)CTGCC utr-variant-3-prime
rs275139 -- 168,085,162(+) GAAGA(A/G)GAGGA utr-variant-3-prime
rs275140 -- 168,085,885(+) ACCCC(A/G)GGGAG intron-variant
rs275141 -- 168,086,213(+) TAACA(A/G)AACTT intron-variant
rs275142 -- 168,086,483(+) GGCAA(A/C)CTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR161 Gene

Variant ID Type Subtype PubMed ID
esv32660 CNV Loss 17666407
nsv872525 CNV Gain 21882294
nsv506964 CNV Insertion 20534489
esv2666700 CNV Deletion 23128226
esv2719239 CNV Deletion 23290073
nsv441719 CNV CNV 18776908
nsv825309 CNV Loss 20364138

Variation tolerance for GPR161 Gene

Residual Variation Intolerance Score: 8.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR161 Gene

HapMap Linkage Disequilibrium report
GPR161
Human Gene Mutation Database (HGMD)
GPR161

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR161 Gene

Disorders for GPR161 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GPR161 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
pituitary stalk interruption syndrome
  • ectopic neurohypophysis
hcl-v
  • hairy cell leukaemia variant
spindle cell hemangioma
  • sch
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPR161

Genetic Association Database (GAD)
GPR161
Human Genome Epidemiology (HuGE) Navigator
GPR161
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR161
genes like me logo Genes that share disorders with GPR161: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR161 Gene

Publications for GPR161 Gene

  1. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 48 67
  2. False positive non-synonymous polymorphisms of G-protein coupled receptor genes. (PMID: 11959142) Small K.M. … Liggett S.B. (FEBS Lett. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. (PMID: 24599592) Feigin M.E. … Muthuswamy S.K. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3

Products for GPR161 Gene

Sources for GPR161 Gene

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